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Search results 1 to 100 out of 527 for Hira

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0.042s
Type Details Score
Gene
Type: gene
Organism: Drosophila melanogaster
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Domain
Type: Domain
Description: The Hira proteins are found in a range of eukaryotes and are implicated in the assembly of repressive chromatin. These proteins also contain .
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein
Organism: Mus musculus
Length: 1015  
Fragment?: false
Gene
Type: gene
Organism: Homo sapiens
Publication  
First Author: Hira K
Year: 2001
Journal: Int Arch Allergy Immunol
Title: Establishment and characterization of a murine mast cell line derived from NC/Nga mice.
Volume: 125 Suppl 1
Pages: 67-70
Publication
First Author: Magnaghi P
Year: 1998
Journal: Nat Genet
Title: HIRA, a mammalian homologue of Saccharomyces cerevisiae transcriptional co-repressors, interacts with Pax3.
Volume: 20
Issue: 1
Pages: 74-7
Publication
First Author: Dilg D
Year: 2016
Journal: PLoS One
Title: HIRA Is Required for Heart Development and Directly Regulates Tnni2 and Tnnt3.
Volume: 11
Issue: 8
Pages: e0161096
Publication
First Author: Li Y
Year: 2017
Journal: J Cell Biol
Title: Histone chaperone HIRA regulates neural progenitor cell proliferation and neurogenesis via β-catenin.
Volume: 216
Issue: 7
Pages: 1975-1992
Publication
First Author: Valenzuela N
Year: 2017
Journal: J Cell Sci
Title: HIRA deficiency in muscle fibers causes hypertrophy and susceptibility to oxidative stress.
Volume: 130
Issue: 15
Pages: 2551-2563
Publication
First Author: Rai TS
Year: 2014
Journal: Genes Dev
Title: HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia.
Volume: 28
Issue: 24
Pages: 2712-25
Publication
First Author: Blake GET
Year: 2021
Journal: Nat Commun
Title: Defective folate metabolism causes germline epigenetic instability and distinguishes Hira as a phenotype inheritance biomarker.
Volume: 12
Issue: 1
Pages: 3714
Publication
First Author: Valenzuela N
Year: 2016
Journal: Dis Model Mech
Title: Cardiomyocyte-specific conditional knockout of the histone chaperone HIRA in mice results in hypertrophy, sarcolemmal damage and focal replacement fibrosis.
Volume: 9
Issue: 3
Pages: 335-45
Publication
First Author: Soni S
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Transcription factor EKLF (KLF1) recruitment of the histone chaperone HIRA is essential for β-globin gene expression.
Volume: 111
Issue: 37
Pages: 13337-42
Publication
First Author: Roberts C
Year: 2002
Journal: Mol Cell Biol
Title: Targeted mutagenesis of the Hira gene results in gastrulation defects and patterning abnormalities of mesoendodermal derivatives prior to early embryonic lethality.
Volume: 22
Issue: 7
Pages: 2318-28
Publication
First Author: Scamps C
Year: 1996
Journal: Biochim Biophys Acta
Title: The HIR protein family: isolation and characterization of a complete murine cDNA.
Volume: 1306
Issue: 1
Pages: 5-8
Publication
First Author: Wilming LG
Year: 1997
Journal: Hum Mol Genet
Title: The murine homologue of HIRA, a DiGeorge syndrome candidate gene, is expressed in embryonic structures affected in human CATCH22 patients.
Volume: 6
Issue: 2
Pages: 247-58
Publication
First Author: van der Heijden GW
Year: 2005
Journal: Mech Dev
Title: Asymmetry in histone H3 variants and lysine methylation between paternal and maternal chromatin of the early mouse zygote.
Volume: 122
Issue: 9
Pages: 1008-22
Publication
First Author: Halford S
Year: 1993
Journal: Hum Mol Genet
Title: Isolation of a putative transcriptional regulator from the region of 22q11 deleted in DiGeorge syndrome, Shprintzen syndrome and familial congenital heart disease.
Volume: 2
Issue: 12
Pages: 2099-107
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Publication
First Author: Lorain S
Year: 2001
Journal: Biochim Biophys Acta
Title: Identification of human and mouse HIRA-interacting protein-5 (HIRIP5), two mammalian representatives in a family of phylogenetically conserved proteins with a role in the biogenesis of Fe/S proteins.
Volume: 1517
Issue: 3
Pages: 376-83
GO Term
UniProt Feature
Begin: 1
Description: Protein HIRA
Type: chain
End: 1015
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Lin CJ
Year: 2014
Journal: Dev Cell
Title: Hira-mediated H3.3 incorporation is required for DNA replication and ribosomal RNA transcription in the mouse zygote.
