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Search results 1 to 100 out of 638 for Hdac3

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Hits by Pathway

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Hits by Category

Type Details Score
Gene
8841 | HDAC3
Type: gene
Organism: human
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Gene
84578 | Hdac3
Type: gene
Organism: rat
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Gene
738624 | HDAC3
Type: gene
Organism: chimpanzee
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Gene
478040 | HDAC3
Type: gene
Organism: dog, domestic
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Gene
404125 | HDAC3
Type: gene
Organism: cattle
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Gene
395506 | HDAC3
Type: gene
Organism: chicken
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Gene
393965 | hdac3
Type: gene
Organism: zebrafish
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Gene
704467 | HDAC3
Type: gene
Organism: macaque, rhesus
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Gene
549637 | hdac3
Type: gene
Organism: frog, western clawed
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Protein Coding Gene
MGI:1343091 | Hdac3
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
Probe: MGI:6194049
Assay Type: Immunohistochemistry
Annotation Date: 2018-08-10
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3102528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6194076
Age: postnatal adult
Image: 2 HDAC3
Note: Authors report pronounced enrichment of expression around the nucleolus.
Specimen Label: 2 HDAC3
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
Probe: MGI:6194049
Assay Type: Immunohistochemistry
Annotation Date: 2018-08-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160331
Pattern: Regionally restricted
Stage: TS01
Assay Id: MGI:6194076
Age: embryonic day 0.5
Image: 1A HDAC3 1-Cell
Note: Expression in pronucleus/nucleus.
Specimen Label: 1A HDAC3 1-Cell
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:6194049
Assay Type: Immunohistochemistry
Annotation Date: 2018-08-10
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:318653
Pattern: Regionally restricted
Stage: TS03
Assay Id: MGI:6194076
Age: embryonic day 2.5
Image: 1A HDAC3 8-Cell
Note: Authors state the intensity of nuclear expression displayed a progressive decrease during preimplantation development
Specimen Label: 1A HDAC3 8-Cell
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
Probe: MGI:6194049
Assay Type: Immunohistochemistry
Annotation Date: 2018-08-10
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:160404
Pattern: Regionally restricted
Stage: TS04
Assay Id: MGI:6194076
Age: embryonic day 3.0
Image: 1A HDAC3 Morula
Note: Authors state the intensity of nuclear expression displayed a progressive decrease during preimplantation development
Specimen Label: 1A HDAC3 Morula
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
Probe: MGI:6194049
Assay Type: Immunohistochemistry
Annotation Date: 2018-08-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3102528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6194076
Age: postnatal adult
Image: 1A HDAC3 Oocyte
Note: Expression concentrated in nucleus.
Specimen Label: 1A HDAC3 Oocyte
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:6194049
Assay Type: Immunohistochemistry
Annotation Date: 2018-08-10
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:318643
Pattern: Regionally restricted
Stage: TS03
Assay Id: MGI:6194076
Age: embryonic day 2.0
Image: 1A HDAC3 4-Cell
Note: Authors state the intensity of nuclear expression displayed a progressive decrease during preimplantation development
Specimen Label: 1A HDAC3 4-Cell
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:6194049
Assay Type: Immunohistochemistry
Annotation Date: 2018-08-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Pattern: Regionally restricted
Stage: TS02
Assay Id: MGI:6194076
Age: embryonic day 1.0
Image: 1A HDAC3 2-Cell
Note: Authors state the intensity of nuclear expression displayed a progressive decrease during preimplantation development
Specimen Label: 1A HDAC3 2-Cell
Detected: true
Specimen Num: 3
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Publication
32760002 | J:294730
First Author: Nguyen HCB
Year: 2020
Journal: Nature
Title: Dichotomous engagement of HDAC3 activity governs inflammatory responses.
Volume: 584
Issue: 7820
Pages: 286-290
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Publication
29035278 | J:252596
First Author: Janardhan HP
Year: 2017
Journal: J Clin Invest
Title: Hdac3 regulates lymphovenous and lymphatic valve formation.
Volume: 127
Issue: 11
Pages: 4193-4206
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Publication
21228185 | J:168224
First Author: McQuown SC
Year: 2011
Journal: J Neurosci
Title: HDAC3 is a critical negative regulator of long-term memory formation.
Volume: 31
Issue: 2
Pages: 764-74
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Publication
22561686 | J:187466
First Author: Sun Z
Year: 2012
Journal: Nat Med
Title: Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration.
Volume: 18
Issue: 6
Pages: 934-42
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Publication
27068467 | J:235180
First Author: Goldfarb Y
Year: 2016
Journal: Cell Rep
Title: HDAC3 Is a Master Regulator of mTEC Development.
Volume: 15
Issue: 3
Pages: 651-665
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Publication
32731255 | J:297402
First Author: Wu SE
Year: 2020
Journal: Nature
Title: Microbiota-derived metabolite promotes HDAC3 activity in the gut.
Volume: 586
Issue: 7827
Pages: 108-112
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Publication
23575859 | J:196668
First Author: Rogge GA
Year: 2013
Journal: J Neurosci
Title: HDAC3 is a negative regulator of cocaine-context-associated memory formation.
Volume: 33
Issue: 15
Pages: 6623-32
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Publication
23921131 | J:201622
First Author: Summers AR
Year: 2013
Journal: J Clin Invest
Title: HDAC3 is essential for DNA replication in hematopoietic progenitor cells.
Volume: 123
Issue: 7
Pages: 3112-23
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Publication
32971093 | J:305086
 
