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Search results 1 to 93 out of 93 for Hcar1

0.027s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
27198 | HCAR1
Type: gene
Organism: human
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Gene
100492010 | hcar1
Type: gene
Organism: frog, western clawed
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Gene
689936 | Hcar1
Type: gene
Organism: rat
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Gene
486252 | HCAR1
Type: gene
Organism: dog, domestic
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Gene
452331 | HCAR1
Type: gene
Organism: chimpanzee
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Gene
538759 | HCAR1
Type: gene
Organism: cattle
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Gene
702825 | HCAR1
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:2441671 | Hcar1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
39332673 | J:358463
First Author: Modaresinejad M
Year: 2024
Journal: Am J Pathol
Title: Endoplasmic Reticulum Stress Delays Choroid Development in the HCAR1 Knockout Mouse.
Volume: 194
Issue: 12
Pages: 2382-2397
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Publication
30926749 | J:276518
First Author: de Castro Abrantes H
Year: 2019
Journal: J Neurosci
Title: The Lactate Receptor HCAR1 Modulates Neuronal Network Activity through the Activation of Gα and Gβγ Subunits.
Volume: 39
Issue: 23
Pages: 4422-4433
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Protein
A0A4Y1JWM1
Organism: Mus musculus/domesticus
Length: 343  
Fragment?: false
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Publication
37940970 | J:342333
First Author: Mohammad Nezhady MA
Year: 2023
Journal: Cell Commun Signal
Title: Lack of HCAR1, the lactate GPCR, signaling promotes autistic-like behavior.
Volume: 21
Issue: 1
Pages: 196
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Publication
34737351 | J:312937
First Author: Órdenes P
Year: 2021
Journal: Sci Rep
Title: Lactate activates hypothalamic POMC neurons by intercellular signaling.
Volume: 11
Issue: 1
Pages: 21644
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Publication
31999787 | J:285469
First Author: Kwon E
Year: 2020
Journal: PLoS One
Title: Hydrocarboxylic acid receptor 1 in BAT regulates glucose uptake in mice fed a high-fat diet.
Volume: 15
Issue: 1
Pages: e0228320
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Publication
28534495 | J:249691
 
First Author: Morland C
Year: 2017
Journal: Nat Commun
Title: Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1.
Volume: 8
Pages: 15557
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Publication
19047060 | J:147219
First Author: Liu C
Year: 2009
Journal: J Biol Chem
Title: Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81.
Volume: 284
Issue: 5
Pages: 2811-22
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Protein Coding Gene
MGP_CAROLIEiJ_G0027736 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0030081 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0030046 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0029982 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0030057 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0029774 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2441671 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0030510 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0029183 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0029744 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0029894 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0029850 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0029983 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0029881 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0030551 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0028897 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0029258 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0024316 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0028734 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
32071396 | J:297950
First Author: Brown TP
Year: 2020
Journal: Oncogene
Title: The lactate receptor GPR81 promotes breast cancer growth via a paracrine mechanism involving antigen-presenting cells in the tumor microenvironment.
Volume: 39
Issue: 16
Pages: 3292-3304
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Publication
18952058 | J:144870
First Author: Cai TQ
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Role of GPR81 in lactate-mediated reduction of adipose lipolysis.
Volume: 377
Issue: 3
Pages: 987-91
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Publication
37604388 | J:340639
 
First Author: Geiseler SJ
Year: 2023
Journal: Neurosci Lett
Title: Pre-stroke exercise does not reduce atrophy in healthy young adult mice.
Volume: 814
Pages: 137447
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Publication
20374963 | J:159613
First Author: Ahmed K
Year: 2010
Journal: Cell Metab
Title: An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through GPR81.
Volume: 11
Issue: 4
Pages: 311-9
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Publication
29386257 | J:258427
First Author: Ranganathan P
Year: 2018
Journal: J Immunol
Title: GPR81, a Cell-Surface Receptor for Lactate, Regulates Intestinal Homeostasis and Protects Mice from Experimental Colitis.
Volume: 200
Issue: 5
Pages: 1781-1789
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Publication
27615440 | J:345898
First Author: Madaan A
Year: 2017
Journal: Am J Obstet Gynecol
Title: Lactate produced during labor modulates uterine inflammation via GPR81 (HCA(1)).
Volume: 216
Issue: 1
Pages: 60.e1-60.e17
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Publication
31220454 | J:282266
First Author: Madaan A
Year: 2019
Journal: Am J Pathol
Title: Müller Cell-Localized G-Protein-Coupled Receptor 81 (Hydroxycarboxylic Acid Receptor 1) Regulates Inner Retinal Vasculature via Norrin/Wnt Pathways.
Volume: 189
Issue: 9
Pages: 1878-1896
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GXD Expression
GXD Expression
     
