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Search results 1 to 100 out of 118 for Hcst

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
10870 | HCST
Type: gene
Organism: human
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Gene
612627 | HCST
Type: gene
Organism: dog, domestic
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Gene
767892 | HCST
Type: gene
Organism: cattle
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Gene
100101460 | hcst
Type: gene
Organism: zebrafish
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Gene
574152 | HCST
Type: gene
Organism: macaque, rhesus
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Gene
474146 | Hcst
Type: gene
Organism: rat
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Gene
748082 | HCST
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:1344360 | Hcst
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR009861 | HCST
Type: Family
Description: Hematopoietic cell signal transducer (HCST, also known as DAP10) is a transmembrane adaptor that associates with an activation receptor, NKG2D, which is found on NK and subsets of T cells. The ligands for this receptor include MHC class I chain-related (MIC) protein A and protein B and UL16-binding proteins []. In activated mouse natural killer (NK) cells, the NKG2D receptor associates with two intracellular adaptors, DAP10 and DAP12, which trigger phosphatidyl inositol 3 kinase (PI3K) and Syk family protein tyrosine kinases, respectively. It has been suggested that the DAP10-PI3K pathway is sufficient to initiate NKG2D-mediated killing of target cells [].
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Protein
Q9QUJ0
Organism: Mus musculus/domesticus
Length: 79  
Fragment?: false
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Protein
B7ZNZ7
Organism: Mus musculus/domesticus
Length: 78  
Fragment?: false
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Publication
12740576 | -
First Author: Zompi S
Year: 2003
Journal: Nat Immunol
Title: NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases.
Volume: 4
Issue: 6
Pages: 565-72
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Publication
18097042 | -
First Author: Marusina AI
Year: 2008
Journal: J Immunol
Title: Regulation of human DAP10 gene expression in NK and T cells by Ap-1 transcription factors.
Volume: 180
Issue: 1
Pages: 409-17
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Publication
23690625 | J:197407
First Author: Nakamura K
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Fratricide of natural killer cells dressed with tumor-derived NKG2D ligand.
Volume: 110
Issue: 23
Pages: 9421-6
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Publication
25366966 | J:219657
First Author: Nabekura T
Year: 2014
Journal: J Exp Med
Title: Antigen-specific expansion and differentiation of natural killer cells by alloantigen stimulation.
Volume: 211
Issue: 12
Pages: 2455-65
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Publication
19251634 | J:147155
First Author: Inui M
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Signal adaptor DAP10 associates with MDL-1 and triggers osteoclastogenesis in cooperation with DAP12.
Volume: 106
Issue: 12
Pages: 4816-21
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Protein Coding Gene
MGP_CAROLIEiJ_G0029518 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0032018 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0031995 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0031928 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0032002 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0031721 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1344360 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0032468 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0031055 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0031687 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0031839 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0031796 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0031920 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0031832 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0032496 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0030781 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0031165 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0012752 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0030614 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
10528161 | J:69934
First Author: Chang C
Year: 1999
Journal: J Immunol
Title: Cutting edge: KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties.
Volume: 163
Issue: 9
Pages: 4651-4
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Publication
10426994 | J:56494
First Author: Wu J
Year: 1999
Journal: Science
Title: An activating immunoreceptor complex formed by NKG2D and DAP10.
Volume: 285
Issue: 5428
Pages: 730-2
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Publication
17100879 | J:148086
 
First Author: Hyka-Nouspikel N
Year: 2006
Journal: Immunol Rev
Title: Physiological roles of murine DAP10 adapter protein in tumor immunity and autoimmunity.
Volume: 214
Pages: 106-17
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Publication
17785813 | J:148231
First Author: Hyka-Nouspikel N
Year: 2007
Journal: J Immunol
Title: DAP10 deficiency breaks the immune tolerance against transplantable syngeneic melanoma.
Volume: 179
Issue: 6
Pages: 3763-71
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Publication
11398969 | J:69925
First Author: Yim D
Year: 2001
Journal: Immunogenetics
Title: Molecular cloning and characterization of pig immunoreceptor DAP10 and NKG2D.
Volume: 53
Issue: 3
Pages: 243-9
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GXD Expression
GXD Expression
 
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1868128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691446
Age: postnatal adult
Image: UC Davis_1885541
Note: vas deferens
Specimen Label: UC Davis_1885541
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
 
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1868128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691446
Age: postnatal adult
Image: UC Davis_1885542
Note: vas deferens
Specimen Label: UC Davis_1885542
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
 
