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Search results 1 to 100 out of 369 for Hamp

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Truksa J
Year: 2009
Journal: Br J Haematol
Title: Suppression of the hepcidin-encoding gene Hamp permits iron overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6.
Volume: 147
Issue: 4
Pages: 571-81
Publication  
First Author: Wang X
Year: 2021
Journal: Nutrients
Title: Oral Administration of Ginger-Derived Lipid Nanoparticles and Dmt1 siRNA Potentiates the Effect of Dietary Iron Restriction and Mitigates Pre-Existing Iron Overload in Hamp KO Mice.
Volume: 13
Issue: 5
Publication
First Author: Hulko M
Year: 2006
Journal: Cell
Title: The HAMP domain structure implies helix rotation in transmembrane signaling.
Volume: 126
Issue: 5
Pages: 929-40
Publication
First Author: Dunin-Horkawicz S
Year: 2010
Journal: J Mol Biol
Title: Comprehensive analysis of HAMP domains: implications for transmembrane signal transduction.
Volume: 397
Issue: 5
Pages: 1156-74
Publication
First Author: Airola MV
Year: 2013
Journal: PLoS Biol
Title: HAMP domain conformers that propagate opposite signals in bacterial chemoreceptors.
Volume: 11
Issue: 2
Pages: e1001479
Publication
First Author: Airola MV
Year: 2010
Journal: Structure
Title: Structure of concatenated HAMP domains provides a mechanism for signal transduction.
Volume: 18
Issue: 4
Pages: 436-48
Publication
First Author: Sasu BJ
Year: 2010
Journal: Blood
Title: Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia.
Volume: 115
Issue: 17
Pages: 3616-24
Publication
First Author: Cooke KS
Year: 2013
Journal: Blood
Title: A fully human anti-hepcidin antibody modulates iron metabolism in both mice and nonhuman primates.
Volume: 122
Issue: 17
Pages: 3054-61
Publication
First Author: Aravind L
Year: 1999
Journal: FEMS Microbiol Lett
Title: The cytoplasmic helical linker domain of receptor histidine kinase and methyl-accepting proteins is common to many prokaryotic signalling proteins.
Volume: 176
Issue: 1
Pages: 111-6
Protein Domain
Type: Domain
Description: The HAMP domain (present in Histidine kinases, Adenyl cyclases, Methyl-accepting proteins and Phosphatases) is an approximately 50-amino acid α-helical region common to chemoreceptors and histidine kinases that is present in several multidomain sensor proteins that participate in a variety of signal transduction processes. It is found in bacterial sensor and chemotaxis proteins and in eukaryotic histidine kinases. The bacterial proteins are usually integral membrane proteins and part of a two-component signal transduction pathway. One or several copies of the HAMP domain can be found in association with other domains, such as the histidine kinase domain, the bacterial chemotaxis sensory transducer domain, the PAS repeat, the EAL domain, the GGDEF domain, the protein phosphatase 2C-like domain, the guanylate cyclase domain, or the response regulatory domain. It has been suggested that the HAMP domain possesses a role of regulating the phosphorylation or methylation of homodimeric receptors by transmitting the conformational changes in periplasmic ligand-binding domains to cytoplasmic signalling kinase and methyl-acceptor domains [, , ].
Publication
First Author: Lu S
Year: 2015
Journal: Transgenic Res
Title: Inductively coupled mass spectrometry analysis of biometals in conditional Hamp1 and Hamp1 and Hamp2 transgenic mouse models.
Volume: 24
Issue: 4
Pages: 765-73
Publication
First Author: Du X
Year: 2008
Journal: Science
Title: The serine protease TMPRSS6 is required to sense iron deficiency.
Volume: 320
Issue: 5879
Pages: 1088-92
Publication
First Author: Akchurin O
Year: 2016
Journal: Am J Physiol Renal Physiol
Title: Lack of hepcidin ameliorates anemia and improves growth in an adenine-induced mouse model of chronic kidney disease.
Volume: 311
Issue: 5
Pages: F877-F889
Publication
First Author: Yamamoto K
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Interplay of adipocyte and hepatocyte: Leptin upregulates hepcidin.
Volume: 495
Issue: 1
Pages: 1548-1554
Publication
First Author: Fillebeen C
Year: 2019
Journal: Blood
Title: Transferrin receptor 1 controls systemic iron homeostasis by fine-tuning hepcidin expression to hepatocellular iron load.
Volume: 133
Issue: 4
Pages: 344-355
Publication
First Author: Nicolas G
Year: 2003
Journal: Nat Genet
Title: Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis.
Volume: 34
Issue: 1
Pages: 97-101
Publication
First Author: Muckenthaler M
Year: 2003
Journal: Nat Genet
Title: Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis.
