Type |
Details |
Score |
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen L |
Year: |
2014 |
Journal: |
J Immunol |
Title: |
Expression of the mouse MHC class Ib H2-T11 gene product, a paralog of H2-T23 (Qa-1) with shared peptide-binding specificity. |
Volume: |
193 |
Issue: |
3 |
Pages: |
1427-39 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lalanne JL |
Year: |
1985 |
Journal: |
Cell |
Title: |
Expression of class I genes in the major histocompatibility complex: identification of eight distinct mRNAs in DBA/2 mouse liver. |
Volume: |
41 |
Issue: |
2 |
Pages: |
469-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Transy C |
Year: |
1987 |
Journal: |
J Exp Med |
Title: |
A low polymorphic mouse H-2 class I gene from the Tla complex is expressed in a broad variety of cell types. |
Volume: |
166 |
Issue: |
2 |
Pages: |
341-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ito K |
Year: |
1990 |
Journal: |
Cell |
Title: |
Recognition of the product of a novel MHC TL region gene (27b) by a mouse gamma delta T cell receptor. |
Volume: |
62 |
Issue: |
3 |
Pages: |
549-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ohtsuka M |
Year: |
2008 |
Journal: |
BMC Genomics |
Title: |
Major histocompatibility complex (Mhc) class Ib gene duplications, organization and expression patterns in mouse strain C57BL/6. |
Volume: |
9 |
|
Pages: |
178 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hermel E |
Year: |
2004 |
Journal: |
Immunogenetics |
Title: |
Polymorphism and conservation of the genes encoding Qa1 molecules. |
Volume: |
56 |
Issue: |
9 |
Pages: |
639-49 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
254
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Brorson KA |
Year: |
1989 |
Journal: |
Immunogenetics |
Title: |
Analysis of a new class I gene mapping to the Hmt region of the mouse. |
Volume: |
30 |
Issue: |
4 |
Pages: |
273-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hermel E |
Year: |
1999 |
Journal: |
Immunogenetics |
Title: |
CTL and sequence analyses of MHC class IB antigens Qa1(c) (H2-T23(r)) and Qa1(d) (H2-T23(f)). |
Volume: |
49 |
Issue: |
7-8 |
Pages: |
712-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Connolly DJ |
Year: |
1993 |
Journal: |
J Immunol |
Title: |
A cDNA clone encoding the mouse Qa-1a histocompatibility antigen and proposed structure of the putative peptide binding site. |
Volume: |
151 |
Issue: |
11 |
Pages: |
6089-98 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim HJ |
Year: |
2011 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
CD8+ T regulatory cells express the Ly49 Class I MHC receptor and are defective in autoimmune prone B6-Yaa mice. |
Volume: |
108 |
Issue: |
5 |
Pages: |
2010-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yao Y |
Year: |
2013 |
Journal: |
Eur J Immunol |
Title: |
Glatiramer acetate ameliorates inflammatory bowel disease in mice through the induction of Qa-1-restricted CD8⁺ regulatory cells. |
Volume: |
43 |
Issue: |
1 |
Pages: |
125-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lu CC |
Year: |
2011 |
Journal: |
J Neurosci |
Title: |
Developmental profiling of spiral ganglion neurons reveals insights into auditory circuit assembly. |
Volume: |
31 |
Issue: |
30 |
Pages: |
10903-18 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim HJ |
Year: |
2024 |
Journal: |
J Clin Invest |
Title: |
A narrow T cell receptor repertoire instructs thymic differentiation of MHC class Ib-restricted CD8+ regulatory T cells. |
Volume: |
134 |
Issue: |
1 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Holderried TA |
Year: |
2013 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Genetic disruption of CD8+ Treg activity enhances the immune response to viral infection. |
Volume: |
110 |
Issue: |
52 |
Pages: |
21089-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Linehan JL |
Year: |
2018 |
Journal: |
Cell |
Title: |
Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair. |
Volume: |
172 |
Issue: |
4 |
Pages: |
784-796.e18 |
|
•
•
•
•
•
|
Publication |
First Author: |
Richards S |
Year: |
1989 |
Journal: |
EMBO J |
Title: |
Genetic and molecular mapping of the Hmt region of mouse. |
Volume: |
8 |
Issue: |
12 |
Pages: |
3749-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nagarajan NA |
Year: |
2012 |
Journal: |
Nat Immunol |
Title: |
Nonclassical MHC class Ib-restricted cytotoxic T cells monitor antigen processing in the endoplasmic reticulum. |
Volume: |
13 |
Issue: |
6 |
Pages: |
579-86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen L |
Year: |
2011 |
Journal: |
J Immunol |
Title: |
