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Search results 1 to 100 out of 477 for Hcn4

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Type Details Score
Gene
Type: gene
Organism: Not Specified
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
GXD Expression  
Probe: MGI:7281415
Assay Type: Immunohistochemistry
Annotation Date: 2022-06-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:7281477
Age: embryonic day 13.0
Image: S1I HCN4
Specimen Label: S1I HCN4
Detected: true
Specimen Num: 1
Publication  
First Author: Yang B
Year: 2020
Journal: J Mol Cell Cardiol
Title: Mitochondrial thioredoxin-2 maintains HCN4 expression and prevents oxidative stress-mediated sick sinus syndrome.
Volume: 138
Pages: 291-303
Publication
First Author: Xu X
Year: 2010
Journal: J Biol Chem
Title: Structural basis for the cAMP-dependent gating in the human HCN4 channel.
Volume: 285
Issue: 47
Pages: 37082-91
Publication      
First Author: Zobeiri M
Year: 2019
Journal: Cereb Cortex
Title: The Hyperpolarization-Activated HCN4 Channel is Important for Proper Maintenance of Oscillatory Activity in the Thalamocortical System.
Publication
First Author: Liang X
Year: 2013
Journal: Circ Res
Title: HCN4 dynamically marks the first heart field and conduction system precursors.
Volume: 113
Issue: 4
Pages: 399-407
Publication
First Author: Kozasa Y
Year: 2018
Journal: J Physiol
Title: HCN4 pacemaker channels attenuate the parasympathetic response and stabilize the spontaneous firing of the sinoatrial node.
Volume: 596
Issue: 5
Pages: 809-825
Publication
First Author: Fenske S
Year: 2020
Journal: Nat Commun
Title: cAMP-dependent regulation of HCN4 controls the tonic entrainment process in sinoatrial node pacemaker cells.
Volume: 11
Issue: 1
Pages: 5555
Publication
First Author: Herrmann S
Year: 2007
Journal: EMBO J
Title: HCN4 provides a 'depolarization reserve' and is not required for heart rate acceleration in mice.
Volume: 26
Issue: 21
Pages: 4423-32
Publication      
First Author: D'Souza A
Year: 2020
Journal: Heart Rhythm
Title: A circadian clock in the sinus node mediates day-night rhythms in Hcn4 and heart rate.
Publication
First Author: Ye B
Year: 2009
Journal: J Biol Chem
Title: Proteolytic processing of HCN2 and co-assembly with HCN4 in the generation of cardiac pacemaker channels.
Volume: 284
Issue: 38
Pages: 25553-9
Publication
First Author: Garcia-Frigola C
Year: 2003
Journal: Gene Expr Patterns
Title: Expression of the hyperpolarization-activated cyclic nucleotide-gated cation channel HCN4 during mouse heart development.
Volume: 3
Issue: 6
Pages: 777-83
Publication
First Author: Harzheim D
Year: 2008
Journal: EMBO J
Title: Cardiac pacemaker function of HCN4 channels in mice is confined to embryonic development and requires cyclic AMP.
Volume: 27
Issue: 4
Pages: 692-703
Publication
First Author: Nakagawa T
Year: 2020
Journal: Mol Brain
Title: Expression of the pacemaker channel HCN4 in excitatory interneurons in the dorsal horn of the murine spinal cord.
Volume: 13
Issue: 1
Pages: 127
Publication
First Author: Vedantham V
Year: 2013
Journal: Dev Biol
Title: Spatiotemporal regulation of an Hcn4 enhancer defines a role for Mef2c and HDACs in cardiac electrical patterning.
Volume: 373
Issue: 1
Pages: 149-62
Publication
First Author: Stieber J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart.
Volume: 100
Issue: 25
Pages: 15235-40
GXD Expression
Probe: MGI:6450086
Assay Type: Immunohistochemistry
Annotation Date: 2020-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3574128
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6450186
Age: postnatal month 2-3
Image: 9G
Note: Hcn4 and Tacr3 co-immunolabeling was noted in the inner plexiform layer.
