Type |
Details |
Score |
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Parganas E |
Year: |
1998 |
Journal: |
Cell |
Title: |
Jak2 is essential for signaling through a variety of cytokine receptors. |
Volume: |
93 |
Issue: |
3 |
Pages: |
385-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wilkinson DG |
Year: |
1987 |
Journal: |
Development |
Title: |
A molecular analysis of mouse development from 8 to 10 days post coitum detects changes only in embryonic globin expression. |
Volume: |
99 |
Issue: |
4 |
Pages: |
493-500 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tamura K |
Year: |
2000 |
Journal: |
Cell |
Title: |
Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. |
Volume: |
102 |
Issue: |
2 |
Pages: |
221-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Song H |
Year: |
2008 |
Journal: |
J Biol Chem |
Title: |
Inactivation of G-protein-coupled receptor 48 (Gpr48/Lgr4) impairs definitive erythropoiesis at midgestation through down-regulation of the ATF4 signaling pathway. |
Volume: |
283 |
Issue: |
52 |
Pages: |
36687-97 |
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Regier DS |
Year: |
2005 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Diacylglycerol kinase iota regulates Ras guanyl-releasing protein 3 and inhibits Rap1 signaling. |
Volume: |
102 |
Issue: |
21 |
Pages: |
7595-600 |
|
•
•
•
•
•
|
Publication |
First Author: |
Leder A |
Year: |
1985 |
Journal: |
Mol Cell Biol |
Title: |
Characterization, expression, and evolution of the mouse embryonic zeta-globin gene. |
Volume: |
5 |
Issue: |
5 |
Pages: |
1025-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Farace MG |
Year: |
1984 |
Journal: |
Gene |
Title: |
Molecular cloning and sequence analysis of a cDNA coding for the mouse alpha-like embryonic globin chain x. |
Volume: |
31 |
Issue: |
1-3 |
Pages: |
241-5 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
142
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGI and IMPC |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Elbediwy A |
Year: |
2016 |
Journal: |
Development |
Title: |
Integrin signalling regulates YAP and TAZ to control skin homeostasis. |
Volume: |
143 |
Issue: |
10 |
Pages: |
1674-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pierce AM |
Year: |
1998 |
Journal: |
Oncogene |
Title: |
Deregulated expression of E2F1 induces hyperplasia and cooperates with ras in skin tumor development. |
Volume: |
16 |
Issue: |
10 |
Pages: |
1267-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pierce AM |
Year: |
1999 |
Journal: |
Mol Cell Biol |
Title: |
E2F1 has both oncogenic and tumor-suppressive properties in a transgenic model. |
Volume: |
19 |
Issue: |
9 |
Pages: |
6408-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Russell JL |
Year: |
2006 |
Journal: |
Oncogene |
Title: |
E2F1 suppresses skin carcinogenesis via the ARF-p53 pathway. |
Volume: |
25 |
Issue: |
6 |
Pages: |
867-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Henderson CJ |
Year: |
2011 |
Journal: |
Cancer Res |
Title: |
Increased skin papilloma formation in mice lacking glutathione transferase GSTP. |
Volume: |
71 |
Issue: |
22 |
Pages: |
7048-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ortiz ML |
Year: |
2015 |
Journal: |
J Exp Med |
Title: |
Immature myeloid cells directly contribute to skin tumor development by recruiting IL-17-producing CD4+ T cells. |
Volume: |
212 |
Issue: |
3 |
Pages: |
351-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yi Z |
Year: |
2006 |
Journal: |
PLoS Genet |
Title: |
Sox6 directly silences epsilon globin expression in definitive erythropoiesis. |
Volume: |
2 |
Issue: |
2 |
Pages: |
e14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Robert-Moreno A |
Year: |
2007 |
Journal: |
Leukemia |
Title: |
The notch pathway positively regulates programmed cell death during erythroid differentiation. |
Volume: |
21 |
Issue: |
7 |
Pages: |
1496-503 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhu S |
Year: |
2002 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
CCAAT/enhancer binding protein-beta is a mediator of keratinocyte survival and skin tumorigenesis involving oncogenic Ras signaling. |
Volume: |
99 |
Issue: |
1 |
Pages: |
207-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Smith MK |
Year: |
1998 |
Journal: |
Carcinogenesis |
Title: |
Co-operation between follicular ornithine decarboxylase and v-Ha-ras induces spontaneous papillomas and malignant conversion in transgenic skin. |
Volume: |
19 |
Issue: |
8 |
Pages: |
1409-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gilmour SK |
Year: |
1999 |
Journal: |
Cell Growth Differ |
Title: |
Effect of elevated levels of ornithine decarboxylase on cell cycle progression in skin. |
Volume: |
10 |
Issue: |
11 |
Pages: |
739-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lan L |
Year: |
2000 |
Journal: |
Cancer Res |
