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Search results 1 to 100 out of 356 for Hfe

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Domain
Type: Family
Description: Protein HFE is a member of the major histocompatibility complex class I-like family and a negative regulator of iron absorption. Mutations in the gene encoding HFE cause hereditary hemochromatosis (HH), a hereditary disease characterised by excessive intestinal absorption of dietary iron resulting in a pathological increase in total body iron stores []. HFE interacts with transferrin receptor (TFR), a key protein involved in iron transport. An alteration in this regulatory mechanism could play a role in the pathogenesis of hereditary hemochromatosis [].HFE, while structurally homologous to MHC I, is unable to bind peptides []. However, several lines of evidence indicate that the role of HFE may extend toward a role inimmunity. HFE may influence antigen presentation [, ]. Furthermore, HFE appears to inhibit antigen-specific CD8(+) T-lymphocyte activation, probably due to altered intracellular processing of MHC I antigens [].HFE gene variants correlate with body iron levels and have shown association with cancer risk, including childhood acute lymphoblastic leukemia [, ].
Protein
Organism: Mus musculus/domesticus
Length: 34  
Fragment?: true
Gene
Type: gene
Organism: human
Publication
First Author: de Almeida SF
Year: 2005
Journal: Blood
Title: HFE cross-talks with the MHC class I antigen presentation pathway.
Volume: 106
Issue: 3
Pages: 971-7
Publication
First Author: Reuben A
Year: 2014
Journal: Eur J Immunol
Title: The WT hemochromatosis protein HFE inhibits CD8⁺ T-lymphocyte activation.
Volume: 44
Issue: 6
Pages: 1604-14
Publication
First Author: Lebrón JA
Year: 1998
Journal: Cell
Title: Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor.
Volume: 93
Issue: 1
Pages: 111-23
Publication
First Author: Kennedy AE
Year: 2014
Journal: Leuk Res
Title: Examination of HFE associations with childhood leukemia risk and extension to other iron regulatory genes.
Volume: 38
Issue: 9
Pages: 1055-60
Publication
First Author: Reuben A
Year: 2015
Journal: Mol Immunol
Title: T lymphocyte-derived TNF and IFN-γ repress HFE expression in cancer cells.
Volume: 65
Issue: 2
Pages: 259-66
Publication
First Author: Riegert P
Year: 1998
Journal: Immunogenetics
Title: The mouse HFE gene.
Volume: 47
Issue: 2
Pages: 174-7
Publication
First Author: Vujić Spasić M
Year: 2008
Journal: Cell Metab
Title: Hfe acts in hepatocytes to prevent hemochromatosis.
Volume: 7
Issue: 2
Pages: 173-8
Publication
First Author: Golub MS
Year: 2005
Journal: Nutr Neurosci
Title: Movement disorders in the Hfe knockout mouse.
Volume: 8
Issue: 4
Pages: 239-44
Publication
First Author: Schmidt PJ
Year: 2010
Journal: Blood
Title: Hepcidin induction by transgenic overexpression of Hfe does not require the Hfe cytoplasmic tail, but does require hemojuvelin.
Volume: 116
Issue: 25
Pages: 5679-87
Publication
First Author: Ajioka RS
Year: 2002
Journal: Blood
Title: Regulation of iron absorption in Hfe mutant mice.
Volume: 100
Issue: 4
Pages: 1465-9
Publication
First Author: Feder JN
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding.
Volume: 95
Issue: 4
Pages: 1472-7
Publication
First Author: de Almeida SF
Year: 2007
Journal: J Immunol
Title: Stimulation of an unfolded protein response impairs MHC class I expression.
Volume: 178
Issue: 6
Pages: 3612-9
Publication
First Author: Feder JN
Year: 1996
Journal: Nat Genet
Title: A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis.
Volume: 13
Issue: 4
Pages: 399-408
Publication
First Author: Gao J
Year: 2010
Journal: Blood
Title: Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice.
