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Search results 1 to 100 out of 263 for Hexa

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0.053s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: cat, domestic
Gene
Type: gene
Organism: sheep
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Gene
Type: gene
Organism: human
Publication
First Author: Norflus F
Year: 1996
Journal: DNA Cell Biol
Title: Promoters for the human beta-hexosaminidase genes, HEXA and HEXB.
Volume: 15
Issue: 2
Pages: 89-97
Publication
First Author: Yamanaka S
Year: 1994
Journal: Genomics
Title: Structure and expression of the mouse beta-hexosaminidase genes, Hexa and Hexb.
Volume: 21
Issue: 3
Pages: 588-96
Publication
First Author: Wakamatsu N
Year: 1994
Journal: Genomics
Title: Structural organization, sequence, and expression of the mouse HEXA gene encoding the alpha subunit of hexosaminidase A.
Volume: 24
Issue: 1
Pages: 110-9
Publication
First Author: Yamanaka S
Year: 1994
Journal: Proc Natl Acad Sci U S A
Title: Targeted disruption of the Hexa gene results in mice with biochemical and pathologic features of Tay-Sachs disease.
Volume: 91
Issue: 21
Pages: 9975-9
Publication
First Author: Cohen-Tannoudji M
Year: 1995
Journal: Mamm Genome
Title: Disruption of murine Hexa gene leads to enzymatic deficiency and to neuronal lysosomal storage, similar to that observed in Tay-Sachs disease.
Volume: 6
Issue: 12
Pages: 844-9
Publication
First Author: Miklyaeva EI
Year: 2004
Journal: Brain Res
Title: Late onset Tay-Sachs disease in mice with targeted disruption of the Hexa gene: behavioral changes and pathology of the central nervous system.
Volume: 1001
Issue: 1-2
Pages: 37-50
Publication
First Author: Bianconi S
Year: 1994
Journal: Biochem Mol Biol Int
Title: Organization of the gene for the alpha-subunit of mouse beta-N-acetylhexosaminidase (HEXa).
Volume: 34
Issue: 3
Pages: 579-86
Publication
First Author: Sango K
Year: 1995
Journal: Nat Genet
Title: Mouse models of Tay-Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism.
Volume: 11
Issue: 2
Pages: 170-6
Publication
First Author: Sengul T
Year: 2023
Journal: PLoS One
Title: Autophagic flux is impaired in the brain tissue of Tay-Sachs disease mouse model.
Volume: 18
Issue: 3
Pages: e0280650
Publication
First Author: Guidotti JE
Year: 1999
Journal: Hum Mol Genet
Title: Adenoviral gene therapy of the Tay-Sachs disease in hexosaminidase A-deficient knock-out mice.
Volume: 8
Issue: 5
Pages: 831-8
Publication
First Author: Phaneuf D
Year: 1996
Journal: Hum Mol Genet
Title: Dramatically different phenotypes in mouse models of human Tay-Sachs and Sandhoff diseases.
Volume: 5
Issue: 1
Pages: 1-14
Publication
First Author: Seyrantepe V
Year: 2010
Journal: PLoS Genet
Title: Mice doubly-deficient in lysosomal hexosaminidase A and neuraminidase 4 show epileptic crises and rapid neuronal loss.
Volume: 6
Issue: 9
Pages: e1001118
Publication
First Author: Seyrantepe V
Year: 2018
Journal: Exp Neurol
Title: Murine Sialidase Neu3 facilitates GM2 degradation and bypass in mouse model of Tay-Sachs disease.
Volume: 299
Issue: Pt A
Pages: 26-41
Publication
First Author: Sango K
Year: 1996
Journal: Nat Genet
Title: Mice lacking both subunits of lysosomal beta-hexosaminidase display gangliosidosis and mucopolysaccharidosis.
Volume: 14
Issue: 3
Pages: 348-52
Publication  
First Author: Kot S
Year: 2021
Journal: Int J Mol Sci
Title: Investigating Immune Responses to the scAAV9-HEXM Gene Therapy Treatment in Tay-Sachs Disease and Sandhoff Disease Mouse Models.
Volume: 22
Issue: 13
Publication
First Author: Yuziuk JA
Year: 1998
Journal: J Biol Chem
Title: Specificity of mouse GM2 activator protein and beta-N-acetylhexosaminidases A and B. Similarities and differences with their human counterparts in the catabolism of GM2.
Volume: 273
Issue: 1
Pages: 66-72
Publication
First Author: Yasue M
Year: 1991
Journal: Cytogenet Cell Genet
Title: Chromosomal assignments of 23 biochemical loci of the rat by using rat x mouse somatic cell hybrids.
