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Search results 1 to 100 out of 477 for Hdac6

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
10013 | HDAC6
Type: gene
Organism: human
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Gene
513602 | HDAC6
Type: gene
Organism: cattle
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Gene
100610515 | HDAC6
Type: gene
Organism: chimpanzee
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Gene
565482 | hdac6
Type: gene
Organism: zebrafish
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Gene
711363 | HDAC6
Type: gene
Organism: macaque, rhesus
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Gene
100379853 | hdac6
Type: gene
Organism: frog, western clawed
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Gene
108348065 | Hdac6
Type: gene
Organism: rat
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Gene
480907 | HDAC6
Type: gene
Organism: dog, domestic
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Protein Coding Gene
MGI:1333752 | Hdac6
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
119369038 | LOC119369038
Type: gene
Organism: human
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Gene
119369039 | LOC119369039
Type: gene
Organism: human
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Gene
119407398 | LOC119407398
Type: gene
Organism: human
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Gene
119407413 | LOC119407413
Type: gene
Organism: human
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Publication
22022450 | J:179588
First Author: Beurel E
Year: 2011
Journal: PLoS One
Title: HDAC6 regulates LPS-tolerance in astrocytes.
Volume: 6
Issue: 10
Pages: e25804
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Publication
24667272 | J:211194
 
First Author: Sánchez de Diego A
Year: 2014
Journal: Nat Commun
Title: Dido3-dependent HDAC6 targeting controls cilium size.
Volume: 5
Pages: 3500
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Publication
19457097 | J:257316
First Author: Perez M
Year: 2009
Journal: J Neurochem
Title: Tau--an inhibitor of deacetylase HDAC6 function.
Volume: 109
Issue: 6
Pages: 1756-66
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Publication
24302573 | J:207921
 
First Author: Chen PB
Year: 2013
Journal: Elife
Title: Hdac6 regulates Tip60-p400 function in stem cells.
Volume: 2
Pages: e01557
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Publication
28854366 | J:254281
First Author: Tseng JH
Year: 2017
Journal: Cell Rep
Title: The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology.
Volume: 20
Issue: 9
Pages: 2169-2183
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Publication
26746851 | J:229929
First Author: Choi SJ
Year: 2016
Journal: EMBO J
Title: HDAC6 regulates cellular viral RNA sensing by deacetylation of RIG-I.
Volume: 35
Issue: 4
Pages: 429-42
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Publication
25330030 | J:223444
First Author: Yan B
Year: 2014
Journal: PLoS One
Title: HDAC6 deacetylase activity is critical for lipopolysaccharide-induced activation of macrophages.
Volume: 9
Issue: 10
Pages: e110718
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Publication
32849638 | J:308200
 
First Author: Wang Y
Year: 2020
Journal: Front Immunol
Title: HDAC6 Mediates Poly (I:C)-Induced TBK1 and Akt Phosphorylation in Macrophages.
Volume: 11
Pages: 1776
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Publication
18794144 | J:264466
First Author: Lee YS
Year: 2008
Journal: Cancer Res
Title: The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis.
Volume: 68
Issue: 18
Pages: 7561-9
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Publication
30102568 | J:286737
First Author: Lieber AD
Year: 2019
Journal: FASEB J
Title: Loss of HDAC6 alters gut microbiota and worsens obesity.
Volume: 33
Issue: 1
Pages: 1098-1109
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Publication
17389687 | J:122042
First Author: Tran AD
Year: 2007
Journal: J Cell Sci
Title: HDAC6 deacetylation of tubulin modulates dynamics of cellular adhesions.
Volume: 120
Issue: Pt 8
Pages: 1469-79
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Publication
26507311 | J:234450
 
