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Search results 1 to 100 out of 378 for Hbb-b2

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Type Details Score
Protein Coding Gene
MGI:96022 | Hbb-b2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
24880340 | J:211331
First Author: Kautz L
Year: 2014
Journal: Nat Genet
Title: Identification of erythroferrone as an erythroid regulator of iron metabolism.
Volume: 46
Issue: 7
Pages: 678-84
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Publication
10441738 | J:56833
First Author: Ueda Y
Year: 1999
Journal: Mamm Genome
Title: Nucleotide sequences of the mouse globin beta gene cDNAs in a wild derived new haplotype Hbb(w1).
Volume: 10
Issue: 9
Pages: 879-82
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Publication
28151426 | J:241070
First Author: Li H
Year: 2017
Journal: Blood
Title: Decreasing TfR1 expression reverses anemia and hepcidin suppression in β-thalassemic mice.
Volume: 129
Issue: 11
Pages: 1514-1526
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Publication
36322932 | J:340932
First Author: Xiao X
Year: 2023
Journal: Blood
Title: Regulation of iron homeostasis by hepatocyte TfR1 requires HFE and contributes to hepcidin suppression in β-thalassemia.
Volume: 141
Issue: 4
Pages: 422-432
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Publication
31151988 | J:280265
First Author: Guerra A
Year: 2019
Journal: Blood
Title: Lack of Gdf11 does not improve anemia or prevent the activity of RAP-536 in a mouse model of β-thalassemia.
Volume: 134
Issue: 6
Pages: 568-572
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Publication
33941818 | J:317174
First Author: Feola M
Year: 2021
Journal: Commun Biol
Title: Pleckstrin-2 is essential for erythropoiesis in β-thalassemic mice, reducing apoptosis and enhancing enucleation.
Volume: 4
Issue: 1
Pages: 517
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Publication
7935410 | J:20916
First Author: Detloff PJ
Year: 1994
Journal: Mol Cell Biol
Title: Deletion and replacement of the mouse adult beta-globin genes by a "plug and socket" repeated targeting strategy.
Volume: 14
Issue: 10
Pages: 6936-43
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Publication
27995414 | J:312254
First Author: Charoenphandhu N
Year: 2017
Journal: Mol Cell Biochem
Title: Na+/H+ exchanger 3 inhibitor diminishes hepcidin-enhanced duodenal calcium transport in hemizygous β-globin knockout thalassemic mice.
Volume: 427
Issue: 1-2
Pages: 201-208
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Publication
32385316 | J:292190
First Author: Lotinun S
Year: 2020
Journal: Sci Rep
Title: Nephrectomy Does not Exacerbate Cancellous Bone loss in Thalassemic Mice.
Volume: 10
Issue: 1
Pages: 7786
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Publication
32745462 | J:297475
First Author: Ghoti H
Year: 2020
Journal: Am J Pathol
Title: Heparanase Level and Procoagulant Activity Are Increased in Thalassemia and Attenuated by Janus Kinase 2 Inhibition.
Volume: 190
Issue: 10
Pages: 2146-2154
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Publication
27959920 | J:254213
First Author: Shah SN
Year: 2016
Journal: PLoS One
Title: Evaluation of Stem Cell-Derived Red Blood Cells as a Transfusion Product Using a Novel Animal Model.
Volume: 11
Issue: 12
Pages: e0166657
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Publication
15545996 | J:94421
First Author: Kong Y
Year: 2004
Journal: J Clin Invest
Title: Loss of alpha-hemoglobin-stabilizing protein impairs erythropoiesis and exacerbates beta-thalassemia.
Volume: 114
Issue: 10
Pages: 1457-66
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Publication
32344432 | J:301310
First Author: Aprile A
Year: 2020
Journal: Blood
Title: Hematopoietic stem cell function in β-thalassemia is impaired and is rescued by targeting the bone marrow niche.
Volume: 136
Issue: 5
Pages: 610-622
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Publication
35622784 | J:325119
First Author: Wanna-Udom S
Year: 2022
Journal: PLoS One
Title: High phosphate intake induces bone loss in nephrectomized thalassemic mice.
