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Search results 1 to 100 out of 904 for Gpx4

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0.043s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: guinea pig
Gene
Type: gene
Organism: rat
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Liang H
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Gpx4 protects mitochondrial ATP generation against oxidative damage.
Volume: 356
Issue: 4
Pages: 893-8
Protein
Organism: Mus musculus/domesticus
Length: 253  
Fragment?: false
Publication
First Author: Jia M
Year: 2020
Journal: Nat Immunol
Title: Redox homeostasis maintained by GPX4 facilitates STING activation.
Volume: 21
Issue: 7
Pages: 727-735
Publication
First Author: Ingold I
Year: 2018
Journal: Cell
Title: Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis.
Volume: 172
Issue: 3
Pages: 409-422.e21
Publication
First Author: Imai H
Year: 2009
Journal: J Biol Chem
Title: Depletion of selenoprotein GPx4 in spermatocytes causes male infertility in mice.
Volume: 284
Issue: 47
Pages: 32522-32
Publication
First Author: Chen L
Year: 2021
Journal: Sci Rep
Title: Overexpression of ferroptosis defense enzyme Gpx4 retards motor neuron disease of SOD1G93A mice.
Volume: 11
Issue: 1
Pages: 12890
Publication
First Author: Scimeca MS
Year: 2005
Journal: Exp Biol Med (Maywood)
Title: Effects of gpx4 haploid insufficiency on GPx4 activity, selenium concentration, and paraquat-induced protein oxidation in murine tissues.
Volume: 230
Issue: 10
Pages: 709-14
Publication
First Author: Yant LJ
Year: 2003
Journal: Free Radic Biol Med
Title: The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults.
Volume: 34
Issue: 4
Pages: 496-502
Publication
First Author: Garry MR
Year: 2008
Journal: Free Radic Biol Med
Title: Sensitivity of mouse lung fibroblasts heterozygous for GPx4 to oxidative stress.
Volume: 44
Issue: 6
Pages: 1075-87
Publication  
First Author: Li H
Year: 2023
Journal: Biochem Biophys Res Commun
Title: GPX4 aggravates experimental autoimmune encephalomyelitis by inhibiting the functions of CD4(+) T cells.
Volume: 642
Pages: 57-65
Publication
First Author: Mannes AM
Year: 2011
Journal: FASEB J
Title: Cysteine mutant of mammalian GPx4 rescues cell death induced by disruption of the wild-type selenoenzyme.
Volume: 25
Issue: 7
Pages: 2135-44
Publication
First Author: Li J
Year: 2023
Journal: Sci Transl Med
Title: Tumor-specific GPX4 degradation enhances ferroptosis-initiated antitumor immune response in mouse models of pancreatic cancer.
Volume: 15
Issue: 720
Pages: eadg3049
Publication
First Author: Yoo SE
Year: 2012
Journal: Free Radic Biol Med
Title: Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain.
Volume: 52
Issue: 9
Pages: 1820-7
Publication
First Author: Schwärzler J
Year: 2022
Journal: Int J Obes (Lond)
Title: Adipocyte GPX4 protects against inflammation, hepatic insulin resistance and metabolic dysregulation.
Volume: 46
Issue: 5
Pages: 951-959
Publication
First Author: Muri J
Year: 2019
Journal: Cell Rep
Title: B1 and Marginal Zone B Cells but Not Follicular B2 Cells Require Gpx4 to Prevent Lipid Peroxidation and Ferroptosis.
Volume: 29
Issue: 9
Pages: 2731-2744.e4
Publication
First Author: Katunga LA
Year: 2015
Journal: Mol Metab
Title: Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy.
Volume: 4
Issue: 6
Pages: 493-506
Publication
First Author: Xu C
Year: 2021
Journal: Cell Rep
Title: The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity.
Volume: 35
Issue: 11
Pages: 109235
Publication
First Author: Friedmann Angeli JP
Year: 2014
Journal: Nat Cell Biol
Title: Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice.
Volume: 16
Issue: 12
Pages: 1180-91
Publication
First Author: Ran Q
Year: 2004
Journal: J Biol Chem
Title: Transgenic mice overexpressing glutathione peroxidase 4 are protected against oxidative stress-induced apoptosis.
