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Search results 1 to 100 out of 103 for Gpr4

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Type Details Score
Gene
2828 | GPR4
Type: gene
Organism: human
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Gene
512876 | GPR4
Type: gene
Organism: cattle
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Gene
428904 | GPR4
Type: gene
Organism: chicken
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Gene
563762 | gpr4
Type: gene
Organism: zebrafish
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Gene
716148 | GPR4
Type: gene
Organism: macaque, rhesus
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Gene
100490705 | gpr4
Type: gene
Organism: frog, western clawed
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Gene
308408 | Gpr4
Type: gene
Organism: rat
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Gene
484440 | GPR4
Type: gene
Organism: dog, domestic
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Gene
468922 | GPR4
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:2441992 | Gpr4
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
35165253 | J:321623
First Author: Li R
Year: 2022
Journal: Cell Death Dis
Title: The proton-activated G protein-coupled receptor GPR4 regulates the development of osteoarthritis via modulating CXCL12/CXCR7 signaling.
Volume: 13
Issue: 2
Pages: 152
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Publication
20798260 | J:185906
First Author: Sun X
Year: 2010
Journal: J Am Soc Nephrol
Title: Deletion of the pH sensor GPR4 decreases renal acid excretion.
Volume: 21
Issue: 10
Pages: 1745-55
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Publication
32058960 | J:287083
First Author: Krewson EA
Year: 2020
Journal: iScience
Title: The Proton-Sensing GPR4 Receptor Regulates Paracellular Gap Formation and Permeability of Vascular Endothelial Cells.
Volume: 23
Issue: 2
Pages: 100848
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Publication
27940273 | J:255680
First Author: Sanderlin EJ
Year: 2017
Journal: Biochim Biophys Acta
Title: GPR4 deficiency alleviates intestinal inflammation in a mouse model of acute experimental colitis.
Volume: 1863
Issue: 2
Pages: 569-584
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Publication
26068853 | J:224758
First Author: Kumar NN
Year: 2015
Journal: Science
Title: PHYSIOLOGY. Regulation of breathing by CO₂ requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons.
Volume: 348
Issue: 6240
Pages: 1255-60
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Publication
29089376 | J:328966
First Author: Dong B
Year: 2017
Journal: Biochem J
Title: GPR4 knockout improves renal ischemia-reperfusion injury and inhibits apoptosis via suppressing the expression of CHOP.
Volume: 474
Issue: 24
Pages: 4065-4074
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Publication
17145776 | J:118276
First Author: Yang LV
Year: 2007
Journal: Mol Cell Biol
Title: Vascular abnormalities in mice deficient for the G protein-coupled receptor GPR4 that functions as a pH sensor.
Volume: 27
Issue: 4
Pages: 1334-47
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Publication
27681561 | J:283503
First Author: Sun X
Year: 2016
Journal: Am J Physiol Renal Physiol
Title: Deletion of proton-sensing receptor GPR4 associates with lower blood pressure and lower binding of angiotensin II receptor in SFO.
Volume: 311
Issue: 6
Pages: F1260-F1266
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Publication
29894771 | J:317615
 
First Author: Hosford PS
Year: 2018
Journal: Neuropharmacology
Title: CNS distribution, signalling properties and central effects of G-protein coupled receptor 4.
Volume: 138
Pages: 381-392
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Publication
22045552 | J:232324
First Author: Wyder L
Year: 2011
Journal: Angiogenesis
Title: Reduced pathological angiogenesis and tumor growth in mice lacking GPR4, a proton sensing receptor.
Volume: 14
Issue: 4
Pages: 533-44
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Publication
25343248 | J:222480
First Author: Dong B
Year: 2014
Journal: PLoS One
Title: Ischemia/reperfusion-induced CHOP expression promotes apoptosis and impairs renal function recovery: the role of acidosis and GPR4.
Volume: 9
Issue: 10
Pages: e110944
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Publication
25972512 | J:281320
First Author: Sun X
Year: 2015
Journal: Am J Physiol Renal Physiol
Title: Adaptation by the collecting duct to an exogenous acid load is blunted by deletion of the proton-sensing receptor GPR4.
Volume: 309
Issue: 2
Pages: F120-36
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Protein Coding Gene
MGP_CAROLIEiJ_G0029278 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0031765 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0031741 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0031667 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0031746 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0031468 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2441992 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0032212 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0030811 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0031430 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0031585 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0031537 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0031668 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0031573 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0032240 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0030535 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0030911 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0021138 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0030362 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
     
