Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry represent GRIP2. In mice GRIP2 functions downstream of Notch3/RBP-Jkappa to regulate myogenic tone in the brain arteries []. In Xenopus GRIP2 is involved in primordial germ cell development and migration []. Glutamate receptor-interacting proteins (GRIPs) are multi-PDZ domain scaffolding proteins required for dendrite development. There are two members of the GRIP family: GRIP1 and GRIP2/ABP (AMPA receptor binding protein) []. GRIPs regulate AMPAR receptor trafficking and neuronal plasticity [, ]. They also bind various receptor and signalling proteins, such as EphB receptors, ephrinB ligands, the proteoglycan NG2, the Fraser syndrome protein Fras1, and matrix metalloproteinase 5 []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Fouillade C |
Year: |
2013 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature. |
Volume: |
33 |
Issue: |
1 |
Pages: |
76-86 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
591
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Kirilenko P |
Year: |
2008 |
Journal: |
Differentiation |
Title: |
The efficiency of Xenopus primordial germ cell migration depends on the germplasm mRNA encoding the PDZ domain protein Grip2. |
Volume: |
76 |
Issue: |
4 |
Pages: |
392-403 |
|
•
•
•
•
•
|
Publication |
First Author: |
Geiger JC |
Year: |
2014 |
Journal: |
Dev Cell |
Title: |
The GRIP1/14-3-3 pathway coordinates cargo trafficking and dendrite development. |
Volume: |
28 |
Issue: |
4 |
Pages: |
381-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wyszynski M |
Year: |
2002 |
Journal: |
Neuron |
Title: |
Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting. |
Volume: |
34 |
Issue: |
1 |
Pages: |
39-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lu W |
Year: |
2005 |
Journal: |
Neuron |
Title: |
PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking. |
Volume: |
47 |
Issue: |
3 |
Pages: |
407-21 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1042
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1001
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
119
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
821
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
174
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Takamiya K |
Year: |
2008 |
Journal: |
J Neurosci |
Title: |
The glutamate receptor-interacting protein family of GluR2-binding proteins is required for long-term synaptic depression expression in cerebellar Purkinje cells. |
Volume: |
28 |
Issue: |
22 |
Pages: |
5752-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mao L |
Year: |
2010 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
GRIP1 and 2 regulate activity-dependent AMPA receptor recycling via exocyst complex interactions. |
Volume: |
107 |
Issue: |
44 |
Pages: |
19038-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mejias R |
Year: |
2019 |
Journal: |
Neurobiol Dis |
Title: |
Purkinje cell-specific Grip1/2 knockout mice show increased repetitive self-grooming and enhanced mGluR5 signaling in cerebellum. |
Volume: |
132 |
|
Pages: |
104602 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4425246 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1778023 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825236 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_010840_10 |
|
Specimen Label: |
euxassay_010840_10 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4425246 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1778023 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825236 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_010840_11 |
|
Specimen Label: |
euxassay_010840_11 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4425246 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1778023 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825236 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_010840_14 |
|
Specimen Label: |
euxassay_010840_14 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4425246 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1778023 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825236 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_010840_15 |
|
Specimen Label: |
euxassay_010840_15 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4425246 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1778023 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825236 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_010840_16 |
|
Specimen Label: |
euxassay_010840_16 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4425246 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1718523 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825236 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_010840_11 |
|
Specimen Label: |
euxassay_010840_11 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4425246 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1718523 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825236 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_010840_12 |
|
Specimen Label: |
euxassay_010840_12 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4425246 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1718523 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825236 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_010840_13 |
|
Specimen Label: |
euxassay_010840_13 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4425246 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1690623 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825236 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_010840_10 |
Note: |
basal plate of prosomere 1 |
Specimen Label: |
euxassay_010840_10 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4425246 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1690623 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825236 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_010840_11 |
Note: |
basal plate of prosomere 1 |
Specimen Label: |
euxassay_010840_11 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4425246 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1690623 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825236 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_010840_13 |
