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Search results 1 to 100 out of 448 for Grn

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Drosophila melanogaster
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein
Organism: Mus musculus
Length: 248  
Fragment?: false
Publication
First Author: Huang M
Year: 2020
Journal: Acta Neuropathol Commun
Title: Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations.
Volume: 8
Issue: 1
Pages: 163
Publication  
First Author: Petkau TL
Year: 2016
Journal: Neuroscience
Title: Core neuropathological abnormalities in progranulin-deficient mice are penetrant on multiple genetic backgrounds.
Volume: 315
Pages: 175-95
Publication
First Author: Petkau TL
Year: 2010
Journal: J Comp Neurol
Title: Progranulin expression in the developing and adult murine brain.
Volume: 518
Issue: 19
Pages: 3931-47
Publication  
First Author: Petkau TL
Year: 2021
Journal: Neurobiol Dis
Title: Human progranulin-expressing mice as a novel tool for the development of progranulin-modulating therapeutics.
Volume: 153
Pages: 105314
Publication
First Author: Beel S
Year: 2017
Journal: Hum Mol Genet
Title: Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo.
Volume: 26
Issue: 15
Pages: 2850-2863
Publication
First Author: Nguyen AD
Year: 2013
Journal: J Biol Chem
Title: Secreted progranulin is a homodimer and is not a component of high density lipoproteins (HDL).
Volume: 288
Issue: 12
Pages: 8627-35
Publication
First Author: Nagy D
Year: 2019
Journal: Alzheimers Res Ther
Title: Age-dependent emergence of neurophysiological and behavioral abnormalities in progranulin-deficient mice.
Volume: 11
Issue: 1
Pages: 88
Publication
First Author: Chang MC
Year: 2017
Journal: J Exp Med
Title: Progranulin deficiency causes impairment of autophagy and TDP-43 accumulation.
Volume: 214
Issue: 9
Pages: 2611-2628
Publication
First Author: Petkau TL
Year: 2013
Journal: Neurobiol Aging
Title: Sensitivity to neurotoxic stress is not increased in progranulin-deficient mice.
Volume: 34
Issue: 11
Pages: 2548-50
Publication
First Author: Herdewyn S
Year: 2013
Journal: Neurobiol Aging
Title: Progranulin does not affect motor neuron degeneration in mutant SOD1 mice and rats.
Volume: 34
Issue: 10
Pages: 2302-3
Publication
First Author: Zhou X
Year: 2019
Journal: PLoS One
Title: Progranulin deficiency leads to reduced glucocerebrosidase activity.
Volume: 14
Issue: 7
Pages: e0212382
Publication
First Author: Chen X
Year: 2013
Journal: J Neurosci
Title: Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells.
Volume: 33
Issue: 21
Pages: 9202-13
Publication  
First Author: Voshtani R
Year: 2019
Journal: Cancer Lett
Title: Progranulin promotes melanoma progression by inhibiting natural killer cell recruitment to the tumor microenvironment.
Volume: 465
Pages: 24-35
Publication
First Author: Nguyen AD
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay.
Volume: 115
Issue: 12
Pages: E2849-E2858
Publication
First Author: Hosokawa M
Year: 2018
Journal: Exp Anim
Title: Progranulin haploinsufficiency reduces amyloid beta deposition in Alzheimer's disease model mice.
Volume: 67
Issue: 1
Pages: 63-70
Publication
First Author: Arrant AE
Year: 2017
Journal: Brain
Title: Restoring neuronal progranulin reverses deficits in a mouse model of frontotemporal dementia.
Volume: 140
Issue: 5
Pages: 1447-1465
Publication  
First Author: Petkau TL
Year: 2017
Journal: Neurobiol Dis
Title: Conditional loss of progranulin in neurons is not sufficient to cause neuronal ceroid lipofuscinosis-like neuropathology in mice.
Volume: 106
Pages: 14-22
Publication  
First Author: Arrant AE
Year: 2015
Journal: eNeuro
Title: Effects of Exercise on Progranulin Levels and Gliosis in Progranulin-Insufficient Mice.
Volume: 2
Issue: 3
Publication
First Author: Arrant AE
Year: 2016
Journal: Genes Brain Behav
Title: Progranulin haploinsufficiency causes biphasic social dominance abnormalities in the tube test.