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1868128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691446
Age: postnatal adult
Image: UC Davis_1885543
Note: vas deferens
Specimen Label: UC Davis_1885543
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691446
Age: postnatal adult
Image: UC Davis_1885534
Specimen Label: UC Davis_1885534
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691446
Age: postnatal adult
Image: UC Davis_1885535
Specimen Label: UC Davis_1885535
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1928728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691446
Age: postnatal adult
Image: UC Davis_1885537
Specimen Label: UC Davis_1885537
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1928728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691446
Age: postnatal adult
Image: UC Davis_1885538
Specimen Label: UC Davis_1885538
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1928728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691446
Age: postnatal adult
Image: UC Davis_1885539
Specimen Label: UC Davis_1885539
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1928728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691446
Age: postnatal adult
Image: UC Davis_1885540
Specimen Label: UC Davis_1885540
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1683328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691446
Age: postnatal adult
Image: UC Davis_1885544
Specimen Label: UC Davis_1885544
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1929028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691446
Age: postnatal adult
Image: UC Davis_1885536
Specimen Label: UC Davis_1885536
Detected: true
Specimen Num: 4
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Publication
11491539 | J:71139
First Author: Wilson MJ
Year: 2001
Journal: Immunogenetics
Title: The mouse Dap10 gene.
Volume: 53
Issue: 4
Pages: 347-50
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Publication
19074552 | J:172961
First Author: Aoki N
Year: 2009
Journal: J Leukoc Biol
Title: Expression and functional role of MDL-1 (CLEC5A) in mouse myeloid lineage cells.
Volume: 85
Issue: 3
Pages: 508-17
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Publication
27810928 | J:237515
First Author: Nabekura T
Year: 2016
Journal: J Exp Med
Title: Tracking the fate of antigen-specific versus cytokine-activated natural killer cells after cytomegalovirus infection.
Volume: 213
Issue: 12
Pages: 2745-2758
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Publication
28378389 | J:246795
First Author: Kavazović I
Year: 2017
Journal: Eur J Immunol
Title: NKG2D stimulation of CD8+ T cells during priming promotes their capacity to produce cytokines in response to viral infection in mice.
Volume: 47
Issue: 7
Pages: 1123-1135
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Publication
16086018 | J:100453
First Author: Ogasawara K
Year: 2005
Journal: Nat Immunol
Title: Function of NKG2D in natural killer cell-mediated rejection of mouse bone marrow grafts.
Volume: 6
Issue: 9
Pages: 938-45
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Publication
12426564 | J:80426
First Author: Gilfillan S
Year: 2002
Journal: Nat Immunol
Title: NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation.
Volume: 3
Issue: 12
Pages: 1150-5
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Publication
15294961 | J:92687
First Author: Rosen DB
Year: 2004
Journal: J Immunol
Title: A Structural basis for the association of DAP12 with mouse, but not human, NKG2D.
Volume: 173
Issue: 4
Pages: 2470-8
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Publication
19247984 | J:148039
First Author: Tassi I
Year: 2009
Journal: Eur J Immunol
Title: DAP10 associates with Ly49 receptors but contributes minimally to their expression and function in vivo.
Volume: 39
Issue: 4
Pages: 1129-35
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Publication
26680205 | J:234674
First Author: Rapaport AS
Year: 2015
Journal: Immunity
Title: The Inhibitory Receptor NKG2A Sustains Virus-Specific CD8⁺ T Cells in Response to a Lethal Poxvirus Infection.
Volume: 43
Issue: 6
Pages: 1112-24
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Publication
21263069 | J:169407
First Author: Bolanos FD
Year: 2011
Journal: J Immunol
Title: Activation receptor-induced tolerance of mature NK cells in vivo requires signaling through the receptor and is reversible.
Volume: 186
Issue: 5
Pages: 2765-71
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Publication
19332875 | J:147867
First Author: Orr MT
Year: 2009
Journal: J Exp Med
Title: Ly49H signaling through DAP10 is essential for optimal natural killer cell responses to mouse cytomegalovirus infection.
Volume: 206
Issue: 4
Pages: 807-17
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Publication
22244846 | J:181185
First Author: Markiewicz MA
Year: 2012
Journal: Immunity
Title: RAE1ε ligand expressed on pancreatic islets recruits NKG2D receptor-expressing cytotoxic T cells independent of T cell receptor recognition.
Volume: 36
Issue: 1
Pages: 132-41
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Publication
23804716 | J:205724
First Author: Wensveen FM
Year: 2013
Journal: J Immunol
Title: NKG2D induces Mcl-1 expression and mediates survival of CD8 memory T cell precursors via phosphatidylinositol 3-kinase.
Volume: 191
Issue: 3
Pages: 1307-15
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Publication
16116168 | J:113240
First Author: Markiewicz MA
Year: 2005
Journal: J Immunol
Title: Costimulation through NKG2D enhances murine CD8+ CTL function: similarities and differences between NKG2D and CD28 costimulation.
Volume: 175
Issue: 5
Pages: 2825-33
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Publication
17952078 | J:127764
First Author: Horng T
Year: 2007
Journal: Nat Immunol
Title: NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway.
Volume: 8
Issue: 12
Pages: 1345-52
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Publication
16887996 | J:138391
First Author: Graham DB
Year: 2006
Journal: J Immunol
Title: Vav1 controls DAP10-mediated natural cytotoxicity by regulating actin and microtubule dynamics.
Volume: 177
Issue: 4
Pages: 2349-55
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Publication
17928527 | J:130085
First Author: Yamanishi Y
Year: 2008
Journal: Blood
Title: Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells.
Volume: 111
Issue: 2
Pages: 688-98
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Publication
19503107 | J:150133
First Author: Otero K
Year: 2009
Journal: Nat Immunol
Title: Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and beta-catenin.
Volume: 10
Issue: 7
Pages: 734-43
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Publication
12925893 | J:84089
First Author: Denny P
Year: 2003
Journal: Mamm Genome
Title: A major locus conferring susceptibility to infection by Streptococcus pneumoniae in mice.
Volume: 14
Issue: 7
Pages: 448-53
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Publication
22084441 | J:180387
First Author: Saether PC
Year: 2011
Journal: J Immunol
Title: Rat and mouse CD94 associate directly with the activating transmembrane adaptor proteins DAP12 and DAP10 and activate NK cell cytotoxicity.
Volume: 187
Issue: 12
Pages: 6365-73
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Publication
20817736 | J:166868
First Author: Enomoto Y
Year: 2010
Journal: J Biol Chem
Title: Characterization of leukocyte mono-immunoglobulin-like receptor 7 (LMIR7)/CLM-3 as an activating receptor: its similarities to and differences from LMIR4/CLM-5.
Volume: 285
Issue: 46
Pages: 35274-83
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Publication
12426565 | J:219772
First Author: Diefenbach A
Year: 2002
Journal: Nat Immunol
Title: Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D.
Volume: 3
Issue: 12
Pages: 1142-9
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Publication
15365099 | J:93939
First Author: Cella M
Year: 2004
Journal: J Exp Med
Title: Differential requirements for Vav proteins in DAP10- and ITAM-mediated NK cell cytotoxicity.
Volume: 200
Issue: 6
Pages: 817-23
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Publication
28087665 | J:247734
First Author: Lenartić M
Year: 2017
Journal: J Immunol
Title: NKG2D Promotes B1a Cell Development and Protection against Bacterial Infection.
Volume: 198
Issue: 4
Pages: 1531-1542
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Publication
22005300 | J:178724
First Author: Cheung R
Year: 2011
Journal: J Clin Invest
Title: Activation of MDL-1 (CLEC5A) on immature myeloid cells triggers lethal shock in mice.
Volume: 121
Issue: 11
Pages: 4446-61
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Publication
20484116 | J:185412
First Author: Peng Q
Year: 2010
Journal: Sci Signal
Title: TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1.
Volume: 3
Issue: 122
Pages: ra38
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Publication
15878887 | J:100668
First Author: Xie X
Year: 2005
Journal: Biol Reprod
Title: Pathways participating in activation of mouse uterine natural killer cells during pregnancy.
Volume: 73
Issue: 3
Pages: 510-8
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Publication
32453422 | J:294935
 
