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Search results 1 to 100 out of 1172 for Grb10

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Type Details Score
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: rat
Protein Domain
Type: Family
Description: The Grb7 (growth factor receptor-bound 7) family includes Grb7, Grb10, and Grb14. These are adapter proteins mediating signal transduction from multiple cell surface receptors to diverse downstream pathways. They are composed of an N-terminal proline-rich domain, a Ras Associating-like (RA) domain, a Pleckstrin Homology (PH) domain, a PIR (phosphorylated insulin receptor interacting region) domain (also known as the family-specific BPS region), and a C-terminal SH2 domain []. Grb10 inhibits insulin receptor kinase activity and mediates insulin-stimulated degradation of the insulin receptor []. It binds to the regulatory kinase loop of the insulin receptor (IR) via its SH2 and BPS domains []. Grb10 is directly phosphorylated by mTORC1 and may participate in a feedback inhibition of the phosphatidylinositol 3-kinase (PI3K) and extracellular signal-regulated, mitogen-activated protein kinase (ERK-MAPK) pathways [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Ramos FJ
Year: 2006
Journal: Am J Physiol Endocrinol Metab
Title: Grb10 mediates insulin-stimulated degradation of the insulin receptor: a mechanism of negative regulation.
Volume: 290
Issue: 6
Pages: E1262-6
Publication
First Author: Yu Y
Year: 2011
Journal: Science
Title: Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling.
Volume: 332
Issue: 6035
Pages: 1322-6
Publication
First Author: Depetris RS
Year: 2009
Journal: Nat Struct Mol Biol
Title: Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14.
Volume: 16
Issue: 8
Pages: 833-9
Protein
Organism: Mus musculus/domesticus
Length: 621  
Fragment?: false
Publication
First Author: Charalambous M
Year: 2010
Journal: Dev Biol
Title: Maternally-inherited Grb10 reduces placental size and efficiency.
Volume: 337
Issue: 1
Pages: 1-8
Protein
Organism: Mus musculus/domesticus
Length: 116  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 84  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 171  
Fragment?: true
Publication  
First Author: Lim MA
Year: 2004
Journal: Front Biosci
Title: Grb10: more than a simple adaptor protein.
Volume: 9
Pages: 387-403
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Publication
First Author: Holt LJ
Year: 2012
Journal: FASEB J
Title: Grb10 regulates the development of fiber number in skeletal muscle.
Volume: 26
Issue: 9
Pages: 3658-69
Publication
First Author: Dent CL
Year: 2020
Journal: Genes Brain Behav
Title: Mice lacking paternal expression of imprinted Grb10 are risk-takers.
Volume: 19
Issue: 7
Pages: e12679
Protein
Organism: Mus musculus/domesticus
Length: 550  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 299  
Fragment?: true
Publication
First Author: Liu H
Year: 2023
Journal: Nat Metab
Title: Hypothalamic Grb10 enhances leptin signalling and promotes weight loss.
Volume: 5
Issue: 1
Pages: 147-164
Publication
First Author: Urschel S
Year: 2005
Journal: J Biol Chem
Title: Phosphorylation of grb10 regulates its interaction with 14-3-3.
Volume: 280
Issue: 17
Pages: 16987-93
Publication
First Author: Kebache S
Year: 2007
Journal: J Biol Chem
Title: Grb10 and active Raf-1 kinase promote Bad-dependent cell survival.
Volume: 282
Issue: 30
Pages: 21873-83
Publication
First Author: Liu M
Year: 2014
Journal: Cell Metab
Title: Grb10 promotes lipolysis and thermogenesis by phosphorylation-dependent feedback inhibition of mTORC1.
Volume: 19
Issue: 6
Pages: 967-80
Publication
First Author: Giovannone B
Year: 2003
Journal: J Biol Chem
Title: Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling.
Volume: 278
Issue: 34
Pages: 31564-73
Publication
First Author: Yan X
Year: 2016
Journal: Cell Rep
Title: Deletion of the Imprinted Gene Grb10 Promotes Hematopoietic Stem Cell Self-Renewal and Regeneration.
Volume: 17
Issue: 6
Pages: 1584-1594
Publication
First Author: Ooi J
Year: 1995
Journal: Oncogene
Title: The cloning of Grb10 reveals a new family of SH2 domain proteins.
Volume: 10
Issue: 8
Pages: 1621-30
Publication
First Author: Mori K
Year: 2005
Journal: Mol Cell Endocrinol
Title: Distinct Grb10 domain requirements for effects on glucose uptake and insulin signaling.
Volume: 230
Issue: 1-2
Pages: 39-50
Publication
First Author: Tezuka N
Year: 2007
Journal: Biochem Biophys Res Commun
Title: GRB10 binds to LRP6, the Wnt co-receptor and inhibits canonical Wnt signaling pathway.
Volume: 356
Issue: 3
Pages: 648-54
Publication
First Author: Charalambous M
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism.