Volume: 17
Issue: 5
Pages: e0268732
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Publication
35396390 | J:323325
First Author: Charoenphandhu N
Year: 2022
Journal: Sci Rep
Title: Mild-intensity physical activity prevents cardiac and osseous iron deposition without affecting bone mechanical property or porosity in thalassemic mice.
Volume: 12
Issue: 1
Pages: 5959
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Publication
32107334 | J:321861
First Author: Nai A
Year: 2021
Journal: Haematologica
Title: NCOA4-mediated ferritinophagy in macrophages is crucial to sustain erythropoiesis in mice.
Volume: 106
Issue: 3
Pages: 795-805
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Publication
23975182 | J:295312
First Author: Franco SS
Year: 2014
Journal: Haematologica
Title: Resveratrol accelerates erythroid maturation by activation of FoxO3 and ameliorates anemia in beta-thalassemic mice.
Volume: 99
Issue: 2
Pages: 267-75
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Publication
22490684 | J:185154
First Author: Nai A
Year: 2012
Journal: Blood
Title: Deletion of TMPRSS6 attenuates the phenotype in a mouse model of β-thalassemia.
Volume: 119
Issue: 21
Pages: 5021-9
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Publication
19414861 | J:150292
First Author: Tanno T
Year: 2009
Journal: Blood
Title: Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells.
Volume: 114
Issue: 1
Pages: 181-6
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Publication
14615383 | J:88563
First Author: Romero JR
Year: 2004
Journal: Blood
Title: Expression of HbC and HbS, but not HbA, results in activation of K-Cl cotransport activity in transgenic mouse red cells.
Volume: 103
Issue: 6
Pages: 2384-90
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Publication
15820143 | J:124445
First Author: Vadolas J
Year: 2005
Journal: Biochim Biophys Acta
Title: Transgene copy number-dependent rescue of murine beta-globin knockout mice carrying a 183 kb human beta-globin BAC genomic fragment.
Volume: 1728
Issue: 3
Pages: 150-62
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Publication
23524968 | J:197624
First Author: Guo S
Year: 2013
Journal: J Clin Invest
Title: Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice.
Volume: 123
Issue: 4
Pages: 1531-41
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Publication
17003365 | J:144004
First Author: He Z
Year: 2007
Journal: Blood
Title: Dynamic posttranscriptional regulation of epsilon-globin gene expression in vivo.
Volume: 109
Issue: 2
Pages: 795-801
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Publication
19734452 | J:154187
First Author: Chen ML
Year: 2009
Journal: Blood
Title: Erythroid dysplasia, megaloblastic anemia, and impaired lymphopoiesis arising from mitochondrial dysfunction.
Volume: 114
Issue: 19
Pages: 4045-53
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Publication
24780610 | J:215274
First Author: Thongchote K
Year: 2014
Journal: Am J Physiol Endocrinol Metab
Title: Running exercise alleviates trabecular bone loss and osteopenia in hemizygous β-globin knockout thalassemic mice.
Volume: 306
Issue: 12
Pages: E1406-17
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Publication
23223430 | J:194619
First Author: Schmidt PJ
Year: 2013
Journal: Blood
Title: An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(-/-) mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia.
Volume: 121
Issue: 7
Pages: 1200-8
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Publication
8524813 | J:30155
First Author: Yang B
Year: 1995
Journal: Proc Natl Acad Sci U S A
Title: A mouse model for beta 0-thalassemia.
Volume: 92
Issue: 25
Pages: 11608-12
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Publication
15555579 | J:94046
First Author: He Z
Year: 2004
Journal: Biochem Biophys Res Commun
Title: Effect of zeta-globin substitution on the O2-transport properties of Hb S in vitro and in vivo.
Volume: 325
Issue: 4
Pages: 1376-82
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Publication
11154217 | J:66961
First Author: Fabry ME
Year: 2001
Journal: Blood
Title: Second generation knockout sickle mice: the effect of HbF.