Probe: MGI:3694349
Assay Type: RT-PCR
Annotation Date: 2007-01-23
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1754424
Stage: TS24
Assay Id: MGI:3694356
Age: embryonic day 16.0
Image: 5
Specimen Label: E16
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3694349
Assay Type: RT-PCR
Annotation Date: 2007-01-23
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1754427
Stage: TS27
Assay Id: MGI:3694356
Age: postnatal day 1
Image: 5
Specimen Label: P1
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:3694349
Assay Type: RT-PCR
Annotation Date: 2007-01-23
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:3694356
Age: postnatal day 7
Image: 5
Specimen Label: P7
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:3694349
Assay Type: RT-PCR
Annotation Date: 2007-01-23
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:3694356
Age: postnatal adult
Image: 5
Specimen Label: Adult
Specimen Num: 4
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Publication
33057165 | J:299020
First Author: Sato K
Year: 2020
Journal: Sci Rep
Title: The protective role of proton-sensing TDAG8 in the brain injury in a mouse ischemia reperfusion model.
Volume: 10
Issue: 1
Pages: 17193
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Publication
31896584 | J:283791
First Author: Wenzel J
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Impaired endothelium-mediated cerebrovascular reactivity promotes anxiety and respiration disorders in mice.
Volume: 117
Issue: 3
Pages: 1753-1761
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Publication
15927955 | J:100820
First Author: Ikeno Y
Year: 2005
Journal: J Biol Chem
Title: Secretory phospholipases A2 induce neurite outgrowth in PC12 cells through lysophosphatidylcholine generation and activation of G2A receptor.
Volume: 280
Issue: 30
Pages: 28044-52
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Publication
26196745 | J:228833
First Author: Kamide Y
Year: 2015
Journal: Biochem Biophys Res Commun
Title: Acidic environment augments FcεRI-mediated production of IL-6 and IL-13 in mast cells.
Volume: 464
Issue: 3
Pages: 949-55
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
37894341 | J:342129
 
First Author: Marie MA
Year: 2023
Journal: Cancers (Basel)
Title: GPR4 Knockout Attenuates Intestinal Inflammation and Forestalls the Development of Colitis-Associated Colorectal Cancer in Murine Models.
Volume: 15
Issue: 20
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Publication
38527054 | J:346735
First Author: Caratis F
Year: 2024
Journal: PLoS One
Title: The proton-sensing receptors TDAG8 and GPR4 are differentially expressed in human and mouse oligodendrocytes: Exploring their role in neuroinflammation and multiple sclerosis.
Volume: 19
Issue: 3
Pages: e0283060
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Allele
Gpr4<em1Gpt> | MGI:6887882
Name: G protein-coupled receptor 4; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Gpr4<tm1(cre)Skas> | MGI:7446684
Name: G protein-coupled receptor 4; targeted mutation 1, Sergey Kasparov
Allele Type: Targeted
Attribute String: Recombinase
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Allele
Tg(Gpr4-EGFP)GU23Gsat | MGI:4847103
Name: transgene insertion GU23, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Strain
MGI:5003847 | STOCK Tg(Gpr4-EGFP)GU23Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Genotype
Genotype
Symbol: Gpr4/Gpr4<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: BALB/c
Zygosity: cn
Has Mutant Allele: true
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Publication
7832990 | -
First Author: Heiber M
Year: 1995
Journal: DNA Cell Biol
Title: Isolation of three novel human genes encoding G protein-coupled receptors.
Volume: 14
Issue: 1
Pages: 25-35
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Publication
8595909 | -
First Author: Mahadevan MS
Year: 1995
Journal: Genomics
Title: Isolation of a novel G protein-coupled receptor (GPR4) localized to chromosome 19q13.3.
Volume: 30
Issue: 1
Pages: 84-8
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Protein Domain
IPR002276 | GPR4_orph
Type: Family
Description: G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups []. The term clan can be used to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence []. The currently known clan members include rhodopsin-like GPCRs (Class A, GPCRA), secretin-like GPCRs (Class B, GPCRB), metabotropic glutamate receptor family (Class C, GPCRC), fungal mating pheromone receptors (Class D, GPCRD), cAMP receptors (Class E, GPCRE) and frizzled/smoothened (Class F, GPCRF) [, , , , ]. GPCRs are major drug targets, and are consequently the subject of considerable research interest. It has been reported that the repertoire of GPCRs for endogenous ligands consists of approximately 400 receptors in humans and mice []. Most GPCRs are identified on the basis of their DNA sequences, rather than the ligand they bind, those that are unmatched to known natural ligands are designated by as orphan GPCRs, or unclassified GPCRs [].The rhodopsin-like GPCRs (GPCRA) represent a widespread protein family that includes hormone, neurotransmitter and light receptors, all of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character, the amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7 transmembrane (TM) helices [, , ].Several 7TM receptors have been cloned but their endogenous ligands are unknown; these have been termed orphan receptors. A novel GPCR (GPR4) from the critical myotonic dystrophy (DM) region on chromosome 19q13.3 has been sequenced [, ]. The gene is intronless and contain an open reading frame encoding a protein of 362amino acids. Two isoforms of GPR4 are expressed in humans, differing in their 3'untranslated region as a result of the use of alternate polyadenylation signals. GPR4 iswidely expressed, with higher levels in kidney, heart, and especially lung []. Sequenceanalysis suggests that GPR4 is a peptide receptor; it shares strongest similarity withpurinergic receptors and receptors for angiotensin II, platelet activating factor, thrombinand bradykinin [, ].
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Publication
15665078 | J:96112
First Author: Radu CG
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells.
Volume: 102
Issue: 5
Pages: 1632-7
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Publication
26117715 | J:225720
 
