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Search results 1 to 100 out of 192 for Gsdme

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0.054s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: Gasdermin-E, also known as DFNA5, is involved in the p53-regulated cellular response to response to DNA damage probably by cooperating with p53 []. It can be cleaved by CASP3 into two parts: GSDME-N and GSDME-C. The GSDME-N fragment can perforate membranes and thereby induce pyroptosis []. Purified GSDME-N has been shown to efficiently lyse phosphoinositide/cardiolipin-containing liposomes and form pores on membranes made of artificial or natural phospholipid mixtures [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Wang Y
Year: 2017
Journal: Nature
Title: Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin.
Volume: 547
Issue: 7661
Pages: 99-103
Protein
Organism: Mus musculus/domesticus
Length: 512  
Fragment?: false
Publication
First Author: Ding J
Year: 2016
Journal: Nature
Title: Pore-forming activity and structural autoinhibition of the gasdermin family.
Volume: 535
Issue: 7610
Pages: 111-6
Protein
Organism: Mus musculus/domesticus
Length: 399  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 399  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 123  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 424  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 512  
Fragment?: false
Publication
First Author: Masuda Y
Year: 2006
Journal: J Hum Genet
Title: The potential role of DFNA5, a hearing impairment gene, in p53-mediated cellular response to DNA damage.
Volume: 51
Issue: 8
Pages: 652-64
Publication  
First Author: Croes L
Year: 2019
Journal: Cancers (Basel)
Title: Determination of the Potential Tumor-Suppressive Effects of Gsdme in a Chemically Induced and in a Genetically Modified Intestinal Cancer Mouse Model.
Volume: 11
Issue: 8
Publication
First Author: Tan G
Year: 2021
Journal: Cell Rep
Title: Gasdermin-E-mediated pyroptosis participates in the pathogenesis of Crohn's disease by promoting intestinal inflammation.
Volume: 35
Issue: 11
Pages: 109265
Publication  
First Author: Wu M
Year: 2021
Journal: Front Cell Dev Biol
Title: Gasdermin E Deletion Attenuates Ureteral Obstruction- and 5/6 Nephrectomy-Induced Renal Fibrosis and Kidney Dysfunction.
Volume: 9
Pages: 754134
Publication
First Author: Xia W
Year: 2021
Journal: Cell Death Dis
Title: Gasdermin E deficiency attenuates acute kidney injury by inhibiting pyroptosis and inflammation.
Volume: 12
Issue: 2
Pages: 139
Publication
First Author: Dong S
Year: 2022
Journal: J Biol Chem
Title: Gasdermin E is required for induction of pyroptosis and severe disease during enterovirus 71 infection.
Volume: 298
Issue: 5
Pages: 101850
Publication
First Author: Neel DV
Year: 2023
Journal: Neuron
Title: Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration.
Volume: 111
Issue: 8
Pages: 1222-1240.e9
Publication
First Author: Minns MS
Year: 2023
Journal: Nat Commun
Title: NLRP3 selectively drives IL-1β secretion by Pseudomonas aeruginosa infected neutrophils and regulates corneal disease severity.
Volume: 14
Issue: 1
Pages: 5832
Publication    
First Author: Sun K
Year: 2022
Journal: Elife
Title: Fracture healing is delayed in the absence of gasdermin-interleukin-1 signaling.
Volume: 11
Publication
First Author: Li Y
Year: 2021
Journal: Cell Death Differ
Title: GSDME-mediated pyroptosis promotes inflammation and fibrosis in obstructive nephropathy.
Volume: 28
Issue: 8
Pages: 2333-2350
Publication  
First Author: Luo X
Year: 2023
Journal: Int Immunopharmacol
Title: Cyclophosphamide induced intestinal injury is alleviated by blocking the TLR9/caspase3/GSDME mediated intestinal epithelium pyroptosis.
Volume: 119
Pages: 110244
Publication  
First Author: Tan G
Year: 2022
Journal: Cancer Lett
Title: Radiosensitivity of colorectal cancer and radiation-induced gut damages are regulated by gasdermin E.
Volume: 529
Pages: 1-10
Publication
First Author: Zhai Z
Year: 2022
Journal: Arthritis Rheumatol
Title: Attenuation of Rheumatoid Arthritis Through the Inhibition of Tumor Necrosis Factor-Induced Caspase 3/Gasdermin E-Mediated Pyroptosis.
Volume: 74
Issue: 3
Pages: 427-440
Publication
First Author: Zhang Z
Year: 2020
Journal: Nature
Title: Gasdermin E suppresses tumour growth by activating anti-tumour immunity.
Volume: 579
Issue: 7799
Pages: 415-420
Publication
First Author: Xu W
Year: 2021
Journal: Cell Metab
Title: Apaf-1 Pyroptosome Senses Mitochondrial Permeability Transition.
Volume: 33
Issue: 2
Pages: 424-436.e10
Publication      
First Author: Chen KW
Year: 2019
Journal: EMBO J
Title: Extrinsic and intrinsic apoptosis activate pannexin-1 to drive NLRP3 inflammasome assembly.
Publication  
First Author: Chen KW
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: RIPK1 activates distinct gasdermins in macrophages and neutrophils upon pathogen blockade of innate immune signaling.
Volume: 118
Issue: 28
Publication
First Author: Hashimoto S
Year: 2023
Journal: Sci Rep
Title: Neuronal glutathione loss leads to neurodegeneration involving gasdermin activation.
Volume: 13
Issue: 1
Pages: 1109
Publication
First Author: Sarhan J
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection.
Volume: 115
Issue: 46
Pages: E10888-E10897
Publication
First Author: Donado CA
Year: 2020
Journal: Cell Rep
Title: A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling.
Volume: 31
Issue: 1
Pages: 107466
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Van Laer L
Year: 1998
Journal: Nat Genet
Title: Nonsyndromic hearing impairment is associated with a mutation in DFNA5.
Volume: 20
Issue: 2
Pages: 194-7
Publication
First Author: Van Laer L
Year: 2005
Journal: Neurobiol Dis
Title: Mice lacking Dfna5 show a diverging number of cochlear fourth row outer hair cells.
Volume: 19
Issue: 3
Pages: 386-99
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3284528
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1697428
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1754928
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3280928
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1757728
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3599828
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 10
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 11
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 12
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 13
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 14
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 15
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1720228
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 16
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Absent
Sex: Pooled
Emaps: EMAPS:1750328
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: false
Specimen Num: 17
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 18
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1832128
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 19
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1842628
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 20
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 21
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3511228
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 22
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1914328
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 23
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1742828
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 24
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3288928
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 25
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1718528
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 26
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1775128
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 27
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1683328
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 28
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1788628
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 29
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1789128
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 30
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1885228
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 31
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1866628
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 32
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3276428
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 33
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3519728
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 34
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3515128
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 35
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3528528
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 36
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3514028
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 37
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 38
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Female
Emaps: EMAPS:1775928
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 39
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Female
Emaps: EMAPS:1775928
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 40
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 41
GXD Expression    
Probe: MGI:1205186
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Male
Emaps: EMAPS:1929028
Stage: TS28
Assay Id: MGI:1205188
Age: postnatal week 6-8
Image: st96_420
Specimen Label: None
Detected: true
Specimen Num: 42