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Search results 1 to 100 out of 792 for Grem1

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Hits by Strain

Hits by Category

Type Details Score
Gene
key_1584436 | Grem1
Type: gene
Organism: Not Specified
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Gene
26585 | GREM1
Type: gene
Organism: human
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Gene
539079 | GREM1
Type: gene
Organism: cattle
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Gene
395826 | GREM1
Type: gene
Organism: chicken
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Gene
574176 | GREM1
Type: gene
Organism: macaque, rhesus
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Gene
100101711 | grem1
Type: gene
Organism: frog, western clawed
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Gene
50566 | Grem1
Type: gene
Organism: rat
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Gene
487475 | GREM1
Type: gene
Organism: dog, domestic
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Gene
467642 | GREM1
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:1344337 | Grem1
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
100131315 | GREM1-AS1
Type: gene
Organism: human
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GXD Expression
GXD Expression
Probe: MGI:5810996
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:5823627
Age: embryonic day 10.5
Image: S1A - Grem1 - E10.5
Note: This gene exhibits category 1 expression: staining is observed in the posterior/posterior-distal limb bud.
Specimen Label: S1A - Grem1 - E10.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:5810996
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640619
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:5823627
Age: embryonic day 11.5
Image: S1A - Grem1 - E11.5
Note: This gene exhibits category 1 expression: staining is observed in the posterior/posterior-distal limb bud.
Specimen Label: S1A - Grem1 - E11.5
Detected: true
Specimen Num: 2
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Publication
19401426 | J:154340
First Author: Roxburgh SA
Year: 2009
Journal: Diabetes
Title: Allelic depletion of grem1 attenuates diabetic kidney disease.
Volume: 58
Issue: 7
Pages: 1641-50
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Publication
35768509 | J:330294
First Author: Lan L
Year: 2022
Journal: Nature
Title: GREM1 is required to maintain cellular heterogeneity in pancreatic cancer.
Volume: 607
Issue: 7917
Pages: 163-168
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Publication
25419707 | J:227790
First Author: Davis H
Year: 2015
Journal: Nat Med
Title: Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche.
Volume: 21
Issue: 1
Pages: 62-70
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Publication
21281623 | J:171473
First Author: Nie X
Year: 2011
Journal: Dev Biol
Title: Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis.
Volume: 352
Issue: 1
Pages: 141-51
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Publication
33819486 | J:343887
First Author: Koppens MAJ
Year: 2021
Journal: Gastroenterology
Title: Bone Morphogenetic Protein Pathway Antagonism by Grem1 Regulates Epithelial Cell Fate in Intestinal Regeneration.
Volume: 161
Issue: 1
Pages: 239-254.e9
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Publication
37034712 | J:340408
     
First Author: Ng JQ
Year: 2023
Journal: bioRxiv
Title: Loss of Grem1 -articular cartilage progenitor cells causes osteoarthritis.
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Publication
34548488 | J:312378
First Author: Malkmus J
Year: 2021
Journal: Nat Commun
Title: Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity.
Volume: 12
Issue: 1
Pages: 5557
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GXD Expression
GXD Expression
Probe: MGI:5705077
Assay Type: RNA in situ
Annotation Date: 2018-04-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:6149012
Age: embryonic day 10.5
Image: 2B
Note: Grem1 expression is upregulated in anterior part of limb bud.
Specimen Label: 2B
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:5705077
Assay Type: RNA in situ
Annotation Date: 2018-04-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1677917
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:6149012
Age: embryonic day 10.5
Image: 2F
Note: Grem1 expression is upregulated in anterior part of limb bud.
Specimen Label: 2F
Detected: true
Specimen Num: 8
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Publication
24700818 | J:207959
First Author: Li Q
Year: 2014
Journal: Development
Title: A Gli silencer is required for robust repression of gremlin in the vertebrate limb bud.
Volume: 141
Issue: 9
Pages: 1906-14
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GXD Expression
GXD Expression
Probe: MGI:5705077
Assay Type: RNA in situ
Annotation Date: 2018-04-03
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1640617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:6149012
Age: embryonic day 10.5
Image: 2C
Note: Low levels of Grem1 expression in posterior part of limb bud.
Specimen Label: 2C
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:5705077
Assay Type: RNA in situ
Annotation Date: 2018-04-03
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1640617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:6149012
Age: embryonic day 10.5
Image: 2C'
Note: Low levels of Grem1 expression in posterior part of limb bud.
Specimen Label: 2C'
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:5705077
Assay Type: RNA in situ
Annotation Date: 2018-04-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640817
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:6149012
Age: embryonic day 10.5
Image: 2A
Note: Authors state that normal Grem1 expression is in posterior part of distal limb mesenchyme, close to Fgf4 expression in apical ectodermal ridge.
Specimen Label: 2A
Detected: true
Specimen Num: 1
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Publication
25594183 | J:219328
First Author: Worthley DL
Year: 2015
Journal: Cell
Title: Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential.
Volume: 160
Issue: 1-2
Pages: 269-84
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Publication
37907525 | J:342246
First Author: Ng JQ
Year: 2023
Journal: Nat Commun
Title: Loss of Grem1-lineage chondrogenic progenitor cells causes osteoarthritis.
Volume: 14
Issue: 1
Pages: 6909
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Publication
34184027 | J:308785
 