Volume: 115
Issue: 16
Pages: 3374-81
Publication
First Author: Ahmad KA
Year: 2002
Journal: Blood Cells Mol Dis
Title: Decreased liver hepcidin expression in the Hfe knockout mouse.
Volume: 29
Issue: 3
Pages: 361-6
Publication
First Author: Benesova K
Year: 2012
Journal: PLoS One
Title: Hfe deficiency impairs pulmonary neutrophil recruitment in response to inflammation.
Volume: 7
Issue: 6
Pages: e39363
Publication
First Author: Zhou XY
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: HFE gene knockout produces mouse model of hereditary hemochromatosis.
Volume: 95
Issue: 5
Pages: 2492-7
Publication
First Author: Bensaid M
Year: 2004
Journal: Gastroenterology
Title: Multigenic control of hepatic iron loading in a murine model of hemochromatosis.
Volume: 126
Issue: 5
Pages: 1400-8
Publication
First Author: Laftah AH
Year: 2003
Journal: Br J Haematol
Title: Hypoxic response of iron absorption is not affected by the Hfe gene knock-out in mice.
Volume: 123
Issue: 1
Pages: 170-2
Publication
First Author: Gutiérrez L
Year: 2009
Journal: Biochim Biophys Acta
Title: Iron speciation study in Hfe knockout mice tissues: magnetic and ultrastructural characterisation.
Volume: 1792
Issue: 6
Pages: 541-7
Publication
First Author: Abgueguen E
Year: 2006
Journal: Mamm Genome
Title: Differential expression of genes related to HFE and iron status in mouse duodenal epithelium.
Volume: 17
Issue: 5
Pages: 430-50
Publication
First Author: Wu XG
Year: 2014
Journal: Blood
Title: HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression.
Volume: 124
Issue: 8
Pages: 1335-43
GXD Expression      
Probe: MGI:6174821
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6190502
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Hfe
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:6174821
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6190502
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Hfe
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:6174821
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6190502
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Hfe
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6174821
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6190502
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Hfe
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6174821
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190502
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Hfe
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6174821
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190502
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Hfe
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6174821
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190502
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Hfe
Detected: true
Specimen Num: 7
Publication
First Author: Rodriguez A
Year: 2009
Journal: PLoS One
Title: Global transcriptional response to Hfe deficiency and dietary iron overload in mouse liver and duodenum.
Volume: 4
Issue: 9
Pages: e7212
Publication
First Author: Constante M
Year: 2006
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Distinct requirements for Hfe in basal and induced hepcidin levels in iron overload and inflammation.
Volume: 291
Issue: 2
Pages: G229-37
Publication
First Author: Tomatsu S
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Contribution of the H63D mutation in HFE to murine hereditary hemochromatosis.
Volume: 100
Issue: 26
Pages: 15788-93
Publication
First Author: Bahram S
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Experimental hemochromatosis due to MHC class I HFE deficiency: immune status and iron metabolism.
Volume: 96
Issue: 23
Pages: 13312-7
Publication
First Author: Turoczi T
Year: 2003
Journal: Circ Res
Title: HFE mutation and dietary iron content interact to increase ischemia/reperfusion injury of the heart in mice.
Volume: 92
Issue: 11
Pages: 1240-6
Publication
First Author: Chua AC
Year: 2004
Journal: Blood
Title: Nontransferrin-bound iron uptake by hepatocytes is increased in the Hfe knockout mouse model of hereditary hemochromatosis.
Volume: 104
Issue: 5
Pages: 1519-25
Publication
First Author: Miranda CJ
Year: 2003
Journal: Blood
Title: Hfe deficiency increases susceptibility to cardiotoxicity and exacerbates changes in iron metabolism induced by doxorubicin.
