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Search results 1 to 100 out of 673 for Hesx1

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0.042s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Family
Description: Hesx1 is a class of homeodomain proteins that bind to DNA []. It has been shown that Hesx1 functions as a transcriptional repressor required for normal forebrain development, eyes and other structures such as the olfactory placodes and pituitary gland []. It has been described that alterations in Hesx1 produce impairment of its DNA binding properties leading to Septo-Optic Dysplasia (SOD) in humans, which exhibits optic nerve and pituitary gland hypoplasia as well as midline brain abnormalities like absence of the corpus callosum and septum pellucidum [].This entry represents Hesx1A, Hesx1B and ANF-1.
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Dattani MT
Year: 1998
Journal: Nat Genet
Title: Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse.
Volume: 19
Issue: 2
Pages: 125-33
Publication
First Author: Brickman JM
Year: 2001
Journal: Development
Title: Molecular effects of novel mutations in Hesx1/HESX1 associated with human pituitary disorders.
Volume: 128
Issue: 24
Pages: 5189-99
GXD Expression      
Probe: MGI:3845955
Assay Type: RT-PCR
Annotation Date: 2009-05-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1751820
Stage: TS20
Assay Id: MGI:3846162
Age: embryonic day 12.5
Specimen Label: Hesx1
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3845955
Assay Type: RT-PCR
Annotation Date: 2009-05-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185813
Stage: TS13
Assay Id: MGI:3846159
Age: embryonic day 8.5
Specimen Label: Hesx1
Detected: true
Specimen Num: 7
Publication
First Author: Ermakova GV
Year: 2007
Journal: Dev Biol
Title: The homeodomain factor Xanf represses expression of genes in the presumptive rostral forebrain that specify more caudal brain regions.
Volume: 307
Issue: 2
Pages: 483-97
Protein
Organism: Mus musculus/domesticus
Length: 185  
Fragment?: false
Publication
First Author: Carvalho LR
Year: 2010
Journal: Mol Endocrinol
Title: Corepressors TLE1 and TLE3 interact with HESX1 and PROP1.
Volume: 24
Issue: 4
Pages: 754-65
Publication
First Author: Pozzi S
Year: 2019
Journal: Stem Cell Reports
Title: Genetic Deletion of Hesx1 Promotes Exit from the Pluripotent State and Impairs Developmental Diapause.
Volume: 13
Issue: 6
Pages: 970-979
Publication
First Author: Gaston-Massuet C
Year: 2008
Journal: Dev Biol
Title: Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development.
Volume: 324
Issue: 2
Pages: 322-33
Publication
First Author: Andoniadou CL
Year: 2007
Journal: Development
Title: Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain.
Volume: 134
Issue: 8
Pages: 1499-508
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2014-01-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:5532320
Age: embryonic day 8.5
Image: 4D Hesx1 left
Specimen Label: 4D Hesx1 left
Detected: true
Specimen Num: 3
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2014-01-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:5532320
Age: embryonic day 8.5
Image: 4D Hesx1 right
Specimen Label: 4D Hesx1 right
Detected: true
Specimen Num: 4
Publication
First Author: Li WZ
Year: 2015
Journal: Biochem Biophys Res Commun
Title: Hesx1 enhances pluripotency by working downstream of multiple pluripotency-associated signaling pathways.
Volume: 464
Issue: 3
Pages: 936-42
Publication
First Author: Kato Y
Year: 2010
Journal: Mol Cell Endocrinol
Title: Pituitary homeodomain transcription factors HESX1 and PROP1 form a heterodimer on the inverted TAAT motif.
Volume: 315
Issue: 1-2
Pages: 168-73
GXD Expression      
Probe: MGI:7464583
Assay Type: RNA in situ
Annotation Date: 2023-04-21
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:7464824
Age: embryonic day 7.5
Specimen Label: 4 Hesx1 E7.5 -/-
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:7464583
Assay Type: RNA in situ
Annotation Date: 2023-04-21
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:7464824
Age: embryonic day 8.5
Specimen Label: 4 Hesx1 E8.5 -/-
Detected: false
Specimen Num: 3
GXD Expression  
Probe: MGI:7464583
Assay Type: RNA in situ
Annotation Date: 2023-04-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608911
Pattern: Regionally restricted
Stage: TS11
Assay Id: MGI:7464824
Age: embryonic day 7.5
Note: Expression in prospective forebrain.
