Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
goat |
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•
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•
•
|
Gene |
Type: |
gene |
Organism: |
rabbit, European |
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•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
333
|
Fragment?: |
false |
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•
•
•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
•
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Protein Domain |
Type: |
Family |
Description: |
The YobH-like protein family includes the YobH protein from E. coli , which is functionally uncharacterised. Proteins in this family are approximately 80 amino acids in length and contain two conserved sequence motifs: GYG and GLGL. |
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•
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Allele |
Name: |
potassium voltage-gated channel, subfamily Q, member 5; targeted mutation 1.1, Thomas J Jentsch |
Allele Type: |
Targeted |
Attribute String: |
Dominant negative |
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•
•
•
•
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Publication |
First Author: |
Tzingounis AV |
Year: |
2010 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The KCNQ5 potassium channel mediates a component of the afterhyperpolarization current in mouse hippocampus. |
Volume: |
107 |
Issue: |
22 |
Pages: |
10232-7 |
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•
•
•
•
•
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Strain |
Attribute String: |
mutant stock, targeted mutation |
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•
•
•
•
•
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Allele |
Name: |
potassium voltage-gated channel, subfamily Q, member 4; targeted mutation 1.2, Thomas J Jentsch |
Allele Type: |
Targeted |
Attribute String: |
Dominant negative |
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•
•
•
•
•
|
Genotype |
Symbol: |
Kcnq5/Kcnq5 |
Background: |
involves: 129S2/SvPas |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Kcnq4/Kcnq4<+> |
Background: |
involves: 129/Sv * C57BL/6 |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Kcnq4/Kcnq4 |
Background: |
involves: 129/Sv * C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Fidzinski P |
Year: |
2015 |
Journal: |
Nat Commun |
Title: |
KCNQ5 K(+) channels control hippocampal synaptic inhibition and fast network oscillations. |
Volume: |
6 |
|
Pages: |
6254 |
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•
•
•
|
Publication |
First Author: |
Cang C |
Year: |
2015 |
Journal: |
Cell |
Title: |
TMEM175 Is an Organelle K(+) Channel Regulating Lysosomal Function. |
Volume: |
162 |
Issue: |
5 |
Pages: |
1101-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Testoni G |
Year: |
2017 |
Journal: |
Cell Metab |
Title: |
Lack of Glycogenin Causes Glycogen Accumulation and Muscle Function Impairment. |
Volume: |
26 |
Issue: |
1 |
Pages: |
256-266.e4 |
|
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•
•
•
•
|
Publication |
First Author: |
Kharkovets T |
Year: |
2006 |
Journal: |
EMBO J |
Title: |
Mice with altered KCNQ4 K+ channels implicate sensory outer hair cells in human progressive deafness. |
Volume: |
25 |
Issue: |
3 |
Pages: |
642-52 |
|
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•
•
•
•
|
Publication |
First Author: |
Heidenreich M |
Year: |
2011 |
Journal: |
Nat Neurosci |
Title: |
KCNQ4 K(+) channels tune mechanoreceptors for normal touch sensation in mouse and man. |
Volume: |
15 |
Issue: |
1 |
Pages: |
138-45 |
|
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•
•
•
•
|
Publication |
First Author: |
Silverman SK |
Year: |
1996 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A regenerative link in the ionic fluxes through the weaver potassium channel underlies the pathophysiology of the mutation. |
Volume: |
93 |
Issue: |
26 |
Pages: |
15429-34 |
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•
•
•
•
|
Publication |
First Author: |
Rajan S |
Year: |
2000 |
Journal: |
J Biol Chem |
Title: |
TASK-3, a novel tandem pore domain acid-sensitive K+ channel. An extracellular histiding as pH sensor. |
Volume: |
275 |
Issue: |
22 |
Pages: |
16650-7 |
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•
•
•
•
•
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Publication |
First Author: |
McLerie M |
Year: |
2003 |
Journal: |
J Mol Cell Cardiol |
Title: |
Dominant-negative suppression of I(K1) in the mouse heart leads to altered cardiac excitability. |
Volume: |
35 |
Issue: |
4 |
Pages: |
367-78 |
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•
•
•
•
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Publication |
First Author: |
Spitzmaul G |
Year: |
2013 |
Journal: |
J Biol Chem |
Title: |
Vestibular role of KCNQ4 and KCNQ5 K+ channels revealed by mouse models. |
Volume: |
288 |
Issue: |
13 |
Pages: |
9334-44 |
|
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•
•
•
•
|
Publication |
First Author: |
Schleifenbaum J |
Year: |
2014 |
Journal: |
Circ Res |
Title: |
Stretch-activation of angiotensin II type 1a receptors contributes to the myogenic response of mouse mesenteric and renal arteries. |
Volume: |
115 |
Issue: |
2 |
Pages: |
263-72 |
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•
•
•
•
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Publication |
First Author: |
Dobler T |
Year: |
2007 |
Journal: |
J Physiol |
Title: |
TRESK two-pore-domain K+ channels constitute a significant component of background potassium currents in murine dorsal root ganglion neurones. |
Volume: |
585 |
Issue: |
Pt 3 |
Pages: |
867-79 |
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•
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