Volume: 279
Issue: 53
Pages: 55137-46
Publication  
First Author: Czyżowska A
Year: 2023
Journal: Redox Biol
Title: Elevated phospholipid hydroperoxide glutathione peroxidase (GPX4) expression modulates oxylipin formation and inhibits age-related skeletal muscle atrophy and weakness.
Volume: 64
Pages: 102761
Publication
First Author: Ingold I
Year: 2015
Journal: J Biol Chem
Title: Expression of a Catalytically Inactive Mutant Form of Glutathione Peroxidase 4 (Gpx4) Confers a Dominant-negative Effect in Male Fertility.
Volume: 290
Issue: 23
Pages: 14668-78
Publication
First Author: Liang H
Year: 2009
Journal: Free Radic Biol Med
Title: Glutathione peroxidase 4 differentially regulates the release of apoptogenic proteins from mitochondria.
Volume: 47
Issue: 3
Pages: 312-20
Publication
First Author: Yoshida M
Year: 2019
Journal: Nat Commun
Title: Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis.
Volume: 10
Issue: 1
Pages: 3145
Publication
First Author: Koulajian K
Year: 2013
Journal: Am J Physiol Endocrinol Metab
Title: Overexpression of glutathione peroxidase 4 prevents β-cell dysfunction induced by prolonged elevation of lipids in vivo.
Volume: 305
Issue: 2
Pages: E254-62
Publication
First Author: Roggia MF
Year: 2014
Journal: PLoS One
Title: Protective role of glutathione peroxidase 4 in laser-induced choroidal neovascularization in mice.
Volume: 9
Issue: 6
Pages: e98864
Publication
First Author: Tsubouchi K
Year: 2019
Journal: J Immunol
Title: Involvement of GPx4-Regulated Lipid Peroxidation in Idiopathic Pulmonary Fibrosis Pathogenesis.
Volume: 203
Issue: 8
Pages: 2076-2087
Publication
First Author: Ueta T
Year: 2012
Journal: J Biol Chem
Title: Glutathione peroxidase 4 is required for maturation of photoreceptor cells.
Volume: 287
Issue: 10
Pages: 7675-82
Publication  
First Author: Tadokoro T
Year: 2020
Journal: JCI Insight
Title: Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity.
Volume: 5
Issue: 9
Publication
First Author: Brütsch SH
Year: 2015
Journal: Antioxid Redox Signal
Title: Expression of inactive glutathione peroxidase 4 leads to embryonic lethality, and inactivation of the Alox15 gene does not rescue such knock-in mice.
Volume: 22
Issue: 4
Pages: 281-93
Publication
First Author: Ran Q
Year: 2007
Journal: J Gerontol A Biol Sci Med Sci
Title: Reduction in glutathione peroxidase 4 increases life span through increased sensitivity to apoptosis.
Volume: 62
Issue: 9
Pages: 932-42
Publication
First Author: Mayr L
Year: 2020
Journal: Nat Commun
Title: Dietary lipids fuel GPX4-restricted enteritis resembling Crohn's disease.
Volume: 11
Issue: 1
Pages: 1775
Publication
First Author: Schneider M
Year: 2009
Journal: FASEB J
Title: Mitochondrial glutathione peroxidase 4 disruption causes male infertility.
Volume: 23
Issue: 9
Pages: 3233-42
Publication  
First Author: Hambright WS
Year: 2017
Journal: Redox Biol
Title: Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration.
Volume: 12
Pages: 8-17
Publication
First Author: Liang H
Year: 2009
Journal: J Biol Chem
Title: Short form glutathione peroxidase 4 is the essential isoform required for survival and somatic mitochondrial functions.
Volume: 284
Issue: 45
Pages: 30836-44
Publication
First Author: Altamura S
Year: 2020
Journal: Haematologica
Title: Glutathione peroxidase 4 and vitamin E control reticulocyte maturation, stress erythropoiesis and iron homeostasis.