An MHC class Ib-restricted CD8+ T cell response to lymphocytic choriomeningitis virus. |
Volume: |
187 |
Issue: |
12 |
Pages: |
6463-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Anderson CK |
Year: |
2019 |
Journal: |
Cell Rep |
Title: |
Qa-1-Restricted CD8+ T Cells Can Compensate for the Absence of Conventional T Cells during Viral Infection. |
Volume: |
27 |
Issue: |
2 |
Pages: |
537-548.e5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hequet O |
Year: |
2020 |
Journal: |
Eur J Immunol |
Title: |
CD8+ T cells mediate ultraviolet A-induced immunomodulation in a model of extracorporeal photochemotherapy. |
Volume: |
50 |
Issue: |
5 |
Pages: |
725-735 |
|
•
•
•
•
•
|
Publication |
First Author: |
Choi JY |
Year: |
2020 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Regulatory CD8 T cells that recognize Qa-1 expressed by CD4 T-helper cells inhibit rejection of heart allografts. |
Volume: |
117 |
Issue: |
11 |
Pages: |
6042-6046 |
|
•
•
•
•
•
|
Publication |
First Author: |
Middelburg J |
Year: |
2023 |
Journal: |
Cell Rep |
Title: |
The MHC-E peptide ligands for checkpoint CD94/NKG2A are governed by inflammatory signals, whereas LILRB1/2 receptors are peptide indifferent. |
Volume: |
42 |
Issue: |
12 |
Pages: |
113516 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lu L |
Year: |
2007 |
Journal: |
Immunity |
Title: |
Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. |
Volume: |
26 |
Issue: |
5 |
Pages: |
593-604 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim HJ |
Year: |
2010 |
Journal: |
Nature |
Title: |
Inhibition of follicular T-helper cells by CD8(+) regulatory T cells is essential for self tolerance. |
Volume: |
467 |
Issue: |
7313 |
Pages: |
328-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Leavenworth JW |
Year: |
2011 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Mobilization of natural killer cells inhibits development of collagen-induced arthritis. |
Volume: |
108 |
Issue: |
35 |
Pages: |
14584-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lu L |
Year: |
2008 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Regulation of CD8+ regulatory T cells: Interruption of the NKG2A-Qa-1 interaction allows robust suppressive activity and resolution of autoimmune disease. |
Volume: |
105 |
Issue: |
49 |
Pages: |
19420-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu HC |
Year: |
2017 |
Journal: |
Cell Rep |
Title: |
Lymphocytes Negatively Regulate NK Cell Activity via Qa-1b following Viral Infection. |
Volume: |
21 |
Issue: |
9 |
Pages: |
2528-2540 |
|
•
•
•
•
•
|
Publication |
First Author: |
Manoharan Valerio M |
Year: |
2023 |
Journal: |
Front Immunol |
Title: |
The promiscuous development of an unconventional Qa1b-restricted T cell population. |
Volume: |
14 |
|
Pages: |
1250316 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bian Y |
Year: |
2017 |
Journal: |
PLoS Pathog |
Title: |
MHC Ib molecule Qa-1 presents Mycobacterium tuberculosis peptide antigens to CD8+ T cells and contributes to protection against infection. |
Volume: |
13 |
Issue: |
5 |
Pages: |
e1006384 |
|
•
•
•
•
•
|
Publication |
First Author: |
Won HY |
Year: |
2023 |
Journal: |
J Autoimmun |
Title: |
Cytokine receptor γc effectuates the generation of proinflammatory innate CD8 T cells by non-classical MHC-I molecules. |
Volume: |
138 |
|
Pages: |
103059 |
|
•
•
•
•
•
|
Publication |
First Author: |
Swanson PA 2nd |
Year: |
2008 |
Journal: |
J Exp Med |
Title: |
An MHC class Ib-restricted CD8 T cell response confers antiviral immunity. |
Volume: |
205 |
Issue: |
7 |
Pages: |
1647-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hu D |
Year: |
2004 |
Journal: |
Nat Immunol |
Title: |
Analysis of regulatory CD8 T cells in Qa-1-deficient mice. |
Volume: |
5 |
Issue: |
5 |
Pages: |
516-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Shang S |
Year: |
2016 |
Journal: |
PLoS Pathog |
Title: |
Nonclassical MHC Ib-restricted CD8+ T Cells Recognize Mycobacterium tuberculosis-Derived Protein Antigens and Contribute to Protection Against Infection. |
Volume: |
12 |
Issue: |
6 |
Pages: |
e1005688 |
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tang FL |
Year: |
2020 |
Journal: |
Cell Death Differ |
Title: |
Coupling of terminal differentiation deficit with neurodegenerative pathology in Vps35-deficient pyramidal neurons. |
Volume: |
27 |
Issue: |
7 |
Pages: |
2099-2116 |
|
•
•
•
•
•
|
Publication |
First Author: |
Marin IA |
Year: |
2022 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The nonclassical MHC class I Qa-1 expressed in layer 6 neurons regulates activity-dependent plasticity via microglial CD94/NKG2 in the cortex. |
