Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Mortimer A |
Year: |
1978 |
Journal: |
Mouse News Lett |
Title: |
Hdc - kidney histidine decarboxylase. |
Volume: |
59 |
|
Pages: |
30 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Publication |
First Author: |
Li Y |
Year: |
2023 |
Journal: |
J Allergy Clin Immunol |
Title: |
The Hdc GC box is critical for Hdc gene transcription and histamine-mediated anaphylaxis. |
Volume: |
152 |
Issue: |
1 |
Pages: |
195-204.e3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jindachomthong K |
Year: |
2022 |
Journal: |
Front Mol Neurosci |
Title: |
White matter abnormalities in the Hdc knockout mouse, a model of tic and OCD pathophysiology. |
Volume: |
15 |
|
Pages: |
1037481 |
|
•
•
•
•
•
|
Publication |
First Author: |
Abdurakhmanova S |
Year: |
2017 |
Journal: |
J Comp Neurol |
Title: |
Behavioral and stereological characterization of Hdc KO mice: Relation to Tourette syndrome. |
Volume: |
525 |
Issue: |
16 |
Pages: |
3476-3487 |
|
•
•
•
•
•
|
Publication |
First Author: |
Greferath U |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
The role of histamine in the retina: studies on the Hdc knockout mouse. |
Volume: |
9 |
Issue: |
12 |
Pages: |
e116025 |
|
•
•
•
•
•
|
Publication |
First Author: |
Malzac P |
Year: |
1996 |
Journal: |
Hum Genet |
Title: |
Chromosomal localization of the human and mouse histidine decarboxylase genes by in situ hybridization. Exclusion of the HDC gene from the Prader-Willi syndrome region. |
Volume: |
97 |
Issue: |
3 |
Pages: |
359-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bruneau G |
Year: |
1992 |
Journal: |
Hum Genet |
Title: |
Preparation of a rat brain histidine decarboxylase (HDC) cDNA probe by PCR and assignment of the human HDC gene to chromosome 15. |
Volume: |
90 |
Issue: |
3 |
Pages: |
235-8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6174742 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
|
Stage: |
TS19 |
Assay Id: |
MGI:6190491 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S2 - E11.5 - Hdc |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6174742 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:6190491 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Table S2 - E13.5 - Hdc |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6174742 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689424 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:6190491 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
Table S2 - E15.5 - Hdc |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6174742 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689426 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6190491 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Table S2 - E18.5 - Hdc |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6174742 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190491 |
Age: |
postnatal day 4 |
|
|
Specimen Label: |
Table S2 - P4 - Hdc |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6174742 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190491 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
Table S2 - P14 - Hdc |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6174742 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190491 |
Age: |
postnatal day 28 |
|
|
Specimen Label: |
Table S2 - P28 - Hdc |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Martin SAM |
Year: |
1984 |
Journal: |
Mouse News Lett |
Title: |
Induction of histidine decarboxylase by thyroxine |
Volume: |
70 |
|
Pages: |
75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Morin F |
Year: |
2021 |
Journal: |
J Immunol |
Title: |
Conditional Deletions of Hdc Confirm Roles of Histamine in Anaphylaxis and Circadian Activity but Not in Autoimmune Encephalomyelitis. |
Volume: |
206 |
Issue: |
9 |
Pages: |
2029-2037 |
|
•
•
•
•
•
|
Publication |
First Author: |
Deng L |
Year: |
2015 |
Journal: |
Sci Rep |
Title: |
Histamine deficiency exacerbates myocardial injury in acute myocardial infarction through impaired macrophage infiltration and increased cardiomyocyte apoptosis. |
Volume: |
5 |
|
Pages: |
13131 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhu B |
Year: |
2022 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Abnormal histidine metabolism promotes macrophage lipid accumulation under Ox-LDL condition. |
Volume: |
588 |
|
Pages: |
161-167 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ding S |
Year: |
2018 |
Journal: |
Cell Death Dis |
Title: |
Histamine deficiency aggravates cardiac injury through miR-206/216b-Atg13 axis-mediated autophagic-dependant apoptosis. |
Volume: |
9 |
Issue: |
6 |
Pages: |
694 |
|
•
•
•
•
•
|
Author |
|
•
•
•
•
•
|
Author |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang XD |
Year: |
2011 |
Journal: |
Nat Med |
Title: |
Histamine deficiency promotes inflammation-associated carcinogenesis through reduced myeloid maturation and accumulation of CD11b+Ly6G+ immature myeloid cells. |
