|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 118 for Heph

<< First    < Previous  |  Next >    Last >>
0.612s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Drosophila melanogaster
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Domain
Type: Family
Description: Hephaestin (HEPH) is a membrane-bound ceruloplasmin homologue that plays a critical role in intestinal iron absorption [, , ]. It may function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis [, ]. Hephaestin interacts with another protein involved in intestinal iron absorption, ferroportin 1 [, , ]. In mouse, defects in HEPH can lead to severe microcytic hypochronic anemia []. .
Publication
First Author: Vulpe CD
Year: 1999
Journal: Nat Genet
Title: Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse.
Volume: 21
Issue: 2
Pages: 195-9
Publication
First Author: Frazer DM
Year: 2001
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Cloning and gastrointestinal expression of rat hephaestin: relationship to other iron transport proteins.
Volume: 281
Issue: 4
Pages: G931-9
Publication
First Author: Syed BA
Year: 2002
Journal: Protein Eng
Title: Analysis of the human hephaestin gene and protein: comparative modelling of the N-terminus ecto-domain based upon ceruloplasmin.
Volume: 15
Issue: 3
Pages: 205-14
Publication
First Author: Eisenstein RS
Year: 2000
Journal: Nutr Rev
Title: Discovery of the ceruloplasmin homologue hephaestin: new insight into the copper/iron connection.
Volume: 58
Issue: 1
Pages: 22-6
Publication
First Author: Griffiths TA
Year: 2005
Journal: Biochemistry
Title: Recombinant expression and functional characterization of human hephaestin: a multicopper oxidase with ferroxidase activity.
Volume: 44
Issue: 45
Pages: 14725-31
Publication
First Author: Han O
Year: 2007
Journal: J Cell Biochem
Title: Colocalization of ferroportin-1 with hephaestin on the basolateral membrane of human intestinal absorptive cells.
Volume: 101
Issue: 4
Pages: 1000-10
Publication
First Author: Yeh KY
Year: 2009
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Iron feeding induces ferroportin 1 and hephaestin migration and interaction in rat duodenal epithelium.
Volume: 296
Issue: 1
Pages: G55-65
Publication
First Author: Yeh KY
Year: 2011
Journal: Gastroenterology
Title: Interactions between ferroportin and hephaestin in rat enterocytes are reduced after iron ingestion.
Volume: 141
Issue: 1
Pages: 292-9, 299.e1
Protein
Organism: Mus musculus
Length: 847  
Fragment?: false
Protein
Organism: Mus musculus
Length: 411  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1157  
Fragment?: false
Publication
First Author: Chen H
Year: 2003
Journal: Blood
Title: Systemic regulation of Hephaestin and Ireg1 revealed in studies of genetic and nutritional iron deficiency.
Volume: 102
Issue: 5
Pages: 1893-9
Publication
First Author: Hahn P
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration.
Volume: 101
Issue: 38
Pages: 13850-5
Publication  
First Author: Grewal MS
Year: 1962
Journal: Genet Res
Title: A sex-linked anemia in the mouse
Volume: 3
Pages: 238-247
Publication  
First Author: Falconer DS
Year: 1962
Journal: Genet Res
Title: The genetics of sex-linked anaemia in the mouse.
Volume: 3
Pages: 248-50
Publication  
First Author: Grewal MS
Year: 1962
Journal: Mouse News Lett
Title: sla - sex-linked anemia
Volume: 26
Pages: 43
Publication
First Author: B├ędard YC
Year: 1976
Journal: Lab Invest
Title: Uptake of circulating iron by the duodenum of normal mice and mice with altered iron stores, including sex-linked anemia: high resolution radioautographic study.
Volume: 34
Issue: 6
Pages: 611-5
Publication
First Author: Kuo YM
Year: 2004
Journal: Gut
Title: Mislocalisation of hephaestin, a multicopper ferroxidase involved in basolateral intestinal iron transport, in the sex linked anaemia mouse.