Title: |
Inhibition of ornithine decarboxylase (ODC) decreases tumor vascularization and reverses spontaneous tumors in ODC/Ras transgenic mice. |
Volume: |
60 |
Issue: |
20 |
Pages: |
5696-703 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hobbs CA |
Year: |
2006 |
Journal: |
Cancer Res |
Title: |
Tip60 protein isoforms and altered function in skin and tumors that overexpress ornithine decarboxylase. |
Volume: |
66 |
Issue: |
16 |
Pages: |
8116-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pang CJ |
Year: |
2012 |
Journal: |
Mol Cell Biol |
Title: |
Kruppel-like factor 1 (KLF1), KLF2, and Myc control a regulatory network essential for embryonic erythropoiesis. |
Volume: |
32 |
Issue: |
13 |
Pages: |
2628-44 |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion TG.AC, Philip Leder |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant strain, coisogenic, transgenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
transgenic, mutant strain, coisogenic |
|
•
•
•
•
•
|
Publication |
First Author: |
Leder A |
Year: |
1990 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: effects of phorbol esters and retinoic acid. |
Volume: |
87 |
Issue: |
23 |
Pages: |
9178-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Martin KR |
Year: |
2002 |
Journal: |
Nutr Cancer |
Title: |
Timing of supplementation with the antioxidant N-acetyl-L-cysteine reduces tumor multiplicity in novel, cancer-prone p53 haploinsufficient Tg.AC (v-Ha-ras) transgenic mice but has no impact on malignant progression. |
Volume: |
43 |
Issue: |
1 |
Pages: |
59-66 |
|
•
•
•
•
•
|
Publication |
First Author: |
Leung HW |
Year: |
2005 |
Journal: |
Regul Toxicol Pharmacol |
Title: |
Review of the carcinogenic activity of diethanolamine and evidence of choline deficiency as a plausible mode of action. |
Volume: |
43 |
Issue: |
3 |
Pages: |
260-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Siegel CT |
Year: |
2000 |
Journal: |
J Exp Med |
Title: |
Enhanced growth of primary tumors in cancer-prone mice after immunization against the mutant region of an inherited oncoprotein. |
Volume: |
191 |
Issue: |
11 |
Pages: |
1945-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cannon RE |
Year: |
1997 |
Journal: |
Mol Carcinog |
Title: |
Kinetics of wound-induced v-Ha-ras transgene expression and papilloma development in transgenic Tg.AC mice. |
Volume: |
20 |
Issue: |
1 |
Pages: |
108-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Torrey CE |
Year: |
2005 |
Journal: |
Int J Toxicol |
Title: |
Evaluation of the carcinogenic potential of clofibrate in the FVB/Tg.AC mouse after dermal application--part II. |
Volume: |
24 |
Issue: |
5 |
Pages: |
327-39 |
|
•
•
•
•
•
|
Publication |
First Author: |
Battalora MS |
Year: |
2001 |
Journal: |
Carcinogenesis |
Title: |
Age-dependent skin tumorigenesis and transgene expression in the Tg.AC (v-Ha-ras) transgenic mouse. |
Volume: |
22 |
Issue: |
4 |
Pages: |
651-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Boone CW |
Year: |
1998 |
Journal: |
Mutat Res |
Title: |
Use of Druckrey analysis to quantitatively evaluate the chemopreventive efficacy of N-difluoromethylornithine (DFMO), a prototype proliferation inhibitor. |
Volume: |
402 |
Issue: |
1-2 |
Pages: |
173-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Owens DM |
Year: |
1995 |
Journal: |
Cancer Res |
Title: |
Genetic alterations cooperate with v-Ha-ras to accelerate multistage carcinogenesis in TG.AC transgenic mouse skin. |
Volume: |
55 |
Issue: |
14 |
Pages: |
3171-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Honchel R |
Year: |
2001 |
Journal: |
Mol Carcinog |
Title: |
Loss of palindromic symmetry in Tg.AC mice with a nonresponder phenotype. |
Volume: |
30 |
Issue: |
2 |
Pages: |
99-110 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dicken J |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Transcriptional reprogramming of CD11b+Esam(hi) dendritic cell identity and function by loss of Runx3. |
Volume: |
8 |
Issue: |
10 |
Pages: |
e77490 |
|
•
•
•
•
•
|
Publication |
First Author: |
Spalding JW |
Year: |
1993 |
Journal: |
Carcinogenesis |
Title: |
Chemically induced skin carcinogenesis in a transgenic mouse line (TG.AC) carrying a v-Ha-ras gene. |
Volume: |
14 |
Issue: |
7 |
Pages: |
1335-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chan EL |
Year: |
2007 |
Journal: |
Mol Carcinog |
Title: |
Homozygous K5Cre transgenic mice have wavy hair and accelerated malignant progression in a murine model of skin carcinogenesis. |
Volume: |
46 |
Issue: |
1 |
Pages: |
49-59 |
|
•
•
•
•
•
|
Publication |
First Author: |
El-Abaseri TB |
Year: |
2005 |
Journal: |
Cancer Res |
Title: |
Chemoprevention of UV light-induced skin tumorigenesis by inhibition of the epidermal growth factor receptor. |
Volume: |
65 |
Issue: |
9 |
Pages: |
3958-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tober KL |
