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Search results 1 to 100 out of 1224 for Grb10

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
100151701 | grb10
Type: gene
Organism: frog, western clawed
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Gene
2887 | GRB10
Type: gene
Organism: human
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Gene
498416 | Grb10
Type: gene
Organism: rat
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Gene
463410 | GRB10
Type: gene
Organism: chimpanzee
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Gene
607755 | GRB10
Type: gene
Organism: dog, domestic
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Gene
407210 | GRB10
Type: gene
Organism: cattle
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Gene
420948 | GRB10
Type: gene
Organism: chicken
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Gene
694786 | GRB10
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR035036 | Grb10
Type: Family
Description: The Grb7 (growth factor receptor-bound 7) family includes Grb7, Grb10, and Grb14. These are adapter proteins mediating signal transduction from multiple cell surface receptors to diverse downstream pathways. They are composed of an N-terminal proline-rich domain, a Ras Associating-like (RA) domain, a Pleckstrin Homology (PH) domain, a PIR (phosphorylated insulin receptor interacting region) domain (also known as the family-specific BPS region), and a C-terminal SH2 domain []. Grb10 inhibits insulin receptor kinase activity and mediates insulin-stimulated degradation of the insulin receptor []. It binds to the regulatory kinase loop of the insulin receptor (IR) via its SH2 and BPS domains []. Grb10 is directly phosphorylated by mTORC1 and may participate in a feedback inhibition of the phosphatidylinositol 3-kinase (PI3K) and extracellular signal-regulated, mitogen-activated protein kinase (ERK-MAPK) pathways [].
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Protein Coding Gene
MGI:103232 | Grb10
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
16434550 | -
First Author: Ramos FJ
Year: 2006
Journal: Am J Physiol Endocrinol Metab
Title: Grb10 mediates insulin-stimulated degradation of the insulin receptor: a mechanism of negative regulation.
Volume: 290
Issue: 6
Pages: E1262-6
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Publication
21659605 | -
First Author: Yu Y
Year: 2011
Journal: Science
Title: Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling.
Volume: 332
Issue: 6035
Pages: 1322-6
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Publication
19648926 | -
First Author: Depetris RS
Year: 2009
Journal: Nat Struct Mol Biol
Title: Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14.
Volume: 16
Issue: 8
Pages: 833-9
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Protein
Q60760
Organism: Mus musculus/domesticus
Length: 621  
Fragment?: false
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Publication
19833122 | J:157036
First Author: Charalambous M
Year: 2010
Journal: Dev Biol
Title: Maternally-inherited Grb10 reduces placental size and efficiency.
Volume: 337
Issue: 1
Pages: 1-8
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Protein
B1ATS7
Organism: Mus musculus/domesticus
Length: 116  
Fragment?: true
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Protein
B1ATS8
Organism: Mus musculus/domesticus
Length: 84  
Fragment?: true
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Protein
Q5SUW0
Organism: Mus musculus/domesticus
Length: 171  
Fragment?: true
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Publication
14766376 | -
 
First Author: Lim MA
Year: 2004
Journal: Front Biosci
Title: Grb10: more than a simple adaptor protein.
Volume: 9
Pages: 387-403
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Gene
26058 | GIGYF2
Type: gene
Organism: human
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Gene
64599 | GIGYF1
Type: gene
Organism: human
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Publication
22623587 | J:187449
First Author: Holt LJ
Year: 2012
Journal: FASEB J
Title: Grb10 regulates the development of fiber number in skeletal muscle.
Volume: 26
Issue: 9
Pages: 3658-69
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Publication
32488937 | J:329845
First Author: Dent CL
Year: 2020
Journal: Genes Brain Behav
Title: Mice lacking paternal expression of imprinted Grb10 are risk-takers.