Volume: 30
Issue: 3
Pages: 268-79
Publication
First Author: Chen C
Year: 2020
Journal: Cell Rep
Title: HIRA, a DiGeorge Syndrome Candidate Gene, Confers Proper Chromatin Accessibility on HSCs and Supports All Stages of Hematopoiesis.
Volume: 30
Issue: 7
Pages: 2136-2149.e4
Publication
First Author: Goldberg AD
Year: 2010
Journal: Cell
Title: Distinct factors control histone variant H3.3 localization at specific genomic regions.
Volume: 140
Issue: 5
Pages: 678-91
Protein Domain
Type: Conserved_site
Description: The HirA B (Histone regulatory homologue A binding) motif is the essential binding interface between and ASF1a, of approx. 40 residues. It forms an antiparallel beta-hairpin that binds perpendicular to the strands of the beta-sandwich of ASF1a N-terminal core domain, via beta-sheet, salt bridge and van der Waals interactions []. The two histone chaperone proteins, HIRA and ASF1a, form a heterodimer with histones H3 and H4. HIRA is the human orthologue of Hir proteins known to silence histone gene expression and create transcriptionally silent heterochromatin in yeast, flies, plants and humans. The HIR complex is composed of HIR1, HIR2, HIR3 and HPC2, and interacts with ASF1. The HIR complex cooperates with ASF1 to promote replication-independent chromatin assembly. The HIR complex is also required for the periodic repression of three of the four histone gene loci during cell cycle as well as for autogenous regulation of the HTA1-HTB1 locus by H2A and H2B. DNA-binding by the HIR complex may repress transcription by inhibiting nucleosome remodeling by the SWI/SNF complex. The HIR complex may also be required for transcriptional silencing of centromeric, telomeric and mating-type loci in the absence of CAF-1.
Publication
First Author: Sarai N
Year: 2013
Journal: EMBO J
Title: WHSC1 links transcription elongation to HIRA-mediated histone H3.3 deposition.
Volume: 32
Issue: 17
Pages: 2392-406
Publication
First Author: Yang JH
Year: 2011
Journal: Biochem Biophys Res Commun
Title: Histone chaperones cooperate to mediate Mef2-targeted transcriptional regulation during skeletal myogenesis.
Volume: 407
Issue: 3
Pages: 541-7
Publication
First Author: Song TY
Year: 2012
Journal: Biochem Biophys Res Commun
Title: The role of histone chaperones in osteoblastic differentiation of C2C12 myoblasts.
Volume: 423
Issue: 4
Pages: 726-32
Publication
First Author: Devaraju P
Year: 2017
Journal: Mol Psychiatry
Title: Haploinsufficiency of the 22q11.2 microdeletion gene Mrpl40 disrupts short-term synaptic plasticity and working memory through dysregulation of mitochondrial calcium.
Volume: 22
Issue: 9
Pages: 1313-1326
Publication
First Author: Stark KL
Year: 2008
Journal: Nat Genet
Title: Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model.
Volume: 40
Issue: 6
Pages: 751-60
Publication
First Author: Paylor R
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndrome.
Volume: 103
Issue: 20
Pages: 7729-34
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Lai KM
Year: 2015
Journal: PLoS One
Title: Diverse Phenotypes and Specific Transcription Patterns in Twenty Mouse Lines with Ablated LincRNAs.
Volume: 10
Issue: 4
Pages: e0125522
Publication
First Author: Mattei MG
Year: 1994
Journal: Genomics
Title: Mapping of the Tuple1 gene to mouse chromosome 16A-B1.