Specimen Label: 9G
Detected: true
Specimen Num: 13
GXD Expression
Probe: MGI:6450086
Assay Type: Immunohistochemistry
Annotation Date: 2020-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6450186
Age: postnatal month 2-3
Image: 3J
Note: Hcn4 labels type 3a bipolar cells and co-labeled with Irx6:b-gal positive bipolar cells.
Specimen Label: 3J
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:6450086
Assay Type: Immunohistochemistry
Annotation Date: 2020-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6450186
Age: postnatal month 2-3
Image: 6H/J
Note: In the mutant, Hcn4 expression continued, but Cabp5 expression was reduced in type 3a cells.
Specimen Label: 6H/J
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:6450086
Assay Type: Immunohistochemistry
Annotation Date: 2020-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6450186
Age: postnatal month 2-3
Image: S4 Irx6;Vsx1
Note: Expression was detected in type 3a bipolar cells. Expression of Hcn4 was not detected in all Irx6:bgal-positive cells.
Specimen Label: S4 Irx6;Vsx1
Detected: true
Specimen Num: 15
GXD Expression
Probe: MGI:6450086
Assay Type: Immunohistochemistry
Annotation Date: 2020-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6450186
Age: postnatal month 2-3
Image: S4 Irx6;Vsx1<+/AltB5>
Note: Expression was detected in type 3a bipolar cells. Expression of Hcn4 was not detected in all Irx6:bgal-positive cells.
Specimen Label: S4 Irx6;Vsx1<+/AltB5>
Detected: true
Specimen Num: 14
GXD Expression
Probe: MGI:6450086
Assay Type: Immunohistochemistry
Annotation Date: 2020-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3574128
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6450186
Age: postnatal month 2-3
Image: 7D/F
Note: The axon terminals of Hcn4 immunopositive type 3 bipolar cells were normally positioned in sublamina 2 (between the two outermost Calb2-labeled bands).
Specimen Label: 7D/F
Detected: true
Specimen Num: 7
Publication  
First Author: Ren H
Year: 2022
Journal: Front Physiol
Title: High-Resolution 3D Heart Models of Cardiomyocyte Subpopulations in Cleared Murine Heart.
Volume: 13
Pages: 779514
Publication
First Author: Hoesl E
Year: 2008
Journal: J Mol Cell Cardiol
Title: Tamoxifen-inducible gene deletion in the cardiac conduction system.
Volume: 45
Issue: 1
Pages: 62-9
Publication
First Author: Nakashima N
Year: 2013
Journal: J Physiol
Title: Hyperpolarisation-activated cyclic nucleotide-gated channels regulate the spontaneous firing rate of olfactory receptor neurons and affect glomerular formation in mice.
Volume: 591
Issue: 7
Pages: 1749-69
Publication
First Author: Kharouf Q
Year: 2020
Journal: Br J Pharmacol
Title: The hyperpolarization-activated cyclic nucleotide-gated 4 channel as a potential anti-seizure drug target.
Volume: 177
Issue: 16
Pages: 3712-3729
Publication
First Author: Ishii TM
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Peripheral N- and C-terminal domains determine deactivation kinetics of HCN channels.
Volume: 359
Issue: 3
Pages: 592-8
Publication
First Author: Alig J
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Control of heart rate by cAMP sensitivity of HCN channels.
Volume: 106
Issue: 29
Pages: 12189-94
Publication
First Author: Sah R
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity.
Volume: 110
Issue: 32
Pages: E3037-46
Publication
First Author: Baruscotti M
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4.
Volume: 108
Issue: 4
Pages: 1705-10
Publication  
First Author: Peng SC
Year: 2017
Journal: Neuroscience
Title: Contribution of presynaptic HCN channels to excitatory inputs of spinal substantia gelatinosa neurons.
Volume: 358
Pages: 146-157
Publication
First Author: Ye B
Year: 2008
Journal: Biochemistry
Title: Caveolin-3 associates with and affects the function of hyperpolarization-activated cyclic nucleotide-gated channel 4.
Volume: 47
Issue: 47
Pages: 12312-8
Publication
First Author: Später D
Year: 2013
Journal: Nat Cell Biol
Title: A HCN4+ cardiomyogenic progenitor derived from the first heart field and human pluripotent stem cells.