Specimen Label: 4 Hesx1 E7.5 WT
Detected: true
Specimen Num: 1
Publication
First Author: Martinez-Barbera JP
Year: 2000
Journal: Dev Biol
Title: The homeobox gene Hesx1 is required in the anterior neural ectoderm for normal forebrain formation.
Volume: 223
Issue: 2
Pages: 422-30
Publication
First Author: Quirk J
Year: 2002
Journal: J Mol Endocrinol
Title: Hesx1 homeodomain protein represses transcription as a monomer and antagonises transactivation of specific sites as a homodimer.
Volume: 28
Issue: 3
Pages: 193-205
Publication
First Author: Matsuda K
Year: 2014
Journal: Genes Cells
Title: Dkk1-dependent inhibition of Wnt signaling activates Hesx1 expression through its 5' enhancer and directs forebrain precursor development.
Volume: 19
Issue: 5
Pages: 374-85
Publication
First Author: Sajedi E
Year: 2008
Journal: Dis Model Mech
Title: Analysis of mouse models carrying the I26T and R160C substitutions in the transcriptional repressor HESX1 as models for septo-optic dysplasia and hypopituitarism.
Volume: 1
Issue: 4-5
Pages: 241-54
GXD Expression
Probe: MGI:1321253
Assay Type: RNA in situ
Annotation Date: 1999-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603910
Pattern: Regionally restricted
Stage: TS10
Assay Id: MGI:1321308
Age: embryonic day 7.5
Image: 5J
Note: Hesx1 became anteriorly expressed with cer-l.
Specimen Label: 5J
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6174808
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6190498
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Hesx1
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:6174808
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6190498
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Hesx1
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:6174808
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:6190498
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Hesx1
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:6174808
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:6190498
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Hesx1
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:6174808
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190498
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Hesx1
Detected: false
Specimen Num: 5
GXD Expression      
Probe: MGI:6174808
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190498
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Hesx1
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:6174808
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190498
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Hesx1
Detected: false
Specimen Num: 7
GXD Expression  
Probe: MGI:31029
Assay Type: RNA in situ
Annotation Date: 1999-02-02
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1607311
Stage: TS11
Assay Id: MGI:1328550
Age: embryonic day 7.5-7.75
Image: 6L
Note: Hesx1 was used as a marker for rostral neural ectoderm in these mutants.
Specimen Label: 6L
Detected: false
Specimen Num: 3
Publication
First Author: Andoniadou CL
Year: 2011
Journal: Development
Title: HESX1- and TCF3-mediated repression of Wnt/β-catenin targets is required for normal development of the anterior forebrain.
Volume: 138
Issue: 22
Pages: 4931-42
Publication
First Author: Jayakody SA
Year: 2012
Journal: J Clin Invest
Title: SOX2 regulates the hypothalamic-pituitary axis at multiple levels.
Volume: 122
Issue: 10
Pages: 3635-46
Publication
First Author: Thomas PQ
Year: 1995
Journal: J Biol Chem
Title: Sequence, genomic organization, and expression of the novel homeobox gene Hesx1.
Volume: 270
Issue: 8
Pages: 3869-75
Publication
First Author: Susa T
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Homeodomain transcription factor Hesx1/Rpx occupies Prop-1 activation sites in porcine follicle stimulating hormone (FSH) beta subunit promoter.
Volume: 357
Issue: 3
Pages: 712-7
Publication
First Author: Dattani MT
Year: 1999
Journal: Acta Paediatr Suppl
Title: HESX1: a novel gene implicated in a familial form of septo-optic dysplasia.
Volume: 88
Issue: 433
Pages: 49-54
Publication
First Author: Huelsken J
Year: 2000
Journal: J Cell Biol
Title: Requirement for beta-catenin in anterior-posterior axis formation in mice.