First Author: Zhu T
Year: 2016
Journal: Neurobiol Aging
Title: HDAC6 alleviates prion peptide-mediated neuronal death via modulating PI3K-Akt-mTOR pathway.
Volume: 37
Pages: 91-102
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Publication
35534985 | J:326515
First Author: Phorl S
Year: 2022
Journal: Cancer Sci
Title: Opposing roles of HDAC6 in liver regeneration and hepatocarcinogenesis.
Volume: 113
Issue: 7
Pages: 2311-2322
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Publication
35575093 | J:327725
 
First Author: Lin YH
Year: 2022
Journal: J Clin Invest
Title: HDAC6 modulates myofibril stiffness and diastolic function of the heart.
Volume: 132
Issue: 10
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Publication
20075865 | J:158377
First Author: Lee JY
Year: 2010
Journal: EMBO J
Title: HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy.
Volume: 29
Issue: 5
Pages: 969-80
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Publication
29415205 | J:285515
First Author: Benoy V
Year: 2018
Journal: Brain
Title: HDAC6 is a therapeutic target in mutant GARS-induced Charcot-Marie-Tooth disease.
Volume: 141
Issue: 3
Pages: 673-687
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Gene
119407402 | LOC119407402
Type: gene
Organism: human
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Publication
28251586 | J:319489
First Author: Zhang X
Year: 2017
Journal: Protein Cell
Title: Overexpression of Hdac6 extends reproductive lifespan in mice.
Volume: 8
Issue: 5
Pages: 360-364
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Publication
32697819 | J:305623
 
First Author: Osseni A
Year: 2020
Journal: J Cell Biol
Title: HDAC6 regulates microtubule stability and clustering of AChRs at neuromuscular junctions.
Volume: 219
Issue: 8
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Publication
38409164 | J:345971
First Author: Ranjbarvaziri S
Year: 2024
Journal: Nat Commun
Title: Targeting HDAC6 to treat heart failure with preserved ejection fraction in mice.
Volume: 15
Issue: 1
Pages: 1352
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Publication
26869226 | J:246268
First Author: Núñez-Andrade N
Year: 2016
Journal: J Cell Sci
Title: HDAC6 regulates the dynamics of lytic granules in cytotoxic T lymphocytes.
Volume: 129
Issue: 7
Pages: 1305-1311
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Publication
32796032 | J:298721
First Author: Xie S
Year: 2020
Journal: J Biol Chem
Title: HDAC6 regulates antibody-dependent intracellular neutralization of viruses via deacetylation of TRIM21.
Volume: 295
Issue: 42
Pages: 14343-14351
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Publication
22328923 | J:224059
First Author: Fukada M
Year: 2012
Journal: PLoS One
Title: Loss of deacetylation activity of Hdac6 affects emotional behavior in mice.
Volume: 7
Issue: 2
Pages: e30924
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Publication
32147437 | J:299195
 
First Author: Picci C
Year: 2020
Journal: Exp Neurol
Title: HDAC6 inhibition promotes α-tubulin acetylation and ameliorates CMT2A peripheral neuropathy in mice.
Volume: 328
Pages: 113281
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Publication
24882211 | J:215334
First Author: Zhang M
Year: 2014
Journal: Mol Cell
Title: HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutSα.
Volume: 55
Issue: 1
Pages: 31-46
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Publication
28273454 | J:251370
First Author: Mobley RJ
Year: 2017
Journal: Cell Rep
Title: MAP3K4 Controls the Chromatin Modifier HDAC6 during Trophoblast Stem Cell Epithelial-to-Mesenchymal Transition.
Volume: 18
Issue: 10
Pages: 2387-2400
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GXD Expression
GXD Expression
   
Probe: MGI:6174738
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6190490
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Hdac6
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6174738
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6190490
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Hdac6
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6174738
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6190490
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Hdac6
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6174738
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6190490
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Hdac6
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6174738
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190490
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Hdac6
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6174738
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190490
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Hdac6
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6174738
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190490
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Hdac6
Detected: true
Specimen Num: 7
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Publication
32943500 | J:297637
 