Volume: |
119 |
Issue: |
23 |
Pages: |
e2203965119 |
|
•
•
•
•
•
|
Publication |
First Author: |
Clement M |
Year: |
2015 |
Journal: |
Circulation |
Title: |
Control of the T follicular helper-germinal center B-cell axis by CD8⁺ regulatory T cells limits atherosclerosis and tertiary lymphoid organ development. |
Volume: |
131 |
Issue: |
6 |
Pages: |
560-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ferez M |
Year: |
2021 |
Journal: |
J Exp Med |
Title: |
Viral infection modulates Qa-1b in infected and bystander cells to properly direct NK cell killing. |
Volume: |
218 |
Issue: |
5 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou J |
Year: |
2008 |
Journal: |
J Immunol |
Title: |
Cutting edge: engagement of NKG2A on CD8+ effector T cells limits immunopathology in influenza pneumonia. |
Volume: |
180 |
Issue: |
1 |
Pages: |
25-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Varthaman A |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
Physiological induction of regulatory Qa-1-restricted CD8+ T cells triggered by endogenous CD4+ T cell responses. |
Volume: |
6 |
Issue: |
6 |
Pages: |
e21628 |
|
•
•
•
•
•
|
Publication |
First Author: |
van Montfoort N |
Year: |
2018 |
Journal: |
Cell |
Title: |
NKG2A Blockade Potentiates CD8 T Cell Immunity Induced by Cancer Vaccines. |
Volume: |
175 |
Issue: |
7 |
Pages: |
1744-1755.e15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stocks BT |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
Host Expression of the CD8 Treg/NK Cell Restriction Element Qa-1 is Dispensable for Transplant Tolerance. |
Volume: |
7 |
Issue: |
1 |
Pages: |
11181 |
|
•
•
•
•
•
|
Publication |
First Author: |
Colmenero P |
Year: |
2007 |
Journal: |
J Immunol |
Title: |
Qa-1(b)-dependent modulation of dendritic cell and NK cell cross-talk in vivo. |
Volume: |
179 |
Issue: |
7 |
Pages: |
4608-15 |
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•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
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|
•
•
•
•
•
|
Publication |
First Author: |
University of California, Davis |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the University of California, Davis |
|
|
|
|
•
•
•
•
•
|
Allele |
Name: |
histocompatibility 2, T region locus 23; targeted mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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•
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•
•
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Publication |
First Author: |
Attaya M |
Year: |
1992 |
Journal: |
Nature |
Title: |
Ham-2 corrects the class I antigen-processing defect in RMA-S cells. |
Volume: |
355 |
Issue: |
6361 |
Pages: |
647-9 |
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•
•
•
•
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Publication |
First Author: |
Tajima A |
Year: |
2003 |
Journal: |
J Immunol |
Title: |
Blastocyst MHC, a putative murine homologue of HLA-G, protects TAP-deficient tumor cells from natural killer cell-mediated rejection in vivo. |
Volume: |
171 |
Issue: |
4 |
Pages: |
1715-21 |
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•
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•
•
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Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
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Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
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•
•
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
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•
•
•
•
•
|
Publication |
First Author: |
Krog HH |
Year: |
1977 |
Journal: |
Hereditas |
Title: |
Genetic characterization of important mouse strains used in cancer research. |
Volume: |
87 |
Issue: |
2 |
Pages: |
201-4 |
|
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•
•
•
•
|
Publication |
First Author: |
Lindahl KF |
Year: |
1980 |
Journal: |
Eur J Immunol |
Title: |
Qed-1--a target for unrestricted killing by T cells. |
Volume: |
10 |
Issue: |
4 |
Pages: |
289-98 |
|
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•
•
•
•
|
Publication |
First Author: |
Stanton TH |
Year: |
1981 |
Journal: |
J Immunol |
Title: |
Recognition of alternate alleles and mapping of the Qa1 locus. |
Volume: |
127 |
Issue: |
4 |
Pages: |
1640-3 |
|
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•
•
•
•
|
Publication |
First Author: |
Stanton TH |
Year: |
1980 |
Journal: |
Immunogenetics |
Title: |
Biochemical identification of the Qa-1 alloantigen. |
Volume: |
11 |
Issue: |
3 |
Pages: |
309-14 |