Probe: MGI:4837400
Assay Type: RT-PCR
Annotation Date: 2010-11-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:4837434
Age: embryonic day 9.5
Specimen Label: None
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:4837400
Assay Type: RT-PCR
Annotation Date: 2010-11-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:4837434
Age: embryonic day 9.5
Specimen Label: None
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:6857993
Assay Type: Immunohistochemistry
Annotation Date: 2022-01-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3574228
Pattern: Widespread
Stage: TS28
Assay Id: MGI:6857995
Age: postnatal adult
Image: 1H/I
Note: Expression in all layers of adult mouse retina.
Specimen Label: 1H/I
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:6857993
Assay Type: Immunohistochemistry
Annotation Date: 2022-01-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3574224
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:6857995
Age: embryonic day 16.0
Image: 1E/F
Note: Expression in all layers of embryonic mouse retina. Predominant expression in retinal ganglion cells (RGCs) and in the RGC fiber layer.
Specimen Label: 1E/F
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:6857993
Assay Type: Immunohistochemistry
Annotation Date: 2022-01-26
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3573928
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6857995
Age: postnatal adult
Image: 1H/I
Note: Predominant expression in retinal ganglion cells (RGCs) and in the RGC fiber layer.
Specimen Label: 1H/I
Detected: true
Specimen Num: 2
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Publication
37138018 | J:339570
First Author: Ordonez-Moreno LA
Year: 2023
Journal: Leukemia
Title: Lactate-a new player in G-CSF-induced mobilization of hematopoietic stem/progenitor cells.
Volume: 37
Issue: 8
Pages: 1757-1761
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Publication
30543778 | J:295069
First Author: Lee YS
Year: 2018
Journal: Cell Host Microbe
Title: Microbiota-Derived Lactate Accelerates Intestinal Stem-Cell-Mediated Epithelial Development.
Volume: 24
Issue: 6
Pages: 833-846.e6
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Publication
34208876 | J:314286
 
First Author: Laroche S
Year: 2021
Journal: Cells
Title: Participation of L-Lactate and Its Receptor HCAR1/GPR81 in Neurovisual Development.
Volume: 10
Issue: 7
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Publication
19633298 | J:156360
First Author: Jeninga EH
Year: 2009
Journal: J Biol Chem
Title: Peroxisome proliferator-activated receptor gamma regulates expression of the anti-lipolytic G-protein-coupled receptor 81 (GPR81/Gpr81).
Volume: 284
Issue: 39
Pages: 26385-93
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Publication
32669546 | J:291976
First Author: Khatib-Massalha E
Year: 2020
Journal: Nat Commun
Title: Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling.
Volume: 11
Issue: 1
Pages: 3547
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Publication
20178780 | J:160012
First Author: Jerome-Majewska LA
Year: 2010
Journal: Dev Biol
Title: The trafficking protein Tmed2/p24beta(1) is required for morphogenesis of the mouse embryo and placenta.
Volume: 341
Issue: 1
Pages: 154-66
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Publication
- | J:94077
     
First Author: Mutant Mouse Regional Resource Centers
Year: 2004
Journal: Unpublished
Title: Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC)
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Publication
- | J:237616
     