First Author: Ichinose M
Year: 2021
Journal: Development
Title: The BMP antagonist gremlin 1 contributes to the development of cortical excitatory neurons, motor balance and fear responses.
Volume: 148
Issue: 14
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Publication
17785465 | J:126375
First Author: Gazzerro E
Year: 2007
Journal: J Biol Chem
Title: Conditional deletion of gremlin causes a transient increase in bone formation and bone mass.
Volume: 282
Issue: 43
Pages: 31549-57
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Publication
28100499 | J:273728
First Author: Church RH
Year: 2017
Journal: Am J Physiol Renal Physiol
Title: Gremlin1 plays a key role in kidney development and renal fibrosis.
Volume: 312
Issue: 6
Pages: F1141-F1157
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Publication
21412775 | J:274152
First Author: Canalis E
Year: 2012
Journal: J Cell Physiol
Title: Gremlin1 is required for skeletal development and postnatal skeletal homeostasis.
Volume: 227
Issue: 1
Pages: 269-77
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Publication
32297672 | J:292063
First Author: Rowan SC
Year: 2020
Journal: J Pathol
Title: Gremlin 1 depletion in vivo causes severe enteropathy and bone marrow failure.
Volume: 251
Issue: 2
Pages: 117-122
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Publication
37401390 | J:341245
First Author: Mthunzi L
Year: 2023
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Gremlin 1 is required for macrophage M2 polarization.
Volume: 325
Issue: 2
Pages: L270-L276
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Publication
18545679 | J:182488
First Author: Kami D
Year: 2008
Journal: PLoS One
Title: Gremlin enhances the determined path to cardiomyogenesis.
Volume: 3
Issue: 6
Pages: e2407
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Publication
25194662 | J:216373
First Author: Siddique I
Year: 2014
Journal: Am J Pathol
Title: Gremlin promotes peritoneal membrane injury in an experimental mouse model and is associated with increased solute transport in peritoneal dialysis patients.
Volume: 184
Issue: 11
Pages: 2976-84
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Publication
27428020 | J:240356
First Author: Koli K
Year: 2016
Journal: PLoS One
Title: Gremlin-1 Overexpression in Mouse Lung Reduces Silica-Induced Lymphocyte Recruitment - A Link to Idiopathic Pulmonary Fibrosis through Negative Correlation with CXCL10 Chemokine.
Volume: 11
Issue: 7
Pages: e0159010
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Publication
20359476 | J:161416
First Author: Collette NM
Year: 2010
Journal: Dev Biol
Title: Genetic evidence that SOST inhibits WNT signaling in the limb.
Volume: 342
Issue: 2
Pages: 169-79
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Publication
29483821 | J:272082
First Author: Wang H
Year: 2018
Journal: Int J Biol Sci
Title: Disruption of Gen1 Causes Congenital Anomalies of the Kidney and Urinary Tract in Mice.
Volume: 14
Issue: 1
Pages: 10-20
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Publication
21832168 | J:182788
First Author: Myers M
Year: 2011
Journal: Biol Reprod
Title: Loss of gremlin delays primordial follicle assembly but does not affect female fertility in mice.
Volume: 85
Issue: 6
Pages: 1175-82
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Publication
2997621 | J:8077
First Author: Woychik RP
Year: 1985
Journal: Nature
Title: An inherited limb deformity created by insertional mutagenesis in a transgenic mouse.
Volume: 318
Issue: 6041
Pages: 36-40
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Publication
1673046 | J:11112
First Author: Maas RL
Year: 1991
Journal: Am J Hum Genet
Title: A human gene homologous to the formin gene residing at the murine limb deformity locus: chromosomal location and RFLPs.
Volume: 48
Issue: 4
Pages: 687-95
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Publication
1643305 | J:1741
First Author: Vogt TF
Year: 1992
Journal: Mamm Genome
Title: The same genomic region is disrupted in two transgene-induced limb deformity alleles.
Volume: 3
Issue: 8
Pages: 431-7
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Publication
- | J:22163
 
