Type |
Details |
Score |
Publication |
First Author: |
Jones J |
Year: |
1991 |
Journal: |
Biochem Genet |
Title: |
The molecular characterization of an A:T to G:C transition in the Hbb-b1 gene of the murine homologue of hemoglobin Rainier. |
Volume: |
29 |
Issue: |
11-12 |
Pages: |
617-26 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Kautz L |
Year: |
2014 |
Journal: |
Nat Genet |
Title: |
Identification of erythroferrone as an erythroid regulator of iron metabolism. |
Volume: |
46 |
Issue: |
7 |
Pages: |
678-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ueda Y |
Year: |
1999 |
Journal: |
Mamm Genome |
Title: |
Nucleotide sequences of the mouse globin beta gene cDNAs in a wild derived new haplotype Hbb(w1). |
Volume: |
10 |
Issue: |
9 |
Pages: |
879-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Feola M |
Year: |
2021 |
Journal: |
Commun Biol |
Title: |
Pleckstrin-2 is essential for erythropoiesis in β-thalassemic mice, reducing apoptosis and enhancing enucleation. |
Volume: |
4 |
Issue: |
1 |
Pages: |
517 |
|
•
•
•
•
•
|
Publication |
First Author: |
Romero JR |
Year: |
2004 |
Journal: |
Blood |
Title: |
Expression of HbC and HbS, but not HbA, results in activation of K-Cl cotransport activity in transgenic mouse red cells. |
Volume: |
103 |
Issue: |
6 |
Pages: |
2384-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matte A |
Year: |
2010 |
Journal: |
Free Radic Biol Med |
Title: |
Peroxiredoxin-2 expression is increased in beta-thalassemic mouse red cells but is displaced from the membrane as a marker of oxidative stress. |
Volume: |
49 |
Issue: |
3 |
Pages: |
457-66 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mirciov CS |
Year: |
2017 |
Journal: |
PLoS One |
Title: |
Characterization of Putative Erythroid Regulators of Hepcidin in Mouse Models of Anemia. |
Volume: |
12 |
Issue: |
1 |
Pages: |
e0171054 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu F |
Year: |
2010 |
Journal: |
J Am Soc Nephrol |
Title: |
Anion exchanger 1 interacts with nephrin in podocytes. |
Volume: |
21 |
Issue: |
9 |
Pages: |
1456-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Detloff PJ |
Year: |
1994 |
Journal: |
Mol Cell Biol |
Title: |
Deletion and replacement of the mouse adult beta-globin genes by a "plug and socket" repeated targeting strategy. |
Volume: |
14 |
Issue: |
10 |
Pages: |
6936-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang H |
Year: |
2019 |
Journal: |
J Clin Invest |
Title: |
In vivo hematopoietic stem cell gene therapy ameliorates murine thalassemia intermedia. |
Volume: |
129 |
Issue: |
2 |
Pages: |
598-615 |
|
•
•
•
•
•
|
Publication |
First Author: |
Russell JE |
Year: |
1998 |
Journal: |
Blood |
Title: |
Reversal of lethal alpha- and beta-thalassemias in mice by expression of human embryonic globins. |
Volume: |
92 |
Issue: |
9 |
Pages: |
3057-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adamsky K |
Year: |
2004 |
Journal: |
Br J Haematol |
Title: |
Decreased hepcidin mRNA expression in thalassemic mice. |
Volume: |
124 |
Issue: |
1 |
Pages: |
123-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kobayashi H |
Year: |
2012 |
Journal: |
J Immunol |
Title: |
Myeloid cell-derived hypoxia-inducible factor attenuates inflammation in unilateral ureteral obstruction-induced kidney injury. |
Volume: |
188 |
Issue: |
10 |
Pages: |
5106-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gardenghi S |
Year: |
2010 |
Journal: |
J Clin Invest |
Title: |
Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice. |
Volume: |
120 |
Issue: |
12 |
Pages: |
4466-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Franco SS |
Year: |
2014 |
Journal: |
Haematologica |
Title: |
Resveratrol accelerates erythroid maturation by activation of FoxO3 and ameliorates anemia in beta-thalassemic mice. |
Volume: |
99 |
Issue: |
2 |
Pages: |
267-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Castro-Mollo M |
Year: |
2021 |
Journal: |
Elife |
Title: |
The hepcidin regulator erythroferrone is a new member of the erythropoiesis-iron-bone circuitry. |
Volume: |
10 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Parrow NL |
Year: |
2012 |
Journal: |
Blood |
Title: |
Decreased hepcidin expression in murine β-thalassemia is associated with suppression of Bmp/Smad signaling. |
Volume: |
119 |
Issue: |
13 |
Pages: |
3187-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang B |
Year: |
1995 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A mouse model for beta 0-thalassemia. |
Volume: |
92 |
Issue: |
25 |
Pages: |
11608-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Charoenphandhu N |
Year: |
2019 |
Journal: |
Sci Rep |
Title: |
Responses of primary osteoblasts and osteoclasts from hemizygous β-globin knockout thalassemic mice with elevated plasma glucose to 1,25-dihydroxyvitamin D3. |
Volume: |
9 |