Volume: 53
Issue: 2
Pages: 201-6
Publication
First Author: Schulz K
Year: 2011
Journal: J Neurosci
Title: Iron efflux from oligodendrocytes is differentially regulated in gray and white matter.
Volume: 31
Issue: 37
Pages: 13301-11
Publication
First Author: Bannerman RM
Year: 1966
Journal: Science
Title: Sex-linked anemia: a hypochromic anemia of mice.
Volume: 151
Issue: 3710
Pages: 581-2
Publication
First Author: Kingston PJ
Year: 1978
Journal: Br J Haematol
Title: Iron deficiency anaemia in newborn sla mice: a genetic defect of placental iron transport.
Volume: 40
Issue: 2
Pages: 265-76
Publication
First Author: Wolkow N
Year: 2012
Journal: Am J Pathol
Title: Ferroxidase hephaestin's cell-autonomous role in the retinal pigment epithelium.
Volume: 180
Issue: 4
Pages: 1614-24
Publication
First Author: Levy JE
Year: 2000
Journal: J Clin Invest
Title: Genes that modify the hemochromatosis phenotype in mice.
Volume: 105
Issue: 9
Pages: 1209-16
Publication
First Author: Zheng J
Year: 2018
Journal: FEBS Lett
Title: Ablation of hephaestin and ceruloplasmin results in iron accumulation in adipocytes and type 2 diabetes.
Volume: 592
Issue: 3
Pages: 394-401
Publication
First Author: Bannerman RM
Year: 1976
Journal: Fed Proc
Title: Genetic defects of iron transport.
Volume: 35
Issue: 11
Pages: 2281-5
Publication
First Author: Hadziahmetovic M
Year: 2008
Journal: Invest Ophthalmol Vis Sci
Title: Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD.
Volume: 49
Issue: 6
Pages: 2728-36
Publication
First Author: Hadziahmetovic M
Year: 2011
Journal: Invest Ophthalmol Vis Sci
Title: The oral iron chelator deferiprone protects against iron overload-induced retinal degeneration.
Volume: 52
Issue: 2
Pages: 959-68
Publication
First Author: Zhao L
Year: 2015
Journal: J Neurochem
Title: Cp/Heph mutant mice have iron-induced neurodegeneration diminished by deferiprone.
Volume: 135
Issue: 5
Pages: 958-74
Publication
First Author: Dunaief JL
Year: 2006
Journal: Invest Ophthalmol Vis Sci
Title: Iron induced oxidative damage as a potential factor in age-related macular degeneration: the Cogan Lecture.
Volume: 47
Issue: 11
Pages: 4660-4
Publication  
First Author: Jiang B
Year: 2016
Journal: Sci Rep
Title: Hephaestin and ceruloplasmin facilitate iron metabolism in the mouse kidney.
Volume: 6
Pages: 39470
Publication
First Author: Xu E
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Deletion of hephaestin and ceruloplasmin induces a serious systemic iron deficiency and disrupts iron homeostasis.
Volume: 503
Issue: 3
Pages: 1905-1910
Publication
First Author: Chen Z
Year: 2019
Journal: Sci Rep
Title: Multi-copper ferroxidase deficiency leads to iron accumulation and oxidative damage in astrocytes and oligodendrocytes.
Volume: 9
Issue: 1
Pages: 9437
Publication  
First Author: Chen M
Year: 2018
Journal: Redox Biol
Title: Ceruloplasmin and hephaestin jointly protect the exocrine pancreas against oxidative damage by facilitating iron efflux.
Volume: 17
Pages: 432-439
Publication
First Author: Jiang R
Year: 2015
Journal: J Nutr
Title: Hephaestin and ceruloplasmin play distinct but interrelated roles in iron homeostasis in mouse brain.
Volume: 145
Issue: 5
Pages: 1003-9
Publication
First Author: Ueda K
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Iron promotes oxidative cell death caused by bisretinoids of retina.
