|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 442 for Hexb

<< First    < Previous  |  Next >    Last >>
0.088s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: horse
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication  
Year: 2019
Journal: J Am Assoc Lab Anim Sci
Title: Abstracts of Scientific Presentations 2019 AALAS National Meeting.
Volume: 58
Issue: 5
Pages: 607-726
Publication
First Author: Eichler A
Year: 2023
Journal: J Neurosci
Title: Microglial Cytokines Mediate Plasticity Induced by 10 Hz Repetitive Magnetic Stimulation.
Volume: 43
Issue: 17
Pages: 3042-3060
Publication
First Author: Sargeant TJ
Year: 2012
Journal: PLoS Genet
Title: Characterization of inducible models of Tay-Sachs and related disease.
Volume: 8
Issue: 9
Pages: e1002943
Publication
First Author: Masuda T
Year: 2020
Journal: Nat Immunol
Title: Novel Hexb-based tools for studying microglia in the CNS.
Volume: 21
Issue: 7
Pages: 802-815
Publication
First Author: Sango K
Year: 1995
Journal: Nat Genet
Title: Mouse models of Tay-Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism.
Volume: 11
Issue: 2
Pages: 170-6
Publication
First Author: Triggs-Raine BL
Year: 1994
Journal: Biochim Biophys Acta
Title: Characterization of the murine beta-hexosaminidase (HEXB) gene.
Volume: 1227
Issue: 1-2
Pages: 79-86
Publication
First Author: Phaneuf D
Year: 1996
Journal: Hum Mol Genet
Title: Dramatically different phenotypes in mouse models of human Tay-Sachs and Sandhoff diseases.
Volume: 5
Issue: 1
Pages: 1-14
Publication
First Author: Buccoliero R
Year: 2004
Journal: J Neurochem
Title: Phospholipid synthesis is decreased in neuronal tissue in a mouse model of Sandhoff disease.
Volume: 90
Issue: 1
Pages: 80-8
Publication
First Author: Jeyakumar M
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Delayed symptom onset and increased life expectancy in Sandhoff disease mice treated with N-butyldeoxynojirimycin.
Volume: 96
Issue: 11
Pages: 6388-93
Publication
First Author: Terashima T
Year: 2009
Journal: J Clin Invest
Title: DRG-targeted helper-dependent adenoviruses mediate selective gene delivery for therapeutic rescue of sensory neuronopathies in mice.
Volume: 119
Issue: 7
Pages: 2100-112
Publication
First Author: Ogawa Y
Year: 2013
Journal: PLoS One
Title: Impaired neural differentiation of induced pluripotent stem cells generated from a mouse model of Sandhoff disease.
Volume: 8
Issue: 1
Pages: e55856
Publication
First Author: Ogawa Y
Year: 2017
Journal: PLoS One
Title: Abnormal differentiation of Sandhoff disease model mouse-derived multipotent stem cells toward a neural lineage.
Volume: 12
Issue: 6
Pages: e0178978
Publication
First Author: Niemir N
Year: 2018
Journal: Hum Mol Genet
Title: Intravenous administration of scAAV9-Hexb normalizes lifespan and prevents pathology in Sandhoff disease mice.
Volume: 27
Issue: 6
Pages: 954-968
Publication
First Author: Juneja SC
Year: 2002
Journal: Reprod Fertil Dev
Title: Development of infertility at young adult age in a mouse model of human Sandhoff disease.
Volume: 14
Issue: 7-8
Pages: 407-12
Publication
First Author: Yamanaka S
Year: 1994
Journal: Genomics
Title: Structure and expression of the mouse beta-hexosaminidase genes, Hexa and Hexb.
Volume: 21
Issue: 3
Pages: 588-96
Publication  
First Author: Ogawa Y
Year: 2017
Journal: Sci Rep
Title: FcRγ-dependent immune activation initiates astrogliosis during the asymptomatic phase of Sandhoff disease model mice.