Volume: 57
Issue: 2-3
Pages: 142-8
Publication
First Author: Trasler J
Year: 1998
Journal: Endocrinology
Title: Characterization of the testis and epididymis in mouse models of human Tay Sachs and Sandhoff diseases and partial determination of accumulated gangliosides.
Volume: 139
Issue: 7
Pages: 3280-8
Publication
First Author: Liu Y
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: Mouse model of GM2 activator deficiency manifests cerebellar pathology and motor impairment.
Volume: 94
Issue: 15
Pages: 8138-43
Publication
First Author: Adamali HI
Year: 1999
Journal: J Androl
Title: I. Abnormalities in cells of the testis, efferent ducts, and epididymis in juvenile and adult mice with beta-hexosaminidase A and B deficiency.
Volume: 20
Issue: 6
Pages: 779-802
Publication
First Author: Adamali HI
Year: 1999
Journal: J Androl
Title: II. Characterization and development of the regional- and cellular-specific abnormalities in the epididymis of mice with beta-hexosaminidase A deficiency.
Volume: 20
Issue: 6
Pages: 803-24
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication  
First Author: Beccari T
Year: 1992
Journal: Biochem J
Title: Cloning and sequence analysis of a cDNA encoding the alpha-subunit of mouse beta-N-acetylhexosaminidase and comparison with the human enzyme.
Volume: 285 ( Pt 2)
Pages: 593-6
Publication
First Author: Jeyakumar M
Year: 2002
Journal: Neurobiol Dis
Title: An inducible mouse model of late onset Tay-Sachs disease.
Volume: 10
Issue: 3
Pages: 201-10
Publication
First Author: Platt FM
Year: 1997
Journal: Science
Title: Prevention of lysosomal storage in Tay-Sachs mice treated with N-butyldeoxynojirimycin.
Volume: 276
Issue: 5311
Pages: 428-31
GXD Expression      
Probe: MGI:3772812
Assay Type: RT-PCR
Annotation Date: 2008-03-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689420
Stage: TS20
Assay Id: MGI:3772863
Age: embryonic day 12.0
Specimen Label: E12
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3772812
Assay Type: RT-PCR
Annotation Date: 2008-03-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689422
Stage: TS22
Assay Id: MGI:3772863
Age: embryonic day 14.0
Specimen Label: E14
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3772812
Assay Type: RT-PCR
Annotation Date: 2008-03-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:3772863
Age: embryonic day 16.0
Specimen Label: E16
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3772812
Assay Type: RT-PCR
Annotation Date: 2008-03-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:3772863
Age: embryonic day 18.0
Specimen Label: E18
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3772812
Assay Type: RT-PCR
Annotation Date: 2008-03-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:3772863
Age: postnatal day 1
Specimen Label: P1
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3772812
Assay Type: RT-PCR
Annotation Date: 2008-03-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3772863
Age: postnatal day 10
Specimen Label: P10
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3772812
Assay Type: RT-PCR
Annotation Date: 2008-03-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3772863
Age: postnatal adult
Specimen Label: A
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:4430586
Assay Type: RT-PCR
Annotation Date: 2010-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:4430593
Age: embryonic day 13.0
Specimen Label: E13
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:4430586
Assay Type: RT-PCR
Annotation Date: 2010-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:4430593
Age: embryonic day 18.0
Specimen Label: E18
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:4430586
Assay Type: RT-PCR
Annotation Date: 2010-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:4430593
Age: postnatal day 0
Specimen Label: P0
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:4430586
Assay Type: RT-PCR
Annotation Date: 2010-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:4430593
Age: postnatal day 3
Specimen Label: P3
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:4430586
Assay Type: RT-PCR
Annotation Date: 2010-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4430593
Age: postnatal day 6
Specimen Label: P6
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:4430586
Assay Type: RT-PCR
Annotation Date: 2010-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4430593
Age: postnatal day 13
Specimen Label: P13
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:4430586
Assay Type: RT-PCR
Annotation Date: 2010-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4430593
Age: postnatal day 21
Specimen Label: P21
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:4430586
Assay Type: RT-PCR
Annotation Date: 2010-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4430593
Age: postnatal month 1
Specimen Label: 1M
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:4430586
Assay Type: RT-PCR
Annotation Date: 2010-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4430593
Age: postnatal month 3
Specimen Label: 3M
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:4430586
Assay Type: RT-PCR
Annotation Date: 2010-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:4430623
Age: embryonic day 13.0
Specimen Label: E13
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:4430586
Assay Type: RT-PCR
Annotation Date: 2010-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:4430623
Age: embryonic day 18.0
Specimen Label: E18
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:4430586
Assay Type: RT-PCR
Annotation Date: 2010-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:4430623
Age: postnatal day 0
Specimen Label: P0
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:4430586
Assay Type: RT-PCR
Annotation Date: 2010-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:4430623
