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Search results 1 to 85 out of 85 for Hilpda

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
29923 | HILPDA
Type: gene
Organism: human
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Gene
463702 | HILPDA
Type: gene
Organism: chimpanzee
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Gene
100125928 | HILPDA
Type: gene
Organism: cattle
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Gene
100361568 | Hilpda
Type: gene
Organism: rat
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Gene
100688487 | HILPDA
Type: gene
Organism: dog, domestic
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Gene
701261 | HILPDA
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1916823 | Hilpda
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
28739822 | J:301866
First Author: VandeKopple MJ
Year: 2017
Journal: J Endocrinol
Title: Stress-responsive HILPDA is necessary for thermoregulation during fasting.
Volume: 235
Issue: 1
Pages: 27-38
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Publication
32049012 | J:287480
First Author: van Dierendonck XAMH
Year: 2020
Journal: Cell Rep
Title: HILPDA Uncouples Lipid Droplet Accumulation in Adipose Tissue Macrophages from Inflammation and Metabolic Dysregulation.
Volume: 30
Issue: 6
Pages: 1811-1822.e6
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Publication
37061197 | J:343174
First Author: Povero D
Year: 2023
Journal: J Hepatol
Title: HILPDA promotes NASH-driven HCC development by restraining intracellular fatty acid flux in hypoxia.
Volume: 79
Issue: 2
Pages: 378-393
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Publication
37422000 | J:339180
 
First Author: Deng L
Year: 2023
Journal: Mol Metab
Title: HILPDA is a lipotoxic marker in adipocytes that mediates the autocrine negative feedback regulation of triglyceride hydrolysis by fatty acids and alleviates cellular lipotoxic stress.
Volume: 75
Pages: 101773
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Publication
28323980 | J:245494
First Author: Dijk W
Year: 2017
Journal: Endocrinology
Title: Hypoxia-Inducible Lipid Droplet-Associated Is Not a Direct Physiological Regulator of Lipolysis in Adipose Tissue.
Volume: 158
Issue: 5
Pages: 1231-1251
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Publication
24876382 | J:338773
First Author: Mattijssen F
Year: 2014
Journal: J Biol Chem
Title: Hypoxia-inducible lipid droplet-associated (HILPDA) is a novel peroxisome proliferator-activated receptor (PPAR) target involved in hepatic triglyceride secretion.
Volume: 289
Issue: 28
Pages: 19279-93
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Publication
36476935 | J:332914
First Author: Gong Z
Year: 2022
Journal: Cell Metab
Title: Lipid-laden lung mesenchymal cells foster breast cancer metastasis via metabolic reprogramming of tumor cells and natural killer cells.
Volume: 34
Issue: 12
Pages: 1960-1976.e9
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Publication
33484195 | J:309541
First Author: Petkevicius K
Year: 2021
Journal: FASEB J
Title: Norepinephrine promotes triglyceride storage in macrophages via beta2-adrenergic receptor activation.
Volume: 35
Issue: 2
Pages: e21266
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Publication
28760743 | J:253318
First Author: Maier A
Year: 2017
Journal: FASEB J
Title: Hypoxia-inducible protein 2 Hig2/Hilpda mediates neutral lipid accumulation in macrophages and contributes to atherosclerosis in apolipoprotein E-deficient mice.
Volume: 31
Issue: 11
Pages: 4971-4984
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Protein Coding Gene
MGP_CAROLIEiJ_G0028165 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0030517 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0030490 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0030417 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0030500 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0030213 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1916823 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0030954 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0029615 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0030191 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0030335 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0030289 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0030422 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0030325 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0030984 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0029329 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0029691 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0021923 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0029165 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
27900258 | J:302085
First Author: DiStefano MT
Year: 2016
Journal: Mol Metab
Title: Adipocyte-specific Hypoxia-inducible gene 2 promotes fat deposition and diet-induced insulin resistance.
Volume: 5
Issue: 12
Pages: 1149-1161
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Publication
- | J:175369
     