Volume: 7
Pages: 40518
Publication
First Author: Yamaguchi A
Year: 2004
Journal: J Clin Invest
Title: Possible role of autoantibodies in the pathophysiology of GM2 gangliosidoses.
Volume: 113
Issue: 2
Pages: 200-8
Publication  
First Author: Ogawa Y
Year: 2018
Journal: Neurobiol Dis
Title: Inhibition of astrocytic adenosine receptor A2A attenuates microglial activation in a mouse model of Sandhoff disease.
Volume: 118
Pages: 142-154
Publication
First Author: Sango K
Year: 1996
Journal: Nat Genet
Title: Mice lacking both subunits of lysosomal beta-hexosaminidase display gangliosidosis and mucopolysaccharidosis.
Volume: 14
Issue: 3
Pages: 348-52
Publication
First Author: Keilani S
Year: 2012
Journal: J Neurosci
Title: Lysosomal dysfunction in a mouse model of Sandhoff disease leads to accumulation of ganglioside-bound amyloid-β peptide.
Volume: 32
Issue: 15
Pages: 5223-36
Publication
First Author: Norflus F
Year: 1996
Journal: DNA Cell Biol
Title: Promoters for the human beta-hexosaminidase genes, HEXA and HEXB.
Volume: 15
Issue: 2
Pages: 89-97
Publication
First Author: Trasler J
Year: 1998
Journal: Endocrinology
Title: Characterization of the testis and epididymis in mouse models of human Tay Sachs and Sandhoff diseases and partial determination of accumulated gangliosides.
Volume: 139
Issue: 7
Pages: 3280-8
Publication
First Author: Liu Y
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: Mouse model of GM2 activator deficiency manifests cerebellar pathology and motor impairment.
Volume: 94
Issue: 15
Pages: 8138-43
Publication      
First Author: Ogawa Y
Year: 2019
Journal: Neurosci Res
Title: Abnormal organization during neurodevelopment in a mouse model of Sandhoff disease.
Publication
First Author: Adamali HI
Year: 1999
Journal: J Androl
Title: I. Abnormalities in cells of the testis, efferent ducts, and epididymis in juvenile and adult mice with beta-hexosaminidase A and B deficiency.
Volume: 20
Issue: 6
Pages: 779-802
Publication
First Author: Kohno K
Year: 2022
Journal: Science
Title: A spinal microglia population involved in remitting and relapsing neuropathic pain.
Volume: 376
Issue: 6588
Pages: 86-90
Publication
First Author: Tsuji D
Year: 2005
Journal: J Neurochem
Title: Specific induction of macrophage inflammatory protein 1-alpha in glial cells of Sandhoff disease model mice associated with accumulation of N-acetylhexosaminyl glycoconjugates.
Volume: 92
Issue: 6
Pages: 1497-507
Publication
First Author: Wieghofer P
Year: 2021
Journal: EMBO J
Title: Mapping the origin and fate of myeloid cells in distinct compartments of the eye by single-cell profiling.
Volume: 40
Issue: 6
Pages: e105123
Publication
First Author: Faust TE
Year: 2023
Journal: Cell Rep
Title: A comparative analysis of microglial inducible Cre lines.
Volume: 42
Issue: 9
Pages: 113031
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Bapat B
Year: 1988
Journal: FEBS Lett
Title: Cloning and sequence analysis of a cDNA encoding the beta-subunit of mouse beta-hexosaminidase.
Volume: 237
Issue: 1-2
Pages: 191-5
Publication
First Author: Miller DJ
Year: 1993
Journal: J Cell Biol
Title: Egg cortical granule N-acetylglucosaminidase is required for the mouse zona block to polyspermy.
Volume: 123
Issue: 6 Pt 1
Pages: 1431-40
Publication
First Author: Pelled D
Year: 2003
Journal: Neuropathol Appl Neurobiol
Title: Reduced rates of axonal and dendritic growth in embryonic hippocampal neurones cultured from a mouse model of Sandhoff disease.