Issue: |
1 |
Pages: |
13963 |
|
•
•
•
•
•
|
Publication |
First Author: |
Arezes J |
Year: |
2020 |
Journal: |
Blood |
Title: |
Antibodies against the erythroferrone N-terminal domain prevent hepcidin suppression and ameliorate murine thalassemia. |
Volume: |
135 |
Issue: |
8 |
Pages: |
547-557 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vadolas J |
Year: |
2006 |
Journal: |
J Biol Chem |
Title: |
Humanized beta-thalassemia mouse model containing the common IVSI-110 splicing mutation. |
Volume: |
281 |
Issue: |
11 |
Pages: |
7399-405 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kong Y |
Year: |
2004 |
Journal: |
J Clin Invest |
Title: |
Loss of alpha-hemoglobin-stabilizing protein impairs erythropoiesis and exacerbates beta-thalassemia. |
Volume: |
114 |
Issue: |
10 |
Pages: |
1457-66 |
|
•
•
•
•
•
|
Publication |
First Author: |
Makropoulos DA |
Year: |
2013 |
Journal: |
Curr Pharm Biotechnol |
Title: |
CNTO 530 increases expression of HbA and HbF in murine models of β-thalassemia and sickle cell anemia. |
Volume: |
14 |
Issue: |
2 |
Pages: |
242-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
May C |
Year: |
2002 |
Journal: |
Blood |
Title: |
Successful treatment of murine beta-thalassemia intermedia by transfer of the human beta-globin gene. |
Volume: |
99 |
Issue: |
6 |
Pages: |
1902-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
He Z |
Year: |
2004 |
Journal: |
Nat Med |
Title: |
Antisickling effects of an endogenous human alpha-like globin. |
Volume: |
10 |
Issue: |
4 |
Pages: |
365-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lotinun S |
Year: |
2020 |
Journal: |
Sci Rep |
Title: |
Nephrectomy Does not Exacerbate Cancellous Bone loss in Thalassemic Mice. |
Volume: |
10 |
Issue: |
1 |
Pages: |
7786 |
|
•
•
•
•
•
|
Publication |
First Author: |
Anderson ER |
Year: |
2013 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia. |
Volume: |
110 |
Issue: |
50 |
Pages: |
E4922-30 |
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•
•
•
•
•
|
Publication |
First Author: |
Charoenphandhu N |
Year: |
2017 |
Journal: |
Mol Cell Biochem |
Title: |
Na+/H+ exchanger 3 inhibitor diminishes hepcidin-enhanced duodenal calcium transport in hemizygous β-globin knockout thalassemic mice. |
Volume: |
427 |
Issue: |
1-2 |
Pages: |
201-208 |
|
•
•
•
•
•
|
Publication |
First Author: |
Libani IV |
Year: |
2008 |
Journal: |
Blood |
Title: |
Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in beta-thalassemia. |
Volume: |
112 |
Issue: |
3 |
Pages: |
875-85 |
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•
•
•
•
•
|
Publication |
First Author: |
Xiao X |
Year: |
2023 |
Journal: |
Blood |
Title: |
Regulation of iron homeostasis by hepatocyte TfR1 requires HFE and contributes to hepcidin suppression in β-thalassemia. |
Volume: |
141 |
Issue: |
4 |
Pages: |
422-432 |
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•
•
•
•
|
Publication |
First Author: |
Gorczynski RM |
Year: |
2017 |
Journal: |
Int Immunopharmacol |
Title: |
An altered REDOX environment, assisted by over-expression of fetal hemoglobins, protects from inflammatory colitis and reduces inflammatory cytokine expression. |
Volume: |
50 |
|
Pages: |
69-76 |
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•
•
•
•
•
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Publication |
First Author: |
Fabry ME |
Year: |
2001 |
Journal: |
Blood |
Title: |
Second generation knockout sickle mice: the effect of HbF. |
Volume: |
97 |
Issue: |
2 |
Pages: |
410-8 |
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•
•
•
•
•
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Publication |
First Author: |
Charoenphandhu N |
Year: |
2022 |
Journal: |
Sci Rep |
Title: |
Mild-intensity physical activity prevents cardiac and osseous iron deposition without affecting bone mechanical property or porosity in thalassemic mice. |
Volume: |
12 |
Issue: |
1 |
Pages: |
5959 |
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•
•
•
•
•
|
Publication |
First Author: |
Wallace KL |
Year: |
2009 |
Journal: |
Blood |
Title: |
NKT cells mediate pulmonary inflammation and dysfunction in murine sickle cell disease through production of IFN-gamma and CXCR3 chemokines. |
Volume: |
114 |
Issue: |
3 |
Pages: |
667-76 |
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•
•
•
•
•
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Publication |
First Author: |
Schmidt PJ |
Year: |
2013 |
Journal: |
Blood |
Title: |
An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(-/-) mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia. |
Volume: |
121 |
Issue: |
7 |
Pages: |
1200-8 |
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•
•
•
•
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Publication |
First Author: |
Aschemeyer S |
Year: |
2017 |
Journal: |
Am J Hematol |