Volume: 34
Issue: 1
Pages: 102-7
Publication
First Author: Besson-Fournier C
Year: 2012
Journal: Blood
Title: Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling.
Volume: 120
Issue: 2
Pages: 431-9
Publication
First Author: Nai A
Year: 2012
Journal: Blood
Title: Deletion of TMPRSS6 attenuates the phenotype in a mouse model of β-thalassemia.
Volume: 119
Issue: 21
Pages: 5021-9
Publication
First Author: Wang CY
Year: 2017
Journal: Blood
Title: Smad1/5 is required for erythropoietin-mediated suppression of hepcidin in mice.
Volume: 130
Issue: 1
Pages: 73-83
Publication
First Author: Kämmerer L
Year: 2020
Journal: Blood
Title: Fetal liver hepcidin secures iron stores in utero.
Volume: 136
Issue: 13
Pages: 1549-1557
Publication
First Author: Yuki KE
Year: 2013
Journal: PLoS One
Title: Suppression of hepcidin expression and iron overload mediate Salmonella susceptibility in ankyrin 1 ENU-induced mutant.
Volume: 8
Issue: 2
Pages: e55331
Publication
First Author: Vecchi C
Year: 2014
Journal: Gastroenterology
Title: Gluconeogenic signals regulate iron homeostasis via hepcidin in mice.
Volume: 146
Issue: 4
Pages: 1060-9
Publication
First Author: Truksa J
Year: 2009
Journal: Blood
Title: Two BMP responsive elements, STAT, and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1, and HJV responsiveness.
Volume: 113
Issue: 3
Pages: 688-95
Protein Domain
Type: Domain
Description: Aer2 soluble receptor from Pseudomonas aeruginosa contains three successive HAMP domains in the N-terminal region. HAMP domains are widespread prokaryotic signaling modules. This entry is the third N-terminal HAMP domain (HAMP3). HAMP3 adopts a conformation resembling Af1503, with only minor differences in helical tilt and orientation []. The basic construction of each HAMP domain consists of a monomeric unit of two parallel α-helices (AS1 and AS2) joined by an elongated connector of 12-14 residues form a parallel four-helix bundle [].
Publication
First Author: Lou DQ
Year: 2004
Journal: Blood
Title: Functional differences between hepcidin 1 and 2 in transgenic mice.
Volume: 103
Issue: 7
Pages: 2816-21
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication    
First Author: Lakhal-Littleton S
Year: 2016
Journal: Elife
Title: An essential cell-autonomous role for hepcidin in cardiac iron homeostasis.
Volume: 5
Publication
First Author: Shu W
Year: 2019
Journal: Invest Ophthalmol Vis Sci
Title: Iron Accumulates in Retinal Vascular Endothelial Cells But Has Minimal Retinal Penetration After IP Iron Dextran Injection in Mice.
Volume: 60
Issue: 13
Pages: 4378-4387
Publication
First Author: Baumann BH
Year: 2019
Journal: Am J Pathol
Title: Liver-Specific, but Not Retina-Specific, Hepcidin Knockout Causes Retinal Iron Accumulation and Degeneration.
Volume: 189
Issue: 9
Pages: 1814-1830
Publication
First Author: Zumerle S
Year: 2014
Journal: Blood
Title: Targeted disruption of hepcidin in the liver recapitulates the hemochromatotic phenotype.
Volume: 123
Issue: 23
Pages: 3646-50
Publication  
First Author: Zhang KR
Year: 2023
Journal: Dis Model Mech
Title: Oxidative stress induces lysosomal membrane permeabilization and ceramide accumulation in retinal pigment epithelial cells.
Volume: 16
Issue: 7
Publication
First Author: Lesbordes-Brion JC
Year: 2006
Journal: Blood
Title: Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis.
Volume: 108
Issue: 4
Pages: 1402-5
Publication  
First Author: Willemetz A
Year: 2017
Journal: Front Immunol
Title: Iron- and Hepcidin-Independent Downregulation of the Iron Exporter Ferroportin in Macrophages during Salmonella Infection.
Volume: 8
Pages: 498
Publication
First Author: Shen GS
Year: 2014
Journal: Calcif Tissue Int
Title: Hepcidin1 knockout mice display defects in bone microarchitecture and changes of bone formation markers.
Volume: 94
Issue: 6
Pages: 632-9
Publication
First Author: Ramey G
Year: 2007
Journal: FEBS Lett
Title: Iron overload in Hepc1(-/-) mice is not impairing glucose homeostasis.
Volume: 581
Issue: 5
Pages: 1053-7
Publication
First Author: Houamel D
Year: 2016
Journal: J Am Soc Nephrol
Title: Hepcidin as a Major Component of Renal Antibacterial Defenses against Uropathogenic Escherichia coli.