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein Domain
IPR028016 | HCAR1_rcpt
Type: Family
Description: The hydroxycarboxylic acid receptors []are members of the rhodopsin-like G protein-coupled receptor (GPCR) family. There are three hydroxycarboxylic acid receptors, termed HCAR1-3. The family was formerly known as nicotinic acid receptor family, although nicotinic acid only shows submicromolar potency at HCAR2 [, ].The receptors respond to organic acids, including the endogenous short chain fatty acids, butyric acid and L-lactic acid, as well as the lipid lowering agents nicotinic acid (niacin), acipimox and acifran [, , ]. There is an increasing number of synthetic ligands mainly targeted at HCAR2 and HCAR3 receptors [, ]. All three receptors are expressed in adipocytes, and are coupled to Gi type G-proteins mediating antilipolytic effects in fat cells [, , , ]. HCAR2 and HCAR3 are also expressed in a variety of immune cells including monocytes, macrophages, neutrophils and Langerhans cells [, ]. HCAR1 and HCAR2 are found in most mammalian species, whereas HCAR3 is only present in higher primates []. There is evidence that these receptors can mediate anti-inflammatory effects. HCAR2 has been shown to be a receptor for the anti-dyslipidemic drug nicotinic acid (niacin) as well as for the anti-psoriatic drug monomethyl-fumarate [, ]. This entry represents hydroxycarboxylic acid receptor 1, also known as lactate receptor 1, G protein coupled receptor 104 and G-protein coupled receptor 81. The endogenous ligand for HCAR1 is L-lactic acid [].
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Publication
12646212 | J:82939
First Author: Soga T
Year: 2003
Journal: Biochem Biophys Res Commun
Title: Molecular identification of nicotinic acid receptor.
Volume: 303
Issue: 1
Pages: 364-9
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Publication
21454438 | -
First Author: Offermanns S
Year: 2011
Journal: Pharmacol Rev
Title: International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B).
Volume: 63
Issue: 2
Pages: 269-90
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Publication
12563315 | J:82225
First Author: Tunaru S
Year: 2003
Journal: Nat Med
Title: PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect.
Volume: 9
Issue: 3
Pages: 352-5
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Publication
12522134 | -
First Author: Wise A
Year: 2003
Journal: J Biol Chem
Title: Molecular identification of high and low affinity receptors for nicotinic acid.
Volume: 278
Issue: 11
Pages: 9869-74
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Publication
19524438 | -
First Author: Skinner PJ
Year: 2009
Journal: Bioorg Med Chem Lett
Title: 5-N,N-Disubstituted 5-aminopyrazole-3-carboxylic acids are highly potent agonists of GPR109b.
Volume: 19
Issue: 15
Pages: 4207-9
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Publication
19309152 | -
First Author: Shen HC
Year: 2009
Journal: J Med Chem
Title: Discovery of novel tricyclic full agonists for the G-protein-coupled niacin receptor 109A with minimized flushing in rats.
Volume: 52
Issue: 8
Pages: 2587-602
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Publication
17008871 | -
First Author: Maciejewski-Lenoir D
Year: 2006
Journal: J Invest Dermatol
Title: Langerhans cells release prostaglandin D2 in response to nicotinic acid.
Volume: 126
Issue: 12
Pages: 2637-46
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Publication
19237584 | -
First Author: Irukayama-Tomobe Y
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B.
Volume: 106
Issue: 10
Pages: 3930-4
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Publication
22654812 | -
 
First Author: Ahmed K
Year: 2011
Journal: Front Endocrinol (Lausanne)
Title: Biological roles and therapeutic potential of hydroxy-carboxylic Acid receptors.
Volume: 2
Pages: 51
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Protein Domain
IPR028017 | HCAR2/3_rcpt
Type: Family
Description: The hydroxycarboxylic acid receptors []are members of the rhodopsin-like G protein-coupled receptor (GPCR) family. There are three hydroxycarboxylic acid receptors, termed HCAR1-3. The family was formerly known as nicotinic acid receptor family, although nicotinic acid only shows submicromolar potency at HCAR2 [, ].The receptors respond to organic acids, including the endogenous short chain fatty acids, butyric acid and L-lactic acid, as well as the lipid lowering agents nicotinic acid (niacin), acipimox and acifran [, , ]. There is an increasing number of synthetic ligands mainly targeted at HCAR2 and HCAR3 receptors [, ]. All three receptors are expressed in adipocytes, and are coupled to Gi type G-proteins mediating antilipolytic effects in fat cells [, , , ]. HCAR2 and HCAR3 are also expressed in a variety of immune cells including monocytes, macrophages, neutrophils and Langerhans cells [, ]. HCAR1 and HCAR2 are found in most mammalian species, whereas HCAR3 is only present in higher primates []. There is evidence that these receptors can mediate anti-inflammatory effects. HCAR2 has been shown to be a receptor for the anti-dyslipidemic drug nicotinic acid (niacin) as well as for the anti-psoriatic drug monomethyl-fumarate [, ]. This entry represents two members of hydroxycarboxylic acid receptor family, hydroxycarboxylic acid receptor 2 (also known as niacin receptor 1, G protein-coupled receptor 109A, nicotinic acid receptor, HM74A) and hydroxycarboxylic acid receptor 3 (also known as niacin receptor 2, G protein-coupled receptor 109B, low affinity nicotinic acid receptor). The endogenous ligands of HCAR2 and HCAR3 are beta-D-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively [].
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Protein
Q8C131
Organism: Mus musculus/domesticus
Length: 343  
Fragment?: false
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Protein
E9PZR8
Organism: Mus musculus/domesticus
Length: 351  
Fragment?: false
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Protein
B9UM22
Organism: Mus musculus/domesticus
Length: 351  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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