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Search results 1 to 100 out of 131 for Heph

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
9843 | HEPH
Type: gene
Organism: human
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Gene
117240 | Heph
Type: gene
Organism: rat
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Gene
491926 | HEPH
Type: gene
Organism: dog, domestic
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Gene
465679 | HEPH
Type: gene
Organism: chimpanzee
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Gene
510736 | HEPH
Type: gene
Organism: cattle
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Gene
422168 | HEPH
Type: gene
Organism: chicken
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Gene
709879 | HEPH
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1332240 | Heph
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR027154 | HEPH
Type: Family
Description: Hephaestin (HEPH) is a membrane-bound ceruloplasmin homologue that plays a critical role in intestinal iron absorption [, , ]. It may function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis [, ]. Hephaestin interacts with another protein involved in intestinal iron absorption, ferroportin 1 [, , ]. In mouse, defects in HEPH can lead to severe microcytic hypochronic anemia []. .
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Publication
9988272 | J:52535
First Author: Vulpe CD
Year: 1999
Journal: Nat Genet
Title: Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse.
Volume: 21
Issue: 2
Pages: 195-9
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Publication
11557513 | J:72101
First Author: Frazer DM
Year: 2001
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Cloning and gastrointestinal expression of rat hephaestin: relationship to other iron transport proteins.
Volume: 281
Issue: 4
Pages: G931-9
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Publication
11932491 | -
First Author: Syed BA
Year: 2002
Journal: Protein Eng
Title: Analysis of the human hephaestin gene and protein: comparative modelling of the N-terminus ecto-domain based upon ceruloplasmin.
Volume: 15
Issue: 3
Pages: 205-14
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Publication
10697391 | -
First Author: Eisenstein RS
Year: 2000
Journal: Nutr Rev
Title: Discovery of the ceruloplasmin homologue hephaestin: new insight into the copper/iron connection.
Volume: 58
Issue: 1
Pages: 22-6
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Publication
16274220 | -
First Author: Griffiths TA
Year: 2005
Journal: Biochemistry
Title: Recombinant expression and functional characterization of human hephaestin: a multicopper oxidase with ferroxidase activity.
Volume: 44
Issue: 45
Pages: 14725-31
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Publication
17486601 | -
First Author: Han O
Year: 2007
Journal: J Cell Biochem
Title: Colocalization of ferroportin-1 with hephaestin on the basolateral membrane of human intestinal absorptive cells.
Volume: 101
Issue: 4
Pages: 1000-10
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Publication
18974313 | -
First Author: Yeh KY
Year: 2009
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Iron feeding induces ferroportin 1 and hephaestin migration and interaction in rat duodenal epithelium.
Volume: 296
Issue: 1
Pages: G55-65
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Publication
21473866 | -
First Author: Yeh KY
Year: 2011
Journal: Gastroenterology
Title: Interactions between ferroportin and hephaestin in rat enterocytes are reduced after iron ingestion.
Volume: 141
Issue: 1
Pages: 292-9, 299.e1
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Protein
Q3V2W4
Organism: Mus musculus/domesticus
Length: 411  
Fragment?: false
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Protein
A2AI62
Organism: Mus musculus/domesticus
Length: 847  
Fragment?: false
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Protein
Q9Z0Z4
Organism: Mus musculus/domesticus
Length: 1157  
Fragment?: false
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Publication
12730111 | J:106664
First Author: Chen H
Year: 2003
Journal: Blood
Title: Systemic regulation of Hephaestin and Ireg1 revealed in studies of genetic and nutritional iron deficiency.
Volume: 102
Issue: 5
Pages: 1893-9
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Publication
15365174 | J:92620
First Author: Hahn P
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration.
Volume: 101
Issue: 38
Pages: 13850-5
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Publication
- | J:14
First Author: Falconer DS
Year: 1962
Journal: Genet Res
Title: The genetics of sex-linked anaemia in the mouse.
Volume: 3
Issue: 2
Pages: 248-50
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Publication
- | J:64261
 