First Author: Magupalli VG
Year: 2020
Journal: Science
Title: HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation.
Volume: 369
Issue: 6510
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Publication
23184605 | J:234763
First Author: Govindarajan N
Year: 2013
Journal: EMBO Mol Med
Title: Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease.
Volume: 5
Issue: 1
Pages: 52-63
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Publication
21785432 | J:174508
First Author: d'Ydewalle C
Year: 2011
Journal: Nat Med
Title: HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1-induced Charcot-Marie-Tooth disease.
Volume: 17
Issue: 8
Pages: 968-74
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Publication
31311988 | J:283831
First Author: Rosenjack J
Year: 2019
Journal: Sci Rep
Title: HDAC6 depletion improves cystic fibrosis mouse airway responses to bacterial challenge.
Volume: 9
Issue: 1
Pages: 10282
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Publication
26210454 | J:232518
First Author: Kim HJ
Year: 2015
Journal: Biochem Biophys Res Commun
Title: HDAC6 maintains mitochondrial connectivity under hypoxic stress by suppressing MARCH5/MITOL dependent MFN2 degradation.
Volume: 464
Issue: 4
Pages: 1235-40
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Publication
17785525 | J:125219
First Author: Boyault C
Year: 2007
Journal: Genes Dev
Title: HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates.
Volume: 21
Issue: 17
Pages: 2172-81
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Publication
27737934 | J:238090
First Author: Fukuda T
Year: 2016
Journal: EMBO Rep
Title: Rescue of CAMDI deletion-induced delayed radial migration and psychiatric behaviors by HDAC6 inhibitor.
Volume: 17
Issue: 12
Pages: 1785-1798
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Publication
24858848 | J:214300
First Author: Demos-Davies KM
Year: 2014
Journal: Am J Physiol Heart Circ Physiol
Title: HDAC6 contributes to pathological responses of heart and skeletal muscle to chronic angiotensin-II signaling.
Volume: 307
Issue: 2
Pages: H252-8
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Publication
29890133 | J:270593
First Author: Jung S
Year: 2018
Journal: Biochem Biophys Res Commun
Title: HDAC6 regulates thermogenesis of brown adipocytes through activating PKA to induce UCP1 expression.
Volume: 503
Issue: 1
Pages: 285-290
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Publication
31068376 | J:276813
First Author: Kalinski AL
Year: 2019
Journal: J Cell Biol
Title: Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition.
Volume: 218
Issue: 6
Pages: 1871-1890
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Publication
23580651 | J:315267
First Author: Gal J
Year: 2013
Journal: J Biol Chem
Title: HDAC6 regulates mutant SOD1 aggregation through two SMIR motifs and tubulin acetylation.
Volume: 288
Issue: 21
Pages: 15035-45
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Publication
33329575 | J:308871
 
First Author: Maharaj K
Year: 2020
Journal: Front Immunol
Title: HDAC6 Inhibition Alleviates CLL-Induced T-Cell Dysfunction and Enhances Immune Checkpoint Blockade Efficacy in the Eμ-TCL1 Model.
Volume: 11
Pages: 590072
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Publication
29054408 | J:250624
First Author: Park SY
Year: 2017
Journal: Biochem Biophys Res Commun
Title: HDAC6 deficiency induces apoptosis in mesenchymal stem cells through p53 K120 acetylation.
Volume: 494
Issue: 1-2
Pages: 51-56
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Publication
38043200 | J:344735
 
First Author: Lee SI
Year: 2024
Journal: Biochem Biophys Res Commun
Title: HDAC6 preserves BNIP3 expression and mitochondrial integrity by deacetylating p53 at lysine 320.
Volume: 691
Pages: 149320
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Publication
19033385 | J:146085
First Author: Kalveram B
Year: 2008
Journal: J Cell Sci
Title: The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition.
Volume: 121
Issue: Pt 24
Pages: 4079-88
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Publication
19893491 | J:163064
First Author: Wickström SA
Year: 2010
Journal: EMBO J
Title: CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin.
Volume: 29
Issue: 1
Pages: 131-44
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Publication
33004910 | J:297453
First Author: Corey DA
Year: 2020
Journal: Sci Rep
Title: Alleviation of depression-like behavior in a cystic fibrosis mouse model by Hdac6 depletion.
Volume: 10
Issue: 1
Pages: 16278
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Publication
32973784 | J:306359
 