First Author: Schmitt HM
Year: 2020
Journal: Exp Eye Res
Title: Targeting HDAC3 in the DBA/2J spontaneous mouse model of glaucoma.
Volume: 200
Pages: 108244
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Publication
33454009 | J:304262
First Author: Molstad DHH
Year: 2020
Journal: J Biol Chem
Title: Hdac3 regulates bone modeling by suppressing osteoclast responsiveness to RANKL.
Volume: 295
Issue: 51
Pages: 17713-17723
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Publication
31693860 | J:298523
First Author: Lagosz KB
Year: 2020
Journal: J Dent Res
Title: HDAC3 Regulates Gingival Fibroblast Inflammatory Responses in Periodontitis.
Volume: 99
Issue: 1
Pages: 98-106
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Publication
21030595 | J:221556
First Author: Chini CC
Year: 2010
Journal: J Biol Chem
Title: HDAC3 is negatively regulated by the nuclear protein DBC1.
Volume: 285
Issue: 52
Pages: 40830-7
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Publication
30626716 | J:269518
 
First Author: Kim TH
Year: 2019
Journal: Sci Transl Med
Title: Loss of HDAC3 results in nonreceptive endometrium and female infertility.
Volume: 11
Issue: 474
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Publication
36602872 | J:338007
 
First Author: Eshleman EM
Year: 2023
Journal: J Clin Invest
Title: Intestinal epithelial HDAC3 and MHC class II coordinate microbiota-specific immunity.
Volume: 133
Issue: 4
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Publication
21075309 | J:166832
First Author: Bhaskara S
Year: 2010
Journal: Cancer Cell
Title: Hdac3 is essential for the maintenance of chromatin structure and genome stability.
Volume: 18
Issue: 5
Pages: 436-47
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Publication
27279370 | J:315918
First Author: Philips RL
Year: 2016
Journal: J Immunol
Title: HDAC3 Is Required for the Downregulation of RORγt during Thymocyte Positive Selection.
Volume: 197
Issue: 2
Pages: 541-54
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Publication
30517863 | J:271183
First Author: Rosenberg LH
Year: 2018
Journal: Cell Rep
Title: HDAC3 Regulates the Transition to the Homeostatic Myelinating Schwann Cell State.
Volume: 25
Issue: 10
Pages: 2755-2765.e5
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Publication
28771976 | J:245486
First Author: Zhu X
Year: 2017
Journal: Aging Cell
Title: HDAC3 negatively regulates spatial memory in a mouse model of Alzheimer's disease.
Volume: 16
Issue: 5
Pages: 1073-1082
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Publication
26859354 | J:240077
First Author: Zhang L
Year: 2016
Journal: Dev Cell
Title: Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch.
Volume: 36
Issue: 3
Pages: 316-30
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Publication
24268577 | J:206152
First Author: Sun Z
Year: 2013
Journal: Mol Cell
Title: Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor.
Volume: 52
Issue: 6
Pages: 769-82
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Publication
30626694 | J:273018
First Author: Philips RL
Year: 2019
Journal: J Immunol
Title: Cutting Edge: HDAC3 Protects Double-Positive Thymocytes from P2X7 Receptor-Induced Cell Death.
Volume: 202
Issue: 4
Pages: 1033-1038
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Publication
26077467 | J:223026
 
