| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
rabbit, European |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
goat |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
333
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
The YobH-like protein family includes the YobH protein from E. coli , which is functionally uncharacterised. Proteins in this family are approximately 80 amino acids in length and contain two conserved sequence motifs: GYG and GLGL. |
|
•
•
•
•
•
|
| Allele |
| Name: |
potassium voltage-gated channel, subfamily Q, member 5; targeted mutation 1.1, Thomas J Jentsch |
| Allele Type: |
Targeted |
| Attribute String: |
Dominant negative |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tzingounis AV |
| Year: |
2010 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
The KCNQ5 potassium channel mediates a component of the afterhyperpolarization current in mouse hippocampus. |
| Volume: |
107 |
| Issue: |
22 |
| Pages: |
10232-7 |
|
•
•
•
•
•
|
| Allele |
| Name: |
potassium voltage-gated channel, subfamily Q, member 4; targeted mutation 1.2, Thomas J Jentsch |
| Allele Type: |
Targeted |
| Attribute String: |
Dominant negative |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant stock, targeted mutation |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Kcnq5/Kcnq5 |
| Background: |
involves: 129S2/SvPas |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Kcnq4/Kcnq4<+> |
| Background: |
involves: 129/Sv * C57BL/6 |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Kcnq4/Kcnq4 |
| Background: |
involves: 129/Sv * C57BL/6 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fidzinski P |
| Year: |
2015 |
| Journal: |
Nat Commun |
| Title: |
KCNQ5 K(+) channels control hippocampal synaptic inhibition and fast network oscillations. |
| Volume: |
6 |
|
| Pages: |
6254 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cang C |
| Year: |
2015 |
| Journal: |
Cell |
| Title: |
TMEM175 Is an Organelle K(+) Channel Regulating Lysosomal Function. |
| Volume: |
162 |
| Issue: |
5 |
| Pages: |
1101-12 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Testoni G |
| Year: |
2017 |
| Journal: |
Cell Metab |
| Title: |
Lack of Glycogenin Causes Glycogen Accumulation and Muscle Function Impairment. |
| Volume: |
26 |
| Issue: |
1 |
| Pages: |
256-266.e4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kharkovets T |
| Year: |
2006 |
| Journal: |
EMBO J |
| Title: |
Mice with altered KCNQ4 K+ channels implicate sensory outer hair cells in human progressive deafness. |
| Volume: |
25 |
| Issue: |
3 |
| Pages: |
642-52 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Heidenreich M |
| Year: |
2011 |
| Journal: |
Nat Neurosci |
| Title: |
KCNQ4 K(+) channels tune mechanoreceptors for normal touch sensation in mouse and man. |
| Volume: |
15 |
| Issue: |
1 |
| Pages: |
138-45 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Silverman SK |
| Year: |
1996 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
A regenerative link in the ionic fluxes through the weaver potassium channel underlies the pathophysiology of the mutation. |
| Volume: |
93 |
| Issue: |
26 |
| Pages: |
15429-34 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rajan S |
| Year: |
2000 |
| Journal: |
J Biol Chem |
| Title: |
TASK-3, a novel tandem pore domain acid-sensitive K+ channel. An extracellular histiding as pH sensor. |
| Volume: |
275 |
| Issue: |
22 |
| Pages: |
16650-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
McLerie M |
| Year: |
2003 |
| Journal: |
J Mol Cell Cardiol |
| Title: |
Dominant-negative suppression of I(K1) in the mouse heart leads to altered cardiac excitability. |
| Volume: |
35 |
| Issue: |
4 |
| Pages: |
367-78 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Schleifenbaum J |
| Year: |
2014 |
| Journal: |
Circ Res |
| Title: |
Stretch-activation of angiotensin II type 1a receptors contributes to the myogenic response of mouse mesenteric and renal arteries. |
| Volume: |
115 |
| Issue: |
2 |
| Pages: |
263-72 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Spitzmaul G |
| Year: |
2013 |
| Journal: |
J Biol Chem |
| Title: |
Vestibular role of KCNQ4 and KCNQ5 K+ channels revealed by mouse models. |
| Volume: |
288 |
| Issue: |
13 |
| Pages: |
9334-44 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dobler T |
| Year: |
2007 |
| Journal: |
J Physiol |
| Title: |
TRESK two-pore-domain K+ channels constitute a significant component of background potassium currents in murine dorsal root ganglion neurones. |
| Volume: |
585 |
| Issue: |
Pt 3 |
| Pages: |
867-79 |
|
•
•
•
•
•
|