Volume: 100
Issue: 14
Pages: 8292-7
Publication
First Author: Holt LJ
Year: 2018
Journal: Endocrinology
Title: Ablation of Grb10 Specifically in Muscle Impacts Muscle Size and Glucose Metabolism in Mice.
Volume: 159
Issue: 3
Pages: 1339-1351
Publication
First Author: Wang L
Year: 2007
Journal: Mol Cell Biol
Title: Peripheral disruption of the Grb10 gene enhances insulin signaling and sensitivity in vivo.
Volume: 27
Issue: 18
Pages: 6497-505
Publication
First Author: Mroue R
Year: 2015
Journal: PLoS Genet
Title: Monoallelic loss of the imprinted gene Grb10 promotes tumor formation in irradiated Nf1+/- mice.
Volume: 11
Issue: 5
Pages: e1005235
Publication
First Author: Hansen H
Year: 1996
Journal: J Biol Chem
Title: Interaction between the Grb10 SH2 domain and the insulin receptor carboxyl terminus.
Volume: 271
Issue: 15
Pages: 8882-6
Publication  
First Author: Madon-Simon M
Year: 2014
Journal: BMC Biol
Title: Antagonistic roles in fetal development and adult physiology for the oppositely imprinted Grb10 and Dlk1 genes.
Volume: 12
Pages: 771
Publication
First Author: Cowley M
Year: 2014
Journal: PLoS Biol
Title: Developmental programming mediated by complementary roles of imprinted Grb10 in mother and pup.
Volume: 12
Issue: 2
Pages: e1001799
Publication
First Author: Hikichi T
Year: 2003
Journal: Nucleic Acids Res
Title: Imprinting regulation of the murine Meg1/Grb10 and human GRB10 genes; roles of brain-specific promoters and mouse-specific CTCF-binding sites.
Volume: 31
Issue: 5
Pages: 1398-406
Publication
First Author: Rienecker KDA
Year: 2020
Journal: Genes Brain Behav
Title: Detailed analysis of paternal knockout Grb10 mice suggests effects on stability of social behavior, rather than social dominance.
Volume: 19
Issue: 1
Pages: e12571
Publication
First Author: Holt LJ
Year: 2009
Journal: Mol Endocrinol
Title: Dual ablation of Grb10 and Grb14 in mice reveals their combined role in regulation of insulin signaling and glucose homeostasis.
Volume: 23
Issue: 9
Pages: 1406-14
Publication
First Author: Stein E
Year: 1996
Journal: J Biol Chem
Title: Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells.
Volume: 271
Issue: 38
Pages: 23588-93
Publication
First Author: Laviola L
Year: 1997
Journal: J Clin Invest
Title: The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts.
Volume: 99
Issue: 5
Pages: 830-7
Publication
First Author: Smith FM
Year: 2007
Journal: Mol Cell Biol
Title: Mice with a disruption of the imprinted Grb10 gene exhibit altered body composition, glucose homeostasis, and insulin signaling during postnatal life.
Volume: 27
Issue: 16
Pages: 5871-86
Publication
First Author: O'Neill TJ
Year: 1996
Journal: J Biol Chem
Title: Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling.
Volume: 271
Issue: 37
Pages: 22506-13
Publication
First Author: Arnaud P
Year: 2003
Journal: Hum Mol Genet
Title: Conserved methylation imprints in the human and mouse GRB10 genes with divergent allelic expression suggests differential reading of the same mark.
Volume: 12
Issue: 9
Pages: 1005-19
Publication
First Author: Hoekstra EJ
Year: 2013
Journal: Eur J Neurosci
Title: Lmx1a is an activator of Rgs4 and Grb10 and is responsible for the correct specification of rostral and medial mdDA neurons.
Volume: 37
Issue: 1
Pages: 23-32
Publication
First Author: Luo L
Year: 2018
Journal: J Mol Endocrinol
Title: De-silencing Grb10 contributes to acute ER stress-induced steatosis in mouse liver.
Volume: 60
Issue: 4
Pages: 285-297
Publication
First Author: Yao J
Year: 2017
Journal: Reproduction
Title: Effect of vitrification on in vitro development and imprinted gene Grb10 in mouse embryos.
Volume: 154
Issue: 3
Pages: 97-105
GXD Expression  
Probe: MGI:7595689
Assay Type: RNA in situ
Annotation Date: 2024-02-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7595757
Age: embryonic day 14.5
Note: Slightly lower expression in the dorsal TH domain and in the ventricular zone. The line of cells highly expressing Grb10 dorsally along the entire medial mesodiencephalic dopamine neuronal area was clearly affected.
Specimen Label: 5JJ
Detected: true
Specimen Num: 12
GXD Expression  
Probe: MGI:7595689
Assay Type: RNA in situ
Annotation Date: 2024-02-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7595757
Age: embryonic day 14.5
Note: Slightly lower expression in the dorsal TH domain and in the ventricular zone. The line of cells highly expressing Grb10 dorsally along the entire medial mesodiencephalic dopamine neuronal area was clearly affected.