Volume: 15
Issue: 6
Pages: 588-603
Publication  
First Author: Ward ME
Year: 2017
Journal: Sci Transl Med
Title: Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.
Volume: 9
Issue: 385
Publication
First Author: Ahmed Z
Year: 2010
Journal: Am J Pathol
Title: Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging.
Volume: 177
Issue: 1
Pages: 311-24
Publication  
First Author: Hafler BP
Year: 2014
Journal: Brain Res
Title: Progressive retinal degeneration and accumulation of autofluorescent lipopigments in Progranulin deficient mice.
Volume: 1588
Pages: 168-74
Publication
First Author: Ghoshal N
Year: 2012
Journal: Neurobiol Dis
Title: Core features of frontotemporal dementia recapitulated in progranulin knockout mice.
Volume: 45
Issue: 1
Pages: 395-408
Publication
First Author: Qin J
Year: 2005
Journal: Biol Reprod
Title: Effects of progranulin on blastocyst hatching and subsequent adhesion and outgrowth in the mouse.
Volume: 73
Issue: 3
Pages: 434-42
Publication
First Author: Wang WX
Year: 2010
Journal: Am J Pathol
Title: miR-107 regulates granulin/progranulin with implications for traumatic brain injury and neurodegenerative disease.
Volume: 177
Issue: 1
Pages: 334-45
Publication
First Author: Hu F
Year: 2010
Journal: Neuron
Title: Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.
Volume: 68
Issue: 4
Pages: 654-67
Publication
First Author: Rosen EY
Year: 2011
Journal: Neuron
Title: Functional genomic analyses identify pathways dysregulated by progranulin deficiency, implicating Wnt signaling.
Volume: 71
Issue: 6
Pages: 1030-42
Publication
First Author: Matsubara T
Year: 2012
Journal: Cell Metab
Title: PGRN is a key adipokine mediating high fat diet-induced insulin resistance and obesity through IL-6 in adipose tissue.
Volume: 15
Issue: 1
Pages: 38-50
Publication
First Author: Petkau TL
Year: 2012
Journal: Neurobiol Dis
Title: Synaptic dysfunction in progranulin-deficient mice.
Volume: 45
Issue: 2
Pages: 711-22
Publication
First Author: Minami SS
Year: 2014
Journal: Nat Med
Title: Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models.
Volume: 20
Issue: 10
Pages: 1157-64
Publication  
First Author: Nicholson AM
Year: 2016
Journal: Nat Commun
Title: Prosaposin is a regulator of progranulin levels and oligomerization.
Volume: 7
Pages: 11992
Publication  
First Author: Tanaka Y
Year: 2013
Journal: Neuroscience
Title: Increased lysosomal biogenesis in activated microglia and exacerbated neuronal damage after traumatic brain injury in progranulin-deficient mice.
Volume: 250
Pages: 8-19
Publication  
First Author: Tanaka Y
Year: 2013
Journal: Neuroscience
Title: Exacerbated inflammatory responses related to activated microglia after traumatic brain injury in progranulin-deficient mice.
Volume: 231
Pages: 49-60
Publication
First Author: Filiano AJ
Year: 2013
Journal: J Neurosci
Title: Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice.
Volume: 33
Issue: 12
Pages: 5352-61
Publication  
First Author: Zhou X
Year: 2017
Journal: Nat Commun
Title: Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations.
Volume: 8
Pages: 15277
Publication
First Author: Arrant AE
Year: 2018
Journal: J Neurosci
Title: Progranulin Gene Therapy Improves Lysosomal Dysfunction and Microglial Pathology Associated with Frontotemporal Dementia and Neuronal Ceroid Lipofuscinosis.
Volume: 38
Issue: 9
Pages: 2341-2358
Publication
First Author: Hosokawa M
Year: 2015
Journal: J Neuropathol Exp Neurol
Title: Progranulin reduction is associated with increased tau phosphorylation in P301L tau transgenic mice.
Volume: 74
Issue: 2
Pages: 158-65
Publication
First Author: Werner G
Year: 2020
Journal: EMBO Rep
Title: Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice.
Volume: 21
Issue: 10
Pages: e50241
Publication
First Author: Klein ZA
Year: 2017
Journal: Neuron
Title: Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice.
