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Search results 1 to 100 out of 631 for Gzmb

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Categories

Hits by Pathway

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Hits by Strain

Type Details Score
Gene
3002 | GZMB
Type: gene
Organism: human
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Gene
171528 | Gzmb
Type: gene
Organism: rat
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Gene
490630 | GZMB
Type: gene
Organism: dog, domestic
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Gene
452825 | GZMB
Type: gene
Organism: chimpanzee
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Gene
281731 | GZMB
Type: gene
Organism: cattle
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Gene
716518 | GZMB
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:109267 | Gzmb
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q4FJY0
Organism: Mus musculus/domesticus
Length: 247  
Fragment?: false
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Publication
32504614 | J:300320
First Author: Turner CT
Year: 2021
Journal: J Invest Dermatol
Title: Granzyme B Contributes to Barrier Dysfunction in Oxazolone-Induced Skin Inflammation through E-Cadherin and FLG Cleavage.
Volume: 141
Issue: 1
Pages: 36-47
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Publication
32696761 | J:293993
   
First Author: Chitirala P
Year: 2020
Journal: Elife
Title: Studying the biology of cytotoxic T lymphocytes in vivo with a fluorescent granzyme B-mTFP knock-in mouse.
Volume: 9
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Publication
12182457 | J:102819
First Author: Eisert V
Year: 2002
Journal: Immunobiology
Title: The course of Leishmania major infection in mice lacking granzyme-mediated mechanisms.
Volume: 205
Issue: 3
Pages: 314-20
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Publication
28723565 | J:254864
First Author: Jeevan-Raj B
Year: 2017
Journal: Cell Rep
Title: The Transcription Factor Tcf1 Contributes to Normal NK Cell Development and Function by Limiting the Expression of Granzymes.
Volume: 20
Issue: 3
Pages: 613-626
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Publication
26610869 | J:228204
First Author: Shen Y
Year: 2016
Journal: Am J Pathol
Title: Granzyme B Deficiency Protects against Angiotensin II-Induced Cardiac Fibrosis.
Volume: 186
Issue: 1
Pages: 87-100
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Publication
21248253 | J:169144
First Author: Hartmann W
Year: 2011
Journal: J Immunol
Title: A novel and divergent role of granzyme A and B in resistance to helminth infection.
Volume: 186
Issue: 4
Pages: 2472-81
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Publication
23642129 | J:221762
First Author: Hirota JA
Year: 2013
Journal: Am J Respir Cell Mol Biol
Title: Granzyme B deficiency exacerbates lung inflammation in mice after acute lung injury.
Volume: 49
Issue: 3
Pages: 453-62
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Publication
23663075 | J:200627
First Author: Kobayashi M
Year: 2013
Journal: Clin Exp Immunol
Title: Genetic deletion of granzyme B does not confer resistance to the development of spontaneous diabetes in non-obese diabetic mice.
Volume: 173
Issue: 3
Pages: 411-8
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Publication
15699143 | J:96538
First Author: Revell PA
Year: 2005
Journal: J Immunol
Title: Granzyme B and the downstream granzymes C and/or F are important for cytotoxic lymphocyte functions.
Volume: 174
Issue: 4
Pages: 2124-31
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Publication
25495009 | J:220754
First Author: Parkinson LG
Year: 2015
Journal: Aging Cell
Title: Granzyme B mediates both direct and indirect cleavage of extracellular matrix in skin after chronic low-dose ultraviolet light irradiation.
Volume: 14
Issue: 1
Pages: 67-77
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Publication
25923440 | J:220371
First Author: Xu Y
Year: 2015
Journal: PLoS One
Title: Analysis of GzmbCre as a Model System for Gene Deletion in the Natural Killer Cell Lineage.
Volume: 10
Issue: 4
Pages: e0125211
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Publication
25367158 | J:247303
First Author: Mouchacca P
Year: 2015
Journal: Immunology
Title: Visualization of granzyme B-expressing CD8 T cells during primary and secondary immune responses to Listeria monocytogenes.
Volume: 145
Issue: 1
Pages: 24-33
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Publication
18064039 | J:146384
First Author: Pardo J
Year: 2008
Journal: Cell Death Differ
Title: Granzyme B-induced cell death exerted by ex vivo CTL: discriminating requirements for cell death and some of its signs.