First Author: Choi HK
Year: 2015
Journal: Nat Commun
Title: Programmed cell death 5 mediates HDAC3 decay to promote genotoxic stress response.
Volume: 6
Pages: 7390
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Publication
29689264 | J:273706
First Author: Whitt J
Year: 2018
Journal: Gastroenterology
Title: Disruption of Epithelial HDAC3 in Intestine Prevents Diet-Induced Obesity in Mice.
Volume: 155
Issue: 2
Pages: 501-513
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Publication
29449454 | J:273932
First Author: Shu G
Year: 2018
Journal: Learn Mem
Title: Deleting HDAC3 rescues long-term memory impairments induced by disruption of the neuron-specific chromatin remodeling subunit BAF53b.
Volume: 25
Issue: 3
Pages: 109-114
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Publication
16982804 | J:114550
First Author: Zeng L
Year: 2006
Journal: J Cell Biol
Title: HDAC3 is crucial in shear- and VEGF-induced stem cell differentiation toward endothelial cells.
Volume: 174
Issue: 7
Pages: 1059-69
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Publication
31757939 | J:283938
First Author: Dávalos-Salas M
Year: 2019
Journal: Nat Commun
Title: Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity.
Volume: 10
Issue: 1
Pages: 5291
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Publication
32374402 | J:302518
 
First Author: Tay RE
Year: 2020
Journal: J Exp Med
Title: Hdac3 is an epigenetic inhibitor of the cytotoxicity program in CD8 T cells.
Volume: 217
Issue: 7
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Publication
36930718 | J:334294
First Author: Eichner LJ
Year: 2023
Journal: Sci Adv
Title: HDAC3 is critical in tumor development and therapeutic resistance in Kras-mutant non-small cell lung cancer.
Volume: 9
Issue: 11
Pages: eadd3243
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Publication
32467224 | J:297718
First Author: Szigety KM
Year: 2020
Journal: Genes Dev
Title: HDAC3 ensures stepwise epidermal stratification via NCoR/SMRT-reliant mechanisms independent of its histone deacetylase activity.
Volume: 34
Issue: 13-14
Pages: 973-988
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Publication
32863951 | J:339053
First Author: Liao Y
Year: 2020
Journal: Theranostics
Title: HDAC3 inhibition ameliorates ischemia/reperfusion-induced brain injury by regulating the microglial cGAS-STING pathway.
Volume: 10
Issue: 21
Pages: 9644-9662
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Publication
26211746 | J:260674
First Author: McGee-Lawrence ME
Year: 2016
Journal: J Bone Miner Res
Title: Hdac3 Deficiency Increases Marrow Adiposity and Induces Lipid Storage and Glucocorticoid Metabolism in Osteochondroprogenitor Cells.
Volume: 31
Issue: 1
Pages: 116-28
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Publication
25666992 | J:315820
 
First Author: McGee-Lawrence ME
Year: 2015
Journal: Mol Cell Endocrinol
Title: Conditional deletion of Hdac3 in osteoprogenitor cells attenuates diet-induced systemic metabolic dysfunction.
Volume: 410
Pages: 42-51
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Publication
22802645 | J:188513
First Author: Chen X
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages.
Volume: 109
Issue: 42
Pages: E2865-74
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Publication
33939832 | J:307384
First Author: Yin H
Year: 2021
Journal: Nucleic Acids Res
Title: HDAC3 controls male fertility through enzyme-independent transcriptional regulation at the meiotic exit of spermatogenesis.
Volume: 49
Issue: 9
Pages: 5106-5123
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Publication
28733645 | J:246437
First Author: Ferrari A
Year: 2017
Journal: Nat Commun
Title: HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning.
Volume: 8
Issue: 1
Pages: 93
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Publication
21808063 | J:176726
First Author: Sun Z
Year: 2011
Journal: J Biol Chem
Title: Diet-induced lethality due to deletion of the Hdac3 gene in heart and skeletal muscle.
Volume: 286
Issue: 38
Pages: 33301-9
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Publication
31097476 | J:277562
First Author: Ji H
Year: 2019
Journal: Cancer Res
Title: HDAC3 Deficiency Promotes Liver Cancer through a Defect in H3K9ac/H3K9me3 Transition.
Volume: 79
Issue: 14
Pages: 3676-3688
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Publication
28840938 | J:337659
First Author: McGee-Lawrence ME
Year: 2018
Journal: J Cell Physiol
Title: Loss of Hdac3 in osteoprogenitors increases bone expression of osteoprotegerin, improving systemic insulin sensitivity.
Volume: 233
Issue: 4
Pages: 2671-2680
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Publication
30657451 | J:293937
   
