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Search results 1 to 100 out of 448 for Has2

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0.057s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: This entry represents the hyaluronan synthase 2 (HAS2), which plays a role in hyaluronan/hyaluronic acid (HA) synthesis []. There are three different, but related hyaluronan synthases - HAS1, HAS2 and HAS3. They are multipass transmembrane enzymes, the active sites of which protrude from the inner face of the plasma membrane. HA is an unbranched disaccharide glucuronic acid/N-acetylglucosamine polymer and is one of the main components of the extracellular matrix []. High level of HA in humans is associated with cancer progression [, ]. In vertebrates, different HA polymer length can trigger different biological responses. High-molecular-mass HA represses mitogenic signalling and has anti-inflammatory properties, while low-molecular-mass HA promotes proliferation and inflammation [, ]. A study of the naked mole rat showed that HAS2 is overexpressed in naked mole rat fibroblasts, while the expression levels of HAS1 and HAS3 are similar between mouse, human and naked mole-rat cells []. HAS2 is responsible for the synthesis of the high-molecular-mass HA (HMM-HA), which triggers ECI (early contact inhibition) via the CD44 receptor and plays a key role in mediating the cancer resistance of the naked mole rat [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Gene
Type: gene
Organism: human
Publication
First Author: Tian X
Year: 2013
Journal: Nature
Title: High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat.
Volume: 499
Issue: 7458
Pages: 346-9
Publication
First Author: Toole BP
Year: 2004
Journal: Nat Rev Cancer
Title: Hyaluronan: from extracellular glue to pericellular cue.
Volume: 4
Issue: 7
Pages: 528-39
Publication
First Author: Lipponen P
Year: 2001
Journal: Eur J Cancer
Title: High stromal hyaluronan level is associated with poor differentiation and metastasis in prostate cancer.
Volume: 37
Issue: 7
Pages: 849-56
Publication
First Author: Kothapalli D
Year: 2007
Journal: J Cell Biol
Title: Hyaluronan and CD44 antagonize mitogen-dependent cyclin D1 expression in mesenchymal cells.
Volume: 176
Issue: 4
Pages: 535-44
Publication  
First Author: Tseng V
Year: 2022
Journal: Matrix Biol
Title: 3'UTR shortening of HAS2 promotes hyaluronan hyper-synthesis and bioenergetic dysfunction in pulmonary hypertension.
Volume: 111
Pages: 53-75
Publication
First Author: Klewer SE
Year: 2006
Journal: Gene Expr Patterns
Title: Has2 expression in heart forming regions is independent of BMP signaling.
Volume: 6
Issue: 5
Pages: 462-70
Protein
Organism: Mus musculus/domesticus
Length: 552  
Fragment?: false
Publication  
First Author: Sun Y
Year: 2022
Journal: Biomolecules
Title: FGF9 Promotes Expression of HAS2 in Palatal Elevation via the Wnt/β-Catenin/TCF7L2 Pathway.
Volume: 12
Issue: 11
Publication
First Author: Sugiura K
Year: 2009
Journal: Mol Reprod Dev
Title: Targeted suppression of Has2 mRNA in mouse cumulus cell-oocyte complexes by adenovirus-mediated short-hairpin RNA expression.
Volume: 76
Issue: 6
Pages: 537-47
Publication
First Author: Walker JKL
Year: 2017
Journal: Am J Respir Cell Mol Biol
Title: Targeted HAS2 Expression Lessens Airway Responsiveness in Chronic Murine Allergic Airway Disease.
Volume: 57
Issue: 6
Pages: 702-710
Publication
First Author: Moffatt P
Year: 2011
Journal: Dev Dyn
Title: Hyaluronan production by means of Has2 gene expression in chondrocytes is essential for long bone development.
Volume: 240
Issue: 2
Pages: 404-12
Publication
First Author: Matsumoto K
Year: 2009
Journal: Development
Title: Conditional inactivation of Has2 reveals a crucial role for hyaluronan in skeletal growth, patterning, chondrocyte maturation and joint formation in the developing limb.
Volume: 136
Issue: 16
Pages: 2825-35
Publication  
First Author: Sherpa MT
Year: 2021
Journal: Front Immunol
Title: Has2 Regulates the Development of Ovalbumin-Induced Airway Remodeling and Steroid Insensitivity in Mice.