|
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•
•
•
•
|
Publication |
First Author: |
Steinmetz M |
Year: |
1982 |
Journal: |
Cell |
Title: |
Clusters of genes encoding mouse transplantation antigens. |
Volume: |
28 |
Issue: |
3 |
Pages: |
489-98 |
|
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•
•
•
•
|
Publication |
First Author: |
Lindahl KF |
Year: |
1982 |
Journal: |
Eur J Immunol |
Title: |
Polymorphism of a Qa-1-associated antigen defined by cytotoxic T cells. I. Qed-1a and Qed-1d. |
Volume: |
12 |
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2 |
Pages: |
159-66 |
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Cook RG |
Year: |
1983 |
Journal: |
J Immunol |
Title: |
The Qa-1 alloantigens. II. Evidence for the expression of two Qa-1 molecules by the Qa-1d genotype and for cross-reactivity between Qa-1 and H-2K. |
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130 |
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First Author: |
Jenkins RN |
Year: |
1985 |
Journal: |
Immunogenetics |
Title: |
Correlation of Qa-1 determinants defined by antisera and by cytotoxic T lymphocytes. |
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21 |
Issue: |
3 |
Pages: |
215-25 |
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First Author: |
Landolfi NF |
Year: |
1985 |
Journal: |
J Immunol |
Title: |
The Qa-1 alloantigens. III. Biochemical analysis of the structure and extent of polymorphism of the Qa-1 allelic products. |
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135 |
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1984 |
Journal: |
J Immunogenet |
Title: |
Qa antigens and their differential distribution on lymphoid, myeloid and stem cells. |
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11 |
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5-6 |
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Aldrich CJ |
Year: |
1986 |
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J Immunol |
Title: |
Clonal analysis of the anti-Qa-1 cytotoxic T lymphocyte repertoire: definition of the Qa-1d and Qa-1c alloantigens and cross-reactivity with H-2. |
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136 |
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Immunogenetics |
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Fine map of a region homologous to the rat grc complex in the TL region of the mouse. |
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Year: |
1995 |
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J Exp Med |
Title: |
The class I-b molecule Qa-1 forms heterodimers with H-2Ld and a novel 50-kD glycoprotein encoded centromeric to I-E beta. |
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1996 |
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Immunogenetics |
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Expressed Peromyscus maniculatus (Pema) MHC class I genes: evolutionary implications and the identification of a gene encoding a Qa1-like antigen. |
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J Autoimmun |
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2004 |
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J Immunol |
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The nonclassical MHC class I molecule Qa-1 forms unstable peptide complexes. |
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J Exp Med |
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Transporters associated with antigen processing (TAP)-independent presentation of soluble insulin to alpha/beta T cells by the class Ib gene product, Qa-1(b). |
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A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
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Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord. |
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Zeng L |
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2012 |
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J Immunol |
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A structural basis for antigen presentation by the MHC class Ib molecule, Qa-1b. |
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188 |
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Goodall KJ |
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2020 |
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J Biol Chem |
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The murine CD94/NKG2 ligand, Qa-1b, is a high-affinity, functional ligand for the CD8αα homodimer. |
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