Volume: 102
Issue: 7
Pages: 2574-80
Publication
First Author: Liu Y
Year: 2011
Journal: J Biol Chem
Title: Mutant HFE H63D protein is associated with prolonged endoplasmic reticulum stress and increased neuronal vulnerability.
Volume: 286
Issue: 15
Pages: 13161-70
Publication
First Author: Lebeau A
Year: 2002
Journal: Eur J Clin Invest
Title: Long-term sequelae of HFE deletion in C57BL/6 x 129/O1a mice, an animal model for hereditary haemochromatosis.
Volume: 32
Issue: 8
Pages: 603-12
Publication
First Author: Nandar W
Year: 2014
Journal: Biochim Biophys Acta
Title: H63D HFE genotype accelerates disease progression in animal models of amyotrophic lateral sclerosis.
Volume: 1842
Issue: 12 Pt A
Pages: 2413-26
Publication
First Author: Fleming RE
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Mouse strain differences determine severity of iron accumulation in Hfe knockout model of hereditary hemochromatosis.
Volume: 98
Issue: 5
Pages: 2707-11
Publication
First Author: Trinder D
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Iron uptake from plasma transferrin by the duodenum is impaired in the Hfe knockout mouse.
Volume: 99
Issue: 8
Pages: 5622-6
Publication
First Author: Nixon AM
Year: 2018
Journal: J Neurochem
Title: HFE Genotype Restricts the Response to Paraquat in a Mouse Model of Neurotoxicity.
Volume: 145
Issue: 4
Pages: 299-311
Publication
First Author: Simpson RJ
Year: 2003
Journal: Blood
Title: Duodenal nonheme iron content correlates with iron stores in mice, but the relationship is altered by Hfe gene knock-out.
Volume: 101
Issue: 8
Pages: 3316-8
Publication
First Author: Gnana-Prakasam JP
Year: 2013
Journal: Invest Ophthalmol Vis Sci
Title: Loss of Hfe leads to progression of tumor phenotype in primary retinal pigment epithelial cells.
Volume: 54
Issue: 1
Pages: 63-71
Publication
First Author: Wallace DF
Year: 2011
Journal: Blood
Title: Blunted hepcidin response to inflammation in the absence of Hfe and transferrin receptor 2.
Volume: 117
Issue: 10
Pages: 2960-6
Publication
First Author: Lee P
Year: 2012
Journal: Blood Cells Mol Dis
Title: Severe microcytic anemia but increased erythropoiesis in mice lacking Hfe or Tfr2 and Tmprss6.
Volume: 48
Issue: 3
Pages: 173-8
Publication
First Author: Kent P
Year: 2015
Journal: J Mol Med (Berl)
Title: Hfe and Hjv exhibit overlapping functions for iron signaling to hepcidin.
Volume: 93
Issue: 5
Pages: 489-98
Publication
First Author: Gnana-Prakasam JP
Year: 2009
Journal: Biochem J
Title: Absence of iron-regulatory protein Hfe results in hyperproliferation of retinal pigment epithelium: role of cystine/glutamate exchanger.
Volume: 424
Issue: 2
Pages: 243-52
Publication
First Author: Fergelot P
Year: 2002
Journal: Blood Cells Mol Dis
Title: Iron overload in mice expressing HFE exclusively in the intestinal villi provides evidence that HFE regulates a functional cross-talk between crypt and villi enterocytes.
Volume: 28
Issue: 3
Pages: 348-60
Publication
First Author: Makui H
Year: 2005
Journal: Blood
Title: Contribution of Hfe expression in macrophages to the regulation of hepatic hepcidin levels and iron loading.
Volume: 106
Issue: 6
Pages: 2189-95
Publication
First Author: Xiao X
Year: 2023
Journal: Blood
Title: Regulation of iron homeostasis by hepatocyte TfR1 requires HFE and contributes to hepcidin suppression in β-thalassemia.
