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Search results 1 to 100 out of 1192 for H2ax

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Type Details Score
Gene
3014 | H2AX
Type: gene
Organism: human
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Gene
531733 | H2AX
Type: gene
Organism: cattle
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Gene
100857391 | H2AX
Type: gene
Organism: chicken
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Gene
394048 | h2ax
Type: gene
Organism: zebrafish
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Gene
703073 | H2AX
Type: gene
Organism: macaque, rhesus
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Gene
100487455 | h2ax
Type: gene
Organism: frog, western clawed
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Gene
104001345 | H2AX
Type: gene
Organism: chimpanzee
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Gene
500987 | H2ax
Type: gene
Organism: rat
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Gene
489372 | H2AX
Type: gene
Organism: dog, domestic
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Protein Coding Gene
MGI:102688 | H2ax
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
 
Probe: MGI:5305847
Assay Type: Immunohistochemistry
Annotation Date: 2022-07-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1603917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7311705
Age: embryonic day 10.5
Image: S5B H2ax WT (left)
Note: Expression in specimen not described.
Specimen Label: S5B H2ax WT (left)
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:5305847
Assay Type: Immunohistochemistry
Annotation Date: 2022-07-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1603917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7311705
Age: embryonic day 10.5
Image: S5B H2ax WT (right)
Note: Expression in specimen not described.
Specimen Label: S5B H2ax WT (right)
Specimen Num: 11
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GXD Expression
GXD Expression
 
Probe: MGI:5305847
Assay Type: Immunohistochemistry
Annotation Date: 2022-07-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7311705
Age: embryonic day 10.5
Image: S5B H2ax Ptch KO
Specimen Label: S5B H2ax Ptch KO
Detected: true
Specimen Num: 12
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Publication
12914701 | J:86590
First Author: Celeste A
Year: 2003
Journal: Cell
Title: H2AX haploinsufficiency modifies genomic stability and tumor susceptibility.
Volume: 114
Issue: 3
Pages: 371-383
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Publication
15589157 | J:95016
First Author: Turner JM
Year: 2004
Journal: Curr Biol
Title: BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation.
Volume: 14
Issue: 23
Pages: 2135-42
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Publication
12689589 | J:109017
First Author: Fernandez-Capetillo O
Year: 2003
Journal: Dev Cell
Title: H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis.
Volume: 4
Issue: 4
Pages: 497-508
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GXD Expression
GXD Expression
 
Probe: MGI:5305847
Assay Type: Immunohistochemistry
Annotation Date: 2022-07-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7311705
Age: embryonic day 10.5
Image: S5B H2ax Trp53 KO (left)
Specimen Label: S5B H2ax Trp53 KO (left)
Detected: true
Specimen Num: 15
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GXD Expression
GXD Expression
 
Probe: MGI:5305847
Assay Type: Immunohistochemistry
Annotation Date: 2022-07-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7311705
Age: embryonic day 10.5
Image: S5B H2ax Trp53 Het (left)
Specimen Label: S5B H2ax Trp53 Het (left)
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
 
Probe: MGI:5305847
Assay Type: Immunohistochemistry
Annotation Date: 2022-07-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7311705
Age: embryonic day 10.5
Image: S5B H2ax Trp53 Het (right)
Specimen Label: S5B H2ax Trp53 Het (right)
Detected: true
Specimen Num: 14
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GXD Expression
GXD Expression
 