Specimen Label: 5KK/KK'/KK"
Detected: true
Specimen Num: 13
GXD Expression  
Probe: MGI:7595689
Assay Type: RNA in situ
Annotation Date: 2024-02-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7595757
Age: embryonic day 14.5
Note: Slightly lower expression in the dorsal TH domain and in the ventricular zone. The line of cells highly expressing Grb10 dorsally along the entire medial mesodiencephalic dopamine neuronal area was clearly affected.
Specimen Label: 5LL/LL'
Detected: true
Specimen Num: 14
GXD Expression  
Probe: MGI:7595689
Assay Type: RNA in situ
Annotation Date: 2024-02-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7595757
Age: embryonic day 14.5
Note: Slightly lower expression in the dorsal TH domain and in the ventricular zone. The line of cells highly expressing Grb10 dorsally along the entire medial mesodiencephalic dopamine neuronal area was clearly affected.
Specimen Label: 5MM
Detected: true
Specimen Num: 15
GXD Expression  
Probe: MGI:7595689
Assay Type: RNA in situ
Annotation Date: 2024-02-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7595757
Age: embryonic day 14.5
Note: Slightly lower expression in the dorsal TH domain and in the ventricular zone. The line of cells highly expressing Grb10 dorsally along the entire medial mesodiencephalic dopamine neuronal area was clearly affected.
Specimen Label: 5NN
Detected: true
Specimen Num: 16
Publication
First Author: Zhang J
Year: 2012
Journal: Diabetes
Title: Disruption of growth factor receptor-binding protein 10 in the pancreas enhances β-cell proliferation and protects mice from streptozotocin-induced β-cell apoptosis.
Volume: 61
Issue: 12
Pages: 3189-98
Publication
First Author: Sanz LA
Year: 2008
Journal: EMBO J
Title: A mono-allelic bivalent chromatin domain controls tissue-specific imprinting at Grb10.
Volume: 27
Issue: 19
Pages: 2523-32
Publication
First Author: Juan AM
Year: 2022
Journal: Mol Cell
Title: Tissue-specific Grb10/Ddc insulator drives allelic architecture for cardiac development.
Volume: 82
Issue: 19
Pages: 3613-3631.e7
Publication
First Author: Cao XR
Year: 2008
Journal: Sci Signal
Title: Nedd4 controls animal growth by regulating IGF-1 signaling.
Volume: 1
Issue: 38
Pages: ra5
Publication
First Author: Miyoshi N
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Identification of the Meg1/Grb10 imprinted gene on mouse proximal chromosome 11, a candidate for the Silver-Russell syndrome gene.
Volume: 95
Issue: 3
Pages: 1102-7
Publication
First Author: Morrione A
Year: 1999
Journal: J Biol Chem
Title: mGrb10 interacts with Nedd4.
Volume: 274
Issue: 34
Pages: 24094-9
Publication
First Author: Menheniott TR
Year: 2008
Journal: Mol Cell Biol
Title: Genomic imprinting of Dopa decarboxylase in heart and reciprocal allelic expression with neighboring Grb10.
Volume: 28
Issue: 1
Pages: 386-96
Publication  
First Author: Prickett AR
Year: 2021
Journal: Front Cell Dev Biol
Title: Imprinted Gene Expression and Function of the Dopa Decarboxylase Gene in the Developing Heart.
Volume: 9
Pages: 676543
Publication
First Author: Yamasaki-Ishizaki Y
Year: 2007
Journal: Mol Cell Biol
Title: Role of DNA methylation and histone H3 lysine 27 methylation in tissue-specific imprinting of mouse Grb10.
Volume: 27
Issue: 2
Pages: 732-42
Publication
First Author: Shiura H
Year: 2009
Journal: Hum Mol Genet
Title: Paternal deletion of Meg1/Grb10 DMR causes maternalization of the Meg1/Grb10 cluster in mouse proximal Chromosome 11 leading to severe pre- and postnatal growth retardation.
Volume: 18
Issue: 8
Pages: 1424-38
Publication
First Author: Garfield AS
Year: 2011
Journal: Nature
Title: Distinct physiological and behavioural functions for parental alleles of imprinted Grb10.
Volume: 469
Issue: 7331
Pages: 534-8
Publication
First Author: Reddy MA
Year: 2016
Journal: Arterioscler Thromb Vasc Biol
Title: Regulation of Vascular Smooth Muscle Cell Dysfunction Under Diabetic Conditions by miR-504.
Volume: 36
Issue: 5
Pages: 864-73
Publication
First Author: Deng Y
Year: 2003
Journal: J Biol Chem
Title: Growth factor receptor-binding protein 10 (Grb10) as a partner of phosphatidylinositol 3-kinase in metabolic insulin action.
Volume: 278
Issue: 41
Pages: 39311-22
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: frog, western clawed
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory