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Search results 1 to 100 out of 127 for Grk1

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Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
6011 | GRK1
Type: gene
Organism: human
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Gene
100486335 | grk1
Type: gene
Organism: frog, western clawed
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Protein Domain
IPR032965 | GRK1
Type: Family
Description: Rhodopsin kinase (also known as G-protein-coupled Receptor Kinase 1, GRK1) is a retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade []. Together with recoverin (a Ca2+-binding protein), GRK1 regulates cone phototransduction during photoreceptor light adaptation [, ].
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Gene
81760 | Grk1
Type: gene
Organism: rat
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Gene
467338 | GRK1
Type: gene
Organism: chimpanzee
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Gene
485557 | GRK1
Type: gene
Organism: dog, domestic
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Gene
281457 | GRK1
Type: gene
Organism: cattle
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Gene
395431 | GRK1
Type: gene
Organism: chicken
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Gene
715484 | GRK1
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1345146 | Grk1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
25673692 | J:244804
First Author: Sakurai K
Year: 2015
Journal: J Biol Chem
Title: Regulation of mammalian cone phototransduction by recoverin and rhodopsin kinase.
Volume: 290
Issue: 14
Pages: 9239-50
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Protein
Q9WVL4
Organism: Mus musculus/domesticus
Length: 564  
Fragment?: false
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Publication
25667411 | J:243908
First Author: Chen CK
Year: 2015
Journal: J Gen Physiol
Title: Rhodopsin kinase and recoverin modulate phosphodiesterase during mouse photoreceptor light adaptation.
Volume: 145
Issue: 3
Pages: 213-24
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Publication
1730692 | -
First Author: Inglese J
Year: 1992
Journal: J Biol Chem
Title: Isoprenylation of a protein kinase. Requirement of farnesylation/alpha-carboxyl methylation for full enzymatic activity of rhodopsin kinase.
Volume: 267
Issue: 3
Pages: 1422-5
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Publication
20164334 | J:157837
First Author: Fan J
Year: 2010
Journal: J Neurosci
Title: Deletion of GRK1 causes retina degeneration through a transducin-independent mechanism.
Volume: 30
Issue: 7
Pages: 2496-503
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Publication
10704496 | J:60964
First Author: Lyubarsky AL
Year: 2000
Journal: J Neurosci
Title: Mice lacking G-protein receptor kinase 1 have profoundly slowed recovery of cone-driven retinal responses.
Volume: 20
Issue: 6
Pages: 2209-17
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Publication
21504899 | J:173491
First Author: Osawa S
Year: 2011
Journal: J Biol Chem
Title: Phosphorylation of G protein-coupled receptor kinase 1 (GRK1) is regulated by light but independent of phototransduction in rod photoreceptors.
Volume: 286
Issue: 23
Pages: 20923-9
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Publication
24664735 | J:318794
 
First Author: Zhang H
Year: 2014
Journal: Adv Exp Med Biol
Title: Unc119 gene deletion partially rescues the GRK1 transport defect of Pde6d (- /-) cones.
Volume: 801
Pages: 487-93
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Publication
17496142 | J:121745
First Author: Zhang H
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Deletion of PrBP/delta impedes transport of GRK1 and PDE6 catalytic subunits to photoreceptor outer segments.
Volume: 104
Issue: 21
Pages: 8857-62
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Publication
10097103 | J:54021
First Author: Chen CK
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase.
Volume: 96
Issue: 7
Pages: 3718-22
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Protein
Q4V9Z9
Organism: Mus musculus/domesticus
Length: 564  
Fragment?: false
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Protein
G3X905
Organism: Mus musculus/domesticus
Length: 564  
Fragment?: false
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Publication
26427409 | J:241495
 