Volume: 12
Pages: 770305
Publication
First Author: Kobayashi N
Year: 2010
Journal: Cancer Res
Title: Hyaluronan deficiency in tumor stroma impairs macrophage trafficking and tumor neovascularization.
Volume: 70
Issue: 18
Pages: 7073-83
Publication
First Author: Spicer AP
Year: 1996
Journal: J Biol Chem
Title: Molecular cloning and characterization of a putative mouse hyaluronan synthase.
Volume: 271
Issue: 38
Pages: 23400-6
Publication  
First Author: Li Y
Year: 2016
Journal: Matrix Biol
Title: Hyaluronan synthase 2 regulates fibroblast senescence in pulmonary fibrosis.
Volume: 55
Pages: 35-48
Publication
First Author: van den Berg BM
Year: 2019
Journal: J Am Soc Nephrol
Title: Glomerular Function and Structural Integrity Depend on Hyaluronan Synthesis by Glomerular Endothelium.
Volume: 30
Issue: 10
Pages: 1886-1897
Publication
First Author: Röck K
Year: 2015
Journal: J Invest Dermatol
Title: miR-23a-3p causes cellular senescence by targeting hyaluronan synthase 2: possible implication for skin aging.
Volume: 135
Issue: 2
Pages: 369-377
Publication
First Author: Camenisch TD
Year: 2000
Journal: J Clin Invest
Title: Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme.
Volume: 106
Issue: 3
Pages: 349-60
Publication
First Author: Takeo S
Year: 2004
Journal: J Biol Chem
Title: In vivo hyaluronan synthesis upon expression of the mammalian hyaluronan synthase gene in Drosophila.
Volume: 279
Issue: 18
Pages: 18920-5
Publication
First Author: Stock AE
Year: 2002
Journal: Endocrinology
Title: Induction of hyaluronan synthase 2 by human chorionic gonadotropin in mural granulosa cells of equine preovulatory follicles.
Volume: 143
Issue: 11
Pages: 4375-84
Publication  
First Author: Yang YM
Year: 2019
Journal: Sci Transl Med
Title: Hyaluronan synthase 2-mediated hyaluronan production mediates Notch1 activation and liver fibrosis.
Volume: 11
Issue: 496
Publication
First Author: Itano N
Year: 1999
Journal: J Biol Chem
Title: Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties.
Volume: 274
Issue: 35
Pages: 25085-92
Publication
First Author: Goncharova V
Year: 2012
Journal: J Biol Chem
Title: Hyaluronan expressed by the hematopoietic microenvironment is required for bone marrow hematopoiesis.
Volume: 287
Issue: 30
Pages: 25419-33
Publication
First Author: Lin X
Year: 2022
Journal: Invest Ophthalmol Vis Sci
Title: Hyaluronan Modulates the Biomechanical Properties of the Cornea.
Volume: 63
Issue: 13
Pages: 6
Publication
First Author: Li Y
Year: 2011
Journal: J Exp Med
Title: Severe lung fibrosis requires an invasive fibroblast phenotype regulated by hyaluronan and CD44.
Volume: 208
Issue: 7
Pages: 1459-71
Publication
First Author: Törrönen K
Year: 2014
Journal: Histochem Cell Biol
Title: Tissue distribution and subcellular localization of hyaluronan synthase isoenzymes.
Volume: 141
Issue: 1
Pages: 17-31
Publication
First Author: Spicer AP
Year: 1998
Journal: J Biol Chem
Title: Characterization and molecular evolution of a vertebrate hyaluronan synthase gene family.
Volume: 273
Issue: 4
Pages: 1923-32
Publication
First Author: Morita T
Year: 2016
Journal: Gene Expr Patterns
Title: An in situ hybridization study of Hyaluronan synthase (Has) mRNA in developing mouse molar and incisor tooth germs.
Volume: 21
Issue: 1
Pages: 28-40
Publication
First Author: Shirai M
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: T-box 2, a mediator of Bmp-Smad signaling, induced hyaluronan synthase 2 and Tgfbeta2 expression and endocardial cushion formation.
Volume: 106
Issue: 44
Pages: 18604-9
Publication
First Author: Sapudom J
Year: 2020
Journal: Biomater Sci
Title: Biomimetic tissue models reveal the role of hyaluronan in melanoma proliferation and invasion.