Volume: 95
Issue: 2
Pages: 281-296.e6
Publication
First Author: Ward ME
Year: 2014
Journal: J Exp Med
Title: Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.
Volume: 211
Issue: 10
Pages: 1937-45
Publication
First Author: Wils H
Year: 2012
Journal: J Pathol
Title: Cellular ageing, increased mortality and FTLD-TDP-associated neuropathology in progranulin knockout mice.
Volume: 228
Issue: 1
Pages: 67-76
Publication  
First Author: Götzl JK
Year: 2019
Journal: EMBO Mol Med
Title: Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism.
Volume: 11
Issue: 6
Publication
First Author: Arrant AE
Year: 2018
Journal: Mol Neurodegener
Title: Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency.
Volume: 13
Issue: 1
Pages: 32
Publication  
First Author: Arrant AE
Year: 2019
Journal: Neurobiol Dis
Title: Reduction of microglial progranulin does not exacerbate pathology or behavioral deficits in neuronal progranulin-insufficient mice.
Volume: 124
Pages: 152-162
Publication
First Author: Krabbe G
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia.
Volume: 114
Issue: 19
Pages: 5029-5034
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Baba T
Year: 1993
Journal: FEBS Lett
Title: Exon/intron organization of the gene encoding the mouse epithelin/granulin precursor (acrogranin).
Volume: 322
Issue: 2
Pages: 89-94
Publication
First Author: Baba T
Year: 1993
Journal: Mol Reprod Dev
Title: Acrogranin, an acrosomal cysteine-rich glycoprotein, is the precursor of the growth-modulating peptides, granulins, and epithelins, and is expressed in somatic as well as male germ cells.
Volume: 34
Issue: 3
Pages: 233-43
Publication
First Author: He Z
Year: 2003
Journal: Nat Med
Title: Progranulin is a mediator of the wound response.
Volume: 9
Issue: 2
Pages: 225-9
Publication
First Author: Yin F
Year: 2010
Journal: J Exp Med
Title: Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice.
Volume: 207
Issue: 1
Pages: 117-28
Publication
First Author: Tanaka Y
Year: 2017
Journal: Hum Mol Genet
Title: Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes.
Volume: 26
Issue: 5
Pages: 969-988
Publication
First Author: Zhao YP
Year: 2013
Journal: FEBS Lett
Title: Progranulin deficiency exaggerates, whereas progranulin-derived Atsttrin attenuates, severity of dermatitis in mice.
Volume: 587
Issue: 12
Pages: 1805-10
Publication
First Author: Jackman K
Year: 2013
Journal: J Neurosci
Title: Progranulin deficiency promotes post-ischemic blood-brain barrier disruption.
Volume: 33
Issue: 50
Pages: 19579-89
Publication  
First Author: Du H
Year: 2021
Journal: Life Sci Alliance
Title: A multifaceted role of progranulin in regulating amyloid-beta dynamics and responses.
Volume: 4
Issue: 7
Publication  
First Author: Albuquerque B
Year: 2013
Journal: Front Behav Neurosci
Title: Learning and memory with neuropathic pain: impact of old age and progranulin deficiency.
Volume: 7
Pages: 174
Publication
First Author: Wang C
Year: 2019
Journal: J Neuroinflammation
Title: Progranulin deficiency exacerbates spinal cord injury by promoting neuroinflammation and cell apoptosis in mice.
Volume: 16
Issue: 1
Pages: 238
Publication
First Author: Menzel L
Year: 2017
Journal: Glia
Title: Progranulin protects against exaggerated axonal injury and astrogliosis following traumatic brain injury.
Volume: 65
Issue: 2
Pages: 278-292
Publication
First Author: Hardt S
Year: 2017
Journal: Biochim Biophys Acta
Title: Loss of synaptic zinc transport in progranulin deficient mice may contribute to progranulin-associated psychopathology and chronic pain.
Volume: 1863
Issue: 11
Pages: 2727-2745
Publication
First Author: Hardt S
Year: 2018
Journal: Aging Dis
Title: Progranulin Deficient Mice Develop Nephrogenic Diabetes Insipidus.
Volume: 9
Issue: 5
Pages: 817-830
Publication
First Author: Quaranta V
Year: 2018
Journal: Cancer Res
Title: Macrophage-Derived Granulin Drives Resistance to Immune Checkpoint Inhibition in Metastatic Pancreatic Cancer.