Age: postnatal day 3
Specimen Label: P3
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:4430586
Assay Type: RT-PCR
Annotation Date: 2010-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4430623
Age: postnatal day 6
Specimen Label: P6
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:4430586
Assay Type: RT-PCR
Annotation Date: 2010-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4430623
Age: postnatal day 13
Specimen Label: P13
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:4430586
Assay Type: RT-PCR
Annotation Date: 2010-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4430623
Age: postnatal day 21
Specimen Label: P21
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:4430586
Assay Type: RT-PCR
Annotation Date: 2010-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4430623
Age: postnatal month 1
Specimen Label: 1M
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:4430586
Assay Type: RT-PCR
Annotation Date: 2010-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4430623
Age: postnatal month 5
Specimen Label: 5M
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:4430590
Assay Type: Western blot
Annotation Date: 2010-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4430629
Age: postnatal adult
Specimen Label: WT brain
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:4430590
Assay Type: Western blot
Annotation Date: 2010-03-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4430629
Age: postnatal adult
Specimen Label: TS brain
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:4416523
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3516422
Stage: TS22
Assay Id: MGI:5421872
Age: embryonic day 14.5
Specimen Label: EB2264; Specimen B885
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4416523
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716122
Stage: TS22
Assay Id: MGI:5421872
Age: embryonic day 14.5
Specimen Label: EB2264; Specimen B885
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4416523
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1691622
Stage: TS22
Assay Id: MGI:5421872
Age: embryonic day 14.5
Specimen Label: EB2264; Specimen B885
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4416523
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1760622
Stage: TS22
Assay Id: MGI:5421872
Age: embryonic day 14.5
Specimen Label: EB2264; Specimen B885
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4416523
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737322
Stage: TS22
Assay Id: MGI:5421872
Age: embryonic day 14.5
Specimen Label: EB2264; Specimen B885
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4416523
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3284222
Stage: TS22
Assay Id: MGI:5421872
Age: embryonic day 14.5
Specimen Label: EB2264; Specimen B885
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4416523
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1666522
Stage: TS22
Assay Id: MGI:5421872
Age: embryonic day 14.5
Specimen Label: EB2264; Specimen B885
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4416523
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1619822
Stage: TS22
Assay Id: MGI:5421872
Age: embryonic day 14.5
Specimen Label: EB2264; Specimen B885
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:4416523
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754922
Stage: TS22
Assay Id: MGI:5421872
Age: embryonic day 14.5
Note: Expression was not detected in the corpus striatum (lateral ganglionic eminence).
Specimen Label: EB2264; Specimen B885
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4416523
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1697422
Stage: TS22
Assay Id: MGI:5421872
Age: embryonic day 14.5
Specimen Label: EB2264; Specimen B885
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:4416523
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3276322
Stage: TS22
Assay Id: MGI:5421872
Age: embryonic day 14.5
Note: Expression was not detected in the face/soft tissues.
Specimen Label: EB2264; Specimen B885
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4416523
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1783822
Stage: TS22
Assay Id: MGI:5421872
Age: embryonic day 14.5
Specimen Label: EB2264; Specimen B885
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4416523
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1665922
Stage: TS22
Assay Id: MGI:5421872
Age: embryonic day 14.5
Specimen Label: EB2264; Specimen B885
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4416523
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1706822
Stage: TS22
Assay Id: MGI:5421872
Age: embryonic day 14.5
Specimen Label: EB2264; Specimen B885
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4416523
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1674822
Stage: TS22
Assay Id: MGI:5421872
Age: embryonic day 14.5
Specimen Label: EB2264; Specimen B885
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4416523
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1670622
Stage: TS22
Assay Id: MGI:5421872
Age: embryonic day 14.5
Specimen Label: EB2264; Specimen B885
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4416523
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1738222
Stage: TS22
Assay Id: MGI:5421872
Age: embryonic day 14.5
Specimen Label: EB2264; Specimen B885
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4416523
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1654222
Stage: TS22
Assay Id: MGI:5421872
Age: embryonic day 14.5
Specimen Label: EB2264; Specimen B885
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4416523
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1777922
Stage: TS22
Assay Id: MGI:5421872
Age: embryonic day 14.5
Specimen Label: EB2264; Specimen B885
Detected: false
Specimen Num: 1