Volume: 8
Issue: 5
Pages: 1405-1417
Publication  
First Author: Kim M
Year: 2022
Journal: Biol Open
Title: Synovial joint cavitation initiates with microcavities in interzone and is coupled to skeletal flexion and elongation in developing mouse embryo limbs.
Volume: 11
Issue: 6
Publication
First Author: Sugiyama Y
Year: 1998
Journal: J Invest Dermatol
Title: Putative hyaluronan synthase mRNA are expressed in mouse skin and TGF-beta upregulates their expression in cultured human skin cells.
Volume: 110
Issue: 2
Pages: 116-21
Publication
First Author: Usui T
Year: 2000
Journal: Invest Ophthalmol Vis Sci
Title: Expression regulation of hyaluronan synthase in corneal endothelial cells.
Volume: 41
Issue: 11
Pages: 3261-7
Publication
First Author: Yonemitsu MA
Year: 2020
Journal: Dev Biol
Title: Hyaluronic acid is required for palatal shelf movement and its interaction with the tongue during palatal shelf elevation.
Volume: 457
Issue: 1
Pages: 57-68
Publication
First Author: Tammi R
Year: 2005
Journal: J Invest Dermatol
Title: Hyaluronan synthase induction and hyaluronan accumulation in mouse epidermis following skin injury.
Volume: 124
Issue: 5
Pages: 898-905
Publication
First Author: Takechi M
Year: 2020
Journal: Biochim Biophys Acta Gen Subj
Title: A pericellular hyaluronan matrix is required for the morphological maturation of cortical neurons.
Volume: 1864
Issue: 10
Pages: 129679
Publication  
First Author: Galloway JL
Year: 2013
Journal: Front Physiol
Title: The control and importance of hyaluronan synthase expression in palatogenesis.
Volume: 4
Pages: 10
Publication
First Author: Spicer AP
Year: 1997
Journal: Genomics
Title: Chromosomal localization of the human and mouse hyaluronan synthase genes.
Volume: 41
Issue: 3
Pages: 493-7
Publication
First Author: Kakoi H
Year: 2014
Journal: J Biol Chem
Title: Bone morphogenic protein (BMP) signaling up-regulates neutral sphingomyelinase 2 to suppress chondrocyte maturation via the Akt protein signaling pathway as a negative feedback mechanism.
Volume: 289
Issue: 12
Pages: 8135-50
Publication
First Author: Liu J
Year: 2013
Journal: Dev Biol
Title: Sonic hedgehog signaling directly targets Hyaluronic Acid Synthase 2, an essential regulator of phalangeal joint patterning.
Volume: 375
Issue: 2
Pages: 160-71
Publication
First Author: Del Monte-Nieto G
Year: 2018
Journal: Nature
Title: Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation.
Volume: 557
Issue: 7705
Pages: 439-445
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Semino CE
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: Homologs of the Xenopus developmental gene DG42 are present in zebrafish and mouse and are involved in the synthesis of Nod-like chitin oligosaccharides during early embryogenesis.
Volume: 93
Issue: 10
Pages: 4548-53
Publication
First Author: Puri S
Year: 2020
Journal: Invest Ophthalmol Vis Sci
Title: Epithelial Cell Migration and Proliferation Patterns During Initial Wound Closure in Normal Mice and an Experimental Model of Limbal Stem Cell Deficiency.