Note: |
basal plate of prosomere 1 |
Specimen Label: |
euxassay_010840_13 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4425246 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1690623 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4825236 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_010840_14 |
Note: |
basal plate of prosomere 1 |
Specimen Label: |
euxassay_010840_14 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Han M |
Year: |
2017 |
Journal: |
Behav Brain Res |
Title: |
Mice lacking GRIP1/2 show increased social interactions and enhanced phosphorylation at GluA2-S880. |
Volume: |
321 |
|
Pages: |
176-184 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mejias R |
Year: |
2011 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Gain-of-function glutamate receptor interacting protein 1 variants alter GluA2 recycling and surface distribution in patients with autism. |
Volume: |
108 |
Issue: |
12 |
Pages: |
4920-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Briand LA |
Year: |
2014 |
Journal: |
Neuropsychopharmacology |
Title: |
Disruption of glutamate receptor-interacting protein in nucleus accumbens enhances vulnerability to cocaine relapse. |
Volume: |
39 |
Issue: |
3 |
Pages: |
759-69 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tan HL |
Year: |
2015 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
GRIP1 is required for homeostatic regulation of AMPAR trafficking. |
Volume: |
112 |
Issue: |
32 |
Pages: |
10026-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Monea S |
Year: |
2006 |
Journal: |
J Neurosci |
Title: |
Membrane localization of membrane type 5 matrix metalloproteinase by AMPA receptor binding protein and cleavage of cadherins. |
Volume: |
26 |
Issue: |
8 |
Pages: |
2300-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takamiya K |
Year: |
2004 |
Journal: |
Nat Genet |
Title: |
A direct functional link between the multi-PDZ domain protein GRIP1 and the Fraser syndrome protein Fras1. |
Volume: |
36 |
Issue: |
2 |
Pages: |
172-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vadasz C |
Year: |
2007 |
Journal: |
Neurochem Res |
Title: |
Mapping of QTLs for oral alcohol self-administration in B6.C and B6.I quasi-congenic RQI strains. |
Volume: |
32 |
Issue: |
7 |
Pages: |
1099-112 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2001 |
|
Title: |
Gene Ontology Annotation by the MGI Curatorial Staff |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
806
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
469
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
485
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
485
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
792
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
469
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
837
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Ye B |
Year: |
2000 |
Journal: |
Neuron |
Title: |
GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex. |
Volume: |
26 |
Issue: |
3 |
Pages: |
603-17 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
GRIP1-associated protein 1 (GRIPAP1, also known as GRASP-1) is expressed in the CNS and interacts with GRIP1, GRIP2 and AMPA receptors []. It may regulate neuronal ras signaling and contribute to the regulation of AMPA receptor distribution by NMDA receptor activity []. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
139
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Vinh DB |
Year: |
2002 |
Journal: |
Mol Biol Cell |
Title: |
Reconstitution and characterization of budding yeast gamma-tubulin complex. |
Volume: |
13 |
Issue: |
4 |
Pages: |
1144-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Teixidó-Travesa N |
Year: |
2012 |
Journal: |
J Cell Sci |
Title: |
The where, when and how of microtubule nucleation - one ring to rule them all. |
Volume: |
125 |
Issue: |
Pt 19 |
Pages: |
4445-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hashimoto T |
Year: |
2013 |
Journal: |
Curr Opin Plant Biol |
Title: |
A ring for all: γ-tubulin-containing nucleation complexes in acentrosomal plant microtubule arrays. |
Volume: |
16 |
Issue: |
6 |
Pages: |
698-703 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kollman JM |
Year: |
2011 |
Journal: |
Nat Rev Mol Cell Biol |
Title: |
Microtubule nucleation by γ-tubulin complexes. |
Volume: |
12 |
Issue: |
11 |
Pages: |
709-21 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
The microtubule organizing centres (MTOCs) of eukaryotic cells are the sites of nucleation of microtubules, and are known as the centrosome in animal cells and the spindle pole body in yeast. Gamma-tubulin, which is 30% identical to alpha and beta tubulins that form microtubules, appears to be a key protein involved in nucleation of microtubules.Gamma tubulin can assemble into complexes of various sizes with members of the GCP family. In budding yeast, the gamma tubulin-containing small complex (gammaTuSC) contains gamma tubulin, GCP2 and GCP3 (also known as Spc97 and Spc98). In Drosophila and vertebrates, gamma tubulin forms much larger assemblies, termed gamma-tubulin ring complexes (gammaTuRCs), with gamma tubulin, GCP2, GCP3, GCP4, GCP5 and GCP6. The purified gammaTuSC and gammaTuRC complexes exhibit a 'lock washer' shape []. However, the purified gammaTuSC has been shown to have a much lower microtubule-nucleating activity than intact gammaTuRC []. Several models have been proposed to explain their assembly and nucleation mechanism []. This entry represents the GCP family, whose members include GCP2/3/4/5/6 and Spc97/98 []. They contain the GRIP1 and GRIP2 motifs, which are predicted to participate in protein-protein interactions []. They are gamma tubulin binding proteins that have similar protein structures []. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
372
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
293
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
302
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
128
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
364
 |
Fragment?: |
false |
|
•
•
•
•
•
|