Volume: 97
Issue: 2
Pages: 410-8
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Publication
37256933 | J:336374
First Author: Aprile A
Year: 2023
Journal: Sci Transl Med
Title: Inhibition of FGF23 is a therapeutic strategy to target hematopoietic stem cell niche defects in β-thalassemia.
Volume: 15
Issue: 698
Pages: eabq3679
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Publication
17493845 | J:141719
First Author: Voon HP
Year: 2007
Journal: Blood Cells Mol Dis
Title: Co-inheritance of alpha- and beta-thalassaemia in mice ameliorates thalassaemic phenotype.
Volume: 39
Issue: 2
Pages: 184-8
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Publication
34002695 | J:307104
   
First Author: Castro-Mollo M
Year: 2021
Journal: Elife
Title: The hepcidin regulator erythroferrone is a new member of the erythropoiesis-iron-bone circuitry.
Volume: 10
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Publication
21099112 | J:171864
First Author: Gardenghi S
Year: 2010
Journal: J Clin Invest
Title: Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice.
Volume: 120
Issue: 12
Pages: 4466-77
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Publication
22427201 | J:185177
First Author: Khandros E
Year: 2012
Journal: Blood
Title: Integrated protein quality-control pathways regulate free α-globin in murine β-thalassemia.
Volume: 119
Issue: 22
Pages: 5265-75
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Publication
28135344 | J:247222
First Author: Mirciov CS
Year: 2017
Journal: PLoS One
Title: Characterization of Putative Erythroid Regulators of Hepcidin in Mouse Models of Anemia.
Volume: 12
Issue: 1
Pages: e0171054
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Publication
28774900 | J:243727
 
First Author: Nguyen AT
Year: 2017
Journal: Science
Title: UBE2O remodels the proteome during terminal erythroid differentiation.
Volume: 357
Issue: 6350
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Publication
28641125 | J:273498
 
First Author: Gorczynski RM
Year: 2017
Journal: Int Immunopharmacol
Title: An altered REDOX environment, assisted by over-expression of fetal hemoglobins, protects from inflammatory colitis and reduces inflammatory cytokine expression.
Volume: 50
Pages: 69-76
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Publication
20576809 | J:185927
First Author: Wu F
Year: 2010
Journal: J Am Soc Nephrol
Title: Anion exchanger 1 interacts with nephrin in podocytes.
Volume: 21
Issue: 9
Pages: 1456-67
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Publication
22461476 | J:183628
First Author: Parrow NL
Year: 2012
Journal: Blood
Title: Decreased hepcidin expression in murine β-thalassemia is associated with suppression of Bmp/Smad signaling.
Volume: 119
Issue: 13
Pages: 3187-9
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Publication
27154187 | J:236060
First Author: Casu C
Year: 2016
Journal: Blood
Title: Minihepcidin peptides as disease modifiers in mice affected by β-thalassemia and polycythemia vera.
Volume: 128
Issue: 2
Pages: 265-76
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Publication
23040355 | J:190446
First Author: Brown FC
Year: 2013
Journal: Blood Cells Mol Dis
Title: ENU mutagenesis identifies the first mouse mutants reproducing human β-thalassemia at the genomic level.
Volume: 50
Issue: 2
Pages: 86-92
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Publication
31899794 | J:285066
First Author: Arezes J
Year: 2020
Journal: Blood
Title: Antibodies against the erythroferrone N-terminal domain prevent hepcidin suppression and ameliorate murine thalassemia.
Volume: 135
Issue: 8
Pages: 547-557
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Publication
25616571 | J:259633
First Author: Gelderman MP
Year: 2015
Journal: Haematologica
Title: Reversal of hemochromatosis by apotransferrin in non-transfused and transfused Hbbth3/+ (heterozygous B1/B2 globin gene deletion) mice.
Volume: 100
Issue: 5
Pages: 611-22
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Publication
30422819 | J:270499
First Author: Wang H
Year: 2019
Journal: J Clin Invest
Title: In vivo hematopoietic stem cell gene therapy ameliorates murine thalassemia intermedia.