Title: |
Erythroferrone and matriptase-2 independently regulate hepcidin expression. |
Volume: |
92 |
Issue: |
5 |
Pages: |
E61-E63 |
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•
•
•
•
•
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Publication |
First Author: |
Nai A |
Year: |
2012 |
Journal: |
Blood |
Title: |
Deletion of TMPRSS6 attenuates the phenotype in a mouse model of β-thalassemia. |
Volume: |
119 |
Issue: |
21 |
Pages: |
5021-9 |
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•
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•
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Publication |
First Author: |
Ghoti H |
Year: |
2020 |
Journal: |
Am J Pathol |
Title: |
Heparanase Level and Procoagulant Activity Are Increased in Thalassemia and Attenuated by Janus Kinase 2 Inhibition. |
Volume: |
190 |
Issue: |
10 |
Pages: |
2146-2154 |
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•
•
•
•
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Publication |
First Author: |
Brown FC |
Year: |
2013 |
Journal: |
Blood Cells Mol Dis |
Title: |
ENU mutagenesis identifies the first mouse mutants reproducing human β-thalassemia at the genomic level. |
Volume: |
50 |
Issue: |
2 |
Pages: |
86-92 |
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•
•
•
•
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Publication |
First Author: |
Gelderman MP |
Year: |
2015 |
Journal: |
Haematologica |
Title: |
Reversal of hemochromatosis by apotransferrin in non-transfused and transfused Hbbth3/+ (heterozygous B1/B2 globin gene deletion) mice. |
Volume: |
100 |
Issue: |
5 |
Pages: |
611-22 |
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Publication |
First Author: |
He Z |
Year: |
2004 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Effect of zeta-globin substitution on the O2-transport properties of Hb S in vitro and in vivo. |
Volume: |
325 |
Issue: |
4 |
Pages: |
1376-82 |
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Publication |
First Author: |
Jamrus P |
Year: |
2025 |
Journal: |
Sci Rep |
Title: |
Iron induces blood-brain barrier alteration contributing to cognitive impairment in β-thalassaemia mice. |
Volume: |
15 |
Issue: |
1 |
Pages: |
533 |
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•
•
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Publication |
First Author: |
Jamsai D |
Year: |
2005 |
Journal: |
Genomics |
Title: |
A humanized mouse model for a common beta0-thalassemia mutation. |
Volume: |
85 |
Issue: |
4 |
Pages: |
453-61 |
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Publication |
First Author: |
Guo S |
Year: |
2013 |
Journal: |
J Clin Invest |
Title: |
Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice. |
Volume: |
123 |
Issue: |
4 |
Pages: |
1531-41 |
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Publication |
First Author: |
Shah SN |
Year: |
2016 |
Journal: |
PLoS One |
Title: |
Evaluation of Stem Cell-Derived Red Blood Cells as a Transfusion Product Using a Novel Animal Model. |
Volume: |
11 |
Issue: |
12 |
Pages: |
e0166657 |
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Publication |
First Author: |
Aprile A |
Year: |
2023 |
Journal: |
Sci Transl Med |
Title: |
Inhibition of FGF23 is a therapeutic strategy to target hematopoietic stem cell niche defects in β-thalassemia. |
Volume: |
15 |
Issue: |
698 |
Pages: |
eabq3679 |
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Publication |
First Author: |
Wanna-Udom S |
Year: |
2022 |
Journal: |
PLoS One |
Title: |
High phosphate intake induces bone loss in nephrectomized thalassemic mice. |
Volume: |
17 |
Issue: |
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Pages: |
e0268732 |
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Publication |
First Author: |
Jamsai D |
Year: |
2006 |
Journal: |
Genomics |
Title: |
A humanized BAC transgenic/knockout mouse model for HbE/beta-thalassemia. |
Volume: |
88 |
Issue: |
3 |
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309-15 |
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Publication |
First Author: |
Li H |
Year: |
2017 |
Journal: |
Blood |
Title: |
Decreasing TfR1 expression reverses anemia and hepcidin suppression in β-thalassemic mice. |
Volume: |
129 |
Issue: |
11 |
Pages: |
1514-1526 |
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First Author: |
Matte A |
Year: |
2021 |
Journal: |
J Clin Invest |
Title: |
The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a β-thalassemia mouse model. |
Volume: |
131 |
Issue: |
10 |
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First Author: |
Khandros E |
Year: |
2012 |
Journal: |
Blood |
Title: |
Integrated protein quality-control pathways regulate free α-globin in murine β-thalassemia. |
Volume: |
119 |
Issue: |
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5265-75 |