Volume: 27
Issue: 3
Pages: 835-46
Publication
First Author: Preza GC
Year: 2011
Journal: J Clin Invest
Title: Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload.
Volume: 121
Issue: 12
Pages: 4880-8
Publication
First Author: Kim A
Year: 2014
Journal: Blood
Title: A mouse model of anemia of inflammation: complex pathogenesis with partial dependence on hepcidin.
Volume: 123
Issue: 8
Pages: 1129-36
Publication  
First Author: Deschemin JC
Year: 2017
Journal: Front Physiol
Title: Pulmonary Iron Homeostasis in Hepcidin Knockout Mice.
Volume: 8
Pages: 804
Publication
First Author: Perez E
Year: 2020
Journal: J Immunol
Title: Hepcidin Is Essential for Alveolar Macrophage Function and Is Disrupted by Smoke in a Murine Chronic Obstructive Pulmonary Disease Model.
Volume: 205
Issue: 9
Pages: 2489-2498
Publication
First Author: Ramos E
Year: 2012
Journal: Blood
Title: Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis.
Volume: 120
Issue: 18
Pages: 3829-36
Publication
First Author: Song D
Year: 2014
Journal: Invest Ophthalmol Vis Sci
Title: The oral iron chelator deferiprone protects against systemic iron overload-induced retinal degeneration in hepcidin knockout mice.
Volume: 55
Issue: 7
Pages: 4525-32
Publication
First Author: Stefanova D
Year: 2017
Journal: Blood
Title: Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non-transferrin-bound iron.
Volume: 130
Issue: 3
Pages: 245-257
Publication
First Author: James JV
Year: 2020
Journal: Biochim Biophys Acta Mol Cell Res
Title: Enhanced insulin signaling and its downstream effects in iron-overloaded primary hepatocytes from hepcidin knock-out mice.
Volume: 1867
Issue: 2
Pages: 118621
Publication
First Author: Deschemin JC
Year: 2013
Journal: PLoS One
Title: Role of hepcidin in the setting of hypoferremia during acute inflammation.
Volume: 8
Issue: 4
Pages: e61050
Publication
First Author: Harrington-Kandt R
Year: 2018
Journal: PLoS One
Title: Hepcidin deficiency and iron deficiency do not alter tuberculosis susceptibility in a murine M.tb infection model.
Volume: 13
Issue: 1
Pages: e0191038
Publication
First Author: Liu W
Year: 2023
Journal: Cell Metab
Title: Lactate modulates iron metabolism by binding soluble adenylyl cyclase.
Volume: 35
Issue: 9
Pages: 1597-1612.e6
Publication
First Author: Sun L
Year: 2014
Journal: Gene
Title: Hepcidin deficiency undermines bone load-bearing capacity through inducing iron overload.
Volume: 543
Issue: 1
Pages: 161-5
Publication
First Author: Bauckman KA
Year: 2019
Journal: Am J Physiol Renal Physiol
Title: Dietary restriction of iron availability attenuates UPEC pathogenesis in a mouse model of urinary tract infection.
Volume: 316
Issue: 5
Pages: F814-F822
Publication
First Author: Ginzburg YZ
Year: 2009
Journal: Exp Hematol
Title: Exogenous iron increases hemoglobin in beta-thalassemic mice.
Volume: 37
Issue: 2
Pages: 172-83
Publication
First Author: Tselepis C
Year: 2010
Journal: Biochem J
Title: Characterization of the transition-metal-binding properties of hepcidin.
Volume: 427
Issue: 2
Pages: 289-96
Publication
First Author: Murphy AT
Year: 2007
Journal: Blood
Title: Quantitation of hepcidin from human and mouse serum using liquid chromatography tandem mass spectrometry.
Volume: 110
Issue: 3
Pages: 1048-54
Publication
First Author: Park CH
Year: 2001
Journal: J Biol Chem
Title: Hepcidin, a urinary antimicrobial peptide synthesized in the liver.
Volume: 276
Issue: 11
Pages: 7806-10
Publication
First Author: Shike H
Year: 2002
Journal: Eur J Biochem
Title: Bass hepcidin is a novel antimicrobial peptide induced by bacterial challenge.
Volume: 269
Issue: 8
Pages: 2232-7
Publication
First Author: Dongiovanni P
Year: 2013
Journal: Am J Pathol
Title: Dietary iron overload induces visceral adipose tissue insulin resistance.
Volume: 182
Issue: 6
Pages: 2254-63
Publication
First Author: McLachlan S
Year: 2017
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Hamp1 mRNA and plasma hepcidin levels are influenced by sex and strain but do not predict tissue iron levels in inbred mice.