First Author: Charette JR
Year: 2016
Journal: Adv Exp Med Biol
Title: A Chemical Mutagenesis Screen Identifies Mouse Models with ERG Defects.
Volume: 854
Pages: 177-83
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Publication
21474765 | J:181424
First Author: Sakurai K
Year: 2011
Journal: Invest Ophthalmol Vis Sci
Title: Variation in rhodopsin kinase expression alters the dim flash response shut off and the light adaptation in rod photoreceptors.
Volume: 52
Issue: 9
Pages: 6793-800
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Publication
19834036 | J:160418
First Author: Whitcomb T
Year: 2010
Journal: Invest Ophthalmol Vis Sci
Title: Effect of g protein-coupled receptor kinase 1 (Grk1) overexpression on rod photoreceptor cell viability.
Volume: 51
Issue: 3
Pages: 1728-37
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Publication
31908030 | J:296511
First Author: Kolesnikov AV
Year: 2020
Journal: FASEB J
Title: Phosphorylation at Serine 21 in G protein-coupled receptor kinase 1 (GRK1) is required for normal kinetics of dark adaption in rod but not cone photoreceptors.
Volume: 34
Issue: 2
Pages: 2677-2690
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Publication
12853434 | J:84455
First Author: Zhu X
Year: 2003
Journal: J Neurosci
Title: GRK1-dependent phosphorylation of S and M opsins and their binding to cone arrestin during cone phototransduction in the mouse retina.
Volume: 23
Issue: 14
Pages: 6152-60
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Publication
20688726 | J:171388
First Author: Yetemian RM
Year: 2010
Journal: Invest Ophthalmol Vis Sci
Title: Neovascularization, enhanced inflammatory response, and age-related cone dystrophy in the Nrl-/-Grk1-/- mouse retina.
Volume: 51
Issue: 12
Pages: 6196-206
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Publication
23136436 | J:192462
First Author: Chen CK
Year: 2012
Journal: J Neurosci
Title: Modulation of mouse rod response decay by rhodopsin kinase and recoverin.
Volume: 32
Issue: 45
Pages: 15998-6006
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Publication
19776273 | J:153044
First Author: Doan T
Year: 2009
Journal: J Neurosci
Title: Arrestin competition influences the kinetics and variability of the single-photon responses of mammalian rod photoreceptors.
Volume: 29
Issue: 38
Pages: 11867-79
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Publication
15738050 | J:112480
First Author: Nikonov SS
Year: 2005
Journal: J Gen Physiol
Title: Photoreceptors of Nrl -/- mice coexpress functional S- and M-cone opsins having distinct inactivation mechanisms.
Volume: 125
Issue: 3
Pages: 287-304
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Publication
12802257 | J:126386
 
First Author: Zhang H
Year: 2003
Journal: Mol Vis
Title: Light-dependent redistribution of visual arrestins and transducin subunits in mice with defective phototransduction.
Volume: 9
Pages: 231-7
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Protein Coding Gene
MGP_CAROLIEiJ_G0030841 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0033380 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0033360 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0033291 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0033361 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0033074 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1345146 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0033873 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0032396 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0033047 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0033200 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0033149 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0033294 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0033183 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0033890 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0032109 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0032512 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0021304 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0031951 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:7507561
Assay Type: Western blot
Annotation Date: 2023-07-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:7507581
Age: postnatal week 5
Image: 7
Specimen Label: WT#1
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7507561
Assay Type: Western blot
Annotation Date: 2023-07-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:7507581
Age: postnatal week 5
Image: 7
Specimen Label: WT#2
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7507561
Assay Type: Western blot
Annotation Date: 2023-07-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:7507581
Age: postnatal week 5
Image: 7
Specimen Label: KO#1
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7507561
Assay Type: Western blot
Annotation Date: 2023-07-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:7507581
Age: postnatal week 5
Image: 7
Specimen Label: KO#2
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:7507561
Assay Type: Western blot
Annotation Date: 2023-07-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:7507581
Age: postnatal week 5
Image: 7
Specimen Label: KO#3
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
Probe: MGI:3834366
Assay Type: RNA in situ
Annotation Date: 2009-03-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3834702
Age: postnatal day 14
Image: S7 wt
Note: Expression was detected in rods.
Specimen Label: S7 wt
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:3834366
Assay Type: RNA in situ
Annotation Date: 2009-03-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3834702
Age: postnatal day 14
Image: S7 Nr2e3-/-
Note: Expression was detected in rods as in wild type.
Specimen Label: S7 Nr2e3-/-
Detected: true
Specimen Num: 2
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Publication
16908407 | J:144675
First Author: Krispel CM
Year: 2006
Journal: Neuron
Title: RGS expression rate-limits recovery of rod photoresponses.
Volume: 51
Issue: 4
Pages: 409-16
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Publication
15382206 | J:104812
First Author: Plant SR
Year: 2005
Journal: Glia
Title: Astroglial-derived lymphotoxin-alpha exacerbates inflammation and demyelination, but not remyelination.
Volume: 49
Issue: 1
Pages: 1-14
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Publication
33318667 | J:304867
First Author: Merlini M
Year: 2021
Journal: Nat Neurosci
Title: Microglial Gi-dependent dynamics regulate brain network hyperexcitability.
Volume: 24
Issue: 1
Pages: 19-23
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Publication
20107049 | J:157689
First Author: Chen CK
Year: 2010
Journal: J Neurosci
Title: Background light produces a recoverin-dependent modulation of activated-rhodopsin lifetime in mouse rods.
Volume: 30
Issue: 4
Pages: 1213-20
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Publication
11687607 | J:85250
First Author: Choi S
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Gene expression profiles of light-induced apoptosis in arrestin/rhodopsin kinase-deficient mouse retinas.
Volume: 98
Issue: 23
Pages: 13096-101
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Publication
26664249 | J:228289
 
