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Search results 1 to 83 out of 83 for Grap

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
10750 | GRAP
Type: gene
Organism: human
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Gene
100127598 | grap
Type: gene
Organism: frog, western clawed
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Gene
363616 | Grap
Type: gene
Organism: rat
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Gene
489534 | GRAP
Type: gene
Organism: dog, domestic
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Gene
454496 | GRAP
Type: gene
Organism: chimpanzee
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Gene
534491 | GRAP
Type: gene
Organism: cattle
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Gene
702473 | GRAP
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1918770 | Grap
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
11971956 | J:76243
First Author: Shen R
Year: 2002
Journal: Mol Cell Biol
Title: Grap negatively regulates T-cell receptor-elicited lymphocyte proliferation and interleukin-2 induction.
Volume: 22
Issue: 10
Pages: 3230-6
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Publication
30610177 | J:273017
First Author: Li C
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Dysfunction of GRAP, encoding the GRB2-related adaptor protein, is linked to sensorineural hearing loss.
Volume: 116
Issue: 4
Pages: 1347-1352
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Protein Coding Gene
MGP_CAROLIEiJ_G0016481 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0018443 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0018412 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0018382 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0018383 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0018196 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1918770 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0018835 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0017753 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0018170 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0018279 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0018270 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0018352 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0018294 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0018876 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0017526 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0017805 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0017611 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0017316 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:6313699
Assay Type: RT-PCR
Annotation Date: 2019-06-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759725
Stage: TS25
Assay Id: MGI:6313705
Age: embryonic day 17.5
Image: 2
Specimen Label: Co
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6313699
Assay Type: RT-PCR
Annotation Date: 2019-06-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:6313705
Age: postnatal day 15
Image: 2
Specimen Label: Lu
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6313699
Assay Type: RT-PCR
Annotation Date: 2019-06-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6313705
Age: postnatal day 15
Image: 2
Specimen Label: Li
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6313699
Assay Type: RT-PCR
Annotation Date: 2019-06-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284528
Stage: TS28
Assay Id: MGI:6313705
Age: postnatal day 15
Image: 2
Specimen Label: Hi
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6313699
Assay Type: RT-PCR
Annotation Date: 2019-06-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:6313705
Age: postnatal day 15
Image: 2
Specimen Label: Cx
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6313699
Assay Type: RT-PCR
Annotation Date: 2019-06-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:6313705
Age: postnatal day 15
Image: 2
Specimen Label: Ki
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6313699
Assay Type: RT-PCR
Annotation Date: 2019-06-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Stage: TS28
Assay Id: MGI:6313705
Age: postnatal day 15
Image: 2
Specimen Label: Co
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
Probe: MGI:6313703
Assay Type: Immunohistochemistry
Annotation Date: 2019-06-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757227
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6313706
Age: postnatal day 0
Image: 2B
Note: Expression is in the fibers innervating auditory hair cells, both inner and outer, and the utricular hair cells.
Specimen Label: 2B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:6313703
Assay Type: Immunohistochemistry
Annotation Date: 2019-06-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757227
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6313706
Age: postnatal day 0
Image: S4A
Note: Expression is in the fibers innervating auditory hair cells, both inner and outer, and the utricular hair cells.
Specimen Label: S4A
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:6313703
Assay Type: Immunohistochemistry
Annotation Date: 2019-06-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757227
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6313706
Age: postnatal day 0
Image: S5A
Note: Expression is in the fibers innervating auditory hair cells, both inner and outer, and the utricular hair cells.
Specimen Label: S5A
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:6313703
Assay Type: Immunohistochemistry
Annotation Date: 2019-06-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1780227
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6313706
Age: postnatal day 0
Image: 2B
Note: Expression is in the fibers innervating auditory hair cells, both inner and outer, and the utricular hair cells.
Specimen Label: 2B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:6313703
Assay Type: Immunohistochemistry
Annotation Date: 2019-06-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1780227
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6313706
Age: postnatal day 0
Image: S4A
Note: Expression is in the fibers innervating auditory hair cells, both inner and outer, and the utricular hair cells.