First Author: Wang Y
Year: 2020
Journal: Front Immunol
Title: HDAC6 Mediates Macrophage iNOS Expression and Excessive Nitric Oxide Production in the Blood During Endotoxemia.
Volume: 11
Pages: 1893
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Publication
21847094 | J:177198
First Author: Kaluza D
Year: 2011
Journal: EMBO J
Title: Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin.
Volume: 30
Issue: 20
Pages: 4142-56
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Publication
22457490 | J:183860
First Author: Espallergues J
Year: 2012
Journal: J Neurosci
Title: HDAC6 regulates glucocorticoid receptor signaling in serotonin pathways with critical impact on stress resilience.
Volume: 32
Issue: 13
Pages: 4400-16
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Publication
23364049 | J:194977
First Author: Taes I
Year: 2013
Journal: Hum Mol Genet
Title: Hdac6 deletion delays disease progression in the SOD1G93A mouse model of ALS.
Volume: 22
Issue: 9
Pages: 1783-90
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Publication
31264358 | J:277717
First Author: Lundh M
Year: 2019
Journal: EMBO Rep
Title: Afadin is a scaffold protein repressing insulin action via HDAC6 in adipose tissue.
Volume: 20
Issue: 8
Pages: e48216
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Publication
31218594 | J:294421
First Author: Ishiba R
Year: 2019
Journal: J Mol Histol
Title: Faster regeneration associated to high expression of Fam65b and Hdac6 in dysferlin-deficient mouse.
Volume: 50
Issue: 4
Pages: 375-387
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Publication
27506979 | J:238563
First Author: Ota S
Year: 2016
Journal: Hum Mol Genet
Title: HDAC6 deficiency or inhibition blocks FGFR3 accumulation and improves bone growth in a model of achondroplasia.
Volume: 25
Issue: 19
Pages: 4227-4243
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Publication
23152903 | J:195024
First Author: Liu W
Year: 2012
Journal: PLoS One
Title: HDAC6 regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation in renal epithelial cells.
Volume: 7
Issue: 11
Pages: e49418
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Publication
34326423 | J:321289
First Author: Onishi T
Year: 2021
Journal: Sci Rep
Title: A novel orally active HDAC6 inhibitor T-518 shows a therapeutic potential for Alzheimer's disease and tauopathy in mice.
Volume: 11
Issue: 1
Pages: 15423
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Publication
21677773 | J:174136
First Author: Bobrowska A
Year: 2011
Journal: PLoS One
Title: Hdac6 knock-out increases tubulin acetylation but does not modify disease progression in the R6/2 mouse model of Huntington's disease.
Volume: 6
Issue: 6
Pages: e20696
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Publication
25482409 | J:319873
First Author: Wang D
Year: 2015
Journal: Protein Cell
Title: Overexpression of Hdac6 enhances resistance to virus infection in embryonic stem cells and in mice.
Volume: 6
Issue: 2
Pages: 152-6
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Publication
25070956 | J:215783
First Author: Deakin NO
Year: 2014
Journal: J Cell Biol
Title: Paxillin inhibits HDAC6 to regulate microtubule acetylation, Golgi structure, and polarized migration.
Volume: 206
Issue: 3
Pages: 395-413
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Publication
19641021 | J:164485
First Author: Purev E
Year: 2009
Journal: Mol Biol Cell
Title: c-Cbl and Cbl-b act redundantly to protect osteoclasts from apoptosis and to displace HDAC6 from beta-tubulin, stabilizing microtubules and podosomes.
Volume: 20
Issue: 18
Pages: 4021-30
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Publication
22792322 | J:189648
First Author: Fusco C
Year: 2012
Journal: PLoS One
Title: The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome.
Volume: 7
Issue: 7
Pages: e40440
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Publication
28737768 | J:246354
First Author: Bitler BG
Year: 2017
Journal: Nat Cell Biol
Title: ARID1A-mutated ovarian cancers depend on HDAC6 activity.
Volume: 19
Issue: 8
Pages: 962-973
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Publication
32275885 | J:288356
First Author: Ran J
Year: 2020
Journal: Dev Cell
Title: ASK1-Mediated Phosphorylation Blocks HDAC6 Ubiquitination and Degradation to Drive the Disassembly of Photoreceptor Connecting Cilia.
Volume: 53
Issue: 3
Pages: 287-299.e5
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Protein
Q8CGC3
Organism: Mus musculus/domesticus
Length: 1152  
Fragment?: false
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Publication
22504143 | J:183928
First Author: Kamemura K
Year: 2012
Journal: FEBS Lett
Title: Depression of mitochondrial metabolism by downregulation of cytoplasmic deacetylase, HDAC6.
Volume: 586
Issue: 9
Pages: 1379-83
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Publication
25271058 | J:218417
First Author: Lee JY
Year: 2014
Journal: J Cell Sci
Title: MFN1 deacetylation activates adaptive mitochondrial fusion and protects metabolically challenged mitochondria.
Volume: 127
Issue: Pt 22
Pages: 4954-63
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Publication
18180281 | J:132629
First Author: Zhang Y
Year: 2008
Journal: Mol Cell Biol
Title: Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally.
Volume: 28
Issue: 5
Pages: 1688-701
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Publication
17938201 | J:128914
First Author: Gao YS
Year: 2007
Journal: Mol Cell Biol
Title: Histone deacetylase 6 regulates growth factor-induced actin remodeling and endocytosis.
Volume: 27
Issue: 24
Pages: 8637-47
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Publication
32640546 | J:304218
 
