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Search results 1 to 100 out of 188 for Guca1a

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0.055s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: Guanylyl cyclase-activating protein 1 (GUCA1A, also known as GCAP1) regulates the visual photoresponse []. It binds to and regulates RetGC1 (retinal membrane guanylyl cyclase 1), a key enzyme in photoreceptor physiology that produces the second messenger of phototransduction cGMP in rods and cones [, ]. Photoactivated pigment triggers the decay of cGMP and shuts off cGMP-gated channels in the outer segment. The influx of Ca2+ through the channels stops and the free Ca2+ concentration in the outer segment declines rapidly. Recovery of rods and cones from excitation requires the activation of RetGC1 by GCAPs, which occurs at low Ca2+ concentrations [].Mutations in the GCAP1 gene cause congenital retinal diseases in humans, such as cone dystrophy 3 (COD3) [, ].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Sakurai K
Year: 2011
Journal: J Neurosci
Title: Role of guanylyl cyclase modulation in mouse cone phototransduction.
Volume: 31
Issue: 22
Pages: 7991-8000
Gene
Type: gene
Organism: chicken
Protein
Organism: Mus musculus/domesticus
Length: 202  
Fragment?: false
Publication
First Author: Peshenko IV
Year: 2014
Journal: J Biol Chem
Title: Identification of target binding site in photoreceptor guanylyl cyclase-activating protein 1 (GCAP1).
Volume: 289
Issue: 14
Pages: 10140-54
Publication
First Author: Peshenko IV
Year: 2015
Journal: J Biol Chem
Title: Evaluating the role of retinal membrane guanylyl cyclase 1 (RetGC1) domains in binding guanylyl cyclase-activating proteins (GCAPs).
Volume: 290
Issue: 11
Pages: 6913-24
Publication
First Author: Payne AM
Year: 1998
Journal: Hum Mol Genet
Title: A mutation in guanylate cyclase activator 1A (GUCA1A) in an autosomal dominant cone dystrophy pedigree mapping to a new locus on chromosome 6p21.1.
Volume: 7
Issue: 2
Pages: 273-7
Publication
First Author: Downes SM
Year: 2001
Journal: Arch Ophthalmol
Title: Autosomal dominant cone and cone-rod dystrophy with mutations in the guanylate cyclase activator 1A gene-encoding guanylate cyclase activating protein-1.
Volume: 119
Issue: 1
Pages: 96-105
Publication
First Author: Jiang L
Year: 2013
Journal: PLoS One
Title: RNAi-mediated gene suppression in a GCAP1(L151F) cone-rod dystrophy mouse model.
Volume: 8
Issue: 3
Pages: e57676
Publication
First Author: Buch PK
Year: 2011
Journal: PLoS One
Title: Dominant cone-rod dystrophy: a mouse model generated by gene targeting of the GCAP1/Guca1a gene.
Volume: 6
Issue: 3
Pages: e18089
Publication
First Author: Pertzev A
Year: 2010
Journal: Biochemistry
Title: Ca(2+) sensor GCAP1: A constitutive element of the ONE-GC-modulated odorant signal transduction pathway.
Volume: 49
Issue: 34
Pages: 7303-13
Publication
First Author: López-Begines S
Year: 2018
Journal: Sci Rep
Title: Molecular determinants of Guanylate Cyclase Activating Protein subcellular distribution in photoreceptor cells of the retina.
Volume: 8
Issue: 1
Pages: 2903
Publication
First Author: Reingruber J
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Detection of single photons by toad and mouse rods.
Volume: 110
Issue: 48
Pages: 19378-83
Publication
First Author: Turunen T
Year: 2021
Journal: Sci Rep
Title: Functional modulation of phosphodiesterase-6 by calcium in mouse rod photoreceptors.
Volume: 11
Issue: 1
Pages: 8938
Publication
First Author: Pennesi ME
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Guanylate cyclase-activating protein (GCAP) 1 rescues cone recovery kinetics in GCAP1/GCAP2 knockout mice.
Volume: 100
Issue: 11
Pages: 6783-8
Publication
First Author: Howes KA
Year: 2002
Journal: EMBO J
Title: GCAP1 rescues rod photoreceptor response in GCAP1/GCAP2 knockout mice.