Volume: 313
Issue: 5
Pages: G511-G523
Publication  
First Author: Xu Z
Year: 2017
Journal: Bone
Title: The regulation of iron metabolism by hepcidin contributes to unloading-induced bone loss.
Volume: 94
Pages: 152-161
Publication  
First Author: Wu J
Year: 2019
Journal: Bone
Title: Rapamycin improves bone mass in high-turnover osteoporosis with iron accumulation through positive effects on osteogenesis and angiogenesis.
Volume: 121
Pages: 16-28
Publication
First Author: Guo W
Year: 2020
Journal: Andrology
Title: Hepcidin is not essential for mediating testosterone's effects on erythropoiesis.
Volume: 8
Issue: 1
Pages: 82-90
GXD Expression    
Probe: MGI:2676224
Assay Type: Northern blot
Annotation Date: 2003-10-08
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684623
Stage: TS23
Assay Id: MGI:2676232
Age: embryonic day 15.5
Image: 4
Specimen Label: E15.5
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:2676224
Assay Type: Northern blot
Annotation Date: 2003-10-08
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684623
Stage: TS23
Assay Id: MGI:2676232
Age: embryonic day 15.5
Image: 4
Specimen Label: E15.5
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:2676224
Assay Type: Northern blot
Annotation Date: 2003-10-08
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684625
Stage: TS25
Assay Id: MGI:2676232
Age: embryonic day 17.5
Image: 4
Specimen Label: E17.5
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:2676224
Assay Type: Northern blot
Annotation Date: 2003-10-08
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684625
Stage: TS25
Assay Id: MGI:2676232
Age: embryonic day 17.5
Image: 4
Specimen Label: E17.5
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:2676224
Assay Type: Northern blot
Annotation Date: 2003-10-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684627
Stage: TS27
Assay Id: MGI:2676232
Age: postnatal newborn
Image: 4
Specimen Label: B
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:2676224
Assay Type: Northern blot
Annotation Date: 2003-10-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684627
Stage: TS27
Assay Id: MGI:2676232
Age: postnatal newborn
Image: 4
Specimen Label: B
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:2676224
Assay Type: Northern blot
Annotation Date: 2003-10-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684627
Stage: TS27
Assay Id: MGI:2676232
Age: postnatal day 1
Image: 4
Specimen Label: 1
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:2676224
Assay Type: Northern blot
Annotation Date: 2003-10-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684627
Stage: TS27
Assay Id: MGI:2676232
Age: postnatal day 1
Image: 4
Specimen Label: 1
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:2676224
Assay Type: Northern blot
Annotation Date: 2003-10-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684627
Stage: TS27
Assay Id: MGI:2676232
Age: postnatal day 2
Image: 4
Specimen Label: 2
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:2676224
Assay Type: Northern blot
Annotation Date: 2003-10-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684627
Stage: TS27
Assay Id: MGI:2676232
Age: postnatal day 2
Image: 4
Specimen Label: 2
Detected: true
Specimen Num: 10
GXD Expression    
Probe: MGI:2676224
Assay Type: Northern blot
Annotation Date: 2003-10-08
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2676232
Age: postnatal day 7
Image: 4
Specimen Label: 7
Detected: false
Specimen Num: 11
GXD Expression    
Probe: MGI:2676224
Assay Type: Northern blot
Annotation Date: 2003-10-08
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2676232
Age: postnatal day 14
Image: 4
Specimen Label: 14
Detected: false
Specimen Num: 12
GXD Expression    
Probe: MGI:2676224
Assay Type: Northern blot
Annotation Date: 2003-10-08
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2676232
Age: postnatal day 21
Image: 4
Specimen Label: 21
Detected: false
Specimen Num: 13
GXD Expression    
Probe: MGI:2676224
Assay Type: Northern blot
Annotation Date: 2003-10-08
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2676232
Age: postnatal day 28
Image: 4
Specimen Label: 28
Detected: false
Specimen Num: 14
GXD Expression    
Probe: MGI:2676224
Assay Type: Northern blot
Annotation Date: 2003-10-08
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2676232
Age: postnatal day 42
Image: 4
Specimen Label: 42
Detected: false
Specimen Num: 15
GXD Expression    
Probe: MGI:2676224
Assay Type: Northern blot
Annotation Date: 2003-10-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2676232
Age: postnatal day 56
Image: 4
Specimen Label: 56
Detected: true
Specimen Num: 16
GXD Expression      
Probe: MGI:2676224
Assay Type: Northern blot
Annotation Date: 2003-10-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2676254
Age: postnatal adult
Specimen Label: Houston KO
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:2676224
Assay Type: Northern blot
Annotation Date: 2003-10-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2676255
Age: postnatal adult
Specimen Label: Houston KO
Detected: true
Specimen Num: 1