Year: |
1998 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Comparative expression of novel vascular endothelial growth factor/vascular permeability factor transcripts in skin, papillomas, and carcinomas of v-Ha-ras Tg.AC transgenic mice and FVB/N mice. |
Volume: |
247 |
Issue: |
3 |
Pages: |
644-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yanagida J |
Year: |
2012 |
Journal: |
Carcinogenesis |
Title: |
Accelerated elimination of ultraviolet-induced DNA damage through apoptosis in CDC25A-deficient skin. |
Volume: |
33 |
Issue: |
9 |
Pages: |
1754-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lan L |
Year: |
2005 |
Journal: |
J Invest Dermatol |
Title: |
Suprabasal induction of ornithine decarboxylase in adult mouse skin is sufficient to activate keratinocytes. |
Volume: |
124 |
Issue: |
3 |
Pages: |
602-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Holden HE |
Year: |
1999 |
Journal: |
Toxicol Pathol |
Title: |
Oxymetholone: II. Evaluation in the Tg-AC transgenic mouse model for detection of carcinogens. |
Volume: |
27 |
Issue: |
5 |
Pages: |
507-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Humble MC |
Year: |
2005 |
Journal: |
Oncogene |
Title: |
Biological, cellular, and molecular characteristics of an inducible transgenic skin tumor model: a review. |
Volume: |
24 |
Issue: |
56 |
Pages: |
8217-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gulezian D |
Year: |
2000 |
Journal: |
Toxicol Pathol |
Title: |
Use of transgenic animals for carcinogenicity testing: considerations and implications for risk assessment. |
Volume: |
28 |
Issue: |
3 |
Pages: |
482-99 |
|
•
•
•
•
•
|
Publication |
First Author: |
Eastin WC |
Year: |
1998 |
Journal: |
Toxicol Pathol |
Title: |
The National Toxicology Program evaluation of genetically altered mice as predictive models for identifying carcinogens. |
Volume: |
26 |
Issue: |
4 |
Pages: |
461-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee BM |
Year: |
2000 |
Journal: |
Biol Pharm Bull |
Title: |
Inducible nitric oxide synthase mRNA is upregulated in skin tumors of v-ha-ras transgenic TG-AC mice treated with 12-o-tetradecanoylphorbol-13-acetate. |
Volume: |
23 |
Issue: |
7 |
Pages: |
826-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ridd K |
Year: |
2006 |
Journal: |
Carcinogenesis |
Title: |
Association of gene expression with sequential proliferation, differentiation and tumor formation in murine skin. |
Volume: |
27 |
Issue: |
8 |
Pages: |
1556-66 |
|
•
•
•
•
•
|
Publication |
First Author: |
Healy LN |
Year: |
2001 |
Journal: |
Mutagenesis |
Title: |
Induction and time-dependent accumulation of micronuclei in peripheral blood of transgenic p53+/- mice, Tg.AC (v-Ha-ras) and parental wild-type (C57BL/6 and FVB/N) mice exposed to benzene by inhalation. |
Volume: |
16 |
Issue: |
2 |
Pages: |
163-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Budunova IV |
Year: |
2003 |
Journal: |
Oncogene |
Title: |
Glucocorticoid receptor functions as a potent suppressor of mouse skin carcinogenesis. |
Volume: |
22 |
Issue: |
21 |
Pages: |
3279-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cannon RE |
Year: |
2000 |
Journal: |
Mol Carcinog |
Title: |
Oral administration of dimethylvinyl chloride increases frequency of forestomach papillomas in Tg.AC mice. |
Volume: |
29 |
Issue: |
4 |
Pages: |
229-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ohara M |
Year: |
2003 |
Journal: |
Cancer Sci |
Title: |
Blue light inhibits the growth of skin tumors in the v-Ha-ras transgenic mouse. |
Volume: |
94 |
Issue: |
2 |
Pages: |
205-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Murphy JE |
Year: |
2003 |
Journal: |
J Immunol |
Title: |
IL-1 alpha, innate immunity, and skin carcinogenesis: the effect of constitutive expression of IL-1 alpha in epidermis on chemical carcinogenesis. |
Volume: |
170 |
Issue: |
11 |
Pages: |
5697-703 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dang H |
Year: |
2006 |
Journal: |
Mol Carcinog |
Title: |
Identification of genes and gene ontology processes critical to skin papilloma development in Tg.AC transgenic mice. |
Volume: |
45 |
Issue: |
2 |
Pages: |
126-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Martin KR |
Year: |
2004 |
Journal: |
Toxicol Sci |
Title: |
Tumor profile of novel p53 heterozygous Tg.AC (v-Ha-ras) bitransgenic mice treated with benzo(a)pyrene and fed dietary N-acetyl-L-cysteine (NAC). |
Volume: |
81 |
Issue: |
2 |
Pages: |
293-301 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dunson DB |
Year: |
2000 |
Journal: |
Toxicol Sci |
Title: |
Statistical analysis of skin tumor data from Tg.AC mouse bioassays. |
Volume: |
55 |
Issue: |
2 |
Pages: |
293-302 |
|
•
•
•
•
•
|
Publication |
First Author: |
Quintana RM |
Year: |
2013 |
Journal: |
J Invest Dermatol |
Title: |
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