|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 90 out of 90 for Hhat

0.028s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Domain
Type: Family
Description: Protein-cysteine N-palmitoyltransferase, also known as hedgehog acyltransferase (HHAT), catalyses the N-terminal palmitoylation of Sonic hedgehog (Shh) [, , ]. Shh is a signaling molecule involved in embryonic patterning and organogenesis, and these lipid modifications serve to regulate its movement to form the proper concentration gradient. Overexpression of Hedgehog family proteins contributes to the aetiology of many cancers, thus HHAT inhibition is considered a target for tumour growth suppression [].HHAT is a multipass transmembrane enzyme with a membrane-bound O-acyltransferase (MBOAT) homology domain [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Chen MH
Year: 2004
Journal: Genes Dev
Title: Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates.
Volume: 18
Issue: 6
Pages: 641-59
Publication
First Author: Buglino JA
Year: 2008
Journal: J Biol Chem
Title: Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog.
Volume: 283
Issue: 32
Pages: 22076-88
Protein
Organism: Mus musculus
Length: 499  
Fragment?: false
Protein
Organism: Mus musculus
Length: 507  
Fragment?: false
Publication
First Author: Pepinsky RB
Year: 1998
Journal: J Biol Chem
Title: Identification of a palmitic acid-modified form of human Sonic hedgehog.
Volume: 273
Issue: 22
Pages: 14037-45
Publication
First Author: Matevossian A
Year: 2015
Journal: J Biol Chem
Title: Membrane topology of hedgehog acyltransferase.
Volume: 290
Issue: 4
Pages: 2235-43
Publication
First Author: Konitsiotis AD
Year: 2014
Journal: PLoS One
Title: Attenuation of hedgehog acyltransferase-catalyzed sonic Hedgehog palmitoylation causes reduced signaling, proliferation and invasiveness of human carcinoma cells.
Volume: 9
Issue: 3
Pages: e89899
Protein
Organism: Mus musculus
Length: 367  
Fragment?: true
Publication
First Author: Callier P
Year: 2014
Journal: PLoS Genet
Title: Loss of function mutation in the palmitoyl-transferase HHAT leads to syndromic 46,XY disorder of sex development by impeding Hedgehog protein palmitoylation and signaling.
Volume: 10
Issue: 5
Pages: e1004340
Publication
First Author: Abe Y
Year: 2008
Journal: FEBS J
Title: Mammalian Gup1, a homolog of Saccharomyces cerevisiae glycerol uptake/transporter 1, acts as a negative regulator for N-terminal palmitoylation of Sonic hedgehog.
Volume: 275
Issue: 2
Pages: 318-31
Publication
First Author: Iulianella A
Year: 2018
Journal: Dev Dyn
Title: Ventral neural patterning in the absence of a Shh activity gradient from the floorplate.
Volume: 247
Issue: 1
Pages: 170-184
Publication
First Author: Asciolla JJ
Year: 2019
Journal: Cell Rep
Title: Hedgehog Acyltransferase Promotes Uptake of Palmitoyl-CoA across the Endoplasmic Reticulum Membrane.
Volume: 29
Issue: 13
Pages: 4608-4619.e4
Publication
First Author: Dennis JF
Year: 2012
Journal: PLoS Genet
Title: Mutations in Hedgehog acyltransferase (Hhat) perturb Hedgehog signaling, resulting in severe acrania-holoprosencephaly-agnathia craniofacial defects.
Volume: 8
Issue: 10
Pages: e1002927
Publication
First Author: Coumoul X
Year: 2005
Journal: Nucleic Acids Res
Title: Conditional knockdown of Fgfr2 in mice using Cre-LoxP induced RNA interference.
Volume: 33
Issue: 11
Pages: e102
Publication
First Author: Nelson DK
Year: 2004
Journal: Dev Biol
Title: Frontonasal process-specific disruption of AP-2alpha results in postnatal midfacial hypoplasia, vascular anomalies, and nasal cavity defects.