Volume: 105
Issue: 4
Pages: 937-950
Publication
First Author: Azuma K
Year: 2022
Journal: J Biol Chem
Title: Mitochondrial glutathione peroxidase 4 is indispensable for photoreceptor development and survival in mice.
Volume: 298
Issue: 4
Pages: 101824
Publication
First Author: Borchert A
Year: 2006
Journal: J Biol Chem
Title: The role of phospholipid hydroperoxide glutathione peroxidase isoforms in murine embryogenesis.
Volume: 281
Issue: 28
Pages: 19655-64
Publication
First Author: Chen L
Year: 2015
Journal: J Biol Chem
Title: Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis.
Volume: 290
Issue: 47
Pages: 28097-106
Publication
First Author: Wortmann M
Year: 2013
Journal: Circ Res
Title: Combined deficiency in glutathione peroxidase 4 and vitamin E causes multiorgan thrombus formation and early death in mice.
Volume: 113
Issue: 4
Pages: 408-17
Publication
First Author: Canli Ö
Year: 2016
Journal: Blood
Title: Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors.
Volume: 127
Issue: 1
Pages: 139-48
Publication
First Author: Sakai O
Year: 2015
Journal: PLoS One
Title: Role of Glutathione Peroxidase 4 in Glutamate-Induced Oxytosis in the Retina.
Volume: 10
Issue: 6
Pages: e0130467
Publication
First Author: Ufer C
Year: 2008
Journal: Genes Dev
Title: Translational regulation of glutathione peroxidase 4 expression through guanine-rich sequence-binding factor 1 is essential for embryonic brain development.
Volume: 22
Issue: 13
Pages: 1838-50
Publication
First Author: Su D
Year: 2005
Journal: J Biol Chem
Title: Mammalian selenoprotein thioredoxin-glutathione reductase. Roles in disulfide bond formation and sperm maturation.
Volume: 280
Issue: 28
Pages: 26491-8
Publication
First Author: Wirth EK
Year: 2010
Journal: FASEB J
Title: Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration.
Volume: 24
Issue: 3
Pages: 844-52
Publication  
First Author: Carlson BA
Year: 2016
Journal: Redox Biol
Title: Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration.
Volume: 9
Pages: 22-31
Publication
First Author: Brütsch SH
Year: 2016
Journal: J Biol Chem
Title: Male Subfertility Induced by Heterozygous Expression of Catalytically Inactive Glutathione Peroxidase 4 Is Rescued in Vivo by Systemic Inactivation of the Alox15 Gene.
Volume: 291
Issue: 45
Pages: 23578-23588
Publication
First Author: Tonnus W
Year: 2021
Journal: Nat Commun
Title: Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury.
Volume: 12
Issue: 1
Pages: 4402
Publication
First Author: Sengupta A
Year: 2013
Journal: J Invest Dermatol
Title: Targeted disruption of glutathione peroxidase 4 in mouse skin epithelial cells impairs postnatal hair follicle morphogenesis that is partially rescued through inhibition of COX-2.
Volume: 133
Issue: 7
Pages: 1731-41
Publication  
First Author: Soria-Tiedemann M
Year: 2022
Journal: Int J Mol Sci
Title: Unbalanced Expression of Glutathione Peroxidase 4 and Arachidonate 15-Lipoxygenase Affects Acrosome Reaction and In Vitro Fertilization.
Volume: 23
Issue: 17
Publication
First Author: Li P
Year: 2021
Journal: Nat Immunol
Title: Glutathione peroxidase 4-regulated neutrophil ferroptosis induces systemic autoimmunity.
Volume: 22
Issue: 9
Pages: 1107-1117
Publication
First Author: Dai E
Year: 2020
Journal: Nat Commun
Title: Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173/STING-dependent DNA sensor pathway.
Volume: 11
Issue: 1
Pages: 6339
Publication
First Author: Kang R
Year: 2018
Journal: Cell Host Microbe
Title: Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis.
Volume: 24
Issue: 1
Pages: 97-108.e4
Publication  
First Author: Fradejas-Villar N
Year: 2021
Journal: Redox Biol
Title: Missense mutation in selenocysteine synthase causes cardio-respiratory failure and perinatal death in mice which can be compensated by selenium-independent GPX4.