Probe: MGI:5305847
Assay Type: Immunohistochemistry
Annotation Date: 2022-07-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7311705
Age: embryonic day 10.5
Image: S5B H2ax Trp53 KO (right)
Specimen Label: S5B H2ax Trp53 KO (right)
Detected: true
Specimen Num: 16
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Publication
11571274 | J:341403
First Author: Burma S
Year: 2001
Journal: J Biol Chem
Title: ATM phosphorylates histone H2AX in response to DNA double-strand breaks.
Volume: 276
Issue: 45
Pages: 42462-7
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Publication
12034884 | J:84909
First Author: Bassing CH
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX.
Volume: 99
Issue: 12
Pages: 8173-8
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Publication
11893489 | J:75322
First Author: Redon C
Year: 2002
Journal: Curr Opin Genet Dev
Title: Histone H2A variants H2AX and H2AZ.
Volume: 12
Issue: 2
Pages: 162-9
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Publication
12914700 | J:84879
First Author: Bassing CH
Year: 2003
Journal: Cell
Title: Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors.
Volume: 114
Issue: 3
Pages: 359-70
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Publication
11934988 | J:76360
First Author: Celeste A
Year: 2002
Journal: Science
Title: Genomic instability in mice lacking histone H2AX.
Volume: 296
Issue: 5569
Pages: 922-7
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Publication
19377486 | J:149487
First Author: Economopoulou M
Year: 2009
Journal: Nat Med
Title: Histone H2AX is integral to hypoxia-driven neovascularization.
Volume: 15
Issue: 5
Pages: 553-8
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Publication
15632067 | J:96007
First Author: Kang J
Year: 2005
Journal: Mol Cell Biol
Title: Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression.
Volume: 25
Issue: 2
Pages: 661-70
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Publication
11740565 | J:73342
First Author: Petersen S
Year: 2001
Journal: Nature
Title: AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching.
Volume: 414
Issue: 6864
Pages: 660-665
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Publication
2041781 | J:11221
First Author: Nagata T
Year: 1991
Journal: Nucleic Acids Res
Title: Polyadenylated and 3' processed mRNAs are transcribed from the mouse histone H2A.X gene.
Volume: 19
Issue: 9
Pages: 2441-7
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Publication
7774939 | J:22825
First Author: Porcher C
Year: 1995
Journal: Genomics
Title: Structure of the mouse H2A.X gene and physical linkage to the UPS locus on chromosome 9: assignment of the human H2A.X gene to 11q23 by sequence analysis.
Volume: 25
Issue: 1
Pages: 312-3
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Publication
11242108 | J:126641
First Author: Mahadevaiah SK
Year: 2001
Journal: Nat Genet
Title: Recombinational DNA double-strand breaks in mice precede synapsis.
Volume: 27
Issue: 3
Pages: 271-6
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Publication
19234442 | J:147286
First Author: Cook PJ
Year: 2009
Journal: Nature
Title: Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions.
Volume: 458
Issue: 7238
Pages: 591-6
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Publication
29670103 | J:261942
First Author: Weyemi U
Year: 2018
Journal: Nat Commun
Title: Histone H2AX deficiency causes neurobehavioral deficits and impaired redox homeostasis.
Volume: 9
Issue: 1
Pages: 1526
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Publication
30910969 | J:274575
First Author: Weyemi U
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Histone H2AX promotes neuronal health by controlling mitochondrial homeostasis.
Volume: 116
Issue: 15
Pages: 7471-7476
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Publication
19273588 | J:148995
First Author: Fragkos M
Year: 2009
Journal: Mol Cell Biol
Title: H2AX is required for cell cycle arrest via the p53/p21 pathway.
Volume: 29
Issue: 10
Pages: 2828-40
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Publication
18619440 | J:138309
First Author: Lu C
Year: 2008
Journal: FEBS Lett
Title: Serum starvation induces H2AX phosphorylation to regulate apoptosis via p38 MAPK pathway.
Volume: 582
Issue: 18
Pages: 2703-8
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Publication
31123184 | J:277567
First Author: Chen BR
Year: 2019
Journal: J Cell Biol
Title: XLF and H2AX function in series to promote replication fork stability.
Volume: 218
Issue: 7
Pages: 2113-2123
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Publication
21436033 | J:171217
First Author: Fernando RN
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Cell cycle restriction by histone H2AX limits proliferation of adult neural stem cells.
Volume: 108
Issue: 14
Pages: 5837-42
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Publication
26791933 | J:272297
 