Volume: 15
Issue: 9
Pages: 1098-106
Publication
First Author: Abbas SY
Year: 2006
Journal: Neuroscience
Title: Compartmental distribution of hyperpolarization-activated cyclic-nucleotide-gated channel 2 and hyperpolarization-activated cyclic-nucleotide-gated channel 4 in thalamic reticular and thalamocortical relay neurons.
Volume: 141
Issue: 4
Pages: 1811-25
Publication
First Author: Marger L
Year: 2011
Journal: Channels (Austin)
Title: Functional roles of Ca(v)1.3, Ca(v)3.1 and HCN channels in automaticity of mouse atrioventricular cells: insights into the atrioventricular pacemaker mechanism.
Volume: 5
Issue: 3
Pages: 251-61
Publication
First Author: Wu C
Year: 2017
Journal: Biochem Biophys Res Commun
Title: EP3 activation facilitates bladder excitability via HCN channels on ICCs.
Volume: 485
Issue: 2
Pages: 535-541
Publication
First Author: Hofmann F
Year: 2012
Journal: Cardiovasc Res
Title: Ventricular HCN channels decrease the repolarization reserve in the hypertrophic heart.
Volume: 95
Issue: 3
Pages: 317-26
Publication
First Author: Sun Y
Year: 2007
Journal: Dev Biol
Title: Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells.
Volume: 304
Issue: 1
Pages: 286-96
Publication  
First Author: Seo H
Year: 2015
Journal: Mol Brain
Title: Differential expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits during hippocampal development in the mouse.
Volume: 8
Pages: 13
Publication
First Author: Espinoza-Lewis RA
Year: 2009
Journal: Dev Biol
Title: Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5.
Volume: 327
Issue: 2
Pages: 376-85
Publication
First Author: Ye W
Year: 2015
Journal: Development
Title: A common Shox2-Nkx2-5 antagonistic mechanism primes the pacemaker cell fate in the pulmonary vein myocardium and sinoatrial node.
Volume: 142
Issue: 14
Pages: 2521-32
Publication
First Author: Simmons O
Year: 2015
Journal: Dev Dyn
Title: Persistent Noggin arrests cardiomyocyte morphogenesis and results in early in utero lethality.
Volume: 244
Issue: 3
Pages: 457-67
Publication
First Author: Baggio LL
Year: 2017
Journal: Mol Metab
Title: The autonomic nervous system and cardiac GLP-1 receptors control heart rate in mice.
Volume: 6
Issue: 11
Pages: 1339-1349
Publication
First Author: Mommersteeg MT
Year: 2007
Journal: Circ Res
Title: Molecular pathway for the localized formation of the sinoatrial node.
Volume: 100
Issue: 3
Pages: 354-62
Publication
First Author: Sun C
Year: 2015
Journal: J Biol Chem
Title: The short stature homeobox 2 (Shox2)-bone morphogenetic protein (BMP) pathway regulates dorsal mesenchymal protrusion development and its temporary function as a pacemaker during cardiogenesis.
Volume: 290
Issue: 4
Pages: 2007-23
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Herrmann S
Year: 2011
Journal: Cardiovasc Res
Title: Insights into sick sinus syndrome from an inducible mouse model.