Volume: 78
Issue: 15
Pages: 4253-4269
Publication  
First Author: Zhao YP
Year: 2015
Journal: Sci Rep
Title: Progranulin knockout accelerates intervertebral disc degeneration in aging mice.
Volume: 5
Pages: 9102
Publication
First Author: Elia LP
Year: 2019
Journal: J Neurosci
Title: Genetic Regulation of Neuronal Progranulin Reveals a Critical Role for the Autophagy-Lysosome Pathway.
Volume: 39
Issue: 17
Pages: 3332-3344
Publication
First Author: Van Kampen JM
Year: 2017
Journal: PLoS One
Title: Progranulin gene delivery reduces plaque burden and synaptic atrophy in a mouse model of Alzheimer's disease.
Volume: 12
Issue: 8
Pages: e0182896
Publication
First Author: Telpoukhovskaia MA
Year: 2020
Journal: Sci Rep
Title: Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia.
Volume: 10
Issue: 1
Pages: 13688
Publication
First Author: Evers BM
Year: 2017
Journal: Cell Rep
Title: Lipidomic and Transcriptomic Basis of Lysosomal Dysfunction in Progranulin Deficiency.
Volume: 20
Issue: 11
Pages: 2565-2574
Publication
First Author: Minami SS
Year: 2015
Journal: Biochem Pharmacol
Title: Reducing inflammation and rescuing FTD-related behavioral deficits in progranulin-deficient mice with α7 nicotinic acetylcholine receptor agonists.
Volume: 97
Issue: 4
Pages: 454-462
Publication
First Author: Marschallinger J
Year: 2020
Journal: Nat Neurosci
Title: Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain.
Volume: 23
Issue: 2
Pages: 194-208
Publication
First Author: Öztürk S
Year: 2019
Journal: Leukemia
Title: Rejection of adoptively transferred Eµ-TCL1 chronic lymphocytic leukemia cells in C57BL/6 substrains or knockout mouse lines.
Volume: 33
Issue: 6
Pages: 1514-1539
Publication
First Author: Kayasuga Y
Year: 2007
Journal: Behav Brain Res
Title: Alteration of behavioural phenotype in mice by targeted disruption of the progranulin gene.
Volume: 185
Issue: 2
Pages: 110-8
Publication
First Author: Noguchi T
Year: 2015
Journal: Biochem Biophys Res Commun
Title: Progranulin plays crucial roles in preserving bone mass by inhibiting TNF-α-induced osteoclastogenesis and promoting osteoblastic differentiation in mice.
Volume: 465
Issue: 3
Pages: 638-43
Publication  
First Author: Nedachi T
Year: 2011
Journal: Neuroscience
Title: Progranulin enhances neural progenitor cell proliferation through glycogen synthase kinase 3β phosphorylation.
Volume: 185
Pages: 106-15
Publication
First Author: Murakoshi M
Year: 2021
Journal: Sci Rep
Title: Differential organ-specific inflammatory response to progranulin in high-fat diet-fed mice.
Volume: 11
Issue: 1
Pages: 1194
Publication
First Author: Pickford F
Year: 2011
Journal: Am J Pathol
Title: Progranulin is a chemoattractant for microglia and stimulates their endocytic activity.
Volume: 178
Issue: 1
Pages: 284-95
Publication  
First Author: Kuse Y
Year: 2018
Journal: Mol Vis
Title: Microglia increases the proliferation of retinal precursor cells during postnatal development.
Volume: 24
Pages: 536-545
Publication
First Author: Almeida S
Year: 2011
Journal: PLoS One
Title: Progranulin, a glycoprotein deficient in frontotemporal dementia, is a novel substrate of several protein disulfide isomerase family proteins.
Volume: 6
Issue: 10
Pages: e26454
Publication
First Author: Chiba S
Year: 2009
Journal: J Reprod Dev
Title: Alteration in anxiety with relation to the volume of the locus ceruleus in progranulin-deficient mice.
Volume: 55
Issue: 5
Pages: 518-22
Publication
First Author: Popp MW
Year: 2011
Journal: Angew Chem Int Ed Engl
Title: Making and breaking peptide bonds: protein engineering using sortase.
Volume: 50
Issue: 22
Pages: 5024-32