First Author: Grewal MS
Year: 1962
Journal: Mouse News Lett
Title: sla - sex-linked anemia
Volume: 26
Pages: 43
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Publication
708646 | J:6052
First Author: Kingston PJ
Year: 1978
Journal: Br J Haematol
Title: Iron deficiency anaemia in newborn sla mice: a genetic defect of placental iron transport.
Volume: 40
Issue: 2
Pages: 265-76
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Publication
180329 | J:5660
First Author: Bédard YC
Year: 1976
Journal: Lab Invest
Title: Uptake of circulating iron by the duodenum of normal mice and mice with altered iron stores, including sex-linked anemia: high resolution radioautographic study.
Volume: 34
Issue: 6
Pages: 611-5
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Publication
21917813 | J:177041
First Author: Schulz K
Year: 2011
Journal: J Neurosci
Title: Iron efflux from oligodendrocytes is differentially regulated in gray and white matter.
Volume: 31
Issue: 37
Pages: 13301-11
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Publication
14724150 | J:149735
First Author: Kuo YM
Year: 2004
Journal: Gut
Title: Mislocalisation of hephaestin, a multicopper ferroxidase involved in basolateral intestinal iron transport, in the sex linked anaemia mouse.
Volume: 53
Issue: 2
Pages: 201-6
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Publication
5903585 | J:128474
First Author: Bannerman RM
Year: 1966
Journal: Science
Title: Sex-linked anemia: a hypochromic anemia of mice.
Volume: 151
Issue: 3710
Pages: 581-2
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Publication
- | J:155791
First Author: Grewal MS
Year: 1962
Journal: Genet Res
Title: A sex-linked anemia in the mouse
Volume: 3
Issue: 2
Pages: 238-247
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Publication
22342521 | J:196540
First Author: Wolkow N
Year: 2012
Journal: Am J Pathol
Title: Ferroxidase hephaestin's cell-autonomous role in the retinal pigment epithelium.
Volume: 180
Issue: 4
Pages: 1614-24
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Publication
10791995 | J:62112
First Author: Levy JE
Year: 2000
Journal: J Clin Invest
Title: Genes that modify the hemochromatosis phenotype in mice.
Volume: 105
Issue: 9
Pages: 1209-16
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Publication
35271829 | J:324683
 
First Author: Zhang KR
Year: 2022
Journal: Exp Eye Res
Title: Conditional knockout of hephaestin in the neural retina disrupts retinal iron homeostasis.
Volume: 218
Pages: 109028
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Publication
29355933 | J:258332
First Author: Zheng J
Year: 2018
Journal: FEBS Lett
Title: Ablation of hephaestin and ceruloplasmin results in iron accumulation in adipocytes and type 2 diabetes.
Volume: 592
Issue: 3
Pages: 394-401
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Publication
782924 | J:5681
First Author: Bannerman RM
Year: 1976
Journal: Fed Proc
Title: Genetic defects of iron transport.
Volume: 35
Issue: 11
Pages: 2281-5
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Publication
21051716 | J:171550
First Author: Hadziahmetovic M
Year: 2011
Journal: Invest Ophthalmol Vis Sci
Title: The oral iron chelator deferiprone protects against iron overload-induced retinal degeneration.
Volume: 52
Issue: 2
Pages: 959-68
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Publication
18326691 | J:136925
First Author: Hadziahmetovic M
Year: 2008
Journal: Invest Ophthalmol Vis Sci
Title: Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD.
Volume: 49
Issue: 6
Pages: 2728-36
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Publication
26303407 | J:228531
First Author: Zhao L
Year: 2015
Journal: J Neurochem
Title: Cp/Heph mutant mice have iron-induced neurodegeneration diminished by deferiprone.
Volume: 135
Issue: 5
Pages: 958-74
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Publication
17065470 | J:123093
First Author: Dunaief JL
Year: 2006
Journal: Invest Ophthalmol Vis Sci
Title: Iron induced oxidative damage as a potential factor in age-related macular degeneration: the Cogan Lecture.
Volume: 47
Issue: 11
Pages: 4660-4
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Publication
31263155 | J:285895
First Author: Chen Z
Year: 2019
Journal: Sci Rep
Title: Multi-copper ferroxidase deficiency leads to iron accumulation and oxidative damage in astrocytes and oligodendrocytes.
Volume: 9
Issue: 1
Pages: 9437
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Publication
27991585 | J:272293
 
First Author: Jiang B
Year: 2016
Journal: Sci Rep
Title: Hephaestin and ceruloplasmin facilitate iron metabolism in the mouse kidney.
Volume: 6
Pages: 39470
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Publication
30060949 | J:271447
First Author: Xu E
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Deletion of hephaestin and ceruloplasmin induces a serious systemic iron deficiency and disrupts iron homeostasis.
Volume: 503
Issue: 3
Pages: 1905-1910
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Publication
29883959 | J:273572
 
First Author: Chen M
Year: 2018
Journal: Redox Biol
Title: Ceruloplasmin and hephaestin jointly protect the exocrine pancreas against oxidative damage by facilitating iron efflux.
Volume: 17
Pages: 432-439
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Publication
30647129 | J:352407
First Author: Dlouhy AC
Year: 2019
Journal: J Biol Chem
Title: Fluorescence resonance energy transfer links membrane ferroportin, hephaestin but not ferroportin, amyloid precursor protein complex with iron efflux.
Volume: 294
Issue: 11
Pages: 4202-4214
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Publication
25788583 | J:226963
First Author: Jiang R
Year: 2015
Journal: J Nutr
Title: Hephaestin and ceruloplasmin play distinct but interrelated roles in iron homeostasis in mouse brain.
Volume: 145
Issue: 5
Pages: 1003-9
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Publication
29686088 | J:262070
First Author: Ueda K
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Iron promotes oxidative cell death caused by bisretinoids of retina.
Volume: 115
Issue: 19
Pages: 4963-4968
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Publication
30182051 | J:310497
First Author: Fuqua BK
Year: 2018
Journal: Cell Mol Gastroenterol Hepatol
Title: Severe Iron Metabolism Defects in Mice With Double Knockout of the Multicopper Ferroxidases Hephaestin and Ceruloplasmin.
Volume: 6
Issue: 4
Pages: 405-427
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Publication
15354085 | J:93208
 