Volume: 90
Issue: 1
Pages: 38-48
GXD Expression      
Probe: MGI:3608934
Assay Type: RT-PCR
Annotation Date: 2006-01-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3608937
Age: postnatal week 8
Specimen Label: NTg
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3608941
Assay Type: Western blot
Annotation Date: 2006-01-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3608946
Age: postnatal week 8
Specimen Label: NTg
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3608941
Assay Type: Western blot
Annotation Date: 2006-01-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3608946
Age: postnatal week 8
Specimen Label: NTg
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3707880
Assay Type: RT-PCR
Annotation Date: 2007-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1733125
Stage: TS25
Assay Id: MGI:3708505
Age: embryonic day 17.5
Specimen Label: Fetus
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3707880
Assay Type: RT-PCR
Annotation Date: 2007-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1733127
Stage: TS27
Assay Id: MGI:3708505
Age: postnatal day 1
Specimen Label: Neonate
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3707880
Assay Type: RT-PCR
Annotation Date: 2007-05-15
Strength: Present
Sex: Male
Emaps: EMAPS:1733128
Stage: TS28
Assay Id: MGI:3708505
Age: postnatal week 5-8
Specimen Label: Adult
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:5639241
Assay Type: RT-PCR
Annotation Date: 2015-06-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610521
Stage: TS21
Assay Id: MGI:5639293
Age: embryonic day 13.5
Image: 3
Specimen Label: wild type
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5639241
Assay Type: RT-PCR
Annotation Date: 2015-06-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610521
Stage: TS21
Assay Id: MGI:5639293
Age: embryonic day 13.5
Image: 3
Specimen Label: Pitx2 Het
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5639241
Assay Type: RT-PCR
Annotation Date: 2015-06-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610521
Stage: TS21
Assay Id: MGI:5639293
Age: embryonic day 13.5
Image: 3
Specimen Label: Pitx2 Null
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:5639241
Assay Type: RT-PCR
Annotation Date: 2015-06-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5639305
Age: postnatal day 42
Image: 3
Specimen Label: wild type
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5639241
Assay Type: RT-PCR
Annotation Date: 2015-06-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5639305
Age: postnatal day 42
Image: 3
Specimen Label: Pitx2 Het
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7281407
Assay Type: RT-PCR
Annotation Date: 2022-06-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691021
Stage: TS21
Assay Id: MGI:7281452
Age: embryonic day 13.0
Image: 1
Specimen Label: E13
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7281407
Assay Type: RT-PCR
Annotation Date: 2022-06-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691023
Stage: TS23
Assay Id: MGI:7281452
Age: embryonic day 15.0
Image: 1
Specimen Label: E15
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7281407
Assay Type: RT-PCR
Annotation Date: 2022-06-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691026
Stage: TS26
Assay Id: MGI:7281452
Age: embryonic day 18.0
Image: 1
Specimen Label: E18
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:7281407
Assay Type: RT-PCR
Annotation Date: 2022-06-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691028
Stage: TS28
Assay Id: MGI:7281452
Age: postnatal day 7
Image: 1
Specimen Label: P7
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:7281407
Assay Type: RT-PCR
Annotation Date: 2022-06-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691028
Stage: TS28
Assay Id: MGI:7281452
Age: postnatal day 35
Image: 1
Specimen Label: P35
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:7281407
Assay Type: RT-PCR
Annotation Date: 2022-06-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754421
Stage: TS21
Assay Id: MGI:7281460
Age: embryonic day 13.0
Image: S1
Specimen Label: E13
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7281407
Assay Type: RT-PCR
Annotation Date: 2022-06-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754423
Stage: TS23
Assay Id: MGI:7281460
Age: embryonic day 15.0
Image: S1
Specimen Label: E15
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7281407
Assay Type: RT-PCR
Annotation Date: 2022-06-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754426
Stage: TS26
Assay Id: MGI:7281460
Age: embryonic day 18.0
Image: S1
Specimen Label: E18
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:7281407
Assay Type: RT-PCR
Annotation Date: 2022-06-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7281460
Age: postnatal day 7
Image: S1
Specimen Label: P7
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:7281407
Assay Type: RT-PCR
Annotation Date: 2022-06-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7281460
Age: postnatal day 35
Image: S1
Specimen Label: P35
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:7281407
Assay Type: RT-PCR
Annotation Date: 2022-06-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1904221
Stage: TS21
Assay Id: MGI:7281467
Age: embryonic day 13.0
Image: S1
Specimen Label: E13
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7281407
Assay Type: RT-PCR
Annotation Date: 2022-06-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284523
Stage: TS23
Assay Id: MGI:7281467
Age: embryonic day 15.0
Image: S1
Specimen Label: E15
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7281407
Assay Type: RT-PCR
Annotation Date: 2022-06-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284526
Stage: TS26
Assay Id: MGI:7281467
Age: embryonic day 18.0
Image: S1
Specimen Label: E18
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:7281407
Assay Type: RT-PCR
Annotation Date: 2022-06-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284528
Stage: TS28
Assay Id: MGI:7281467
Age: postnatal day 7
Image: S1
Specimen Label: P7
Detected: true
Specimen Num: 4