Volume: 115
Issue: 19
Pages: 4963-4968
Publication  
First Author: Hahn P
Year: 2004
Journal: Mol Vis
Title: Immunolocalization and regulation of iron handling proteins ferritin and ferroportin in the retina.
Volume: 10
Pages: 598-607
Publication
First Author: Theurl M
Year: 2016
Journal: FASEB J
Title: Mice with hepcidin-resistant ferroportin accumulate iron in the retina.
Volume: 30
Issue: 2
Pages: 813-23
Publication
First Author: Hadziahmetovic M
Year: 2011
Journal: Invest Ophthalmol Vis Sci
Title: Age-dependent retinal iron accumulation and degeneration in hepcidin knockout mice.
Volume: 52
Issue: 1
Pages: 109-18
Publication  
First Author: Sterling J
Year: 2017
Journal: Exp Eye Res
Title: Iron importers Zip8 and Zip14 are expressed in retina and regulated by retinal iron levels.
Volume: 155
Pages: 15-23
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Anderson GJ
Year: 1998
Journal: Genomics
Title: Mapping the gene for sex-linked anemia: an inherited defect of intestinal iron absorption in the mouse.
Volume: 48
Issue: 1
Pages: 34-9
Publication
First Author: Chen H
Year: 2004
Journal: Blood
Title: Hephaestin is a ferroxidase that maintains partial activity in sex-linked anemia mice.
Volume: 103
Issue: 10
Pages: 3933-9
Publication
First Author: Kaneko H
Year: 2011
Journal: Nature
Title: DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration.
Volume: 471
Issue: 7338
Pages: 325-30
Publication
First Author: Fuqua BK
Year: 2014
Journal: PLoS One
Title: The multicopper ferroxidase hephaestin enhances intestinal iron absorption in mice.
Volume: 9
Issue: 6
Pages: e98792
Publication
First Author: Chapman VM
Year: 1971
Journal: Dev Biol
Title: Expression of paternal glucose phosphate isomerase-1 (Gpi-1) in preimplantation stages of mouse embryos.
Volume: 26
Issue: 1
Pages: 153-8
Publication
First Author: Sassa S
Year: 1978
Journal: Exp Hematol
Title: Studies of erythrocyte protoporphyrin in anemic mutant mice: use of a modified hematofluorometer for the detection of heterozygotes for hemolytic disease.
Volume: 6
Issue: 5
Pages: 479-87
Publication      
First Author: Russell ES
Year: 1966
Title: Blood and Blood Formation
Pages: 351-72
Publication      
First Author: Bernstein SE
Year: 1969
Title: Hereditary disorders of the rodent erythron
Pages: 9-33
Publication
First Author: Garchon HJ
Year: 1993
Journal: Curr Opin Immunol
Title: Non-MHC-linked genes in autoimmune diseases.
Volume: 5
Issue: 6
Pages: 894-9
Publication
First Author: Iacovelli J
Year: 2011
Journal: Invest Ophthalmol Vis Sci
Title: Generation of Cre transgenic mice with postnatal RPE-specific ocular expression.
Volume: 52
Issue: 3
Pages: 1378-83
Publication
First Author: Kreimer-Birnbaum M
Year: 1972
Journal: Comp Biochem Physiol A Comp Physiol
Title: Pyrrole pigments in normal and congenitally anaemic mice (+:+, W-W v , ha-ha, nb-nb, mk-mk, f-f and sla-Y).
Volume: 43
Issue: 1
Pages: 21-30
Publication
First Author: Noebels JL
Year: 1990
Journal: Epilepsy Res
Title: Stargazer: a new neurological mutant on chromosome 15 in the mouse with prolonged cortical seizures.
Volume: 7
Issue: 2
Pages: 129-35
Publication
First Author: Nolan PM
Year: 2000
Journal: Nat Genet
Title: A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.
Volume: 25
Issue: 4
Pages: 440-3
Publication
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 4
Pages: 167-80
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication          
First Author: MGD Nomenclature Committee
Year: 1995
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
GO Term