First Author: Hahn P
Year: 2004
Journal: Mol Vis
Title: Immunolocalization and regulation of iron handling proteins ferritin and ferroportin in the retina.
Volume: 10
Pages: 598-607
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Publication
26506980 | J:230844
First Author: Theurl M
Year: 2016
Journal: FASEB J
Title: Mice with hepcidin-resistant ferroportin accumulate iron in the retina.
Volume: 30
Issue: 2
Pages: 813-23
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Publication
20811044 | J:171564
First Author: Hadziahmetovic M
Year: 2011
Journal: Invest Ophthalmol Vis Sci
Title: Age-dependent retinal iron accumulation and degeneration in hepcidin knockout mice.
Volume: 52
Issue: 1
Pages: 109-18
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Publication
28057442 | J:272189
 
First Author: Sterling J
Year: 2017
Journal: Exp Eye Res
Title: Iron importers Zip8 and Zip14 are expressed in retina and regulated by retinal iron levels.
Volume: 155
Pages: 15-23
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Protein Coding Gene
MGP_CAROLIEiJ_G0033253 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0035926 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0035912 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0035828 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0035895 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0035603 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1332240 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0036424 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0034890 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0035579 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0035733 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0035671 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0035823 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0035706 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0036451 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0034589 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0035029 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0031792 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0034418 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
14751926 | J:90549
First Author: Chen H
Year: 2004
Journal: Blood
Title: Hephaestin is a ferroxidase that maintains partial activity in sex-linked anemia mice.
Volume: 103
Issue: 10
Pages: 3933-9
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Publication
9503013 | J:43668
First Author: Anderson GJ
Year: 1998
Journal: Genomics
Title: Mapping the gene for sex-linked anemia: an inherited defect of intestinal iron absorption in the mouse.
Volume: 48
Issue: 1
Pages: 34-9
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Publication
21297615 | J:170350
First Author: Kaneko H
Year: 2011
Journal: Nature
Title: DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration.
Volume: 471
Issue: 7338
Pages: 325-30
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Publication
24896847 | J:217333
First Author: Fuqua BK
Year: 2014
Journal: PLoS One
Title: The multicopper ferroxidase hephaestin enhances intestinal iron absorption in mice.
Volume: 9
Issue: 6
Pages: e98792
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Publication
5111764 | J:5235
First Author: Chapman VM
Year: 1971
Journal: Dev Biol
Title: Expression of paternal glucose phosphate isomerase-1 (Gpi-1) in preimplantation stages of mouse embryos.
Volume: 26
Issue: 1
Pages: 153-8
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Publication
- | J:30699
     
First Author: Bernstein SE
Year: 1969
Title: Hereditary disorders of the rodent erythron
Pages: 9-33
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Publication
- | J:24829
     
First Author: Russell ES
Year: 1966
Title: Blood and Blood Formation
Pages: 351-72
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Publication
658175 | J:5985
First Author: Sassa S
Year: 1978
Journal: Exp Hematol
Title: Studies of erythrocyte protoporphyrin in anemic mutant mice: use of a modified hematofluorometer for the detection of heterozygotes for hemolytic disease.
Volume: 6
Issue: 5
Pages: 479-87
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Publication
8297521 | J:16444
First Author: Garchon HJ
Year: 1993
Journal: Curr Opin Immunol
Title: Non-MHC-linked genes in autoimmune diseases.
Volume: 5
Issue: 6
Pages: 894-9
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Publication
21212186 | J:170522
First Author: Iacovelli J
Year: 2011
Journal: Invest Ophthalmol Vis Sci
Title: Generation of Cre transgenic mice with postnatal RPE-specific ocular expression.
Volume: 52
Issue: 3
Pages: 1378-83
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Publication
4404581 | J:31039
First Author: Kreimer-Birnbaum M
Year: 1972
Journal: Comp Biochem Physiol A Comp Physiol
Title: Pyrrole pigments in normal and congenitally anaemic mice (+:+, W-W v , ha-ha, nb-nb, mk-mk, f-f and sla-Y).
Volume: 43
Issue: 1
Pages: 21-30
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Publication
2289471 | J:11008
First Author: Noebels JL
Year: 1990
Journal: Epilepsy Res
Title: Stargazer: a new neurological mutant on chromosome 15 in the mouse with prolonged cortical seizures.
Volume: 7
Issue: 2
Pages: 129-35
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Publication
10932191 | J:63816
First Author: Nolan PM
Year: 2000
Journal: Nat Genet
Title: A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.
Volume: 25
Issue: 4
Pages: 440-3
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Publication
14621295 | J:86686
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 4
Pages: 167-80
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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