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Search results 1 to 100 out of 127 for Grk1

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Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
6011 | GRK1
Type: gene
Organism: human
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Gene
467338 | GRK1
Type: gene
Organism: chimpanzee
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Gene
485557 | GRK1
Type: gene
Organism: dog, domestic
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Gene
281457 | GRK1
Type: gene
Organism: cattle
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Gene
395431 | GRK1
Type: gene
Organism: chicken
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Gene
715484 | GRK1
Type: gene
Organism: macaque, rhesus
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Gene
100486335 | grk1
Type: gene
Organism: frog, western clawed
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Protein Domain
IPR032965 | GRK1
Type: Family
Description: Rhodopsin kinase (also known as G-protein-coupled Receptor Kinase 1, GRK1) is a retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade []. Together with recoverin (a Ca2+-binding protein), GRK1 regulates cone phototransduction during photoreceptor light adaptation [, ].
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Gene
81760 | Grk1
Type: gene
Organism: rat
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Protein Coding Gene
MGI:1345146 | Grk1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
25673692 | J:244804
First Author: Sakurai K
Year: 2015
Journal: J Biol Chem
Title: Regulation of mammalian cone phototransduction by recoverin and rhodopsin kinase.
Volume: 290
Issue: 14
Pages: 9239-50
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Protein
Q9WVL4
Organism: Mus musculus/domesticus
Length: 564  
Fragment?: false
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Publication
25667411 | J:243908
First Author: Chen CK
Year: 2015
Journal: J Gen Physiol
Title: Rhodopsin kinase and recoverin modulate phosphodiesterase during mouse photoreceptor light adaptation.
Volume: 145
Issue: 3
Pages: 213-24
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Publication
1730692 | -
First Author: Inglese J
Year: 1992
Journal: J Biol Chem
Title: Isoprenylation of a protein kinase. Requirement of farnesylation/alpha-carboxyl methylation for full enzymatic activity of rhodopsin kinase.
Volume: 267
Issue: 3
Pages: 1422-5
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Publication
20164334 | J:157837
First Author: Fan J
Year: 2010
Journal: J Neurosci
Title: Deletion of GRK1 causes retina degeneration through a transducin-independent mechanism.
Volume: 30
Issue: 7
Pages: 2496-503
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Publication
10704496 | J:60964
First Author: Lyubarsky AL
Year: 2000
Journal: J Neurosci
Title: Mice lacking G-protein receptor kinase 1 have profoundly slowed recovery of cone-driven retinal responses.
Volume: 20
Issue: 6
Pages: 2209-17
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Publication
21504899 | J:173491
First Author: Osawa S
Year: 2011
Journal: J Biol Chem
Title: Phosphorylation of G protein-coupled receptor kinase 1 (GRK1) is regulated by light but independent of phototransduction in rod photoreceptors.
Volume: 286
Issue: 23
Pages: 20923-9
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Publication
17496142 | J:121745
First Author: Zhang H
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Deletion of PrBP/delta impedes transport of GRK1 and PDE6 catalytic subunits to photoreceptor outer segments.
Volume: 104
Issue: 21
Pages: 8857-62
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Publication
24664735 | J:318794
 
First Author: Zhang H
Year: 2014
Journal: Adv Exp Med Biol
Title: Unc119 gene deletion partially rescues the GRK1 transport defect of Pde6d (- /-) cones.
Volume: 801
Pages: 487-93
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Publication
10097103 | J:54021
First Author: Chen CK
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase.
Volume: 96
Issue: 7
Pages: 3718-22
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Protein
Q4V9Z9
Organism: Mus musculus/domesticus
Length: 564  
Fragment?: false
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Protein
G3X905
Organism: Mus musculus/domesticus
Length: 564  
Fragment?: false
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Publication
26427409 | J:241495
 