First Author: Philips RL
Year: 2019
Journal: Elife
Title: HDAC3 restrains CD8-lineage genes to maintain a bi-potential state in CD4+CD8+ thymocytes for CD4-lineage commitment.
Volume: 8
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Publication
37752418 | J:346765
First Author: Xu Y
Year: 2023
Journal: BMC Cancer
Title: Hepatocyte-specific HDAC3 ablation promotes hepatocellular carcinoma in females by suppressing Foxa1/2.
Volume: 23
Issue: 1
Pages: 906
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Publication
22347433 | J:283308
First Author: Moumné L
Year: 2012
Journal: PLoS One
Title: Genetic knock-down of HDAC3 does not modify disease-related phenotypes in a mouse model of Huntington's disease.
Volume: 7
Issue: 2
Pages: e31080
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Publication
33602824 | J:313823
First Author: Campbell RR
Year: 2021
Journal: J Neurosci
Title: HDAC3 Activity within the Nucleus Accumbens Regulates Cocaine-Induced Plasticity and Behavior in a Cell-Type-Specific Manner.
Volume: 41
Issue: 13
Pages: 2814-2827
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Publication
31844300 | J:284280
First Author: Wang H
Year: 2019
Journal: Nat Commun
Title: HDAC3 maintains oocyte meiosis arrest by repressing amphiregulin expression before the LH surge.
Volume: 10
Issue: 1
Pages: 5719
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Publication
27866836 | J:251961
First Author: Papazyan R
Year: 2016
Journal: Cell Metab
Title: Physiological Suppression of Lipotoxic Liver Damage by Complementary Actions of HDAC3 and SCAP/SREBP.
Volume: 24
Issue: 6
Pages: 863-874
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Publication
25161285 | J:216390
First Author: Jiang Y
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: HDAC3 controls gap 2/mitosis progression in adult neural stem/progenitor cells by regulating CDK1 levels.
Volume: 111
Issue: 37
Pages: 13541-6
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Publication
26776516 | J:240095
First Author: Shi G
Year: 2016
Journal: Cell Rep
Title: Distinct Roles of HDAC3 in the Core Circadian Negative Feedback Loop Are Critical for Clock Function.
Volume: 14
Issue: 4
Pages: 823-834
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Publication
30397132 | J:267298
First Author: Janczura KJ
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Inhibition of HDAC3 reverses Alzheimer's disease-related pathologies in vitro and in the 3xTg-AD mouse model.
Volume: 115
Issue: 47
Pages: E11148-E11157
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Publication
29523594 | J:262273
 
First Author: Yan Y
Year: 2018
Journal: EMBO Mol Med
Title: Dual inhibition of AKT-mTOR and AR signaling by targeting HDAC3 in PTEN- or SPOP-mutated prostate cancer.
Volume: 10
Issue: 4
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Publication
30804042 | J:274340
First Author: Shapiro MJ
Year: 2019
Journal: J Immunol
Title: NKAP Must Associate with HDAC3 to Regulate Hematopoietic Stem Cell Maintenance and Survival.
Volume: 202
Issue: 8
Pages: 2287-2295
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Publication
27991918 | J:250777
First Author: Hong S
Year: 2017
Journal: Nat Med
Title: Dissociation of muscle insulin sensitivity from exercise endurance in mice by HDAC3 depletion.
Volume: 23
Issue: 2
Pages: 223-234
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Publication
34244427 | J:307965
 