Specimen Label: S4A
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:6313703
Assay Type: Immunohistochemistry
Annotation Date: 2019-06-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1780227
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6313706
Age: postnatal day 0
Image: S5A
Note: Expression is in the fibers innervating auditory hair cells, both inner and outer, and the utricular hair cells.
Specimen Label: S5A
Detected: true
Specimen Num: 3
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:68100
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
19836472 | -
First Author: Cummins TD
Year: 2010
Journal: Biochim Biophys Acta
Title: Quantitative mass spectrometry of diabetic kidney tubules identifies GRAP as a novel regulator of TGF-beta signaling.
Volume: 1804
Issue: 4
Pages: 653-61
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Allele
Grap<em1Smoc> | MGI:7290003
Name: GRB2-related adaptor protein; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6475424 | C57BL/6JSmoc-Grap<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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DO Term
DOID:0111642 | autosomal recessive nonsyndromic deafness 114
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Protein Domain
IPR035645 | GRAP_N_SH3
Type: Domain
Description: GRAP is a GRB-2 like adaptor protein that is highly expressed in lymphoid tissues. It acts as a negative regulator of T cell receptor (TCR)-induced lymphocyte proliferation by downregulating the signaling to the Ras/ERK pathway []. It has been identified as a regulator of TGFbeta signaling in diabetic kidney tubules and may have a role in the pathogenesis of the disease []. GRAP contains an N-terminal SH3 domain, a central SH2 domain, and a C-terminal SH3 domain.
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Publication
1372395 | J:23349
First Author: Clark SG
Year: 1992
Journal: Nature
Title: C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains.
Volume: 356
Issue: 6367
Pages: 340-4
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Protein Domain
IPR043539 | Grb2-like
Type: Family
Description: Growth factor receptor-bound protein 2 (Grb2) is an SH2 and SH3 domain-containing adaptor protein that links receptor tyrosine kinases to Ras signalling []. Grb2 interacts with the cytoplasmic tyrosine kinase ACK1 (activated Cdc42-associated kinase 1) and mediates its interaction with other receptor tyrosine kinases []. ACK1 is implicated in metastatic behaviour, cell spreading and migration, and epidermal growth factor receptor (EGFR) signalling [].Human GRAP and its Drosophila homologue, downstream of receptor kinase (drk), have been shown to have a function in hearing [].This entry includes a group of adapter proteins including Grb2, GRAP and GRAPL from humans. This entry also includes Sem-5 from Caenorhabditis elegans. Sem-5 is an adapter protein which modulates signaling mediated by several receptor tyrosine kinases such as egl-15 and let-23 probably acting upstream of let-60/ras [, ].
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Publication
1322798 | J:23345
First Author: Lowenstein EJ
Year: 1992
Journal: Cell
Title: The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling.
Volume: 70
Issue: 3
Pages: 431-42
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Publication
19815557 | -
First Author: Pao-Chun L
Year: 2009
Journal: J Biol Chem
Title: Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling.
Volume: 284
Issue: 50
Pages: 34954-63
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Publication
16547100 | -
First Author: Hopper NA
Year: 2006
Journal: Genetics
Title: The adaptor protein soc-1/Gab1 modifies growth factor receptor output in Caenorhabditis elegans.
Volume: 173
Issue: 1
Pages: 163-75
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Publication
9872323 | J:52472
First Author: Liu SK
Year: 1998
Journal: Oncogene
Title: Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc.
Volume: 17
Issue: 24
Pages: 3073-82
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Protein
Q9CX99
Organism: Mus musculus/domesticus
Length: 217  
Fragment?: false
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Protein
B1AT95
Organism: Mus musculus/domesticus
Length: 71  
Fragment?: true
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Protein
O89100
Organism: Mus musculus/domesticus
Length: 322  
Fragment?: false
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Protein
Q3U0E8
Organism: Mus musculus/domesticus
Length: 322  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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