Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
horse |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cat, domestic |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6174579 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
|
Stage: |
TS19 |
Assay Id: |
MGI:6190478 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S2 - E11.5 - Gusb |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6174579 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
|
Stage: |
TS21 |
Assay Id: |
MGI:6190478 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Table S2 - E13.5 - Gusb |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6174579 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689426 |
|
Stage: |
TS26 |
Assay Id: |
MGI:6190478 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Table S2 - E18.5 - Gusb |
Detected: |
false |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6174579 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6190478 |
Age: |
postnatal day 4 |
|
|
Specimen Label: |
Table S2 - P4 - Gusb |
Detected: |
false |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6174579 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6190478 |
Age: |
postnatal day 28 |
|
|
Specimen Label: |
Table S2 - P28 - Gusb |
Detected: |
false |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6174579 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689424 |
|
Stage: |
TS24 |
Assay Id: |
MGI:6190478 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
Table S2 - E15.5 - Gusb |
Detected: |
false |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6174579 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6190478 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
Table S2 - P14 - Gusb |
Detected: |
false |
Specimen Num: |
6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ray J |
Year: |
1998 |
Journal: |
Genomics |
Title: |
Cloning of the canine beta-glucuronidase cDNA, mutation identification in canine MPS VII, and retroviral vector-mediated correction of MPS VII cells. |
Volume: |
48 |
Issue: |
2 |
Pages: |
248-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bramwell KK |
Year: |
2014 |
Journal: |
J Clin Invest |
Title: |
Lysosomal β-glucuronidase regulates Lyme and rheumatoid arthritis severity. |
Volume: |
124 |
Issue: |
1 |
Pages: |
311-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kyle JW |
Year: |
1990 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Correction of murine mucopolysaccharidosis VII by a human beta-glucuronidase transgene. |
Volume: |
87 |
Issue: |
10 |
Pages: |
3914-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Daly TM |
Year: |
1999 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Neonatal gene transfer leads to widespread correction of pathology in a murine model of lysosomal storage disease. |
Volume: |
96 |
Issue: |
5 |
Pages: |
2296-300 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
250
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
193
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Donsante A |
Year: |
2001 |
Journal: |
Gene Ther |
Title: |
Observed incidence of tumorigenesis in long-term rodent studies of rAAV vectors. |
Volume: |
8 |
Issue: |
17 |
Pages: |
1343-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Frisella WA |
Year: |
2001 |
Journal: |
Mol Ther |
Title: |
Intracranial injection of recombinant adeno-associated virus improves cognitive function in a murine model of mucopolysaccharidosis type VII. |
Volume: |
3 |
Issue: |
3 |
Pages: |
351-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hofling AA |
Year: |
2003 |
Journal: |
Blood |
Title: |
Engraftment of human CD34+ cells leads to widespread distribution of donor-derived cells and correction of tissue pathology in a novel murine xenotransplantation model of lysosomal storage disease. |
Volume: |
101 |
Issue: |
5 |
Pages: |
2054-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yasue M |
Year: |
1991 |
Journal: |
Cytogenet Cell Genet |
Title: |
Chromosomal assignments of 23 biochemical loci of the rat by using rat x mouse somatic cell hybrids. |
Volume: |
57 |
Issue: |
2-3 |
Pages: |
142-8 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Gallagher PM |
Year: |
1987 |
Journal: |
Genomics |
Title: |
DNA sequence variation within the beta-glucuronidase gene complex among inbred strains of mice. |
Volume: |
1 |
Issue: |
2 |
Pages: |
145-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gallagher PM |
Year: |
1988 |
Journal: |
Genomics |
Title: |
The complete nucleotide sequence of murine beta-glucuronidase mRNA and its deduced polypeptide. |
Volume: |
2 |
Issue: |
3 |
Pages: |
215-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