Volume: 15
Issue: 3
Pages: 567-79
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Publication
19525394 | J:150037
First Author: Regner M
Year: 2009
Journal: J Immunol
Title: Cutting edge: rapid and efficient in vivo cytotoxicity by cytotoxic T cells is independent of granzymes A and B.
Volume: 183
Issue: 1
Pages: 37-40
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Publication
10570179 | J:120037
First Author: Müllbacher A
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes.
Volume: 96
Issue: 24
Pages: 13950-5
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Publication
17599099 | J:141353
First Author: Pardo J
Year: 2007
Journal: Cell Death Differ
Title: Granzyme B is expressed in mouse mast cells in vivo and in vitro and causes delayed cell death independent of perforin.
Volume: 14
Issue: 10
Pages: 1768-79
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Publication
10367905 | J:55398
First Author: Shresta S
Year: 1999
Journal: Immunity
Title: Granzyme A initiates an alternative pathway for granule-mediated apoptosis.
Volume: 10
Issue: 5
Pages: 595-605
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Publication
24113190 | J:315813
 
First Author: Wang S
Year: 2013
Journal: Cell Death Dis
Title: Rapid reuptake of granzyme B leads to emperitosis: an apoptotic cell-in-cell death of immune killer cells inside tumor cells.
Volume: 4
Pages: e856
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Publication
24791744 | J:211058
First Author: Hendel A
Year: 2014
Journal: Lab Invest
Title: Granzyme B releases vascular endothelial growth factor from extracellular matrix and induces vascular permeability.
Volume: 94
Issue: 7
Pages: 716-25
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Publication
25526309 | J:302262
First Author: Prakash MD
Year: 2014
Journal: Immunity
Title: Granzyme B promotes cytotoxic lymphocyte transmigration via basement membrane remodeling.
Volume: 41
Issue: 6
Pages: 960-72
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Publication
35129637 | J:333854
First Author: Tibbs E
Year: 2022
Journal: Cancer Immunol Immunother
Title: Murine myeloid derived suppressor cells possess a range of suppressive mechanisms-Granzyme B is not among them.
Volume: 71
Issue: 9
Pages: 2255-2266
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Publication
12115618 | J:115548
First Author: Pardo J
Year: 2002
Journal: Eur J Immunol
Title: The differential contribution of granzyme A and granzyme B in cytotoxic T lymphocyte-mediated apoptosis is determined by the quality of target cells.
Volume: 32
Issue: 7
Pages: 1980-5
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Publication
23264653 | J:192609
First Author: Bian G
Year: 2013
Journal: J Immunol
Title: Granzyme B-mediated damage of CD8+ T cells impairs graft-versus-tumor effect.
Volume: 190
Issue: 3
Pages: 1341-50
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Publication
17283187 | J:119735
First Author: Cullen SP
Year: 2007
Journal: J Cell Biol
Title: Human and murine granzyme B exhibit divergent substrate preferences.
Volume: 176
Issue: 4
Pages: 435-44
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Publication
24414824 | J:209387
First Author: Zorn CN
Year: 2013
Journal: Eur J Immunol
Title: Secretory lysosomes of mouse mast cells store and exocytose active caspase-3 in a strictly granzyme B dependent manner.
Volume: 43
Issue: 12
Pages: 3209-18
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Publication
23912712 | J:229000
First Author: Hiebert PR
Year: 2013
Journal: Cell Death Differ
Title: Granzyme B degrades extracellular matrix and contributes to delayed wound closure in apolipoprotein E knockout mice.
Volume: 20
Issue: 10
Pages: 1404-14
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Publication
25605735 | J:220026
First Author: Catalán E
Year: 2015
Journal: J Biol Chem
Title: Mouse cytotoxic T cell-derived granzyme B activates the mitochondrial cell death pathway in a Bim-dependent fashion.
Volume: 290
Issue: 11
Pages: 6868-77
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Publication
23840635 | J:203720
First Author: Mouchacca P
Year: 2013
Journal: PLoS One
Title: Visualization of cytolytic T cell differentiation and granule exocytosis with T cells from mice expressing active fluorescent granzyme B.