Volume: 21
Issue: 7
Pages: 1545-54
Publication
First Author: Okawa H
Year: 2010
Journal: J Physiol
Title: Optimal processing of photoreceptor signals is required to maximize behavioural sensitivity.
Volume: 588
Issue: Pt 11
Pages: 1947-60
Publication
First Author: Burns ME
Year: 2002
Journal: Neuron
Title: Dynamics of cyclic GMP synthesis in retinal rods.
Volume: 36
Issue: 1
Pages: 81-91
Publication
First Author: Nymark S
Year: 2012
Journal: J Physiol
Title: Bleaching of mouse rods: microspectrophotometry and suction-electrode recording.
Volume: 590
Issue: 10
Pages: 2353-64
Publication
First Author: López-del Hoyo N
Year: 2012
Journal: PLoS One
Title: Overexpression of guanylate cyclase activating protein 2 in rod photoreceptors in vivo leads to morphological changes at the synaptic ribbon.
Volume: 7
Issue: 8
Pages: e42994
Publication  
First Author: Mendez A
Year: 2002
Journal: Adv Exp Med Biol
Title: Mouse models to study GCAP functions in intact photoreceptors.
Volume: 514
Pages: 361-88
Publication
First Author: Hoyo NL
Year: 2014
Journal: PLoS Genet
Title: Functional EF-hands in neuronal calcium sensor GCAP2 determine its phosphorylation state and subcellular distribution in vivo, and are essential for photoreceptor cell integrity.
Volume: 10
Issue: 7
Pages: e1004480
Publication
First Author: Mendez A
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Role of guanylate cyclase-activating proteins (GCAPs) in setting the flash sensitivity of rod photoreceptors.
Volume: 98
Issue: 17
Pages: 9948-53
Publication  
First Author: Duda T
Year: 2016
Journal: Front Mol Neurosci
Title: Bicarbonate and Ca(2+) Sensing Modulators Activate Photoreceptor ROS-GC1 Synergistically.
Volume: 9
Pages: 5
Publication
First Author: Turunen TT
Year: 2019
Journal: Sci Rep
Title: Determination of basal phosphodiesterase activity in mouse rod photoreceptors with cGMP clamp.
Volume: 9
Issue: 1
Pages: 1183
Publication
First Author: Makino CL
Year: 2004
Journal: J Gen Physiol
Title: Recoverin regulates light-dependent phosphodiesterase activity in retinal rods.
Volume: 123
Issue: 6
Pages: 729-41
Publication
First Author: Plana-Bonamaisó A
Year: 2020
Journal: Cell Death Dis
Title: GCAP neuronal calcium sensor proteins mediate photoreceptor cell death in the rd3 mouse model of LCA12 congenital blindness by involving endoplasmic reticulum stress.
Volume: 11
Issue: 1
Pages: 62
Publication
First Author: Peshenko IV
Year: 2011
Journal: Biochemistry
Title: Enzymatic properties and regulation of the native isozymes of retinal membrane guanylyl cyclase (RetGC) from mouse photoreceptors.
Volume: 50
Issue: 25
Pages: 5590-600
Publication
First Author: Vinberg F
Year: 2018
Journal: Sci Rep
Title: Investigating the Ca2+-dependent and Ca2+-independent mechanisms for mammalian cone light adaptation.
Volume: 8
Issue: 1
Pages: 15864
Publication    
First Author: Yue WW
Year: 2017
Journal: Elife
Title: Spontaneous activation of visual pigments in relation to openness/closedness of chromophore-binding pocket.
Volume: 6
Publication
First Author: Stockman A
Year: 2014
Journal: Invest Ophthalmol Vis Sci
Title: Visual consequences of molecular changes in the guanylate cyclase-activating protein.
Volume: 55
Issue: 3
Pages: 1930-40
Publication
First Author: Hamer RD
Year: 2003
Journal: J Gen Physiol
Title: Multiple steps of phosphorylation of activated rhodopsin can account for the reproducibility of vertebrate rod single-photon responses.
Volume: 122
Issue: 4
Pages: 419-44
Publication    
First Author: Dizhoor AM
Year: 2021
Journal: J Biol Chem
Title: Retinal degeneration-3 protein promotes photoreceptor survival by suppressing activation of guanylyl cyclase rather than accelerating GMP recycling.