Volume: 129
Issue: 2
Pages: 598-615
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Publication
28325862 | J:242853
First Author: Siwaponanan P
Year: 2017
Journal: Blood
Title: Reduced PU.1 expression underlies aberrant neutrophil maturation and function in β-thalassemia mice and patients.
Volume: 129
Issue: 23
Pages: 3087-3099
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Publication
17607360 | J:124209
First Author: Yu X
Year: 2007
Journal: J Clin Invest
Title: An erythroid chaperone that facilitates folding of alpha-globin subunits for hemoglobin synthesis.
Volume: 117
Issue: 7
Pages: 1856-65
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Publication
9787139 | J:114200
First Author: Russell JE
Year: 1998
Journal: Blood
Title: Reversal of lethal alpha- and beta-thalassemias in mice by expression of human embryonic globins.
Volume: 92
Issue: 9
Pages: 3057-63
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Publication
24282296 | J:205514
First Author: Anderson ER
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia.
Volume: 110
Issue: 50
Pages: E4922-30
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Publication
21281810 | J:169076
First Author: Martin L
Year: 2011
Journal: Am J Pathol
Title: A mouse model of β-thalassemia shows a liver-specific down-regulation of Abcc6 expression.
Volume: 178
Issue: 2
Pages: 774-83
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Publication
33822774 | J:312308
 
First Author: Matte A
Year: 2021
Journal: J Clin Invest
Title: The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a β-thalassemia mouse model.
Volume: 131
Issue: 10
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Publication
26276665 | J:230255
First Author: Kautz L
Year: 2015
Journal: Blood
Title: Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of β-thalassemia.
Volume: 126
Issue: 17
Pages: 2031-7
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Publication
16421096 | J:110556
First Author: Vadolas J
Year: 2006
Journal: J Biol Chem
Title: Humanized beta-thalassemia mouse model containing the common IVSI-110 splicing mutation.
Volume: 281
Issue: 11
Pages: 7399-405
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Publication
15034572 | J:131270
First Author: He Z
Year: 2004
Journal: Nat Med
Title: Antisickling effects of an endogenous human alpha-like globin.
Volume: 10
Issue: 4
Pages: 365-7
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Publication
11877258 | J:88672
First Author: May C
Year: 2002
Journal: Blood
Title: Successful treatment of murine beta-thalassemia intermedia by transfer of the human beta-globin gene.
Volume: 99
Issue: 6
Pages: 1902-8
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Publication
14675418 | J:88512
First Author: Adamsky K
Year: 2004
Journal: Br J Haematol
Title: Decreased hepcidin mRNA expression in thalassemic mice.
Volume: 124
Issue: 1
Pages: 123-4
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Publication
12480689 | J:184966
First Author: Rivella S
Year: 2003
Journal: Blood
Title: A novel murine model of Cooley anemia and its rescue by lentiviral-mediated human beta-globin gene transfer.
Volume: 101
Issue: 8
Pages: 2932-9
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Publication
20488244 | J:162428
First Author: Matte A
Year: 2010
Journal: Free Radic Biol Med
Title: Peroxiredoxin-2 expression is increased in beta-thalassemic mouse red cells but is displaced from the membrane as a marker of oxidative stress.
Volume: 49
Issue: 3
Pages: 457-66
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Publication
15780748 | J:97548
First Author: Jamsai D
Year: 2005
Journal: Genomics
Title: A humanized mouse model for a common beta0-thalassemia mutation.
Volume: 85
Issue: 4
Pages: 453-61
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Publication
18480424 | J:138595
First Author: Libani IV
Year: 2008
Journal: Blood
Title: Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in beta-thalassemia.
Volume: 112
Issue: 3
Pages: 875-85
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Publication
26058667 | J:294892
First Author: Matte A
Year: 2015
Journal: Antioxid Redox Signal
Title: The Interplay Between Peroxiredoxin-2 and Nuclear Factor-Erythroid 2 Is Important in Limiting Oxidative Mediated Dysfunction in β-Thalassemic Erythropoiesis.