Volume: |
17 |
Issue: |
1 |
Pages: |
87-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Abudupataer M |
Year: |
2019 |
Journal: |
J Cell Mol Med |
Title: |
Histamine deficiency delays ischaemic skeletal muscle regeneration via inducing aberrant inflammatory responses and repressing myoblast proliferation. |
Volume: |
23 |
Issue: |
12 |
Pages: |
8392-8409 |
|
•
•
•
•
•
|
Publication |
First Author: |
Walker AK |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Characterization of gastric and neuronal histaminergic populations using a transgenic mouse model. |
Volume: |
8 |
Issue: |
3 |
Pages: |
e60276 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
662
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Fu N |
Year: |
2021 |
Journal: |
Cell Mol Gastroenterol Hepatol |
Title: |
Acute Intestinal Inflammation Depletes/Recruits Histamine-Expressing Myeloid Cells From the Bone Marrow Leading to Exhaustion of MB-HSCs. |
Volume: |
11 |
Issue: |
4 |
Pages: |
1119-1138 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li H |
Year: |
2020 |
Journal: |
J Cell Mol Med |
Title: |
Histamine deficiency facilitates coronary microthrombosis after myocardial infarction by increasing neutrophil-platelet interactions. |
Volume: |
24 |
Issue: |
6 |
Pages: |
3504-3520 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu L |
Year: |
2017 |
Journal: |
Atherosclerosis |
Title: |
Histamine promotes the differentiation of macrophages from CD11b+ myeloid cells and formation of foam cells through a Stat6-dependent pathway. |
Volume: |
263 |
|
Pages: |
42-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamamoto J |
Year: |
1990 |
Journal: |
FEBS Lett |
Title: |
cDNA-derived amino acid sequence of L-histidine decarboxylase from mouse mastocytoma P-815 cells. |
Volume: |
276 |
Issue: |
1-2 |
Pages: |
214-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang X |
Year: |
2023 |
Journal: |
Int Immunopharmacol |
Title: |
Disruption of Histamine-H(1)R signaling exacerbates cardiac microthrombosis after periodontal disease via TLR4/NFκB-p65 pathway. |
Volume: |
123 |
|
Pages: |
110774 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pár G |
Year: |
2003 |
Journal: |
Am J Reprod Immunol |
Title: |
Impaired reproduction of histamine deficient (histidine-decarboxylase knockout) mice is caused predominantly by a decreased male mating behavior. |
Volume: |
50 |
Issue: |
2 |
Pages: |
152-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Martin SA |
Year: |
1984 |
Journal: |
Biochem Genet |
Title: |
A regulatory locus, Hdc-e, determines the response of mouse kidney histidine decarboxylase to estrogen. |
Volume: |
22 |
Issue: |
11-12 |
Pages: |
1037-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ohgoh M |
Year: |
1993 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Enhanced expression of the mouse L-histidine decarboxylase gene with a combination of dexamethasone and 12-O-tetradecanoylphorbol-13-acetate. |
Volume: |
196 |
Issue: |
3 |
Pages: |
1113-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Baldan LC |
Year: |
2014 |
Journal: |
Neuron |
Title: |
Histidine decarboxylase deficiency causes tourette syndrome: parallel findings in humans and mice. |
Volume: |
81 |
Issue: |
1 |
Pages: |
77-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Acevedo SF |
Year: |
2006 |
Journal: |
Behav Brain Res |
Title: |
Anxiety and cognition in female histidine decarboxylase knockout (Hdc(-/-)) mice. |
Volume: |
168 |
Issue: |
1 |
Pages: |
92-9 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen J |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
Aggravated myocardial infarction-induced cardiac remodeling and heart failure in histamine-deficient mice. |
Volume: |
7 |
|
Pages: |
44007 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yan H |
Year: |
2014 |
Journal: |
Nat Commun |
Title: |
Histamine H3 receptors aggravate cerebral ischaemic injury by histamine-independent mechanisms. |
Volume: |
5 |
|
Pages: |
3334 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamamoto J |
Year: |
1993 |
Journal: |
Biochim Biophys Acta |
Title: |
Expression and characterization of recombinant mouse mastocytoma histidine decarboxylase. |
Volume: |
1216 |
Issue: |
3 |
Pages: |
431-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Suzuki-Ishigaki S |
Year: |
2000 |
Journal: |
Nucleic Acids Res |
Title: |
The mouse L-histidine decarboxylase gene: structure and transcriptional regulation by CpG methylation in the promoter region. |
Volume: |
28 |
Issue: |
14 |
Pages: |
2627-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Graf A |
Year: |
2014 |
Journal: |
Am J Physiol Gastrointest Liver Physiol |
Title: |
Knockout of histidine decarboxylase decreases bile duct ligation-induced biliary hyperplasia via downregulation of the histidine decarboxylase/VEGF axis through PKA-ERK1/2 signaling. |
Volume: |
307 |
Issue: |
8 |
Pages: |
G813-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ohtsu H |
Year: |
2002 |
Journal: |