First Author: Ail D
Year: 2015
Journal: Neuroscience
Title: Increased expression of the proton-sensing G protein-coupled receptor Gpr65 during retinal degeneration.
Volume: 301
Pages: 496-507
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Protein
Q8BUD0
Organism: Mus musculus/domesticus
Length: 365  
Fragment?: false
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Protein
Q80T57
Organism: Mus musculus/domesticus
Length: 150  
Fragment?: true
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Publication
24613842 | J:219128
First Author: Takahashi M
Year: 2014
Journal: Biochem Biophys Res Commun
Title: Identification of gene expression profile of neural crest-derived cells isolated from submandibular glands of adult mice.
Volume: 446
Issue: 2
Pages: 481-6
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Publication
29066557 | J:250838
First Author: Shi Y
Year: 2017
Journal: J Neurosci
Title: Neuromedin B Expression Defines the Mouse Retrotrapezoid Nucleus.
Volume: 37
Issue: 48
Pages: 11744-11757
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Publication
2111655 | -
 
First Author: Birnbaumer L
Year: 1990
Journal: Annu Rev Pharmacol Toxicol
Title: G proteins in signal transduction.
Volume: 30
Pages: 675-705
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Publication
2830256 | -
First Author: Casey PJ
Year: 1988
Journal: J Biol Chem
Title: G protein involvement in receptor-effector coupling.
Volume: 263
Issue: 6
Pages: 2577-80
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Publication
8386361 | -
First Author: Attwood TK
Year: 1993
Journal: Protein Eng
Title: Design of a discriminating fingerprint for G-protein-coupled receptors.
Volume: 6
Issue: 2
Pages: 167-76
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Publication
12679517 | J:83410
First Author: Vassilatis DK
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: The G protein-coupled receptor repertoires of human and mouse.
Volume: 100
Issue: 8
Pages: 4903-8
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Publication
8170923 | -
First Author: Attwood TK
Year: 1994
Journal: Protein Eng
Title: Fingerprinting G-protein-coupled receptors.
Volume: 7
Issue: 2
Pages: 195-203
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Publication
8081729 | -
First Author: Kolakowski LF Jr
Year: 1994
Journal: Receptors Channels
Title: GCRDb: a G-protein-coupled receptor database.
Volume: 2
Issue: 1
Pages: 1-7
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Publication
15914470 | -
First Author: Foord SM
Year: 2005
Journal: Pharmacol Rev
Title: International Union of Pharmacology. XLVI. G protein-coupled receptor list.
Volume: 57
Issue: 2
Pages: 279-88
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Publication
18948278 | -
First Author: Harmar AJ
Year: 2009
Journal: Nucleic Acids Res
Title: IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels.
Volume: 37
Issue: Database issue
Pages: D680-5
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