First Author: Zhang F
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: HIPK2 phosphorylates HDAC3 for NF-κB acetylation to ameliorate colitis-associated colorectal carcinoma and sepsis.
Volume: 118
Issue: 28
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Publication
27542279 | J:317387
First Author: Chen WB
Year: 2016
Journal: Oncotarget
Title: Conditional ablation of HDAC3 in islet beta cells results in glucose intolerance and enhanced susceptibility to STZ-induced diabetes.
Volume: 7
Issue: 36
Pages: 57485-57497
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Publication
36801398 | J:339461
First Author: Tao Q
Year: 2023
Journal: Lab Invest
Title: HDAC3 Controls Liver Homeostasis More by Facilitating Deoxyribonucleic Acid Damage Repair than by Regulating Transcription in Hepatocytes.
Volume: 103
Issue: 6
Pages: 100120
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Publication
28300292 | J:262229
First Author: Večeřa J
Year: 2018
Journal: J Cell Physiol
Title: HDAC1 and HDAC3 underlie dynamic H3K9 acetylation during embryonic neurogenesis and in schizophrenia-like animals.
Volume: 233
Issue: 1
Pages: 530-548
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Publication
33311522 | J:309278
First Author: Molstad DHH
Year: 2020
Journal: Sci Rep
Title: Hdac3 deletion in myeloid progenitor cells enhances bone healing in females and limits osteoclast fusion via Pmepa1.
Volume: 10
Issue: 1
Pages: 21804
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Publication
28074065 | J:241030
First Author: Mehdipour P
Year: 2017
Journal: Leukemia
Title: HDAC3 activity is required for initiation of leukemogenesis in acute promyelocytic leukemia.
Volume: 31
Issue: 4
Pages: 995-997
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Publication
24594842 | J:210660
First Author: Venkatraman A
Year: 2014
Journal: Hum Mol Genet
Title: The histone deacetylase HDAC3 is essential for Purkinje cell function, potentially complicating the use of HDAC inhibitors in SCA1.
Volume: 23
Issue: 14
Pages: 3733-45
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Publication
37735154 | J:340776
First Author: Shosha E
Year: 2023
Journal: Cell Death Dis
Title: The arginase 1/ornithine decarboxylase pathway suppresses HDAC3 to ameliorate the myeloid cell inflammatory response: implications for retinal ischemic injury.
Volume: 14
Issue: 9
Pages: 621
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Publication
18625706 | J:142328
First Author: Trivedi CM
Year: 2008
Journal: J Biol Chem
Title: Transgenic overexpression of Hdac3 in the heart produces increased postnatal cardiac myocyte proliferation but does not induce hypertrophy.
Volume: 283
Issue: 39
Pages: 26484-9
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Publication
19204783 | J:158064
First Author: Gupta P
Year: 2009
Journal: PLoS One
Title: HDAC3 as a molecular chaperone for shuttling phosphorylated TR2 to PML: a novel deacetylase activity-independent function of HDAC3.
Volume: 4
Issue: 2
Pages: e4363
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Publication
28188262 | J:241879
First Author: Collins CM
Year: 2017
Journal: Dis Model Mech
Title: MAPK signaling pathways and HDAC3 activity are disrupted during differentiation of emerin-null myogenic progenitor cells.
Volume: 10
Issue: 4
Pages: 385-397
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Publication
23798429 | J:198816
First Author: Jain N
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Cell geometric constraints induce modular gene-expression patterns via redistribution of HDAC3 regulated by actomyosin contractility.
Volume: 110
Issue: 28
Pages: 11349-54
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Publication
19341714 | J:148346
First Author: Zhao HL
Year: 2009
Journal: Biochem Biophys Res Commun
Title: The Ski protein can inhibit ligand induced RARalpha and HDAC3 degradation in the retinoic acid signaling pathway.
Volume: 383
Issue: 1
Pages: 119-24
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Publication
16371367 | J:116423
First Author: Gao Z
Year: 2006
Journal: J Biol Chem
Title: Regulation of nuclear translocation of HDAC3 by IkappaBalpha is required for tumor necrosis factor inhibition of peroxisome proliferator-activated receptor gamma function.
Volume: 281
Issue: 7
Pages: 4540-7
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Publication
29634312 | J:266070
First Author: Zhang J
Year: 2018
Journal: Am J Physiol Endocrinol Metab
Title: HDAC3 inhibition in diabetic mice may activate Nrf2 preventing diabetes-induced liver damage and FGF21 synthesis and secretion leading to aortic protection.
Volume: 315
Issue: 2
Pages: E150-E162
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Publication
27651463 | J:247055
First Author: Nanou A
Year: 2017
Journal: Nucleic Acids Res
Title: The dual role of LSD1 and HDAC3 in STAT5-dependent transcription is determined by protein interactions, binding affinities, motifs and genomic positions.
Volume: 45
Issue: 1
Pages: 142-154
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Publication
16129885 | J:101580
First Author: Somech R
Year: 2005
Journal: J Cell Sci
Title: The nuclear-envelope protein and transcriptional repressor LAP2beta interacts with HDAC3 at the nuclear periphery, and induces histone H4 deacetylation.
Volume: 118
Issue: Pt 17
Pages: 4017-25
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Publication
23292142 | J:252085
First Author: You SH
Year: 2013
Journal: Nat Struct Mol Biol
Title: Nuclear receptor co-repressors are required for the histone-deacetylase activity of HDAC3 in vivo.
Volume: 20
Issue: 2
Pages: 182-7
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Publication
20427468 | J:162512
First Author: You SH
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