First Author: Charette JR
Year: 2016
Journal: Adv Exp Med Biol
Title: A Chemical Mutagenesis Screen Identifies Mouse Models with ERG Defects.
Volume: 854
Pages: 177-83
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Publication
21474765 | J:181424
First Author: Sakurai K
Year: 2011
Journal: Invest Ophthalmol Vis Sci
Title: Variation in rhodopsin kinase expression alters the dim flash response shut off and the light adaptation in rod photoreceptors.
Volume: 52
Issue: 9
Pages: 6793-800
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Publication
19834036 | J:160418
First Author: Whitcomb T
Year: 2010
Journal: Invest Ophthalmol Vis Sci
Title: Effect of g protein-coupled receptor kinase 1 (Grk1) overexpression on rod photoreceptor cell viability.
Volume: 51
Issue: 3
Pages: 1728-37
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Publication
31908030 | J:296511
First Author: Kolesnikov AV
Year: 2020
Journal: FASEB J
Title: Phosphorylation at Serine 21 in G protein-coupled receptor kinase 1 (GRK1) is required for normal kinetics of dark adaption in rod but not cone photoreceptors.
Volume: 34
Issue: 2
Pages: 2677-2690
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Publication
12853434 | J:84455
First Author: Zhu X
Year: 2003
Journal: J Neurosci
Title: GRK1-dependent phosphorylation of S and M opsins and their binding to cone arrestin during cone phototransduction in the mouse retina.
Volume: 23
Issue: 14
Pages: 6152-60
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Publication
23136436 | J:192462
First Author: Chen CK
Year: 2012
Journal: J Neurosci
Title: Modulation of mouse rod response decay by rhodopsin kinase and recoverin.
Volume: 32
Issue: 45
Pages: 15998-6006
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Publication
20688726 | J:171388
First Author: Yetemian RM
Year: 2010
Journal: Invest Ophthalmol Vis Sci
Title: Neovascularization, enhanced inflammatory response, and age-related cone dystrophy in the Nrl-/-Grk1-/- mouse retina.
Volume: 51
Issue: 12
Pages: 6196-206
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Publication
19776273 | J:153044
First Author: Doan T
Year: 2009
Journal: J Neurosci
Title: Arrestin competition influences the kinetics and variability of the single-photon responses of mammalian rod photoreceptors.
Volume: 29
Issue: 38
Pages: 11867-79
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Publication
15738050 | J:112480
First Author: Nikonov SS
Year: 2005
Journal: J Gen Physiol
Title: Photoreceptors of Nrl -/- mice coexpress functional S- and M-cone opsins having distinct inactivation mechanisms.
Volume: 125
Issue: 3
Pages: 287-304
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Publication
12802257 | J:126386
 
First Author: Zhang H
Year: 2003
Journal: Mol Vis
Title: Light-dependent redistribution of visual arrestins and transducin subunits in mice with defective phototransduction.
Volume: 9
Pages: 231-7
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Protein Coding Gene
MGP_CAROLIEiJ_G0030841 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0033380 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0033360 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0033291 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0033361 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0033074 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1345146 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0033873 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0032396 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0033047 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0033200 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0033149 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0033294 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0033183 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0033890 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0032109 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0032512 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0021304 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0031951 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:7507561
Assay Type: Western blot
Annotation Date: 2023-07-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:7507581
Age: postnatal week 5
Image: 7
Specimen Label: WT#1
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7507561
Assay Type: Western blot
Annotation Date: 2023-07-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:7507581
Age: postnatal week 5
Image: 7
Specimen Label: WT#2
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7507561
Assay Type: Western blot
Annotation Date: 2023-07-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:7507581
Age: postnatal week 5
Image: 7
Specimen Label: KO#1
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7507561
Assay Type: Western blot
Annotation Date: 2023-07-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:7507581
Age: postnatal week 5
Image: 7
Specimen Label: KO#2
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:7507561
Assay Type: Western blot
Annotation Date: 2023-07-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:7507581
Age: postnatal week 5
Image: 7
Specimen Label: KO#3
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
Probe: MGI:3834366
Assay Type: RNA in situ
Annotation Date: 2009-03-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3834702
Age: postnatal day 14
Image: S7 wt
Note: Expression was detected in rods.
Specimen Label: S7 wt
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:3834366
Assay Type: RNA in situ
Annotation Date: 2009-03-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3834702
Age: postnatal day 14
Image: S7 Nr2e3-/-
Note: Expression was detected in rods as in wild type.
Specimen Label: S7 Nr2e3-/-
Detected: true
Specimen Num: 2
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Publication
16908407 | J:144675
First Author: Krispel CM
Year: 2006
Journal: Neuron
Title: RGS expression rate-limits recovery of rod photoresponses.
Volume: 51
Issue: 4
Pages: 409-16
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Publication
15382206 | J:104812
First Author: Plant SR
Year: 2005
Journal: Glia
Title: Astroglial-derived lymphotoxin-alpha exacerbates inflammation and demyelination, but not remyelination.
Volume: 49
Issue: 1
Pages: 1-14
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Publication
33318667 | J:304867
First Author: Merlini M
Year: 2021
Journal: Nat Neurosci
Title: Microglial Gi-dependent dynamics regulate brain network hyperexcitability.
Volume: 24
Issue: 1
Pages: 19-23
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Publication
20107049 | J:157689
First Author: Chen CK
Year: 2010
Journal: J Neurosci
Title: Background light produces a recoverin-dependent modulation of activated-rhodopsin lifetime in mouse rods.
Volume: 30
Issue: 4
Pages: 1213-20
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Publication
26664249 | J:228289
 