D'Amore MA |
Year: |
1988 |
Journal: |
Biochemistry |
Title: |
Complete sequence and organization of the murine beta-glucuronidase gene. |
Volume: |
27 |
Issue: |
18 |
Pages: |
7131-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wawrzyniak CJ |
Year: |
1989 |
Journal: |
Mol Cell Biol |
Title: |
DNA determinants of structural and regulatory variation within the murine beta-glucuronidase gene complex. |
Volume: |
9 |
Issue: |
9 |
Pages: |
4074-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Funkenstein B |
Year: |
1988 |
Journal: |
Mol Cell Biol |
Title: |
Genomic organization and sequence of the Gus-s alpha allele of the murine beta-glucuronidase gene. |
Volume: |
8 |
Issue: |
3 |
Pages: |
1160-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ohlemiller KK |
Year: |
2002 |
Journal: |
Hear Res |
Title: |
Inner ear pathology in the mucopolysaccharidosis VII mouse. |
Volume: |
169 |
Issue: |
1-2 |
Pages: |
69-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tomatsu S |
Year: |
2002 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Missense models [Gustm(E536A)Sly, Gustm(E536Q)Sly, and Gustm(L175F)Sly] of murine mucopolysaccharidosis type VII produced by targeted mutagenesis. |
Volume: |
99 |
Issue: |
23 |
Pages: |
14982-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kashiwagi M |
Year: |
2022 |
Journal: |
PLoS One |
Title: |
Circulatory C-type natriuretic peptide reduces mucopolysaccharidosis-associated craniofacial hypoplasia in vivo. |
Volume: |
17 |
Issue: |
11 |
Pages: |
e0277140 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vogler C |
Year: |
2001 |
Journal: |
Pediatr Res |
Title: |
A novel model of murine mucopolysaccharidosis type VII due to an intracisternal a particle element transposition into the beta-glucuronidase gene: clinical and pathologic findings. |
Volume: |
49 |
Issue: |
3 |
Pages: |
342-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Casal ML |
Year: |
1998 |
Journal: |
Lab Invest |
Title: |
Variant clinical course of mucopolysaccharidosis type VII in two groups of mice carrying the same mutation. |
Volume: |
78 |
Issue: |
12 |
Pages: |
1575-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sferra TJ |
Year: |
2000 |
Journal: |
Hum Gene Ther |
Title: |
Recombinant adeno-associated virus-mediated correction of lysosomal storage within the central nervous system of the adult mucopolysaccharidosis type VII mouse. |
Volume: |
11 |
Issue: |
4 |
Pages: |
507-19 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vogler C |
Year: |
1993 |
Journal: |
Pediatr Res |
Title: |
Enzyme replacement with recombinant beta-glucuronidase in the newborn mucopolysaccharidosis type VII mouse. |
Volume: |
34 |
Issue: |
6 |
Pages: |
837-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ohlemiller KK |
Year: |
2000 |
Journal: |
Exp Eye Res |
Title: |
Retinal function is improved in a murine model of a lysosomal storage disease following bone marrow transplantation. |
Volume: |
71 |
Issue: |
5 |
Pages: |
469-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sly WS |
Year: |
2001 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Active site mutant transgene confers tolerance to human beta-glucuronidase without affecting the phenotype of MPS VII mice. |
Volume: |
98 |
Issue: |
5 |
Pages: |
2205-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Moullier P |
Year: |
1993 |
Journal: |
Nat Genet |
Title: |
Correction of lysosomal storage in the liver and spleen of MPS VII mice by implantation of genetically modified skin fibroblasts. |
Volume: |
4 |
Issue: |
2 |
Pages: |
154-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Monroy MA |
Year: |
2002 |
Journal: |
Bone |
Title: |
Abnormal osteoclast morphology and bone remodeling in a murine model of a lysosomal storage disease. |
Volume: |
30 |
Issue: |
2 |
Pages: |
352-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Birkenmeier EH |
Year: |
1991 |
Journal: |
Blood |
Title: |
Increased life span and correction of metabolic defects in murine mucopolysaccharidosis type VII after syngeneic bone marrow transplantation. |
Volume: |
78 |
Issue: |
11 |
Pages: |
3081-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Snyder EY |
Year: |
1995 |
Journal: |
Nature |
Title: |
Neural progenitor cell engraftment corrects lysosomal storage throughout the MPS VII mouse brain. |
Volume: |
374 |
Issue: |
6520 |
Pages: |
367-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chang PL |
Year: |
1993 |
Journal: |
Neuroreport |
Title: |
Behavioural abnormalities in a murine model of a human lysosomal storage disease. |
Volume: |
4 |
Issue: |
5 |
Pages: |
507-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sands MS |
