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Search results 1 to 81 out of 81 for Grap

0.043s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
10750 | GRAP
Type: gene
Organism: human
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Gene
454496 | GRAP
Type: gene
Organism: chimpanzee
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Gene
534491 | GRAP
Type: gene
Organism: cattle
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Gene
702473 | GRAP
Type: gene
Organism: macaque, rhesus
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Gene
100127598 | grap
Type: gene
Organism: frog, western clawed
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Gene
363616 | Grap
Type: gene
Organism: rat
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Gene
489534 | GRAP
Type: gene
Organism: dog, domestic
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Protein Coding Gene
MGI:1918770 | Grap
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
11971956 | J:76243
First Author: Shen R
Year: 2002
Journal: Mol Cell Biol
Title: Grap negatively regulates T-cell receptor-elicited lymphocyte proliferation and interleukin-2 induction.
Volume: 22
Issue: 10
Pages: 3230-6
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Publication
30610177 | J:273017
First Author: Li C
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Dysfunction of GRAP, encoding the GRB2-related adaptor protein, is linked to sensorineural hearing loss.
Volume: 116
Issue: 4
Pages: 1347-1352
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Protein Coding Gene
MGP_CAROLIEiJ_G0016481 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0018443 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0018412 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0018382 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0018383 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0018196 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1918770 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0018835 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0017753 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0018170 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0018279 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0018270 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0018352 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0018294 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0018876 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0017526 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0017805 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0017611 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0017316 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:6313699
Assay Type: RT-PCR
Annotation Date: 2019-06-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759725
Stage: TS25
Assay Id: MGI:6313705
Age: embryonic day 17.5
Image: 2
Specimen Label: Co
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6313699
Assay Type: RT-PCR
Annotation Date: 2019-06-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:6313705
Age: postnatal day 15
Image: 2
Specimen Label: Lu
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6313699
Assay Type: RT-PCR
Annotation Date: 2019-06-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6313705
Age: postnatal day 15
Image: 2
Specimen Label: Li
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6313699
Assay Type: RT-PCR
Annotation Date: 2019-06-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284528
Stage: TS28
Assay Id: MGI:6313705
Age: postnatal day 15
Image: 2
Specimen Label: Hi
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6313699
Assay Type: RT-PCR
Annotation Date: 2019-06-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:6313705
Age: postnatal day 15
Image: 2
Specimen Label: Cx
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6313699
Assay Type: RT-PCR
Annotation Date: 2019-06-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:6313705
Age: postnatal day 15
Image: 2
Specimen Label: Ki
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6313699
Assay Type: RT-PCR
Annotation Date: 2019-06-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Stage: TS28
Assay Id: MGI:6313705
Age: postnatal day 15
Image: 2
Specimen Label: Co
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
Probe: MGI:6313703
Assay Type: Immunohistochemistry
Annotation Date: 2019-06-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757227
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6313706
Age: postnatal day 0
Image: 2B
Note: Expression is in the fibers innervating auditory hair cells, both inner and outer, and the utricular hair cells.
Specimen Label: 2B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:6313703
Assay Type: Immunohistochemistry
Annotation Date: 2019-06-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757227
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6313706
Age: postnatal day 0
Image: S4A
Note: Expression is in the fibers innervating auditory hair cells, both inner and outer, and the utricular hair cells.
Specimen Label: S4A
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:6313703
Assay Type: Immunohistochemistry
Annotation Date: 2019-06-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757227
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6313706
Age: postnatal day 0
Image: S5A
Note: Expression is in the fibers innervating auditory hair cells, both inner and outer, and the utricular hair cells.
Specimen Label: S5A
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:6313703
Assay Type: Immunohistochemistry
Annotation Date: 2019-06-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1780227
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6313706
Age: postnatal day 0
Image: 2B
Note: Expression is in the fibers innervating auditory hair cells, both inner and outer, and the utricular hair cells.