Volume: 29
Issue: 4
Pages: 341-9
Publication
First Author: Lecommandeur E
Year: 2017
Journal: J Lipid Res
Title: Alterations in endo-lysosomal function induce similar hepatic lipid profiles in rodent models of drug-induced phospholipidosis and Sandhoff disease.
Volume: 58
Issue: 7
Pages: 1306-1314
Publication
First Author: Kitakaze K
Year: 2016
Journal: J Clin Invest
Title: Protease-resistant modified human β-hexosaminidase B ameliorates symptoms in GM2 gangliosidosis model.
Volume: 126
Issue: 5
Pages: 1691-703
Publication
First Author: Denny CA
Year: 2010
Journal: J Neurochem
Title: Restricted ketogenic diet enhances the therapeutic action of N-butyldeoxynojirimycin towards brain GM2 accumulation in adult Sandhoff disease mice.
Volume: 113
Issue: 6
Pages: 1525-35
Publication
First Author: Sargeant TJ
Year: 2011
Journal: Hum Mol Genet
Title: Adeno-associated virus-mediated expression of β-hexosaminidase prevents neuronal loss in the Sandhoff mouse brain.
Volume: 20
Issue: 22
Pages: 4371-80
Publication
First Author: Sango K
Year: 2005
Journal: Invest Ophthalmol Vis Sci
Title: Impaired neurite outgrowth in the retina of a murine model of Sandhoff disease.
Volume: 46
Issue: 9
Pages: 3420-5
Publication
First Author: Norflus F
Year: 1998
Journal: J Clin Invest
Title: Bone marrow transplantation prolongs life span and ameliorates neurologic manifestations in Sandhoff disease mice.
Volume: 101
Issue: 9
Pages: 1881-8
Publication
First Author: Gulinello M
Year: 2008
Journal: Behav Brain Res
Title: Early deficits in motor coordination and cognitive dysfunction in a mouse model of the neurodegenerative lysosomal storage disorder, Sandhoff disease.
Volume: 193
Issue: 2
Pages: 315-9
Publication
First Author: Sango K
Year: 2002
Journal: Neuropathol Appl Neurobiol
Title: Lysosomal storage results in impaired survival but normal neurite outgrowth in dorsal root ganglion neurones from a mouse model of Sandhoff disease.
Volume: 28
Issue: 1
Pages: 23-34
Publication
First Author: Suzuki K
Year: 2003
Journal: Neuroreport
Title: Neuronal accumulation of alpha- and beta-synucleins in the brain of a GM2 gangliosidosis mouse model.
Volume: 14
Issue: 4
Pages: 551-4
Publication
First Author: Bifsha P
Year: 2007
Journal: Cell Death Differ
Title: Altered gene expression in cells from patients with lysosomal storage disorders suggests impairment of the ubiquitin pathway.
Volume: 14
Issue: 3
Pages: 511-23
Publication
First Author: Shimizu T
Year: 2004
Journal: J Dent Res
Title: Genetic analysis of crown size in the first molars using SMXA recombinant inbred mouse strains.
Volume: 83
Issue: 1
Pages: 45-9
Publication
First Author: Miller DJ
Year: 1993
Journal: Development
Title: Sperm require beta-N-acetylglucosaminidase to penetrate through the egg zona pellucida.
Volume: 118
Issue: 4
Pages: 1279-89
Publication
First Author: O'Brien DA
Year: 1993
Journal: Biol Reprod
Title: Mouse Sertoli cells secrete mannose 6-phosphate containing glycoproteins that are endocytosed by spermatogenic cells.
Volume: 49
Issue: 5
Pages: 1055-65
Publication
First Author: Tifft CJ
Year: 1997
Journal: Ann Med
Title: The beta-hexosaminidase deficiency disorders: development of a clinical paradigm in the mouse.
Volume: 29
Issue: 6
Pages: 557-61
Publication
First Author: Speak AO
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Implications for invariant natural killer T cell ligands due to the restricted presence of isoglobotrihexosylceramide in mammals.