Volume: 141
Issue: 4
Pages: 422-432
Publication
First Author: Demetz E
Year: 2020
Journal: Eur Heart J
Title: The haemochromatosis gene Hfe and Kupffer cells control LDL cholesterol homeostasis and impact on atherosclerosis development.
Volume: 41
Issue: 40
Pages: 3949-3959
Publication
First Author: Knutson MD
Year: 2001
Journal: J Nutr
Title: Expression of stimulator of Fe transport is not enhanced in Hfe knockout mice.
Volume: 131
Issue: 5
Pages: 1459-64
Publication
First Author: Nandar W
Year: 2013
Journal: Biochim Biophys Acta
Title: A mutation in the HFE gene is associated with altered brain iron profiles and increased oxidative stress in mice.
Volume: 1832
Issue: 6
Pages: 729-41
Publication
First Author: Boucherma R
Year: 2012
Journal: Eur J Immunol
Title: Loss of central and peripheral CD8+ T-cell tolerance to HFE in mouse models of human familial hemochromatosis.
Volume: 42
Issue: 4
Pages: 851-62
Publication
First Author: Simpson RJ
Year: 2003
Journal: Gut
Title: Duodenal mucosal reductase in wild-type and Hfe knockout mice on iron adequate, iron deficient, and iron rich feeding.
Volume: 52
Issue: 4
Pages: 510-3
Publication
First Author: Sánchez M
Year: 1998
Journal: Gene
Title: Cloning, sequencing and characterization of the rat hereditary hemochromatosis promoter: comparison of the human, mouse and rat HFE promoter regions.
Volume: 225
Issue: 1-2
Pages: 77-87
QTL
Type: QTL
Organism: mouse, laboratory
QTL
Type: QTL
Organism: mouse, laboratory
QTL
Type: QTL
Organism: mouse, laboratory
QTL
Type: QTL
Organism: mouse, laboratory
Publication
First Author: Gao J
Year: 2009
Journal: Cell Metab
Title: Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression.
Volume: 9
Issue: 3
Pages: 217-27
Publication
First Author: Nairz M
Year: 2009
Journal: Blood
Title: Absence of functional Hfe protects mice from invasive Salmonella enterica serovar Typhimurium infection via induction of lipocalin-2.
Volume: 114
Issue: 17
Pages: 3642-51
Publication
First Author: Albig W
Year: 1998
Journal: J Cell Biochem
Title: The haemochromatosis candidate gene HFE (HLA-H) of man and mouse is located in syntenic regions within the histone gene cluster.
Volume: 69
Issue: 2
Pages: 117-26
Publication
First Author: Ramos P
Year: 2011
Journal: Blood
Title: Enhanced erythropoiesis in Hfe-KO mice indicates a role for Hfe in the modulation of erythroid iron homeostasis.
Volume: 117
Issue: 4
Pages: 1379-89
Protein
Organism: Mus musculus/domesticus
Length: 171  
Fragment?: false
Publication
First Author: Wallace DF
Year: 2009
Journal: Hepatology
Title: Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload.
Volume: 50
Issue: 6
Pages: 1992-2000
Protein
Organism: Mus musculus/domesticus
Length: 359  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 358  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 271  
Fragment?: false
Publication
First Author: Hall EC 2nd
Year: 2010
Journal: Biochim Biophys Acta
Title: Prolyl-peptidyl isomerase, Pin1, phosphorylation is compromised in association with the expression of the HFE polymorphic allele, H63D.
Volume: 1802
Issue: 4
Pages: 389-95
Publication      
First Author: Chaudhary K
Year: 2019
Journal: Am J Physiol Renal Physiol
Title: Renal Iron Accelerates the Progression of Diabetic Nephropathy in HFE (High Fe-iron) Gene Knockout Mouse Model of Iron Overload.
Publication
First Author: Constante M
Year: 2007
Journal: Am J Pathol
Title: Repression of repulsive guidance molecule C during inflammation is independent of Hfe and involves tumor necrosis factor-alpha.