First Author: Nathans J
Year: 2011
Journal: MGI Direct Data Submission
Title: Direct Data Submission 2011/09/14
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GXD Expression
GXD Expression
     
Probe: MGI:7852279
Assay Type: RT-PCR
Annotation Date: 2025-01-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:7852287
Age: embryonic day 18.5
Specimen Label: ROB
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:7852279
Assay Type: RT-PCR
Annotation Date: 2025-01-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3518626
Stage: TS26
Assay Id: MGI:7852287
Age: embryonic day 18.5
Specimen Label: BMF
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7852279
Assay Type: RT-PCR
Annotation Date: 2025-01-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3518626
Stage: TS26
Assay Id: MGI:7852296
Age: embryonic day 18.5
Specimen Label: pdgfb+/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:7852279
Assay Type: RT-PCR
Annotation Date: 2025-01-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3518626
Stage: TS26
Assay Id: MGI:7852296
Age: embryonic day 18.5
Specimen Label: pdgfb-/-
Detected: true
Specimen Num: 2
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Publication
25922078 | J:302186
First Author: DiStefano MT
Year: 2015
Journal: J Biol Chem
Title: The Lipid Droplet Protein Hypoxia-inducible Gene 2 Promotes Hepatic Triglyceride Deposition by Inhibiting Lipolysis.
Volume: 290
Issue: 24
Pages: 15175-84
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Publication
32958928 | J:306037
First Author: Li P
Year: 2020
Journal: Nat Immunol
Title: Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis.
Volume: 21
Issue: 11
Pages: 1444-1455
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Publication
39366382 | J:358143
First Author: Rao Z
Year: 2024
Journal: Immunity
Title: Alarmin-loaded extracellular lipid droplets induce airway neutrophil infiltration during type 2 inflammation.
Volume: 57
Issue: 11
Pages: 2514-2529.e7
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Publication
18483404 | J:356615
First Author: Wallgard E
Year: 2008
Journal: Arterioscler Thromb Vasc Biol
Title: Identification of a core set of 58 gene transcripts with broad and specific expression in the microvasculature.
Volume: 28
Issue: 8
Pages: 1469-76
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Publication
28204537 | J:242046
First Author: Sharma S
Year: 2017
Journal: Hum Mol Genet
Title: Mitochondrial complex II regulates a distinct oxygen sensing mechanism in monocytes.
Volume: 26
Issue: 7
Pages: 1328-1339
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
20624928 | -
First Author: Gimm T
Year: 2010
Journal: FASEB J
Title: Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1.
Volume: 24
Issue: 11
Pages: 4443-58
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Protein
Q9JLS0
Organism: Mus musculus/domesticus
Length: 64  
Fragment?: false
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Publication
15930302 | -
First Author: Togashi A
Year: 2005
Journal: Cancer Res
Title: Hypoxia-inducible protein 2 (HIG2), a novel diagnostic marker for renal cell carcinoma and potential target for molecular therapy.
Volume: 65
Issue: 11
Pages: 4817-26
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Publication
21614900 | -
First Author: Nishimura S
Year: 2011
Journal: Eur J Gynaecol Oncol
Title: Expression of hypoxia-inducible 2 (HIG2) protein in uterine cancer.
Volume: 32
Issue: 2
Pages: 146-9
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Protein Domain
IPR026190 | Hipoxia_HILPDA
Type: Family
Description: Hypoxia-inducible lipid droplet-associated protein (HILPDA), also known as hypoxia-inducible protein 2 (HIG2), increases intracellular lipid accumulation. It stimulates expression of cytokines including IL6, MIF and VEGFA. It also enhances cell growth and proliferation [, ]. Human HILPDA is highly expressed in renal cell carcinoma cells but barely detectable in adjacent normal kidney tissue. It is detected in some cervical and endometrial cancers [, , ].
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Publication
33465519 | J:305674
 
First Author: de la Rosa Rodriguez MA
Year: 2021
Journal: Mol Metab
Title: Hypoxia-inducible lipid droplet-associated induces DGAT1 and promotes lipid storage in hepatocytes.
Volume: 47
Pages: 101168
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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