Volume: 148
Issue: 3
Pages: 567-78
Publication
First Author: Cha KB
Year: 2004
Journal: Mech Dev
Title: WNT5A signaling affects pituitary gland shape.
Volume: 121
Issue: 2
Pages: 183-94
Publication
First Author: Spieler D
Year: 2004
Journal: Dev Biol
Title: Involvement of Pax6 and Otx2 in the forebrain-specific regulation of the vertebrate homeobox gene ANF/Hesx1.
Volume: 269
Issue: 2
Pages: 567-79
Publication
First Author: Gaston-Massuet C
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Transcription factor 7-like 1 is involved in hypothalamo-pituitary axis development in mice and humans.
Volume: 113
Issue: 5
Pages: E548-57
Publication
First Author: Martinez-Barbera JP
Year: 2001
Journal: Int J Dev Biol
Title: Getting your head around Hex and Hesx1: forebrain formation in mouse.
Volume: 45
Issue: 1
Pages: 327-36
Publication
First Author: Carreno G
Year: 2017
Journal: Development
Title: Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors.
Volume: 144
Issue: 18
Pages: 3289-3302
Publication
First Author: Thomas P
Year: 1996
Journal: Curr Biol
Title: Anterior primitive endoderm may be responsible for patterning the anterior neural plate in the mouse embryo.
Volume: 6
Issue: 11
Pages: 1487-96
Publication
First Author: Sajedi E
Year: 2008
Journal: Biochim Biophys Acta
Title: DNMT1 interacts with the developmental transcriptional repressor HESX1.
Volume: 1783
Issue: 1
Pages: 131-43
Publication
First Author: Dasen JS
Year: 2001
Journal: Genes Dev
Title: Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis.
Volume: 15
Issue: 23
Pages: 3193-207
Publication
First Author: Andoniadou CL
Year: 2013
Journal: Cell Stem Cell
Title: Sox2(+) stem/progenitor cells in the adult mouse pituitary support organ homeostasis and have tumor-inducing potential.
Volume: 13
Issue: 4
Pages: 433-45
Publication
First Author: Iwafuchi-Doi M
Year: 2012
Journal: Development
Title: Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells.
Volume: 139
Issue: 21
Pages: 3926-37
Publication
First Author: Tsang TE
Year: 1999
Journal: Cell Mol Biol (Noisy-le-grand)
Title: Experimental analysis of the emergence of left-right asymmetry of the body axis in early postimplantation mouse embryos.
Volume: 45
Issue: 5
Pages: 493-503
Publication
First Author: Gonzalez-Meljem JM
Year: 2023
Journal: PLoS One
Title: An expression and function analysis of the CXCR4/SDF-1 signalling axis during pituitary gland development.
Volume: 18
Issue: 2
Pages: e0280001
Publication
First Author: Haston S
Year: 2017
Journal: Development
Title: MAPK pathway control of stem cell proliferation and differentiation in the embryonic pituitary provides insights into the pathogenesis of papillary craniopharyngioma.
Volume: 144
Issue: 12
Pages: 2141-2152
Publication  
First Author: Cheung LYM
Year: 2020
Journal: Endocrinology
Title: PROP1-Dependent Retinoic Acid Signaling Regulates Developmental Pituitary Morphogenesis and Hormone Expression.
Volume: 161
Issue: 2
Publication
First Author: Gaston-Massuet C
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Increased Wingless (Wnt) signaling in pituitary progenitor/stem cells gives rise to pituitary tumors in mice and humans.
Volume: 108
Issue: 28
Pages: 11482-7
Publication
First Author: Brinkmeier ML
Year: 2020
Journal: J Clin Invest
Title: Rathke's cleft-like cysts arise from Isl1 deletion in murine pituitary progenitors.
Volume: 130
Issue: 8
Pages: 4501-4515
Publication
First Author: Mario Gonzalez-Meljem J
Year: 2017
Journal: Nat Commun
Title: Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma.
Volume: 8
Issue: 1
Pages: 1819
Publication    
First Author: Lodge EJ
Year: 2019
Journal: Elife
Title: Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade.