Volume: 267
Issue: 1
Pages: 72-92
Publication  
First Author: Yun K
Year: 2017
Journal: Differentiation
Title: Hydronephrosis in the Wnt5a-ablated kidney is caused by an abnormal ureter-bladder connection.
Volume: 94
Pages: 1-7
Publication
First Author: Zhu J
Year: 2012
Journal: Genesis
Title: Cre-mediated recombination can induce apoptosis in vivo by activating the p53 DNA damage-induced pathway.
Volume: 50
Issue: 2
Pages: 102-11
Publication
First Author: Li C
Year: 2005
Journal: Development
Title: FGFR1 function at the earliest stages of mouse limb development plays an indispensable role in subsequent autopod morphogenesis.
Volume: 132
Issue: 21
Pages: 4755-64
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression      
Probe: MGI:3052524
Assay Type: Northern blot
Annotation Date: 2004-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603910
Stage: TS10
Assay Id: MGI:3053452
Age: embryonic day 7.0
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:3052524
Assay Type: RNA in situ
Annotation Date: 2004-10-01
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1640517
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:3053341
Age: embryonic day 10.5
Image: 2P
Note: Expression is strong in the distal part of the limb.
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:3052524
Assay Type: RNA in situ
Annotation Date: 2004-10-01
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1606917
Pattern: Non-Uniform
Stage: TS17
Assay Id: MGI:3053341
Age: embryonic day 10.5
Image: 2P
Note: Expression is stronger in the anterior ectoderm.
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:3052524
Assay Type: RNA in situ
Annotation Date: 2004-10-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:3053341
Age: embryonic day 8.5
Image: 2N
Note: Expression is widespread.
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:3052524
Assay Type: RNA in situ
Annotation Date: 2004-10-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:3053341
Age: embryonic day 9.5
Image: 2O
Note: Expression is widespread.
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:3052524
Assay Type: RNA in situ
Annotation Date: 2004-10-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3053341
Age: embryonic day 10.5
Image: 2P
Note: Expression is widespread.
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:3052524
Assay Type: RNA in situ
Annotation Date: 2004-10-01
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1611717
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3053341
Age: embryonic day 10.5
Image: 2P
Detected: true
Specimen Num: 3
Publication
First Author: Kurosaka H
Year: 2014
Journal: J Clin Invest
Title: Disrupting hedgehog and WNT signaling interactions promotes cleft lip pathogenesis.
Volume: 124
Issue: 4
Pages: 1660-71
Publication
First Author: Kitagaki J
Year: 2011
Journal: Development
Title: FGF8 is essential for formation of the ductal system in the male reproductive tract.
Volume: 138
Issue: 24
Pages: 5369-78
Publication
First Author: Kurosaka H
Year: 2015
Journal: PLoS One
Title: Cranial nerve development requires co-ordinated Shh and canonical Wnt signaling.
Volume: 10
Issue: 3
Pages: e0120821
Publication
First Author: Regard JB
Year: 2013
Journal: Nat Med
Title: Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification.
Volume: 19
Issue: 11
Pages: 1505-12
Publication
First Author: Chamberlain CE
Year: 2008
Journal: Development
Title: Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning.
Volume: 135
Issue: 6
Pages: 1097-106
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
UniProt Feature
Begin: 1
Description: Protein-cysteine N-palmitoyltransferase HHAT
Type: chain
End: 499
Protein
Organism: Mus musculus
Length: 473  
Fragment?: false
Allele
Name: hedgehog acyltransferase; transgene insertion 1, Trevor Williams
Allele Type: Transgenic
Attribute String: Null/knockout, Recombinase
Publication categories: ProxyCollection
Strain
Attribute String: mutant stock, transgenic
Genotype
Symbol: Hhat/Hhat<+> Shh/Shh<+>
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Hhat/Hhat
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Tfap2a/Tfap2a Hhat/?
Background: Not Specified
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Hhat/Hhat<+> Ptch1/Ptch1<+>
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Hhat/Hhat<+>
Background: involves: 129S4/SvJaeSor
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Hhat/Hhat H2az2/?
Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
Publication
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112