Volume: 19
Issue: 7
Pages: e12679
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Protein
Q5SUW3
Organism: Mus musculus/domesticus
Length: 550  
Fragment?: false
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Protein
Q3TFU9
Organism: Mus musculus/domesticus
Length: 299  
Fragment?: true
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Publication
36593271 | J:341789
First Author: Liu H
Year: 2023
Journal: Nat Metab
Title: Hypothalamic Grb10 enhances leptin signalling and promotes weight loss.
Volume: 5
Issue: 1
Pages: 147-164
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Publication
15722337 | J:98784
First Author: Urschel S
Year: 2005
Journal: J Biol Chem
Title: Phosphorylation of grb10 regulates its interaction with 14-3-3.
Volume: 280
Issue: 17
Pages: 16987-93
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Publication
17535812 | J:124616
First Author: Kebache S
Year: 2007
Journal: J Biol Chem
Title: Grb10 and active Raf-1 kinase promote Bad-dependent cell survival.
Volume: 282
Issue: 30
Pages: 21873-83
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Publication
24746805 | J:213603
First Author: Liu M
Year: 2014
Journal: Cell Metab
Title: Grb10 promotes lipolysis and thermogenesis by phosphorylation-dependent feedback inhibition of mTORC1.
Volume: 19
Issue: 6
Pages: 967-80
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Publication
12771153 | J:85099
First Author: Giovannone B
Year: 2003
Journal: J Biol Chem
Title: Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling.
Volume: 278
Issue: 34
Pages: 31564-73
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Publication
27806297 | J:242337
First Author: Yan X
Year: 2016
Journal: Cell Rep
Title: Deletion of the Imprinted Gene Grb10 Promotes Hematopoietic Stem Cell Self-Renewal and Regeneration.
Volume: 17
Issue: 6
Pages: 1584-1594
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Publication
7731717 | J:24927
First Author: Ooi J
Year: 1995
Journal: Oncogene
Title: The cloning of Grb10 reveals a new family of SH2 domain proteins.
Volume: 10
Issue: 8
Pages: 1621-30
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Publication
15664450 | J:149197
First Author: Mori K
Year: 2005
Journal: Mol Cell Endocrinol
Title: Distinct Grb10 domain requirements for effects on glucose uptake and insulin signaling.
Volume: 230
Issue: 1-2
Pages: 39-50
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Publication
17376403 | J:163129
First Author: Tezuka N
Year: 2007
Journal: Biochem Biophys Res Commun
Title: GRB10 binds to LRP6, the Wnt co-receptor and inhibits canonical Wnt signaling pathway.
Volume: 356
Issue: 3
Pages: 648-54
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Publication
34861413 | J:360217
First Author: Cai Z
Year: 2022
Journal: J Genet Genomics
Title: GRB10 regulates β-cell mass by inhibiting β-cell proliferation and stimulating β-cell dedifferentiation.
Volume: 49
Issue: 3
Pages: 208-216
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Publication
12829789 | J:84425
First Author: Charalambous M
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism.
Volume: 100
Issue: 14
Pages: 8292-7
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Publication
29370381 | J:258327
First Author: Holt LJ
Year: 2018
Journal: Endocrinology
Title: Ablation of Grb10 Specifically in Muscle Impacts Muscle Size and Glucose Metabolism in Mice.
Volume: 159
Issue: 3
Pages: 1339-1351
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Publication
17620412 | J:125128
First Author: Wang L
Year: 2007
Journal: Mol Cell Biol
Title: Peripheral disruption of the Grb10 gene enhances insulin signaling and sensitivity in vivo.
Volume: 27
Issue: 18
Pages: 6497-505
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Publication
26000738 | J:224780
First Author: Mroue R
Year: 2015
Journal: PLoS Genet
Title: Monoallelic loss of the imprinted gene Grb10 promotes tumor formation in irradiated Nf1+/- mice.
Volume: 11
Issue: 5
Pages: e1005235
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Publication
8621530 | J:200357
First Author: Hansen H
Year: 1996
Journal: J Biol Chem
Title: Interaction between the Grb10 SH2 domain and the insulin receptor carboxyl terminus.