Volume: 8
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Thomas PQ
Year: 1992
Journal: Nucleic Acids Res
Title: HES-1, a novel homeobox gene expressed by murine embryonic stem cells, identifies a new class of homeobox genes.
Volume: 20
Issue: 21
Pages: 5840
Publication
First Author: Webb GC
Year: 1993
Journal: Genomics
Title: Hesx1, a homeobox gene expressed by murine embryonic stem cells, maps to mouse chromosome 14, bands A3-B.
Volume: 18
Issue: 2
Pages: 464-6
GXD Expression    
Probe: MGI:31029
Assay Type: Northern blot
Annotation Date: 1999-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185815
Stage: TS15
Assay Id: MGI:1333950
Age: embryonic day 9.5
Image: 3
Specimen Label: 9.5d h
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:31029
Assay Type: Northern blot
Annotation Date: 1999-04-13
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3185715
Stage: TS15
Assay Id: MGI:1333950
Age: embryonic day 9.5
Image: 3
Specimen Label: 9.5d b
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:31029
Assay Type: Northern blot
Annotation Date: 1999-04-13
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3185817
Stage: TS17
Assay Id: MGI:1333950
Age: embryonic day 10.5
Image: 3
Specimen Label: 10.5d h
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:31029
Assay Type: Northern blot
Annotation Date: 1999-04-13
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3185717
Stage: TS17
Assay Id: MGI:1333950
Age: embryonic day 10.5
Image: 3
Specimen Label: 10.5d b
Detected: false
Specimen Num: 5
GXD Expression    
Probe: MGI:31029
Assay Type: Northern blot
Annotation Date: 1999-04-13
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3185819
Stage: TS19
Assay Id: MGI:1333950
Age: embryonic day 11.5
Image: 3
Specimen Label: 11.5d h
Detected: false
Specimen Num: 6
GXD Expression    
Probe: MGI:31029
Assay Type: Northern blot
Annotation Date: 1999-04-13
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3185719
Stage: TS19
Assay Id: MGI:1333950
Age: embryonic day 11.5
Image: 3
Specimen Label: 11.5d b
Detected: false
Specimen Num: 7
GXD Expression    
Probe: MGI:31029
Assay Type: Northern blot
Annotation Date: 1999-04-13
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3185820
Stage: TS20
Assay Id: MGI:1333950
Age: embryonic day 12.5
Image: 3
Specimen Label: 12.5d h
Detected: false
Specimen Num: 8
GXD Expression    
Probe: MGI:31029
Assay Type: Northern blot
Annotation Date: 1999-04-13
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3185720
Stage: TS20
Assay Id: MGI:1333950
Age: embryonic day 12.5
Image: 3
Specimen Label: 12.5d b
Detected: false
Specimen Num: 9
GXD Expression    
Probe: MGI:31029
Assay Type: Northern blot
Annotation Date: 1999-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:1333966
Age: embryonic day 8.5
Image: 4
Specimen Label: 8.5d
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:1335861
Assay Type: RT-PCR
Annotation Date: 1999-06-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3604013
Stage: TS13
Assay Id: MGI:1337768
Age: embryonic day 8.5
Image: 5
Specimen Label: +RT wt
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:1335861
Assay Type: RT-PCR
Annotation Date: 1999-06-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3604013
Stage: TS13
Assay Id: MGI:1337768
Age: embryonic day 8.5
Image: 5
Specimen Label: +RT -/-
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:1354306
Assay Type: RT-PCR
Annotation Date: 2000-03-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1606211
Stage: TS11
Assay Id: MGI:1354362
Age: embryonic day 7.5
Image: 1
Specimen Label: 7.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:1354306
Assay Type: RT-PCR
Annotation Date: 2000-03-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1624713
Stage: TS13
Assay Id: MGI:1354362
Age: embryonic day 8.5
Image: 1
Specimen Label: 8.5
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:1354306
Assay Type: RT-PCR
Annotation Date: 2000-03-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1624715
Stage: TS15
Assay Id: MGI:1354362
Age: embryonic day 9.5
Image: 1
Specimen Label: 9.5
Detected: true
Specimen Num: 3