First Author: Pak JS
Year: 2015
Journal: Mol Vis
Title: The retinal phenotype of Grk1-/- is compromised by a Crb1 rd8 mutation.
Volume: 21
Pages: 1281-94
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Publication
30947334 | J:274732
First Author: Leinonen H
Year: 2019
Journal: Invest Ophthalmol Vis Sci
Title: A Mixture of U.S. Food and Drug Administration-Approved Monoaminergic Drugs Protects the Retina From Light Damage in Diverse Models of Night Blindness.
Volume: 60
Issue: 5
Pages: 1442-1453
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Publication
20484624 | J:160517
First Author: Lobanova ES
Year: 2010
Journal: J Neurosci
Title: Mechanistic basis for the failure of cone transducin to translocate: why cones are never blinded by light.
Volume: 30
Issue: 20
Pages: 6815-24
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Publication
25910054 | J:221472
   
First Author: Azevedo AW
Year: 2015
Journal: Elife
Title: C-terminal threonines and serines play distinct roles in the desensitization of rhodopsin, a G protein-coupled receptor.
Volume: 4
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Publication
27358455 | J:318617
First Author: Berry J
Year: 2016
Journal: J Neurosci
Title: Effect of Rhodopsin Phosphorylation on Dark Adaptation in Mouse Rods.
Volume: 36
Issue: 26
Pages: 6973-87
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Publication
18187566 | J:131322
First Author: Yamamoto M
Year: 2008
Journal: Am J Pathol
Title: Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells.
Volume: 172
Issue: 2
Pages: 521-33
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Publication
19361994 | J:148930
First Author: Song X
Year: 2009
Journal: Curr Biol
Title: Enhanced arrestin facilitates recovery and protects rods lacking rhodopsin phosphorylation.
Volume: 19
Issue: 8
Pages: 700-5
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Publication
12975449 | J:105946
First Author: Hamer RD
Year: 2003
Journal: J Gen Physiol
Title: Multiple steps of phosphorylation of activated rhodopsin can account for the reproducibility of vertebrate rod single-photon responses.
Volume: 122
Issue: 4
Pages: 419-44
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Publication
12716919 | J:123823
First Author: Mendez A
Year: 2003
Journal: J Neurosci
Title: Light-dependent translocation of arrestin in the absence of rhodopsin phosphorylation and transducin signaling.
Volume: 23
Issue: 8
Pages: 3124-9
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Publication
17591699 | J:125008
First Author: Cho MK
Year: 2007
Journal: Mol Cell Biol
Title: Role of Galpha12 and Galpha13 as novel switches for the activity of Nrf2, a key antioxidative transcription factor.
Volume: 27
Issue: 17
Pages: 6195-208
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Publication
17098744 | J:118545
First Author: Ki SH
Year: 2007
Journal: J Biol Chem
Title: Galpha12 specifically regulates COX-2 induction by sphingosine 1-phosphate. Role for JNK-dependent ubiquitination and degradation of IkappaBalpha.
Volume: 282
Issue: 3
Pages: 1938-47
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Publication
22183407 | J:214071
 
First Author: Hagstrom SA
Year: 2012
Journal: Adv Exp Med Biol
Title: Tulp1 is involved in specific photoreceptor protein transport pathways.
Volume: 723
Pages: 783-9
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Publication
27328943 | J:239714
First Author: Ronquillo CC
Year: 2016
Journal: FASEB J
Title: Ciliopathy-associated IQCB1/NPHP5 protein is required for mouse photoreceptor outer segment formation.
Volume: 30
Issue: 10
Pages: 3400-3412
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Publication
37033230 | J:334815
 
First Author: Ng L
Year: 2023
Journal: Front Endocrinol (Lausanne)
Title: Biphasic expression of thyroid hormone receptor TRβ1 in mammalian retina and anterior ocular tissues.
Volume: 14
Pages: 1174600
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Publication
27008858 | J:234197
First Author: Wong BH
Year: 2016
Journal: J Biol Chem
Title: Mfsd2a Is a Transporter for the Essential ω-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development.
Volume: 291
Issue: 20
Pages: 10501-14
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Publication
33500475 | J:301112
First Author: Maddala R
Year: 2021
Journal: Sci Rep
Title: Absence of S100A4 in the mouse lens induces an aberrant retina-specific differentiation program and cataract.
Volume: 11
Issue: 1
Pages: 2203
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Publication
16110338 | J:107820
First Author: Corbo JC
Year: 2005
Journal: PLoS Genet
Title: A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome.
Volume: 1
Issue: 2
Pages: e11
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Publication
32290105 | J:282558
 
First Author: Collin GB
Year: 2020
Journal: Cells
Title: Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.
Volume: 9
Issue: 4
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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