Volume: 271
Issue: 15
Pages: 8882-6
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Publication
25551289 | J:225662
 
First Author: Madon-Simon M
Year: 2014
Journal: BMC Biol
Title: Antagonistic roles in fetal development and adult physiology for the oppositely imprinted Grb10 and Dlk1 genes.
Volume: 12
Pages: 771
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Publication
24586114 | J:208404
First Author: Cowley M
Year: 2014
Journal: PLoS Biol
Title: Developmental programming mediated by complementary roles of imprinted Grb10 in mother and pup.
Volume: 12
Issue: 2
Pages: e1001799
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Publication
30932322 | J:301800
First Author: Rienecker KDA
Year: 2020
Journal: Genes Brain Behav
Title: Detailed analysis of paternal knockout Grb10 mice suggests effects on stability of social behavior, rather than social dominance.
Volume: 19
Issue: 1
Pages: e12571
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Publication
12595547 | J:82230
First Author: Hikichi T
Year: 2003
Journal: Nucleic Acids Res
Title: Imprinting regulation of the murine Meg1/Grb10 and human GRB10 genes; roles of brain-specific promoters and mouse-specific CTCF-binding sites.
Volume: 31
Issue: 5
Pages: 1398-406
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Publication
19541746 | J:152021
First Author: Holt LJ
Year: 2009
Journal: Mol Endocrinol
Title: Dual ablation of Grb10 and Grb14 in mice reveals their combined role in regulation of insulin signaling and glucose homeostasis.
Volume: 23
Issue: 9
Pages: 1406-14
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Publication
8798570 | J:35493
First Author: Stein E
Year: 1996
Journal: J Biol Chem
Title: Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells.
Volume: 271
Issue: 38
Pages: 23588-93
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Publication
9062339 | J:51720
First Author: Laviola L
Year: 1997
Journal: J Clin Invest
Title: The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts.
Volume: 99
Issue: 5
Pages: 830-7
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Publication
17562854 | J:125017
First Author: Smith FM
Year: 2007
Journal: Mol Cell Biol
Title: Mice with a disruption of the imprinted Grb10 gene exhibit altered body composition, glucose homeostasis, and insulin signaling during postnatal life.
Volume: 27
Issue: 16
Pages: 5871-86
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Publication
8798417 | J:35379
First Author: O'Neill TJ
Year: 1996
Journal: J Biol Chem
Title: Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling.
Volume: 271
Issue: 37
Pages: 22506-13
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Publication
12700169 | J:83167
First Author: Arnaud P
Year: 2003
Journal: Hum Mol Genet
Title: Conserved methylation imprints in the human and mouse GRB10 genes with divergent allelic expression suggests differential reading of the same mark.
Volume: 12
Issue: 9
Pages: 1005-19
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Publication
23106268 | J:209053
First Author: Hoekstra EJ
Year: 2013
Journal: Eur J Neurosci
Title: Lmx1a is an activator of Rgs4 and Grb10 and is responsible for the correct specification of rostral and medial mdDA neurons.
Volume: 37
Issue: 1
Pages: 23-32
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Publication
39343875 | J:355260
First Author: Moorwood K
Year: 2024
Journal: BMC Biol
Title: Grb7, Grb10 and Grb14, encoding the growth factor receptor-bound 7 family of signalling adaptor proteins have overlapping functions in the regulation of fetal growth and post-natal glucose metabolism.
Volume: 22
Issue: 1
Pages: 221
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Publication
29555819 | J:317070
First Author: Luo L
Year: 2018
Journal: J Mol Endocrinol
Title: De-silencing Grb10 contributes to acute ER stress-induced steatosis in mouse liver.
Volume: 60
Issue: 4
Pages: 285-297
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Publication
28696244 | J:320842
First Author: Yao J
Year: 2017
Journal: Reproduction
Title: Effect of vitrification on in vitro development and imprinted gene Grb10 in mouse embryos.