First Author: Pak JS
Year: 2015
Journal: Mol Vis
Title: The retinal phenotype of Grk1-/- is compromised by a Crb1 rd8 mutation.
Volume: 21
Pages: 1281-94
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Publication
11687607 | J:85250
First Author: Choi S
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Gene expression profiles of light-induced apoptosis in arrestin/rhodopsin kinase-deficient mouse retinas.
Volume: 98
Issue: 23
Pages: 13096-101
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Publication
20484624 | J:160517
First Author: Lobanova ES
Year: 2010
Journal: J Neurosci
Title: Mechanistic basis for the failure of cone transducin to translocate: why cones are never blinded by light.
Volume: 30
Issue: 20
Pages: 6815-24
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Publication
25910054 | J:221472
   
First Author: Azevedo AW
Year: 2015
Journal: Elife
Title: C-terminal threonines and serines play distinct roles in the desensitization of rhodopsin, a G protein-coupled receptor.
Volume: 4
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Publication
27358455 | J:318617
First Author: Berry J
Year: 2016
Journal: J Neurosci
Title: Effect of Rhodopsin Phosphorylation on Dark Adaptation in Mouse Rods.
Volume: 36
Issue: 26
Pages: 6973-87
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Publication
30947334 | J:274732
First Author: Leinonen H
Year: 2019
Journal: Invest Ophthalmol Vis Sci
Title: A Mixture of U.S. Food and Drug Administration-Approved Monoaminergic Drugs Protects the Retina From Light Damage in Diverse Models of Night Blindness.
Volume: 60
Issue: 5
Pages: 1442-1453
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Publication
18187566 | J:131322
First Author: Yamamoto M
Year: 2008
Journal: Am J Pathol
Title: Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells.
Volume: 172
Issue: 2
Pages: 521-33
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Publication
19361994 | J:148930
First Author: Song X
Year: 2009
Journal: Curr Biol
Title: Enhanced arrestin facilitates recovery and protects rods lacking rhodopsin phosphorylation.
Volume: 19
Issue: 8
Pages: 700-5
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Publication
12975449 | J:105946
First Author: Hamer RD
Year: 2003
Journal: J Gen Physiol
Title: Multiple steps of phosphorylation of activated rhodopsin can account for the reproducibility of vertebrate rod single-photon responses.
Volume: 122
Issue: 4
Pages: 419-44
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Publication
17098744 | J:118545
First Author: Ki SH
Year: 2007
Journal: J Biol Chem
Title: Galpha12 specifically regulates COX-2 induction by sphingosine 1-phosphate. Role for JNK-dependent ubiquitination and degradation of IkappaBalpha.
Volume: 282
Issue: 3
Pages: 1938-47
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Publication
17591699 | J:125008
First Author: Cho MK
Year: 2007
Journal: Mol Cell Biol
Title: Role of Galpha12 and Galpha13 as novel switches for the activity of Nrf2, a key antioxidative transcription factor.
Volume: 27
Issue: 17
Pages: 6195-208
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Publication
12716919 | J:123823
First Author: Mendez A
Year: 2003
Journal: J Neurosci
Title: Light-dependent translocation of arrestin in the absence of rhodopsin phosphorylation and transducin signaling.
Volume: 23
Issue: 8
Pages: 3124-9
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Publication
27328943 | J:239714
First Author: Ronquillo CC
Year: 2016
Journal: FASEB J
Title: Ciliopathy-associated IQCB1/NPHP5 protein is required for mouse photoreceptor outer segment formation.
Volume: 30
Issue: 10
Pages: 3400-3412
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Publication
22183407 | J:214071
 
First Author: Hagstrom SA
Year: 2012
Journal: Adv Exp Med Biol
Title: Tulp1 is involved in specific photoreceptor protein transport pathways.
Volume: 723
Pages: 783-9
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Publication
37033230 | J:334815
 
First Author: Ng L
Year: 2023
Journal: Front Endocrinol (Lausanne)
Title: Biphasic expression of thyroid hormone receptor TRβ1 in mammalian retina and anterior ocular tissues.
Volume: 14
Pages: 1174600
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Publication
27008858 | J:234197
First Author: Wong BH
Year: 2016
Journal: J Biol Chem
Title: Mfsd2a Is a Transporter for the Essential ω-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development.
Volume: 291
Issue: 20
Pages: 10501-14
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Publication
33500475 | J:301112
First Author: Maddala R
Year: 2021
Journal: Sci Rep
Title: Absence of S100A4 in the mouse lens induces an aberrant retina-specific differentiation program and cataract.
Volume: 11
Issue: 1
Pages: 2203
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Publication
16110338 | J:107820
First Author: Corbo JC
Year: 2005
Journal: PLoS Genet
Title: A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome.
Volume: 1
Issue: 2
Pages: e11
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
32290105 | J:282558
 
First Author: Collin GB
Year: 2020
Journal: Cells
Title: Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.
Volume: 9
Issue: 4
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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