Pages: 100362
Publication
First Author: Sato S
Year: 2018
Journal: J Neurosci
Title: GUCY2D Cone-Rod Dystrophy-6 Is a "Phototransduction Disease" Triggered by Abnormal Calcium Feedback on Retinal Membrane Guanylyl Cyclase 1.
Volume: 38
Issue: 12
Pages: 2990-3000
Publication
First Author: Makino CL
Year: 2012
Journal: PLoS One
Title: Enzymatic relay mechanism stimulates cyclic GMP synthesis in rod photoresponse: biochemical and physiological study in guanylyl cyclase activating protein 1 knockout mice.
Volume: 7
Issue: 10
Pages: e47637
Publication
First Author: Vinberg F
Year: 2018
Journal: J Biol Chem
Title: Guanylate cyclase-activating protein 2 contributes to phototransduction and light adaptation in mouse cone photoreceptors.
Volume: 293
Issue: 19
Pages: 7457-7465
Publication
First Author: Sato S
Year: 2019
Journal: J Neurosci
Title: Apo-Opsin Exists in Equilibrium Between a Predominant Inactive and a Rare Highly Active State.
Volume: 39
Issue: 2
Pages: 212-223
Publication
First Author: Chen J
Year: 2010
Journal: J Neurosci
Title: Channel modulation and the mechanism of light adaptation in mouse rods.
Volume: 30
Issue: 48
Pages: 16232-40
Publication
First Author: Olshevskaya EV
Year: 2012
Journal: J Neurosci
Title: Retinal guanylyl cyclase isozyme 1 is the preferential in vivo target for constitutively active GCAP1 mutants causing congenital degeneration of photoreceptors.
Volume: 32
Issue: 21
Pages: 7208-17
Publication
First Author: Sakurai K
Year: 2015
Journal: J Biol Chem
Title: Regulation of mammalian cone phototransduction by recoverin and rhodopsin kinase.
Volume: 290
Issue: 14
Pages: 9239-50
Publication
First Author: Peshenko IV
Year: 2016
Journal: J Biol Chem
Title: Functional Study and Mapping Sites for Interaction with the Target Enzyme in Retinal Degeneration 3 (RD3) Protein.
Volume: 291
Issue: 37
Pages: 19713-23
Publication
First Author: Wen XH
Year: 2012
Journal: Cell Physiol Biochem
Title: S100B serves as a Ca(2+) sensor for ROS-GC1 guanylate cyclase in cones but not in rods of the murine retina.
Volume: 29
Issue: 3-4
Pages: 417-30
Publication
First Author: Dizhoor AM
Year: 2019
Journal: J Biol Chem
Title: Retinal guanylyl cyclase activation by calcium sensor proteins mediates photoreceptor degeneration in an rd3 mouse model of congenital human blindness.
Volume: 294
Issue: 37
Pages: 13729-13739
Publication
First Author: Fu Y
Year: 2008
Journal: Nat Neurosci
Title: Quantal noise from human red cone pigment.
Volume: 11
Issue: 5
Pages: 565-71
Publication
First Author: Bereta G
Year: 2010
Journal: J Biol Chem
Title: A functional kinase homology domain is essential for the activity of photoreceptor guanylate cyclase 1.
Volume: 285
Issue: 3
Pages: 1899-908
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Cuenca N
Year: 1998
Journal: Invest Ophthalmol Vis Sci
Title: The localization of guanylyl cyclase-activating proteins in the mammalian retina.
Volume: 39
Issue: 7
Pages: 1243-50
Publication
First Author: Subbaraya I
Year: 1994
Journal: J Biol Chem
Title: Molecular characterization of human and mouse photoreceptor guanylate cyclase-activating protein (GCAP) and chromosomal localization of the human gene.
Volume: 269
Issue: 49
Pages: 31080-9
Publication
First Author: Olshevskaya EV
Year: 2004
Journal: J Neurosci
Title: The Y99C mutation in guanylyl cyclase-activating protein 1 increases intracellular Ca2+ and causes photoreceptor degeneration in transgenic mice.
Volume: 24
Issue: 27
Pages: 6078-85
Publication
First Author: Palczewski K
Year: 1994
Journal: Neuron
Title: Molecular cloning and characterization of retinal photoreceptor guanylyl cyclase-activating protein.