Volume: 170
Issue: 2
Pages: 497-504
Publication
First Author: Costa M
Year: 2015
Journal: PLoS One
Title: Lymphocyte gene expression signatures from patients and mouse models of hereditary hemochromatosis reveal a function of HFE as a negative regulator of CD8+ T-lymphocyte activation and differentiation in vivo.
Volume: 10
Issue: 4
Pages: e0124246
Publication
First Author: Alves FM
Year: 2022
Journal: Biochim Biophys Acta Gen Subj
Title: Disruption of Hfe leads to skeletal muscle iron loading and reduction of hemoproteins involved in oxidative metabolism in a mouse model of hereditary hemochromatosis.
Volume: 1866
Issue: 3
Pages: 130082
Publication
First Author: Gleitz HFE
Year: 2020
Journal: Blood
Title: Increased CXCL4 expression in hematopoietic cells links inflammation and progression of bone marrow fibrosis in MPN.
Volume: 136
Issue: 18
Pages: 2051-2064
Publication  
First Author: Guldiken N
Year: 2019
Journal: Cells
Title: Mild Iron Overload as Seen in Individuals Homozygous for the Alpha-1 Antitrypsin Pi*Z Variant Does Not Promote Liver Fibrogenesis in HFE Knockout Mice.
Volume: 8
Issue: 11
Publication
First Author: Finberg KE
Year: 2011
Journal: Blood
Title: Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice.
Volume: 117
Issue: 17
Pages: 4590-9
Publication
First Author: Schmidt PJ
Year: 2008
Journal: Cell Metab
Title: The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression.
Volume: 7
Issue: 3
Pages: 205-14
Author
Publication
First Author: Goswami T
Year: 2006
Journal: J Biol Chem
Title: Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing.
Volume: 281
Issue: 39
Pages: 28494-8
Publication
First Author: Levy JE
Year: 1999
Journal: Blood
Title: The C282Y mutation causing hereditary hemochromatosis does not produce a null allele.
Volume: 94
Issue: 1
Pages: 9-11
Publication
First Author: Rovai A
Year: 2022
Journal: Nat Commun
Title: In vivo adenine base editing reverts C282Y and improves iron metabolism in hemochromatosis mice.
Volume: 13
Issue: 1
Pages: 5215
Publication
First Author: Roy CN
Year: 2004
Journal: Nat Genet
Title: An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice.
Volume: 36
Issue: 5
Pages: 481-5
Publication
First Author: Stevens RG
Year: 2003
Journal: Free Radic Biol Med
Title: Oxidative damage in colon and mammary tissue of the HFE-knockout mouse.
Volume: 34
Issue: 9
Pages: 1212-6
Publication
First Author: Frazer DM
Year: 2004
Journal: Br J Haematol
Title: Increased hepcidin expression and hypoferraemia associated with an acute phase response are not affected by inactivation of HFE.
Volume: 126
Issue: 3
Pages: 434-6
Publication
First Author: Tan TC
Year: 2011
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Altered lipid metabolism in Hfe-knockout mice promotes severe NAFLD and early fibrosis.
Volume: 301
Issue: 5
Pages: G865-76
Publication
First Author: Petrak J
Year: 2007
Journal: Int J Biochem Cell Biol
Title: Iron-independent specific protein expression pattern in the liver of HFE-deficient mice.
Volume: 39
Issue: 5
Pages: 1006-15
Publication  
First Author: Johnstone D
Year: 2012
Journal: Brain Res
Title: Brain transcriptome perturbations in the Hfe(-/-) mouse model of genetic iron loading.
Volume: 1448
Pages: 144-52
Publication
First Author: Griffiths WJ
Year: 2001
Journal: Gastroenterology
Title: Intestinal iron uptake determined by divalent metal transporter is enhanced in HFE-deficient mice with hemochromatosis.
Volume: 120
Issue: 6
Pages: 1420-9