Year: |
1993 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A single-base-pair deletion in the beta-glucuronidase gene accounts for the phenotype of murine mucopolysaccharidosis type VII. |
Volume: |
90 |
Issue: |
14 |
Pages: |
6567-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Casal ML |
Year: |
2000 |
Journal: |
Pediatr Res |
Title: |
Mucopolysaccharidosis type VII in the developing mouse fetus. |
Volume: |
47 |
Issue: |
6 |
Pages: |
750-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Freeman BJ |
Year: |
1999 |
Journal: |
Blood |
Title: |
Behavior and therapeutic efficacy of beta-glucuronidase-positive mononuclear phagocytes in a murine model of mucopolysaccharidosis type VII. |
Volume: |
94 |
Issue: |
6 |
Pages: |
2142-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bastedo L |
Year: |
1994 |
Journal: |
J Clin Invest |
Title: |
Behavioral consequences of bone marrow transplantation in the treatment of murine mucopolysaccharidosis type VII. |
Volume: |
94 |
Issue: |
3 |
Pages: |
1180-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Berry CL |
Year: |
1994 |
Journal: |
Lab Invest |
Title: |
Pathology of the ear in murine mucopolysaccharidosis type VII. Morphologic correlates of hearing loss. |
Volume: |
71 |
Issue: |
3 |
Pages: |
438-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Poorthuis BJ |
Year: |
1994 |
Journal: |
Pediatr Res |
Title: |
Bone marrow transplantation has a significant effect on enzyme levels and storage of glycosaminoglycans in tissues and in isolated hepatocytes of mucopolysaccharidosis type VII mice. |
Volume: |
36 |
Issue: |
2 |
Pages: |
187-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wolfe JH |
Year: |
1992 |
Journal: |
Nat Genet |
Title: |
Herpesvirus vector gene transfer and expression of beta-glucuronidase in the central nervous system of MPS VII mice. |
Volume: |
1 |
Issue: |
5 |
Pages: |
379-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stein CS |
Year: |
1999 |
Journal: |
J Virol |
Title: |
Systemic and central nervous system correction of lysosomal storage in mucopolysaccharidosis type VII mice. |
Volume: |
73 |
Issue: |
4 |
Pages: |
3424-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Coulson-Thomas VJ |
Year: |
2013 |
Journal: |
Stem Cells |
Title: |
Transplantation of human umbilical mesenchymal stem cells cures the corneal defects of mucopolysaccharidosis VII mice. |
Volume: |
31 |
Issue: |
10 |
Pages: |
2116-26 |
|
•
•
•
•
•
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Publication |
First Author: |
O'Connor LH |
Year: |
1998 |
Journal: |
J Clin Invest |
Title: |
Enzyme replacement therapy for murine mucopolysaccharidosis type VII leads to improvements in behavior and auditory function. |
Volume: |
101 |
Issue: |
7 |
Pages: |
1394-400 |
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Publication |
First Author: |
Skorupa AF |
Year: |
1999 |
Journal: |
Exp Neurol |
Title: |
Sustained production of beta-glucuronidase from localized sites after AAV vector gene transfer results in widespread distribution of enzyme and reversal of lysosomal storage lesions in a large volume of brain in mucopolysaccharidosis VII mice. |
Volume: |
160 |
Issue: |
1 |
Pages: |
17-27 |
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Publication |
First Author: |
Ghodsi A |
Year: |
1999 |
Journal: |
Exp Neurol |
Title: |
Systemic hyperosmolality improves beta-glucuronidase distribution and pathology in murine MPS VII brain following intraventricular gene transfer. |
Volume: |
160 |
Issue: |
1 |
Pages: |
109-16 |
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Publication |
First Author: |
Ohashi T |
Year: |
1997 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Adenovirus-mediated gene transfer and expression of human beta-glucuronidase gene in the liver, spleen, and central nervous system in mucopolysaccharidosis type VII mice. |
Volume: |
94 |
Issue: |
4 |
Pages: |
1287-92 |
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Publication |
First Author: |
Woloszynek JC |
Year: |
2004 |
Journal: |
Biochem J |
Title: |
Numerous transcriptional alterations in liver persist after short-term enzyme-replacement therapy in a murine model of mucopolysaccharidosis type VII. |
Volume: |
379 |
Issue: |
Pt 2 |
Pages: |
461-9 |
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Publication |
First Author: |
Parente MK |
Year: |
2016 |
Journal: |
Mol Genet Metab |
Title: |
Integrated analysis of proteome and transcriptome changes in the mucopolysaccharidosis type VII mouse hippocampus. |
Volume: |
118 |
Issue: |
1 |
Pages: |
41-54 |
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