Volume: 8
Issue: 6
Pages: e67239
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Publication
17005566 | J:117624
First Author: Bredemeyer AJ
Year: 2006
Journal: J Biol Chem
Title: Hop cleavage and function in granzyme B-induced apoptosis.
Volume: 281
Issue: 48
Pages: 37130-41
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Publication
20035050 | J:156606
First Author: Chamberlain CM
Year: 2010
Journal: Am J Pathol
Title: Perforin-independent extracellular granzyme B activity contributes to abdominal aortic aneurysm.
Volume: 176
Issue: 2
Pages: 1038-49
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Publication
9362539 | J:44204
First Author: Simon MM
Year: 1997
Journal: J Exp Med
Title: In vitro- and ex vivo-derived cytolytic leukocytes from granzyme A x B double knockout mice are defective in granule-mediated apoptosis but not lysis of target cells.
Volume: 186
Issue: 10
Pages: 1781-6
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Publication
25502180 | J:246135
First Author: Andoniou CE
Year: 2014
Journal: PLoS Pathog
Title: A natural genetic variant of granzyme B confers lethality to a common viral infection.
Volume: 10
Issue: 12
Pages: e1004526
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Publication
15534000 | J:94847
First Author: Pardo J
Year: 2004
Journal: J Cell Biol
Title: Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis.
Volume: 167
Issue: 3
Pages: 457-68
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Publication
15998831 | J:119536
First Author: Martin P
Year: 2005
Journal: Blood
Title: Quiescent and activated mouse granulocytes do not express granzyme A and B or perforin: similarities or differences with human polymorphonuclear leukocytes?
Volume: 106
Issue: 8
Pages: 2871-8
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Publication
20395300 | J:164554
First Author: Martin P
Year: 2010
Journal: J Biol Chem
Title: Granzyme B-induced and caspase 3-dependent cleavage of gelsolin by mouse cytotoxic T cells modifies cytoskeleton dynamics.
Volume: 285
Issue: 24
Pages: 18918-27
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Publication
19838298 | J:154050
First Author: Pardo J
Year: 2009
Journal: PLoS One
Title: Caspase-dependent inhibition of mousepox replication by gzmB.
Volume: 4
Issue: 10
Pages: e7512
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Publication
29743559 | J:302840
First Author: Jaime-Sánchez P
Year: 2018
Journal: Cell Death Differ
Title: Antigen-specific primed cytotoxic T cells eliminate tumour cells in vivo and prevent tumour development, regardless of the presence of anti-apoptotic mutations conferring drug resistance.
Volume: 25
Issue: 9
Pages: 1536-1548
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Publication
30183689 | J:271169
First Author: Wang Y
Year: 2018
Journal: J Clin Invest
Title: SMAD4 promotes TGF-β-independent NK cell homeostasis and maturation and antitumor immunity.
Volume: 128
Issue: 11
Pages: 5123-5136
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Publication
24752302 | J:211304
First Author: Carnevalli LS
Year: 2014
Journal: J Exp Med
Title: Improved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking granzyme B.
Volume: 211
Issue: 5
Pages: 769-79
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Publication
3485287 | J:8216
First Author: Lobe CG
Year: 1986
Journal: Proc Natl Acad Sci U S A
Title: Cloning of two genes that are specifically expressed in activated cytotoxic T lymphocytes.
Volume: 83
Issue: 5
Pages: 1448-52
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Publication
14499263 | J:85893
First Author: Grossman WJ
Year: 2003
Journal: Curr Opin Immunol
Title: The orphan granzymes of humans and mice.
Volume: 15
Issue: 5
Pages: 544-52
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Publication
3555842 | J:39247
First Author: Masson D
Year: 1987
Journal: Cell
Title: A family of serine esterases in lytic granules of cytolytic T lymphocytes.
Volume: 49
Issue: 5
Pages: 679-85
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Publication
8917549 | J:36637
First Author: Pham CT
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: Long-range disruption of gene expression by a selectable marker cassette.