Volume: 104
Issue: 14
Pages: 5971-6
Publication
First Author: García-Faroldi G
Year: 2010
Journal: PLoS One
Title: Polyamines are present in mast cell secretory granules and are important for granule homeostasis.
Volume: 5
Issue: 11
Pages: e15071
GXD Expression      
Probe: MGI:3579165
Assay Type: Northern blot
Annotation Date: 2005-06-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3579579
Age: postnatal day 70
Specimen Label: 10
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:3579165
Assay Type: Northern blot
Annotation Date: 2005-06-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3579579
Age: postnatal day 70
Specimen Label: 5
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3579165
Assay Type: Northern blot
Annotation Date: 2005-06-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Stage: TS28
Assay Id: MGI:3579579
Age: postnatal day 70
Specimen Label: 7
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3579165
Assay Type: Northern blot
Annotation Date: 2005-06-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:3579579
Age: postnatal day 70
Specimen Label: 9
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:3579165
Assay Type: Northern blot
Annotation Date: 2005-06-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:3579579
Age: postnatal day 70
Specimen Label: 8
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:3579165
Assay Type: Northern blot
Annotation Date: 2005-06-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3579579
Age: postnatal day 70
Specimen Label: 3
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3579165
Assay Type: Northern blot
Annotation Date: 2005-06-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3579579
Age: postnatal day 70
Specimen Label: 6
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3579165
Assay Type: Northern blot
Annotation Date: 2005-06-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1842628
Stage: TS28
Assay Id: MGI:3579579
Age: postnatal day 70
Specimen Label: 11
Detected: true
Specimen Num: 11
GXD Expression      
Probe: MGI:3579165
Assay Type: Northern blot
Annotation Date: 2005-06-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3579579
Age: postnatal day 70
Specimen Label: 4
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3579165
Assay Type: Northern blot
Annotation Date: 2005-06-15
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3579579
Age: postnatal day 70
Specimen Label: 1
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3579165
Assay Type: Northern blot
Annotation Date: 2005-06-15
Strength: Present
Sex: Male
Emaps: EMAPS:1929028
Stage: TS28
Assay Id: MGI:3579579
Age: postnatal day 70
Specimen Label: 2
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3772817
Assay Type: RT-PCR
Annotation Date: 2008-03-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689420
Stage: TS20
Assay Id: MGI:3772864
Age: embryonic day 12.0
Specimen Label: E12
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3772817
Assay Type: RT-PCR
Annotation Date: 2008-03-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689422
Stage: TS22
Assay Id: MGI:3772864
Age: embryonic day 14.0
Specimen Label: E14
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3772817
Assay Type: RT-PCR
Annotation Date: 2008-03-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:3772864
Age: embryonic day 16.0
Specimen Label: E16
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3772817
Assay Type: RT-PCR
Annotation Date: 2008-03-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:3772864
Age: embryonic day 18.0
Specimen Label: E18
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3772817
Assay Type: RT-PCR
Annotation Date: 2008-03-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:3772864
Age: postnatal day 1
Specimen Label: P1
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3772817
Assay Type: RT-PCR
Annotation Date: 2008-03-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3772864
Age: postnatal day 10
Specimen Label: P10
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3772817
Assay Type: RT-PCR
Annotation Date: 2008-03-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3772864
Age: postnatal adult
Specimen Label: A
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:4430587
Assay Type: RT-PCR
Annotation Date: 2010-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:4430596
Age: embryonic day 13.0
Specimen Label: E13
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:4430587
Assay Type: RT-PCR
Annotation Date: 2010-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:4430596
Age: embryonic day 18.0
Specimen Label: E18
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:4430587
Assay Type: RT-PCR
Annotation Date: 2010-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:4430596
Age: postnatal day 0
Specimen Label: P0
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:4430587
Assay Type: RT-PCR
Annotation Date: 2010-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:4430596
Age: postnatal day 3
Specimen Label: P3
Detected: true
Specimen Num: 4