First Author: Babic M
Year: 2020
Journal: J Exp Med
Title: NK cell receptor NKG2D enforces proinflammatory features and pathogenicity of Th1 and Th17 cells.
Volume: 217
Issue: 8
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Publication
30224819 | J:280975
First Author: Jelenčić V
Year: 2018
Journal: Nat Immunol
Title: NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development.
Volume: 19
Issue: 10
Pages: 1083-1092
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Publication
31444264 | J:280774
First Author: Piersma SJ
Year: 2019
Journal: J Immunol
Title: Activation Receptor-Dependent IFN-γ Production by NK Cells Is Controlled by Transcription, Translation, and the Proteasome.
Volume: 203
Issue: 7
Pages: 1981-1988
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Publication
36306735 | J:333070
First Author: Wang S
Year: 2022
Journal: Cell
Title: TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways.
Volume: 185
Issue: 22
Pages: 4153-4169.e19
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Publication
12893283 | J:84951
First Author: Kumagai H
Year: 2003
Journal: Biochem Biophys Res Commun
Title: Identification and characterization of a new pair of immunoglobulin-like receptors LMIR1 and 2 derived from murine bone marrow-derived mast cells.
Volume: 307
Issue: 3
Pages: 719-29
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Publication
32726632 | J:295190
First Author: Parikh BA
Year: 2020
Journal: Cell Rep
Title: Control of Viral Infection by Natural Killer Cell Inhibitory Receptors.
Volume: 32
Issue: 4
Pages: 107969
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Publication
26720279 | J:310568
First Author: Parikh BA
Year: 2015
Journal: PLoS Pathog
Title: Dual Requirement of Cytokine and Activation Receptor Triggering for Cytotoxic Control of Murine Cytomegalovirus by NK Cells.
Volume: 11
Issue: 12
Pages: e1005323
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
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First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
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First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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