Volume: 93
Issue: 23
Pages: 13090-5
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Publication
1544892 | J:1548
First Author: Prendergast JA
Year: 1992
Journal: J Biol Chem
Title: Quantitative polymerase chain reaction analysis of cytotoxic cell proteinase gene transcripts in T cells. Pattern of expression is dependent on the nature of the stimulus.
Volume: 267
Issue: 8
Pages: 5090-5
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Publication
3257230 | J:15034
First Author: Jenne D
Year: 1988
Journal: J Immunol
Title: cDNA cloning of granzyme C, a granule-associated serine protease of cytolytic T lymphocytes.
Volume: 140
Issue: 1
Pages: 318-23
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Publication
3518058 | J:22959
First Author: Lobe CG
Year: 1986
Journal: Science
Title: Novel serine proteases encoded by two cytotoxic T lymphocyte-specific genes.
Volume: 232
Issue: 4752
Pages: 858-61
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Publication
3264185 | J:24188
First Author: Lobe CG
Year: 1988
Journal: Biochemistry
Title: Organization of two genes encoding cytotoxic T lymphocyte-specific serine proteases CCPI and CCPII.
Volume: 27
Issue: 18
Pages: 6941-6
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Publication
19414782 | J:149959
First Author: Cai SF
Year: 2009
Journal: J Immunol
Title: Differential expression of granzyme B and C in murine cytotoxic lymphocytes.
Volume: 182
Issue: 10
Pages: 6287-97
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Protein Coding Gene
MGP_CAROLIEiJ_G0019335 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0021391 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0021350 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0021326 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0021353 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0021134 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_109267 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0021793 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0020653 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0021101 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0021221 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0021204 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0021296 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0021228 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0021819 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0020396 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0020705 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0030353 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0020226 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
15699075 | J:96054
First Author: Sebbagh M
Year: 2005
Journal: J Exp Med
Title: Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner.
Volume: 201
Issue: 3
Pages: 465-71
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Publication
8137431 | J:23560
First Author: Heusel JW
Year: 1994
Journal: Cell
Title: Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.
Volume: 76
Issue: 6
Pages: 977-87
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Publication
22792290 | J:189506
First Author: Mollah ZU
Year: 2012
Journal: PLoS One
Title: Granzyme B is dispensable in the development of diabetes in non-obese diabetic mice.
Volume: 7
Issue: 7
Pages: e40357
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Publication
33436591 | J:300866
First Author: Hiroyasu S
Year: 2021
Journal: Nat Commun
Title: Granzyme B inhibition reduces disease severity in autoimmune blistering diseases.
Volume: 12
Issue: 1
Pages: 302
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Publication
19136373 | J:164996
First Author: Freishtat RJ
Year: 2009
Journal: Am J Respir Crit Care Med
Title: Sepsis alters the megakaryocyte-platelet transcriptional axis resulting in granzyme B-mediated lymphotoxicity.
Volume: 179
Issue: 6
Pages: 467-73
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Publication
16901729 | J:113469
First Author: Devadas S
Year: 2006
Journal: Immunity
Title: Granzyme B is critical for T cell receptor-induced cell death of type 2 helper T cells.
Volume: 25
Issue: 2
Pages: 237-47
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Publication
7493755 | J:28160
 
First Author: Shresta S
Year: 1995
Journal: Immunol Rev
Title: Granzyme B plays a critical role in cytotoxic lymphocyte-induced apoptosis.
Volume: 146
Pages: 211-21
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Publication
33674611 | J:304977
First Author: Santos-Zas I
Year: 2021
Journal: Nat Commun
Title: Cytotoxic CD8+ T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling.
Volume: 12
Issue: 1
Pages: 1483
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Publication
21964027 | J:179429
First Author: Haile Y
Year: 2011
Journal: J Immunol
Title: Granule-derived granzyme B mediates the vulnerability of human neurons to T cell-induced neurotoxicity.
Volume: 187
Issue: 9
Pages: 4861-72
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Publication
15356127 | J:92766
First Author: Phillips T
Year: 2004
Journal: J Immunol
Title: A role for the granzyme B inhibitor serine protease inhibitor 6 in CD8+ memory cell homeostasis.