First Author: Zanin M
Year: 2020
Journal: Viruses
Title: Histone Deacetylase 6 Knockout Mice Exhibit Higher Susceptibility to Influenza A Virus Infection.
Volume: 12
Issue: 7
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Publication
28674407 | J:257233
First Author: Boucherat O
Year: 2017
Journal: Sci Rep
Title: HDAC6: A Novel Histone Deacetylase Implicated in Pulmonary Arterial Hypertension.
Volume: 7
Issue: 1
Pages: 4546
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Publication
22210316 | J:196785
First Author: Winkler R
Year: 2012
Journal: Diabetes
Title: Histone deacetylase 6 (HDAC6) is an essential modifier of glucocorticoid-induced hepatic gluconeogenesis.
Volume: 61
Issue: 2
Pages: 513-23
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Publication
24146251 | J:219319
First Author: Zhang D
Year: 2014
Journal: Circulation
Title: Activation of histone deacetylase-6 induces contractile dysfunction through derailment of α-tubulin proteostasis in experimental and human atrial fibrillation.
Volume: 129
Issue: 3
Pages: 346-58
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Publication
29980788 | J:267408
First Author: Li A
Year: 2018
Journal: Oncogene
Title: Histone deacetylase 6 regulates the immunosuppressive properties of cancer-associated fibroblasts in breast cancer through the STAT3-COX2-dependent pathway.
Volume: 37
Issue: 45
Pages: 5952-5966
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Publication
29896294 | J:318477
First Author: Yan B
Year: 2018
Journal: Theranostics
Title: Histone deacetylase 6 modulates macrophage infiltration during inflammation.
Volume: 8
Issue: 11
Pages: 2927-2938
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Publication
25552369 | J:316986
First Author: Dhanyamraju PK
Year: 2015
Journal: Mol Cancer Ther
Title: Histone deacetylase 6 represents a novel drug target in the oncogenic Hedgehog signaling pathway.
Volume: 14
Issue: 3
Pages: 727-39
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Publication
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