Volume: 13
Issue: 2
Pages: 395-404
GXD Expression      
Probe: MGI:5604407
Assay Type: RT-PCR
Annotation Date: 2014-11-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619823
Stage: TS23
Assay Id: MGI:5604415
Age: embryonic day 15.0
Specimen Label: E15
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5604407
Assay Type: RT-PCR
Annotation Date: 2014-11-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619826
Stage: TS26
Assay Id: MGI:5604415
Age: embryonic day 18.0
Specimen Label: E18
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5604407
Assay Type: RT-PCR
Annotation Date: 2014-11-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619827
Stage: TS27
Assay Id: MGI:5604415
Age: postnatal day 1
Specimen Label: P1
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:5604407
Assay Type: RT-PCR
Annotation Date: 2014-11-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619827
Stage: TS27
Assay Id: MGI:5604415
Age: postnatal day 3
Specimen Label: P3
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:5604407
Assay Type: RT-PCR
Annotation Date: 2014-11-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:5604415
Age: postnatal day 7
Specimen Label: P7
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:5604407
Assay Type: RT-PCR
Annotation Date: 2014-11-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:5604415
Age: postnatal day 15
Specimen Label: P15
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:5604407
Assay Type: RT-PCR
Annotation Date: 2014-11-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:5604415
Age: postnatal day 30
Specimen Label: P30
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:5604407
Assay Type: RT-PCR
Annotation Date: 2014-11-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:5604415
Age: postnatal day 60
Specimen Label: P60
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:5604407
Assay Type: RT-PCR
Annotation Date: 2014-11-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:5604415
Age: postnatal day 90
Specimen Label: P90
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:5604407
Assay Type: RT-PCR
Annotation Date: 2014-11-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:5604415
Age: postnatal day 210
Specimen Label: P210
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:6393672
Assay Type: RT-PCR
Annotation Date: 2020-03-10
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:160331
Stage: TS01
Assay Id: MGI:6393693
Age: embryonic day 0.5
Image: S2
Specimen Label: Zygote
Specimen Num: 1
GXD Expression    
Probe: MGI:6393672
Assay Type: RT-PCR
Annotation Date: 2020-03-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:6393693
Age: embryonic day 1.5
Image: S2
Specimen Label: 2-cell
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7435622
Assay Type: RT-PCR
Annotation Date: 2023-02-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:7435660
Age: postnatal day 10
Specimen Label: Wild-type
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7435622
Assay Type: RT-PCR
Annotation Date: 2023-02-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:7435660
Age: postnatal day 10
Specimen Label: Nrl<-/->
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3584851
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716820
Stage: TS20
Assay Id: MGI:3585443
Age: embryonic day 12.0
Specimen Label: E12
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3584851
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716822
Stage: TS22
Assay Id: MGI:3585443
Age: embryonic day 14.0
Specimen Label: E14
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:3584851
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716824
Stage: TS24
Assay Id: MGI:3585443
Age: embryonic day 16.0
Image: E16
Specimen Label: E16
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:3584851
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716826
Stage: TS26
Assay Id: MGI:3585443
Age: embryonic day 18.0
Image: E18
Specimen Label: E18
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:3584851
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716827
Stage: TS27
Assay Id: MGI:3585443
Age: postnatal day 0-1
Image: P0/1
Specimen Label: P0/1
Detected: false
Specimen Num: 5
GXD Expression    
Probe: MGI:3584851
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716827
Stage: TS27
Assay Id: MGI:3585443
Age: postnatal day 2-3
Image: P2/3
Specimen Label: P2/3
Detected: false
Specimen Num: 6
GXD Expression    
Probe: MGI:3584851
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:3585443
Age: postnatal day 4-5
Image: P4/5
Specimen Label: P4/5
Detected: false
Specimen Num: 7
GXD Expression    
Probe: MGI:3584851
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:3585443
Age: postnatal day 6-7
Image: P6/7
Specimen Label: P6/7
Detected: false
Specimen Num: 8
GXD Expression    
Probe: MGI:3584851
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:3585443
Age: postnatal day 8-10
Image: P8/10
Specimen Label: P8/10
Detected: false
Specimen Num: 9
GXD Expression
Probe: MGI:3584851
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Male
Emaps: EMAPS:1915728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3585443
Age: postnatal adult
Image: Adult
Note: Expression was detected in the inner segment.
Specimen Label: Adult
Detected: true
Specimen Num: 10