Volume: 23
Issue: 3
Pages: 717-8
GXD Expression      
Probe: MGI:3663073
Assay Type: RT-PCR
Annotation Date: 2006-10-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1611816
Stage: TS16
Assay Id: MGI:3663143
Age: embryonic day 10.0-10.5
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3663073
Assay Type: RT-PCR
Annotation Date: 2006-10-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1611816
Stage: TS16
Assay Id: MGI:3663143
Age: embryonic day 10.0-10.5
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3028274
Age: postnatal adult
Image: 3
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:5779865
Assay Type: RT-PCR
Annotation Date: 2016-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:5779878
Age: postnatal adult
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:5779866
Assay Type: RT-PCR
Annotation Date: 2016-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:5779880
Age: postnatal adult
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:5779868
Assay Type: RT-PCR
Annotation Date: 2016-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:5779881
Age: postnatal adult
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:5779869
Assay Type: RT-PCR
Annotation Date: 2016-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:5779882
Age: postnatal adult
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:5779870
Assay Type: RT-PCR
Annotation Date: 2016-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:5779883
Age: postnatal adult
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:5779871
Assay Type: RT-PCR
Annotation Date: 2016-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:5779885
Age: postnatal adult
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:5779872
Assay Type: RT-PCR
Annotation Date: 2016-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:5779886
Age: postnatal adult
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:5779873
Assay Type: RT-PCR
Annotation Date: 2016-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:5779887
Age: postnatal adult
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:35646
Assay Type: Northern blot
Annotation Date: 2016-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:5779875
Age: postnatal adult
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:35648
Assay Type: Northern blot
Annotation Date: 2016-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:5779888
Age: postnatal adult
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:35646
Assay Type: RNase protection
Annotation Date: 2016-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:5779877
Age: postnatal adult
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3028274
Age: postnatal adult
Image: 3
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:5779866
Assay Type: RT-PCR
Annotation Date: 2016-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5779880
Age: postnatal adult
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:35646
Assay Type: Northern blot
Annotation Date: 2016-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5779875
Age: postnatal adult
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:35648
Assay Type: Northern blot
Annotation Date: 2016-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5779888
Age: postnatal adult
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:35646
Assay Type: RNase protection
Annotation Date: 2016-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5779877
Age: postnatal adult
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689517
Stage: TS17
Assay Id: MGI:3028147
Age: embryonic day 10.5
Image: 1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689528
Stage: TS28
Assay Id: MGI:3028223
Age: postnatal adult
Image: 3
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Stage: TS28
Assay Id: MGI:3028223
Age: postnatal adult
Image: 3
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2012-12-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640517
Stage: TS17
Assay Id: MGI:5446016
Age: embryonic day 10.5
Image: 1
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2012-12-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640517
Stage: TS17
Assay Id: MGI:5446016
Age: embryonic day 10.5
Image: 1
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2012-12-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640517
Stage: TS17
Assay Id: MGI:5446016
Age: embryonic day 10.5
Image: 1
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2012-12-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640517
Stage: TS17
Assay Id: MGI:5446016
Age: embryonic day 10.5
Image: 1
Detected: true
Specimen Num: 10
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2012-12-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1668117
Stage: TS17
Assay Id: MGI:5446016
Age: embryonic day 10.5
Image: 1
Detected: true
Specimen Num: 15
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2012-12-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1668117
Stage: TS17
Assay Id: MGI:5446016
Age: embryonic day 10.5
Image: 1
Detected: true
Specimen Num: 16
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2012-12-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1668117
Stage: TS17
Assay Id: MGI:5446016
Age: embryonic day 10.5
Image: 1
Detected: true
Specimen Num: 17
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2012-12-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1668117
Stage: TS17
Assay Id: MGI:5446016
Age: embryonic day 10.5
Image: 1
Detected: true
Specimen Num: 18
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697428
Stage: TS28
Assay Id: MGI:3028223
Age: postnatal adult
Image: 3
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3663073
Assay Type: RT-PCR
Annotation Date: 2006-10-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185716
Stage: TS16
Assay Id: MGI:3663143
Age: embryonic day 10.0-10.5
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3663073
Assay Type: RT-PCR
Annotation Date: 2006-10-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185716
Stage: TS16
Assay Id: MGI:3663143
Age: embryonic day 10.0-10.5
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640617
Stage: TS17
Assay Id: MGI:3028147
Age: embryonic day 10.5
Image: 1
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610417
Stage: TS17
Assay Id: MGI:3028147
Age: embryonic day 10.5
Image: 1
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:2678802
Assay Type: Northern blot
Annotation Date: 2003-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2576528
Stage: TS28
Assay Id: MGI:2678803
Age: postnatal
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:3028223
Age: postnatal adult
Image: 3
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:5779866
Assay Type: RT-PCR
Annotation Date: 2016-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:5779880
Age: postnatal adult
Detected: true
Specimen Num: 11
GXD Expression      
Probe: MGI:35646
Assay Type: Northern blot
Annotation Date: 2016-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:5779875
Age: postnatal adult
Detected: true
Specimen Num: 11
GXD Expression      
Probe: MGI:35648
Assay Type: Northern blot
Annotation Date: 2016-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:5779888
Age: postnatal adult
Detected: true
Specimen Num: 11
GXD Expression      
Probe: MGI:35646
Assay Type: RNase protection
Annotation Date: 2016-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:5779877
Age: postnatal adult
Detected: true
Specimen Num: 3