First Author: Messing A
Year: 1990
Journal: Mouse Genome
Title: Insertional mutation at the ld locus (again!) in a line of transgenic mice
Volume: 87
Pages: 107
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Publication
15201225 | J:90991
First Author: Michos O
Year: 2004
Journal: Development
Title: Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis.
Volume: 131
Issue: 14
Pages: 3401-10
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Publication
19229034 | J:144933
First Author: Bénazet JD
Year: 2009
Journal: Science
Title: A self-regulatory system of interlinked signaling feedback loops controls mouse limb patterning.
Volume: 323
Issue: 5917
Pages: 1050-3
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Publication
26141517 | J:319181
First Author: Staloch D
Year: 2015
Journal: J Mol Med (Berl)
Title: Gremlin is a key pro-fibrogenic factor in chronic pancreatitis.
Volume: 93
Issue: 10
Pages: 1085-1093
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Publication
23633963 | J:200023
First Author: Farin HF
Year: 2013
Journal: PLoS Genet
Title: Tbx2 terminates shh/fgf signaling in the developing mouse limb bud by direct repression of gremlin1.
Volume: 9
Issue: 4
Pages: e1003467
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Publication
34928956 | J:317430
First Author: Sharma D
Year: 2021
Journal: PLoS Genet
Title: HES1 is a novel downstream modifier of the SHH-GLI3 Axis in the development of preaxial polydactyly.
Volume: 17
Issue: 12
Pages: e1009982
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Publication
7517224 | J:17401
First Author: Maas R
Year: 1994
Journal: Dev Dyn
Title: Deficient outgrowth of the ureteric bud underlies the renal agenesis phenotype in mice manifesting the limb deformity (ld) mutation.
Volume: 199
Issue: 3
Pages: 214-28
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Publication
25034710 | J:214075
First Author: Norrie JL
Year: 2014
Journal: Dev Biol
Title: Dynamics of BMP signaling in limb bud mesenchyme and polydactyly.
Volume: 393
Issue: 2
Pages: 270-281
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Publication
17554679 | J:123068
First Author: Pavel E
Year: 2007
Journal: Int J Dev Biol
Title: Analysis of a new allele of limb deformity (ld) reveals tissue- and age-specific transcriptional effects of the Ld Global Control Region.
Volume: 51
Issue: 4
Pages: 273-81
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Publication
16908629 | J:112237
First Author: Panman L
Year: 2006
Journal: Development
Title: Differential regulation of gene expression in the digit forming area of the mouse limb bud by SHH and gremlin 1/FGF-mediated epithelial-mesenchymal signalling.
Volume: 133
Issue: 17
Pages: 3419-28
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Publication
9234242 | J:43337
First Author: Wynshaw-Boris A
Year: 1997
Journal: Mol Med
Title: The role of a single formin isoform in the limb and renal phenotypes of limb deformity.
Volume: 3
Issue: 6
Pages: 372-84
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Publication
8792607 | J:35172
First Author: Vogt TF
Year: 1996
Journal: Dev Genet
Title: Polydactyly in the Strong's luxoid mouse is suppressed by limb deformity alleles.
Volume: 19
Issue: 1
Pages: 33-42
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Publication
17522159 | J:122530
First Author: Michos O
Year: 2007
Journal: Development
Title: Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis.
Volume: 134
Issue: 13
Pages: 2397-405
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Publication
23633510 | J:197026
First Author: Sheth R
Year: 2013
Journal: Development
Title: Decoupling the function of Hox and Shh in developing limb reveals multiple inputs of Hox genes on limb growth.
Volume: 140
Issue: 10
Pages: 2130-8
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Publication
18594511 | J:138578
First Author: Verheyden JM
Year: 2008
Journal: Nature
Title: An Fgf/Gremlin inhibitory feedback loop triggers termination of limb bud outgrowth.
Volume: 454
Issue: 7204
Pages: 638-41
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Publication
- | J:210585
     
First Author: Vokes SA
Year: 2014
Journal: MGI Direct Data Submission
Title: Direct data submission for cre-inducible transgene expressing Grem1 under the control of the Rosa26 promoter
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Publication
9006074 | J:38380
First Author: Kuhlman J
Year: 1997
Journal: Development
Title: Limb deformity proteins: role in mesodermal induction of the apical ectodermal ridge.
Volume: 124
Issue: 1
Pages: 133-9
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Publication
19383632 | J:149484
First Author: Zhou F
Year: 2009
Journal: Hum Mol Genet
Title: Formin1 disruption confers oligodactylism and alters Bmp signaling.
Volume: 18
Issue: 13
Pages: 2472-82
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Publication
21303853 | J:169133
First Author: Stafford DA
Year: 2011
Journal: Development
Title: Cooperative activity of noggin and gremlin 1 in axial skeleton development.
Volume: 138
Issue: 5
Pages: 1005-14
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Publication
2320577 | J:10399
First Author: Woychik RP
Year: 1990
Journal: Proc Natl Acad Sci U S A
Title: Molecular and genetic characterization of a radiation-induced structural rearrangement in mouse chromosome 2 causing mutations at the limb deformity and agouti loci.
Volume: 87
Issue: 7
Pages: 2588-92
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Publication
22888807 | J:187726
 