Volume: 173
Issue: 6
Pages: 3801-9
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Publication
22427643 | J:184058
First Author: Hagn M
Year: 2012
Journal: J Immunol
Title: Activated mouse B cells lack expression of granzyme B.
Volume: 188
Issue: 8
Pages: 3886-92
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Publication
27716898 | J:253131
First Author: Frick M
Year: 2017
Journal: Immunology
Title: Distinct patterns of cytolytic T-cell activation by different tumour cells revealed by Ca2+ signalling and granule mobilization.
Volume: 150
Issue: 2
Pages: 199-212
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Publication
28798348 | J:287483
First Author: Malyshkina A
Year: 2017
Journal: Sci Rep
Title: Fas Ligand-mediated cytotoxicity of CD4+ T cells during chronic retrovirus infection.
Volume: 7
Issue: 1
Pages: 7785
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Publication
2300587 | J:10284
First Author: Hanson RD
Year: 1990
Journal: Proc Natl Acad Sci U S A
Title: A cluster of hematopoietic serine protease genes is found on the same chromosomal band as the human alpha/delta T-cell receptor locus.
Volume: 87
Issue: 3
Pages: 960-3
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Publication
2007574 | J:11072
First Author: Heusel JW
Year: 1991
Journal: J Biol Chem
Title: Structure and expression of a cluster of human hematopoietic serine protease genes found on chromosome 14q11.2.
Volume: 266
Issue: 10
Pages: 6152-8
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Publication
8468056 | J:4217
First Author: Caughey GH
Year: 1993
Journal: Genomics
Title: The human mast cell chymase gene (CMA1): mapping to the cathepsin G/granzyme gene cluster and lineage-restricted expression.
Volume: 15
Issue: 3
Pages: 614-20
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Publication
7566124 | J:39246
First Author: Darmon AJ
Year: 1995
Journal: Nature
Title: Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B.
Volume: 377
Issue: 6548
Pages: 446-8
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Publication
8631895 | J:32909
First Author: Gu Y
Year: 1996
Journal: J Biol Chem
Title: Processing and activation of CMH-1 by granzyme B.
Volume: 271
Issue: 18
Pages: 10816-20
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Publication
16280358 | J:111761
First Author: Veugelers K
Year: 2006
Journal: Mol Biol Cell
Title: Granule-mediated killing by granzyme B and perforin requires a mannose 6-phosphate receptor and is augmented by cell surface heparan sulfate.
Volume: 17
Issue: 2
Pages: 623-33
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Publication
17179148 | J:120874
First Author: Casciola-Rosen L
Year: 2007
Journal: J Biol Chem
Title: Mouse and human granzyme B have distinct tetrapeptide specificities and abilities to recruit the bid pathway.
Volume: 282
Issue: 7
Pages: 4545-52
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Publication
22017873 | J:180695
First Author: Afonina IS
Year: 2011
Journal: Mol Cell
Title: Granzyme B-dependent proteolysis acts as a switch to enhance the proinflammatory activity of IL-1α.
Volume: 44
Issue: 2
Pages: 265-78
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Publication
29107333 | J:250809
First Author: Dotiwala F
Year: 2017
Journal: Cell
Title: Granzyme B Disrupts Central Metabolism and Protein Synthesis in Bacteria to Promote an Immune Cell Death Program.
Volume: 171
Issue: 5
Pages: 1125-1137.e11
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Publication
32473350 | J:297619
First Author: Sutton VR
Year: 2020
Journal: Biochim Biophys Acta Proteins Proteom
Title: Differential cleavage of viral polypeptides by allotypic variants of granzyme B skews immunity to mouse cytomegalovirus.
Volume: 1868
Issue: 9
Pages: 140457
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Publication
29445095 | J:322089
First Author: Mao M
Year: 2018
Journal: Cell Death Dis
Title: Granzyme B deficiency promotes osteoblastic differentiation and calcification of vascular smooth muscle cells in hypoxic pulmonary hypertension.
Volume: 9
Issue: 2
Pages: 221
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GXD Expression
GXD Expression
     
Probe: MGI:4881556
Assay Type: RT-PCR
Annotation Date: 2011-02-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:4881559
Age: embryonic day 12.5
Specimen Label: WT
Detected: true
Specimen Num: 1
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