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First Author: |
Nguyen AT |
Year: |
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Journal: |
Science |
Title: |
UBE2O remodels the proteome during terminal erythroid differentiation. |
Volume: |
357 |
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First Author: |
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Year: |
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Journal: |
Am J Pathol |
Title: |
A mouse model of β-thalassemia shows a liver-specific down-regulation of Abcc6 expression. |
Volume: |
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Year: |
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Journal: |
Am J Physiol Endocrinol Metab |
Title: |
Hepcidin and 1,25(OH)2D3 effectively restore Ca2+ transport in β-thalassemic mice: reciprocal phenomenon of Fe2+ and Ca2+ absorption. |
Volume: |
311 |
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Year: |
2018 |
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Blood |
Title: |
Transferrin receptor 2 is a potential novel therapeutic target for β-thalassemia: evidence from a murine model. |
Volume: |
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Blood |
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Erythroid dysplasia, megaloblastic anemia, and impaired lymphopoiesis arising from mitochondrial dysfunction. |
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Blood |
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A novel murine model of Cooley anemia and its rescue by lentiviral-mediated human beta-globin gene transfer. |
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Year: |
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Blood |
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Reduced PU.1 expression underlies aberrant neutrophil maturation and function in β-thalassemia mice and patients. |
Volume: |
129 |
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Journal: |
Blood |
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Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of β-thalassemia. |
Volume: |
126 |
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17 |
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Blood |
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Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells. |
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114 |
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2021 |
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Haematologica |
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NCOA4-mediated ferritinophagy in macrophages is crucial to sustain erythropoiesis in mice. |
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106 |
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Year: |
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Blood Cells Mol Dis |
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39 |
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Year: |
2023 |
Journal: |
FASEB J |
Title: |
Perturbations in lipid metabolism and gut microbiota composition precede cardiac dysfunction in a mouse model of thalassemia. |
Volume: |
37 |
Issue: |
12 |
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e23257 |
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Publication |
First Author: |
He Z |
Year: |
2007 |
Journal: |
Blood |
Title: |
Dynamic posttranscriptional regulation of epsilon-globin gene expression in vivo. |
Volume: |
109 |
Issue: |
2 |
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Publication |
First Author: |
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Year: |
2016 |
Journal: |
Blood |
Title: |
Minihepcidin peptides as disease modifiers in mice affected by β-thalassemia and polycythemia vera. |
Volume: |
128 |
Issue: |
2 |
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Publication |
First Author: |
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Year: |
2007 |
Journal: |
J Clin Invest |
Title: |
An erythroid chaperone that facilitates folding of alpha-globin subunits for hemoglobin synthesis. |
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Aprile A |
Year: |
2020 |
Journal: |
Blood |
Title: |
Hematopoietic stem cell function in β-thalassemia is impaired and is rescued by targeting the bone marrow niche. |
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136 |
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Matte A |
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2015 |
Journal: |
Antioxid Redox Signal |
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The Interplay Between Peroxiredoxin-2 and Nuclear Factor-Erythroid 2 Is Important in Limiting Oxidative Mediated Dysfunction in β-Thalassemic Erythropoiesis. |
Volume: |
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