First Author: Zuniga A
Year: 2012
Journal: BMC Dev Biol
Title: Conserved cis-regulatory regions in a large genomic landscape control SHH and BMP-regulated Gremlin1 expression in mouse limb buds.
Volume: 12
Pages: 23
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Publication
21552539 | J:172359
First Author: Gonçalves A
Year: 2011
Journal: PLoS One
Title: Genetic analysis reveals an unexpected role of BMP7 in initiation of ureteric bud outgrowth in mouse embryos.
Volume: 6
Issue: 4
Pages: e19370
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Publication
35931033 | J:347568
First Author: Goto N
Year: 2022
Journal: Cell Stem Cell
Title: Lymphatics and fibroblasts support intestinal stem cells in homeostasis and injury.
Volume: 29
Issue: 8
Pages: 1246-1261.e6
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Publication
15198975 | J:91385
First Author: Zuniga A
Year: 2004
Journal: Genes Dev
Title: Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression.
Volume: 18
Issue: 13
Pages: 1553-64
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Protein Coding Gene
MGP_CAROLIEiJ_G0024098 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0026297 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0026258 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0026237 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0026271 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0026016 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1344337 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0026718 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0025479 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0025993 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0026132 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0026094 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0026233 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0026113 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0026773 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0025215 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0025548 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0025541 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0025014 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
33903764 | J:305302
First Author: Kapoor VN
Year: 2021
Journal: Nat Immunol
Title: Gremlin 1+ fibroblastic niche maintains dendritic cell homeostasis in lymphoid tissues.
Volume: 22
Issue: 5
Pages: 571-585
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Publication
22247494 | J:196631
First Author: Cahill E
Year: 2012
Journal: Circulation
Title: Gremlin plays a key role in the pathogenesis of pulmonary hypertension.
Volume: 125
Issue: 7
Pages: 920-30
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Publication
- | J:13381
 
First Author: Russell LB
Year: 1960
Journal: Mouse News Lett
Title: Limb-deformity, ld
Volume: 22
Pages: 50
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Publication
17077323 | J:145361
First Author: Stabile H
Year: 2007
Journal: Blood
Title: Bone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor.
Volume: 109
Issue: 5
Pages: 1834-40
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Publication
15539560 | J:95780
First Author: Gazzerro E
Year: 2005
Journal: Endocrinology
Title: Skeletal overexpression of gremlin impairs bone formation and causes osteopenia.
Volume: 146
Issue: 2
Pages: 655-65
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Publication
24160323 | J:202740
First Author: Ciuclan L
Year: 2013
Journal: Am J Pathol
Title: Treatment with anti-gremlin 1 antibody ameliorates chronic hypoxia/SU5416-induced pulmonary arterial hypertension in mice.
Volume: 183
Issue: 5
Pages: 1461-73
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GXD Expression
GXD Expression
     
Probe: MGI:5810893
Assay Type: RT-PCR
Annotation Date: 2023-12-13
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:7565429
Age: postnatal adult
Specimen Label: Het Kidney
Detected: false
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:5810893
Assay Type: RT-PCR
Annotation Date: 2023-12-13
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:7565429
Age: postnatal adult
Specimen Label: M Kidney
Detected: false
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:5810893
Assay Type: RT-PCR
Annotation Date: 2023-12-13
Strength: Present
Sex: Male
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:7565439
Age: postnatal adult
Specimen Label: Het Male
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5810893
Assay Type: RT-PCR
Annotation Date: 2023-12-13
Strength: Absent
Sex: Male
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:7565439
Age: postnatal adult
Specimen Label: Mut Male
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5810893
Assay Type: RT-PCR
Annotation Date: 2023-12-13
Strength: Present
Sex: Female
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:7565439
Age: postnatal adult
Specimen Label: Het Female
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5810893
Assay Type: RT-PCR
Annotation Date: 2023-12-13
Strength: Absent
Sex: Female
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:7565439
Age: postnatal adult
Specimen Label: Mut Female
Detected: false
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5810893
Assay Type: RT-PCR
Annotation Date: 2023-12-13
Strength: Present
Sex: Male
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:7565450
Age: postnatal adult
Specimen Label: Het Male
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5810893
Assay Type: RT-PCR
Annotation Date: 2023-12-13
Strength: Absent
Sex: Male
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:7565450
Age: postnatal adult
Specimen Label: Mut Male
Detected: false
Specimen Num: 2
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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