Eur J Immunol |
Title: |
Plasma extravasation induced by dietary supplemented histamine in histamine-free mice. |
Volume: |
32 |
Issue: |
6 |
Pages: |
1698-708 |
|
•
•
•
•
•
|
Publication |
First Author: |
Provensi G |
Year: |
2014 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Satiety factor oleoylethanolamide recruits the brain histaminergic system to inhibit food intake. |
Volume: |
111 |
Issue: |
31 |
Pages: |
11527-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kennedy L |
Year: |
2018 |
Journal: |
Am J Pathol |
Title: |
Knockout of l-Histidine Decarboxylase Prevents Cholangiocyte Damage and Hepatic Fibrosis in Mice Subjected to High-Fat Diet Feeding via Disrupted Histamine/Leptin Signaling. |
Volume: |
188 |
Issue: |
3 |
Pages: |
600-615 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hunyady B |
Year: |
2003 |
Journal: |
Scand J Gastroenterol |
Title: |
Expanded parietal cell pool in transgenic mice unable to synthesize histamine. |
Volume: |
38 |
Issue: |
2 |
Pages: |
133-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hegyi K |
Year: |
2001 |
Journal: |
Cell Mol Life Sci |
Title: |
Histamine deficiency suppresses murine haptoglobin production and modifies hepatic protein tyrosine phosphorylation. |
Volume: |
58 |
Issue: |
5-6 |
Pages: |
850-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Seike M |
Year: |
2005 |
Journal: |
Exp Dermatol |
Title: |
Inhibition of scratching behaviour caused by contact dermatitis in histidine decarboxylase gene knockout mice. |
Volume: |
14 |
Issue: |
3 |
Pages: |
169-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brabant C |
Year: |
2007 |
Journal: |
Psychopharmacology (Berl) |
Title: |
The psychostimulant and rewarding effects of cocaine in histidine decarboxylase knockout mice do not support the hypothesis of an inhibitory function of histamine on reward. |
Volume: |
190 |
Issue: |
2 |
Pages: |
251-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Michelsen KA |
Year: |
2005 |
Journal: |
Eur J Neurosci |
Title: |
Histamine-immunoreactive neurons in the mouse and rat suprachiasmatic nucleus. |
Volume: |
22 |
Issue: |
8 |
Pages: |
1997-2004 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gao C |
Year: |
2017 |
Journal: |
Am J Pathol |
Title: |
Gut Microbe-Mediated Suppression of Inflammation-Associated Colon Carcinogenesis by Luminal Histamine Production. |
Volume: |
187 |
Issue: |
10 |
Pages: |
2323-2336 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vanhanen J |
Year: |
2013 |
Journal: |
Br J Pharmacol |
Title: |
Histamine is required for H₃ receptor-mediated alcohol reward inhibition, but not for alcohol consumption or stimulation. |
Volume: |
170 |
Issue: |
1 |
Pages: |
177-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Otsuka H |
Year: |
2021 |
Journal: |
Int J Hematol |
Title: |
Histidine decarboxylase deficiency inhibits NBP-induced extramedullary hematopoiesis by modifying bone marrow and spleen microenvironments. |
Volume: |
113 |
Issue: |
3 |
Pages: |
348-361 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dere E |
Year: |
2003 |
Journal: |
Learn Mem |
Title: |
Histidine-decarboxylase knockout mice show deficient nonreinforced episodic object memory, improved negatively reinforced water-maze performance, and increased neo- and ventro-striatal dopamine turnover. |
Volume: |
10 |
Issue: |
6 |
Pages: |
510-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Otsuka H |
Year: |
2021 |
Journal: |
Anat Rec (Hoboken) |
Title: |
Changes in histidine decarboxylase expression influence extramedullary hematopoiesis in postnatal mice. |
Volume: |
304 |
Issue: |
5 |
Pages: |
1136-1150 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rani B |
Year: |
2021 |
Journal: |
Biomolecules |
Title: |
Short- and Long-Term Social Recognition Memory Are Differentially Modulated by Neuronal Histamine. |
Volume: |
11 |
Issue: |
4 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Frick L |
Year: |
2016 |
Journal: |
Brain Behav Immun |
Title: |
Histamine regulation of microglia: Gene-environment interaction in the regulation of central nervous system inflammation. |
Volume: |
57 |
|
Pages: |
326-337 |
|
•
•
•
•
•
|
Publication |
First Author: |
Abdurakhmanova S |
Year: |
2019 |
Journal: |
Genes Brain Behav |
Title: |
Abnormal behavior, striatal dopamine turnover and opioid peptide gene expression in histamine-deficient mice. |
Volume: |
18 |
Issue: |
8 |
Pages: |
e12595 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pap E |
Year: |
2002 |
Journal: |
J Endocrinol |
Title: |
Histidine decarboxylase deficiency in gene knockout mice elevates male sex steroid production. |
Volume: |
175 |
Issue: |
1 |
Pages: |
193-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Numata Y |
Year: |
2006 |
Journal: |
J Invest Dermatol |
Title: |
The accelerating effect of histamine on the cutaneous wound-healing process through the action of basic fibroblast growth factor. |
Volume: |
126 |
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