Volume: 154
Issue: 3
Pages: 97-105
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GXD Expression
GXD Expression
 
Probe: MGI:7595689
Assay Type: RNA in situ
Annotation Date: 2024-02-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7595757
Age: embryonic day 14.5
Note: Slightly lower expression in the dorsal TH domain and in the ventricular zone. The line of cells highly expressing Grb10 dorsally along the entire medial mesodiencephalic dopamine neuronal area was clearly affected.
Specimen Label: 5JJ
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:7595689
Assay Type: RNA in situ
Annotation Date: 2024-02-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7595757
Age: embryonic day 14.5
Note: Slightly lower expression in the dorsal TH domain and in the ventricular zone. The line of cells highly expressing Grb10 dorsally along the entire medial mesodiencephalic dopamine neuronal area was clearly affected.
Specimen Label: 5KK/KK'/KK"
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
 
Probe: MGI:7595689
Assay Type: RNA in situ
Annotation Date: 2024-02-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7595757
Age: embryonic day 14.5
Note: Slightly lower expression in the dorsal TH domain and in the ventricular zone. The line of cells highly expressing Grb10 dorsally along the entire medial mesodiencephalic dopamine neuronal area was clearly affected.
Specimen Label: 5LL/LL'
Detected: true
Specimen Num: 14
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GXD Expression
GXD Expression
 
Probe: MGI:7595689
Assay Type: RNA in situ
Annotation Date: 2024-02-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7595757
Age: embryonic day 14.5
Note: Slightly lower expression in the dorsal TH domain and in the ventricular zone. The line of cells highly expressing Grb10 dorsally along the entire medial mesodiencephalic dopamine neuronal area was clearly affected.
Specimen Label: 5MM
Detected: true
Specimen Num: 15
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GXD Expression
GXD Expression
 
Probe: MGI:7595689
Assay Type: RNA in situ
Annotation Date: 2024-02-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7595757
Age: embryonic day 14.5
Note: Slightly lower expression in the dorsal TH domain and in the ventricular zone. The line of cells highly expressing Grb10 dorsally along the entire medial mesodiencephalic dopamine neuronal area was clearly affected.
Specimen Label: 5NN
Detected: true
Specimen Num: 16
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Publication
22923474 | J:208498
First Author: Zhang J
Year: 2012
Journal: Diabetes
Title: Disruption of growth factor receptor-binding protein 10 in the pancreas enhances β-cell proliferation and protects mice from streptozotocin-induced β-cell apoptosis.
Volume: 61
Issue: 12
Pages: 3189-98
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Publication
18650936 | J:140411
First Author: Sanz LA
Year: 2008
Journal: EMBO J
Title: A mono-allelic bivalent chromatin domain controls tissue-specific imprinting at Grb10.
Volume: 27
Issue: 19
Pages: 2523-32
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Publication
36108632 | J:329940
First Author: Juan AM
Year: 2022
Journal: Mol Cell
Title: Tissue-specific Grb10/Ddc insulator drives allelic architecture for cardiac development.
Volume: 82
Issue: 19
Pages: 3613-3631.e7
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Publication
18812566 | J:207675
First Author: Cao XR
Year: 2008
Journal: Sci Signal
Title: Nedd4 controls animal growth by regulating IGF-1 signaling.
Volume: 1
Issue: 38
Pages: ra5
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Publication
9448292 | J:45655
First Author: Miyoshi N
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Identification of the Meg1/Grb10 imprinted gene on mouse proximal chromosome 11, a candidate for the Silver-Russell syndrome gene.
Volume: 95
Issue: 3
Pages: 1102-7
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Publication
10446181 | J:56881
First Author: Morrione A
Year: 1999
Journal: J Biol Chem
Title: mGrb10 interacts with Nedd4.
Volume: 274
Issue: 34
Pages: 24094-9
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Publication
17967881 | J:128957
First Author: Menheniott TR
Year: 2008
Journal: Mol Cell Biol
Title: Genomic imprinting of Dopa decarboxylase in heart and reciprocal allelic expression with neighboring Grb10.