First Author: Zhao B
Year: 2016
Journal: Sci Rep
Title: H2AX deficiency is associated with erythroid dysplasia and compromised haematopoietic stem cell function.
Volume: 6
Pages: 19589
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Publication
29795555 | J:261858
First Author: Jiang H
Year: 2018
Journal: PLoS Genet
Title: MOF influences meiotic expansion of H2AX phosphorylation and spermatogenesis in mice.
Volume: 14
Issue: 5
Pages: e1007300
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Publication
22730535 | J:189790
First Author: Yin B
Year: 2012
Journal: J Immunol
Title: Redundant and nonredundant functions of ATM and H2AX in αβ T-lineage lymphocytes.
Volume: 189
Issue: 3
Pages: 1372-9
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Publication
16030261 | J:106526
First Author: McManus KJ
Year: 2005
Journal: Mol Biol Cell
Title: ATM-dependent DNA damage-independent mitotic phosphorylation of H2AX in normally growing mammalian cells.
Volume: 16
Issue: 10
Pages: 5013-25
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Publication
28977657 | J:246975
First Author: Feng YL
Year: 2017
Journal: Nucleic Acids Res
Title: H2AX facilitates classical non-homologous end joining at the expense of limited nucleotide loss at repair junctions.
Volume: 45
Issue: 18
Pages: 10614-10633
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Publication
21160476 | J:167994
First Author: Helmink BA
Year: 2011
Journal: Nature
Title: H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes.
Volume: 469
Issue: 7329
Pages: 245-9
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Publication
18599436 | J:138190
First Author: Zha S
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Complementary functions of ATM and H2AX in development and suppression of genomic instability.
Volume: 105
Issue: 27
Pages: 9302-6
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Publication
27006338 | J:331292
First Author: Gruosso T
Year: 2016
Journal: EMBO Mol Med
Title: Chronic oxidative stress promotes H2AX protein degradation and enhances chemosensitivity in breast cancer patients.
Volume: 8
Issue: 5
Pages: 527-49
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Publication
17923115 | J:127325
First Author: Koike M
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Dynamic change of histone H2AX phosphorylation independent of ATM and DNA-PK in mouse skin in situ.
Volume: 363
Issue: 4
Pages: 1009-12
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Publication
18755145 | J:140997
First Author: Koike M
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Tissue-specific DNA-PK-dependent H2AX phosphorylation and gamma-H2AX elimination after X-irradiation in vivo.
Volume: 376
Issue: 1
Pages: 52-5
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Publication
17304220 | J:200413
First Author: Bogliolo M
Year: 2007
Journal: EMBO J
Title: Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability.
Volume: 26
Issue: 5
Pages: 1340-51
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Publication
27260000 | J:310949
First Author: Reichenstein M
Year: 2016
Journal: Oncotarget
Title: Luminal STAT5 mediates H2AX promoter activity in distinct population of basal mammary epithelial cells.
Volume: 7
Issue: 27
Pages: 41781-41797
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Publication
15322096 | J:93974
First Author: Hao LY
Year: 2004
Journal: J Biol Chem
Title: Phosphorylation of H2AX at short telomeres in T cells and fibroblasts.
Volume: 279
Issue: 43
Pages: 45148-54
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Publication
19887394 | J:155456
First Author: Yin B
Year: 2009
Journal: J Exp Med
Title: Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination.
Volume: 206
Issue: 12
Pages: 2625-39
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Publication
20947684 | J:168421
First Author: Yin B
Year: 2011
Journal: Blood
Title: Cellular context-dependent effects of H2ax and p53 deletion on the development of thymic lymphoma.
Volume: 117
Issue: 1
Pages: 175-85
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Publication
32572033 | J:292050
First Author: Collins PL
Year: 2020
Journal: Nat Commun
Title: DNA double-strand breaks induce H2Ax phosphorylation domains in a contact-dependent manner.
Volume: 11
Issue: 1
Pages: 3158
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Publication
12810694 | J:120658
First Author: Reina-San-Martin B
Year: 2003
Journal: J Exp Med
Title: H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation.
Volume: 197
Issue: 12
Pages: 1767-78
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Publication
23966158 | J:317301
First Author: Fusello A
Year: 2013
Journal: Cell Cycle
Title: Histone H2AX suppresses translocations in lymphomas of Eμ-c-Myc transgenic mice that contain a germline amplicon of tumor-promoting genes.
Volume: 12
Issue: 17
Pages: 2867-75
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Publication
14530383 | -
First Author: Fernandez-Capetillo O
Year: 2003
Journal: J Cell Biol
Title: H2AX regulates meiotic telomere clustering.
Volume: 163
Issue: 1
Pages: 15-20
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Publication
19463809 | J:150737
First Author: Yang F
Year: 2009
Journal: Dev Biol
Title: Persistence of histone H2AX phosphorylation after meiotic chromosome synapsis and abnormal centromere cohesion in poly (ADP-ribose) polymerase (Parp-1) null oocytes.
Volume: 331
Issue: 2
Pages: 326-38
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Publication
20231360 | J:162591
First Author: Orsburn B
Year: 2010
Journal: Mol Cell Biol
Title: Differential requirement for H2AX and 53BP1 in organismal development and genome maintenance in the absence of poly(ADP)ribosyl polymerase 1.
Volume: 30
Issue: 10
Pages: 2341-52
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Publication
22946062 | J:200281
First Author: Burrage J
Year: 2012
Journal: J Cell Sci
Title: The SNF2 family ATPase LSH promotes phosphorylation of H2AX and efficient repair of DNA double-strand breaks in mammalian cells.
Volume: 125
Issue: Pt 22
Pages: 5524-34
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GXD Expression
GXD Expression