Volume: 23
Issue: 16
Pages: 1284-97
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Publication
22287545 | J:338784
First Author: Khandros E
Year: 2012
Journal: J Biol Chem
Title: Insights into hemoglobin assembly through in vivo mutagenesis of α-hemoglobin stabilizing protein.
Volume: 287
Issue: 14
Pages: 11325-37
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Publication
16803575 | J:110159
First Author: Nishino T
Year: 2006
Journal: Br J Haematol
Title: Effects of human gamma-globin in murine beta-thalassaemia.
Volume: 134
Issue: 1
Pages: 100-8
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Publication
22203977 | J:179978
First Author: Kauppi M
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Thrombocytopenia and erythrocytosis in mice with a mutation in the gene encoding the hemoglobin β minor chain.
Volume: 109
Issue: 2
Pages: 576-81
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Gene
120093065 | Hbb-b2
Type: gene
Organism: rat
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GXD Expression
GXD Expression
   
Probe: MGI:6174699
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6190481
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Hbb-b2
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6174699
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6190481
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Hbb-b2
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6174699
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6190481
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Hbb-b2
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6174699
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6190481
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Hbb-b2
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6174699
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190481
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Hbb-b2
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6174699
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190481
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Hbb-b2
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6174699
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190481
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Hbb-b2
Detected: true
Specimen Num: 7
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Publication
- | J:4239
First Author: Jones J
Year: 1993
Journal: Mouse Genome
Title: Discrimination of mouse beta-globin haplotypes by allele specific amplification
Volume: 91
Issue: 1
Pages: 124-26
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Publication
2926808 | J:29559
First Author: Shehee WR
Year: 1989
Journal: J Mol Biol
Title: Nucleotide sequence of the BALB/c mouse beta-globin complex.
Volume: 205
Issue: 1
Pages: 41-62
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Publication
6250710 | J:6364
First Author: Jahn CL
Year: 1980
Journal: Cell
Title: DNA sequence organization of the beta-globin complex in the BALB/c mouse.
Volume: 21
Issue: 1
Pages: 159-68
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Publication
519759 | J:32349
First Author: Konkel DA
Year: 1979
Journal: Cell
Title: The evolution and sequence comparison of two recently diverged mouse chromosomal beta--globin genes.
Volume: 18
Issue: 3
Pages: 865-73
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Publication
17431131 | J:145398
First Author: Liu XS
Year: 2007
Journal: Blood
Title: Disruption of palladin leads to defects in definitive erythropoiesis by interfering with erythroblastic island formation in mouse fetal liver.
Volume: 110
Issue: 3
Pages: 870-6
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Publication
11318609 | J:69531
First Author: Dahm K
Year: 2001
Journal: Genomics
Title: Transcripts of Fliz1, a nuclear zinc finger protein, are expressed in discrete foci of the murine fetal liver.
Volume: 73
Issue: 2
Pages: 194-202
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Publication
33859416 | J:308797
First Author: Vinjamur DS
Year: 2021
Journal: Nat Genet
Title: ZNF410 represses fetal globin by singular control of CHD4.
Volume: 53
Issue: 5
Pages: 719-728
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Publication
10359765 | J:55727
First Author: Liu L
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Hemoglobin induction in mouse macrophages.
Volume: 96
Issue: 12
Pages: 6643-7
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Publication
18299925 | J:132822
First Author: Sato JJ
Year: 2008
Journal: Mamm Genome
Title: Discovery of a new HBB haplotype w2 in a wild-derived house mouse, Mus musculus.
Volume: 19
Issue: 3
Pages: 155-62
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Publication
10220430 | J:54883
First Author: Bulger M
Year: 1999
Journal: Proc Natl Acad Sci U S A
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Allele
Hbb-b1<tm1Unc> | MGI:1857295
Name: hemoglobin, beta adult major chain; targeted mutation 1, University of North Carolina
Allele Type: Targeted
Attribute String: Null/knockout
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Strain
MGI:2164262 | B6;129-Hbb-b1<tm1Unc> Hbb-b2<tm1Unc>/J
Attribute String: targeted mutation, mutant stock
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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