Specimen Label: 2B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:6313703
Assay Type: Immunohistochemistry
Annotation Date: 2019-06-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1780227
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6313706
Age: postnatal day 0
Image: S4A
Note: Expression is in the fibers innervating auditory hair cells, both inner and outer, and the utricular hair cells.
Specimen Label: S4A
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:6313703
Assay Type: Immunohistochemistry
Annotation Date: 2019-06-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1780227
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6313706
Age: postnatal day 0
Image: S5A
Note: Expression is in the fibers innervating auditory hair cells, both inner and outer, and the utricular hair cells.
Specimen Label: S5A
Detected: true
Specimen Num: 3
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:68100
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
19836472 | -
First Author: Cummins TD
Year: 2010
Journal: Biochim Biophys Acta
Title: Quantitative mass spectrometry of diabetic kidney tubules identifies GRAP as a novel regulator of TGF-beta signaling.
Volume: 1804
Issue: 4
Pages: 653-61
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Allele
Grap<em1Smoc> | MGI:7290003
Name: GRB2-related adaptor protein; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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DO Term
DOID:0111642 | autosomal recessive nonsyndromic deafness 114
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Protein Domain
IPR035645 | GRAP_N_SH3
Type: Domain
Description: GRAP is a GRB-2 like adaptor protein that is highly expressed in lymphoid tissues. It acts as a negative regulator of T cell receptor (TCR)-induced lymphocyte proliferation by downregulating the signaling to the Ras/ERK pathway []. It has been identified as a regulator of TGFbeta signaling in diabetic kidney tubules and may have a role in the pathogenesis of the disease []. GRAP contains an N-terminal SH3 domain, a central SH2 domain, and a C-terminal SH3 domain.
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Publication
1372395 | J:23349
First Author: Clark SG
Year: 1992
Journal: Nature
Title: C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains.
Volume: 356
Issue: 6367
Pages: 340-4
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Protein Domain
IPR043539 | Grb2-like
Type: Family
Description: Growth factor receptor-bound protein 2 (Grb2) is an SH2 and SH3 domain-containing adaptor protein that links receptor tyrosine kinases to Ras signalling []. Grb2 interacts with the cytoplasmic tyrosine kinase ACK1 (activated Cdc42-associated kinase 1) and mediates its interaction with other receptor tyrosine kinases []. ACK1 is implicated in metastatic behaviour, cell spreading and migration, and epidermal growth factor receptor (EGFR) signalling [].Human GRAP and its Drosophila homologue, downstream of receptor kinase (drk), have been shown to have a function in hearing [].This entry includes a group of adapter proteins including Grb2, GRAP and GRAPL from humans. This entry also includes Sem-5 from Caenorhabditis elegans. Sem-5 is an adapter protein which modulates signaling mediated by several receptor tyrosine kinases such as egl-15 and let-23 probably acting upstream of let-60/ras [, ].
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Publication
1322798 | J:23345
First Author: Lowenstein EJ
Year: 1992
Journal: Cell
Title: The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling.
Volume: 70
Issue: 3
Pages: 431-42
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Publication
19815557 | -
First Author: Pao-Chun L
Year: 2009
Journal: J Biol Chem
Title: Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling.
Volume: 284
Issue: 50
Pages: 34954-63
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Publication
16547100 | -
First Author: Hopper NA
Year: 2006
Journal: Genetics
Title: The adaptor protein soc-1/Gab1 modifies growth factor receptor output in Caenorhabditis elegans.
Volume: 173
Issue: 1
Pages: 163-75
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Publication
9872323 | J:52472
First Author: Liu SK
Year: 1998
Journal: Oncogene
Title: Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc.
Volume: 17
Issue: 24
Pages: 3073-82
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Protein
Q9CX99
Organism: Mus musculus/domesticus
Length: 217  
Fragment?: false
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Protein
B1AT95
Organism: Mus musculus/domesticus
Length: 71  
Fragment?: true
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Protein
O89100
Organism: Mus musculus/domesticus
Length: 322  
Fragment?: false
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Protein
Q3U0E8
Organism: Mus musculus/domesticus
Length: 322  
Fragment?: false
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