Volume: 61
Issue: 10
Pages: 27
GXD Expression      
Probe: MGI:2654814
Assay Type: RT-PCR
Annotation Date: 2003-04-16
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:2654827
Age: embryonic day 10.5
Image: 1
Specimen Label: E10.5 1/3
Specimen Num: 2
GXD Expression      
Probe: MGI:2654814
Assay Type: RT-PCR
Annotation Date: 2003-04-16
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:2654827
Age: embryonic day 14.5
Image: 1
Specimen Label: E14.5 1/3
Specimen Num: 4
GXD Expression      
Probe: MGI:2654815
Assay Type: RT-PCR
Annotation Date: 2003-04-16
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:2654828
Age: embryonic day 10.5
Image: 1
Specimen Label: E10.5 1/5
Specimen Num: 3
GXD Expression      
Probe: MGI:2654815
Assay Type: RT-PCR
Annotation Date: 2003-04-16
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:2654828
Age: embryonic day 14.5
Image: 1
Specimen Label: E14.5 1/5
Specimen Num: 5
GXD Expression    
Probe: MGI:2654812
Assay Type: Northern blot
Annotation Date: 2003-04-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2654830
Age: postnatal adult
Image: 5
Specimen Label: Heart
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:2654812
Assay Type: Northern blot
Annotation Date: 2003-04-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2654830
Age: postnatal adult
Image: 5
Specimen Label: Brain
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:2654812
Assay Type: Northern blot
Annotation Date: 2003-04-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:2654830
Age: postnatal adult
Image: 5
Specimen Label: Spleen
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:2654812
Assay Type: Northern blot
Annotation Date: 2003-04-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:2654830
Age: postnatal adult
Image: 5
Specimen Label: Lung
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:2654812
Assay Type: Northern blot
Annotation Date: 2003-04-16
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2654830
Age: postnatal adult
Image: 5
Specimen Label: Liver
Detected: false
Specimen Num: 5
GXD Expression    
Probe: MGI:2654812
Assay Type: Northern blot
Annotation Date: 2003-04-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:2654830
Age: postnatal adult
Image: 5
Specimen Label: Skeletal muscle
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:2654812
Assay Type: Northern blot
Annotation Date: 2003-04-16
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2654830
Age: postnatal adult
Image: 5
Specimen Label: Kidney
Detected: false
Specimen Num: 7
GXD Expression    
Probe: MGI:2654812
Assay Type: Northern blot
Annotation Date: 2003-04-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:2654833
Age: embryonic day 7.5
Image: 5
Specimen Label: 7.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:2654812
Assay Type: Northern blot
Annotation Date: 2003-04-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:2654833
Age: embryonic day 11.5
Image: 5
Specimen Label: 11.5
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:2654812
Assay Type: Northern blot
Annotation Date: 2003-04-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:2654833
Age: embryonic day 15.5
Image: 5
Specimen Label: 15.5
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:2654812
Assay Type: Northern blot
Annotation Date: 2003-04-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:2654833
Age: embryonic day 17.5
Image: 5
Specimen Label: 17.5
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3720575
Assay Type: RT-PCR
Annotation Date: 2007-09-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1736221
Stage: TS21
Assay Id: MGI:3720753
Age: embryonic day 13.5
Specimen Label: None
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3720575
Assay Type: RT-PCR
Annotation Date: 2007-09-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1736221
Stage: TS21
Assay Id: MGI:3720753
Age: embryonic day 13.5
Specimen Label: None
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3720575
Assay Type: RT-PCR
Annotation Date: 2007-09-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1736221
Stage: TS21
Assay Id: MGI:3720753
Age: embryonic day 13.5
Specimen Label: None
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:5804773
Assay Type: RT-PCR
Annotation Date: 2016-10-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3289722
Stage: TS22
Assay Id: MGI:5804779
Age: embryonic day 14.0
Image: 1
Specimen Label: E14.0
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5804773
Assay Type: RT-PCR
Annotation Date: 2016-10-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3289724
Stage: TS24
Assay Id: MGI:5804779
Age: embryonic day 16.0
Image: 1
Specimen Label: E16.0
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5804773
Assay Type: RT-PCR
Annotation Date: 2016-10-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3289726
Stage: TS26
Assay Id: MGI:5804779
Age: embryonic day 18.0
Image: 1
Specimen Label: E18.0
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6726339
Assay Type: RT-PCR
Annotation Date: 2021-07-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1654621
Stage: TS21
Assay Id: MGI:6726429
Age: embryonic day 13.5
Image: 9
Specimen Label: Control
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6726339
Assay Type: RT-PCR
Annotation Date: 2021-07-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1654621
Stage: TS21
Assay Id: MGI:6726429
Age: embryonic day 13.5
Image: 9
Specimen Label: cKO
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7466095
Assay Type: RT-PCR
Annotation Date: 2023-04-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610520
Stage: TS20
Assay Id: MGI:7466096
Age: embryonic day 12.5
Specimen Label: +/+
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7466095
Assay Type: RT-PCR
Annotation Date: 2023-04-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610520
Stage: TS20
Assay Id: MGI:7466096
Age: embryonic day 12.5
Specimen Label: -/-
Detected: true
Specimen Num: 2