Probe: MGI:5305847
Assay Type: Immunohistochemistry
Annotation Date: 2021-06-18
Strength: Present
Sex: Male
Emaps: EMAPS:3148428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6715978
Age: postnatal day 16
Image: 6b Lepto Meioc-/-
Note: All spermatocytes were positive for H2ax in mutant testis.
Specimen Label: 6b Lepto Meioc-/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:5305847
Assay Type: Immunohistochemistry
Annotation Date: 2021-06-18
Strength: Present
Sex: Male
Emaps: EMAPS:3148428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6715978
Age: postnatal day 16
Image: 6b Zygo-like Meioc-/- top
Note: All spermatocytes were positive for H2ax in mutant testis.
Specimen Label: 6b Zygo-like Meioc-/- top
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:5305847
Assay Type: Immunohistochemistry
Annotation Date: 2021-06-18
Strength: Present
Sex: Male
Emaps: EMAPS:3148428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6715978
Age: postnatal day 16
Image: 6b Zygo-like Meioc-/- bottom
Note: All spermatocytes were positive for H2ax in mutant testis.
Specimen Label: 6b Zygo-like Meioc-/- bottom
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
Probe: MGI:5305847
Assay Type: Immunohistochemistry
Annotation Date: 2021-06-17
Strength: Present
Sex: Male
Emaps: EMAPS:3148428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6715676
Age: postnatal adult
Image: S4e -/-
Note: All spermatocytes were positive for H2ax in the mutant testis.
Specimen Label: S4e -/-
Detected: true
Specimen Num: 21
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Publication
19450528 | J:150434
First Author: Savic V
Year: 2009
Journal: Mol Cell
Title: Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin.
Volume: 34
Issue: 3
Pages: 298-310
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GXD Expression
GXD Expression
Probe: MGI:5305847
Assay Type: Immunohistochemistry
Annotation Date: 2021-06-17
Strength: Weak
Sex: Female
Emaps: EMAPS:2896526
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6715676
Age: embryonic day 18.5
Image: 4e +/+ VASA/g-H2AX
Note: Expression of H2ax was progressively lost during later fetal life in wild type.
Specimen Label: 4e +/+ VASA/g-H2AX
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:5305847
Assay Type: Immunohistochemistry
Annotation Date: 2021-06-17
Strength: Present
Sex: Female
Emaps: EMAPS:2896526
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6715676
Age: embryonic day 18.5
Image: 4e -/- VASA/g-H2AX
Note: An abundance of staining for H2ax was detected in the mutant.
Specimen Label: 4e -/- VASA/g-H2AX
Detected: true
Specimen Num: 4
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Publication
9488723 | -
First Author: Rogakou EP
Year: 1998
Journal: J Biol Chem
Title: DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139.
Volume: 273
Issue: 10
Pages: 5858-68
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Publication
12447390 | -
First Author: Fernandez-Capetillo O
Year: 2002
Journal: Nat Cell Biol
Title: DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1.
Volume: 4
Issue: 12
Pages: 993-7
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UniProt Feature
UniProt Feature
Begin: 2
Description: Histone H2AX
Type: chain
End: 143
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GXD Expression
GXD Expression
Probe: MGI:5305847
Assay Type: Immunohistochemistry
Annotation Date: 2021-06-17
Strength: Weak
Sex: Male
Emaps: EMAPS:1797528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6715676
Age: postnatal day 8
Image: 5a g-H2AX 8-dpp -/-
Note: At 8 dpp H2ax appeared to be globally weaker in the mutant than in wild type testes.
Specimen Label: 5a g-H2AX 8-dpp -/-
Detected: true
Specimen Num: 10
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Publication
12792649 | -
First Author: Celeste A
Year: 2003
Journal: Nat Cell Biol
Title: Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks.
Volume: 5
Issue: 7
Pages: 675-9
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Publication
15059890 | -
First Author: Stiff T
Year: 2004
Journal: Cancer Res
Title: ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation.
Volume: 64
Issue: 7
Pages: 2390-6
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Publication
20488183 | -
First Author: Jiang X
Year: 2010
Journal: FEBS Lett
Title: Acetylation of H2AX on lysine 36 plays a key role in the DNA double-strand break repair pathway.
Volume: 584
Issue: 13
Pages: 2926-30
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Publication
19092802 | J:143888
First Author: Xiao A
Year: 2009
Journal: Nature
Title: WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity.
Volume: 457
Issue: 7225
Pages: 57-62
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Publication
12660252 | -
First Author: Furuta T
Year: 2003
Journal: J Biol Chem
Title: Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.
Volume: 278
Issue: 22
Pages: 20303-12
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Publication
23039116 | J:192634
First Author: Kogo H
Year: 2012
Journal: Genes Cells
Title: HORMAD2 is essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity.
Volume: 17
Issue: 11
Pages: 897-912
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GO Term
GO:0141003 | histone H2AX kinase activity
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Publication
30949703 | J:285969
First Author: Liu H
Year: 2019
Journal: Nucleic Acids Res
Title: SCRE serves as a unique synaptonemal complex fastener and is essential for progression of meiosis prophase I in mice.
Volume: 47
Issue: 11
Pages: 5670-5683
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Publication
30272023 | J:268520
 
First Author: Zhang Q
Year: 2018
Journal: Commun Biol
Title: Evolutionarily-conserved MZIP2 is essential for crossover formation in mammalian meiosis.
Volume: 1
Pages: 147
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Publication
30746471 | J:297328
First Author: Zhang Q
Year: 2019
Journal: Sci Adv
Title: SPO16 binds SHOC1 to promote homologous recombination and crossing-over in meiotic prophase I.
Volume: 5
Issue: 1
Pages: eaau9780
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