Volume: 48
Pages: 102188
Publication
First Author: Seiler A
Year: 2008
Journal: Cell Metab
Title: Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death.
Volume: 8
Issue: 3
Pages: 237-48
Publication
First Author: Matsushita M
Year: 2015
Journal: J Exp Med
Title: T cell lipid peroxidation induces ferroptosis and prevents immunity to infection.
Volume: 212
Issue: 4
Pages: 555-68
Publication  
First Author: Schriever SC
Year: 2017
Journal: Neuroscience
Title: Alterations in neuronal control of body weight and anxiety behavior by glutathione peroxidase 4 deficiency.
Volume: 357
Pages: 241-254
Publication
First Author: Lv Y
Year: 2023
Journal: FASEB J
Title: Estrogen deficiency accelerates postmenopausal atherosclerosis by inducing endothelial cell ferroptosis through inhibiting NRF2/GPX4 pathway.
Volume: 37
Issue: 6
Pages: e22992
Strain
Attribute String: targeted mutation, mutant strain, congenic
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Pfeifer H
Year: 2001
Journal: FASEB J
Title: Identification of a specific sperm nuclei selenoenzyme necessary for protamine thiol cross-linking during sperm maturation.
Volume: 15
Issue: 7
Pages: 1236-8
Publication
First Author: Imai H
Year: 2003
Journal: Biochem Biophys Res Commun
Title: Early embryonic lethality caused by targeted disruption of the mouse PHGPx gene.
Volume: 305
Issue: 2
Pages: 278-86
Publication
First Author: Nakamura T
Year: 2003
Journal: Biochem Biophys Res Commun
Title: Molecular cloning and functional expression of nucleolar phospholipid hydroperoxide glutathione peroxidase in mammalian cells.
Volume: 311
Issue: 1
Pages: 139-48
Publication
First Author: Anderson EJ
Year: 2018
Journal: J Clin Invest
Title: A carnosine analog mitigates metabolic disorders of obesity by reducing carbonyl stress.
Volume: 128
Issue: 12
Pages: 5280-5293
Publication
First Author: Conrad M
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: 12/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases.
Volume: 107
Issue: 36
Pages: 15774-9
Publication  
First Author: Labazi M
Year: 2015
Journal: Free Radic Biol Med
Title: The antioxidant requirement for plasma membrane repair in skeletal muscle.
Volume: 84
Pages: 246-253
Publication
First Author: Conrad M
Year: 2005
Journal: Mol Cell Biol
Title: The nuclear form of phospholipid hydroperoxide glutathione peroxidase is a protein thiol peroxidase contributing to sperm chromatin stability.
Volume: 25
Issue: 17
Pages: 7637-44
Publication
First Author: Schneider M
Year: 2006
Journal: Gene Expr Patterns
Title: Embryonic expression profile of phospholipid hydroperoxide glutathione peroxidase.
Volume: 6
Issue: 5
Pages: 489-94
Publication
First Author: Puglisi R
Year: 2007
Journal: Endocrinology
Title: Mice overexpressing the mitochondrial phospholipid hydroperoxide glutathione peroxidase in male germ cells show abnormal spermatogenesis and reduced fertility.
Volume: 148
Issue: 9
Pages: 4302-9
Publication
First Author: Baseler WA
Year: 2013
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Reversal of mitochondrial proteomic loss in Type 1 diabetic heart with overexpression of phospholipid hydroperoxide glutathione peroxidase.
Volume: 304
Issue: 7
Pages: R553-65
GXD Expression      
Probe: MGI:3801481
Assay Type: RT-PCR
Annotation Date: 2008-08-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160399
Stage: TS09
Assay Id: MGI:3801576
Age: embryonic day 6.5
Specimen Label: E6.5
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3801481
Assay Type: RT-PCR
Annotation Date: 2008-08-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:3801576
Age: embryonic day 7.5
Specimen Label: E7.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3801481
Assay Type: RT-PCR
Annotation Date: 2008-08-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:3801576
Age: embryonic day 8.5
Specimen Label: E8.5
Detected: true
Specimen Num: 3