Volume: 28
Issue: 1
Pages: 386-96
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Publication
17101788 | J:306184
First Author: Yamasaki-Ishizaki Y
Year: 2007
Journal: Mol Cell Biol
Title: Role of DNA methylation and histone H3 lysine 27 methylation in tissue-specific imprinting of mouse Grb10.
Volume: 27
Issue: 2
Pages: 732-42
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Publication
34239874 | J:308675
 
First Author: Prickett AR
Year: 2021
Journal: Front Cell Dev Biol
Title: Imprinted Gene Expression and Function of the Dopa Decarboxylase Gene in the Developing Heart.
Volume: 9
Pages: 676543
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Publication
19174477 | J:146865
First Author: Shiura H
Year: 2009
Journal: Hum Mol Genet
Title: Paternal deletion of Meg1/Grb10 DMR causes maternalization of the Meg1/Grb10 cluster in mouse proximal Chromosome 11 leading to severe pre- and postnatal growth retardation.
Volume: 18
Issue: 8
Pages: 1424-38
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Publication
21270893 | J:209478
First Author: Garfield AS
Year: 2011
Journal: Nature
Title: Distinct physiological and behavioural functions for parental alleles of imprinted Grb10.
Volume: 469
Issue: 7331
Pages: 534-8
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Publication
26941017 | J:246383
First Author: Reddy MA
Year: 2016
Journal: Arterioscler Thromb Vasc Biol
Title: Regulation of Vascular Smooth Muscle Cell Dysfunction Under Diabetic Conditions by miR-504.
Volume: 36
Issue: 5
Pages: 864-73
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Publication
38816743 | J:349178
First Author: Moorwood K
Year: 2024
Journal: BMC Biol
Title: Imprinted Grb10, encoding growth factor receptor bound protein 10, regulates fetal growth independently of the insulin-like growth factor type 1 receptor (Igf1r) and insulin receptor (Insr) genes.
Volume: 22
Issue: 1
Pages: 127
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Publication
12783867 | J:85997
First Author: Deng Y
Year: 2003
Journal: J Biol Chem
Title: Growth factor receptor-binding protein 10 (Grb10) as a partner of phosphatidylinositol 3-kinase in metabolic insulin action.
Volume: 278
Issue: 41
Pages: 39311-22
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Gene
304378 | Gigyf1
Type: gene
Organism: rat
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Gene
460017 | GIGYF2
Type: gene
Organism: chimpanzee
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Gene
472671 | GIGYF1
Type: gene
Organism: chimpanzee
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Gene
489833 | GIGYF1
Type: gene
Organism: dog, domestic
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Gene
612838 | GIGYF2
Type: gene
Organism: dog, domestic
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Gene
506913 | GIGYF2
Type: gene
Organism: cattle
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Gene
532406 | GIGYF1
Type: gene
Organism: cattle
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Gene
100362458 | Gigyf2
Type: gene
Organism: rat
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Gene
424743 | GIGYF2
Type: gene
Organism: chicken
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Gene
100002679 | gigyf1b
Type: gene
Organism: zebrafish
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Gene
561830 | gigyf2
Type: gene
Organism: zebrafish
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Gene
568584 | gigyf1a
Type: gene
Organism: zebrafish
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Gene
712775 | GIGYF1
Type: gene
Organism: macaque, rhesus
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Gene
713675 | GIGYF2
Type: gene
Organism: macaque, rhesus
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Gene
780058 | gigyf1
Type: gene
Organism: frog, western clawed
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Gene
100487831 | gigyf2
Type: gene
Organism: frog, western clawed
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Protein Coding Gene
MGP_CAROLIEiJ_G0016099 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0018048 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0018021 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0017985 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0017989 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0017802 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_103232 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0018441 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0017364 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0017777 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0017887 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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