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Search results 1 to 100 out of 559 for Hira

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0.045s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: frog, western clawed
Protein Domain
Type: Domain
Description: The Hira proteins are found in a range of eukaryotes and are implicated in the assembly of repressive chromatin. These proteins also contain .
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 1015  
Fragment?: false
Gene
Type: gene
Organism: human
GXD Expression  
Probe: MGI:5588110
Assay Type: Immunohistochemistry
Annotation Date: 2014-10-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3522328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5588111
Age: postnatal adult
Image: 4 cerebellum Hira
Specimen Label: 4 cerebellum Hira
Detected: true
Specimen Num: 4
Publication  
First Author: Hira K
Year: 2001
Journal: Int Arch Allergy Immunol
Title: Establishment and characterization of a murine mast cell line derived from NC/Nga mice.
Volume: 125 Suppl 1
Pages: 67-70
Publication  
First Author: Smith R
Year: 2022
Journal: Development
Title: The H3.3 chaperone Hira complex orchestrates oocyte developmental competence.
Volume: 149
Issue: 5
Publication
First Author: Magnaghi P
Year: 1998
Journal: Nat Genet
Title: HIRA, a mammalian homologue of Saccharomyces cerevisiae transcriptional co-repressors, interacts with Pax3.
Volume: 20
Issue: 1
Pages: 74-7
Publication
First Author: Murdaugh RL
Year: 2021
Journal: Stem Cell Reports
Title: The histone H3.3 chaperone HIRA restrains erythroid-biased differentiation of adult hematopoietic stem cells.
Volume: 16
Issue: 8
Pages: 2014-2028
Publication
First Author: Nashun B
Year: 2015
Journal: Mol Cell
Title: Continuous Histone Replacement by Hira Is Essential for Normal Transcriptional Regulation and De Novo DNA Methylation during Mouse Oogenesis.
Volume: 60
Issue: 4
Pages: 611-25
Publication
First Author: Dilg D
Year: 2016
Journal: PLoS One
Title: HIRA Is Required for Heart Development and Directly Regulates Tnni2 and Tnnt3.
Volume: 11
Issue: 8
Pages: e0161096
Publication
First Author: Smith R
Year: 2021
Journal: Reproduction
Title: HIRA contributes to zygote formation in mice and is implicated in human 1PN zygote phenotype.
Volume: 161
Issue: 6
Pages: 697-707
Publication
First Author: Valenzuela N
Year: 2017
Journal: J Cell Sci
Title: HIRA deficiency in muscle fibers causes hypertrophy and susceptibility to oxidative stress.
Volume: 130
Issue: 15
Pages: 2551-2563
Publication
First Author: Rai TS
Year: 2014
Journal: Genes Dev
Title: HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia.
Volume: 28
Issue: 24
Pages: 2712-25
Publication
First Author: Li Y
Year: 2017
Journal: J Cell Biol
Title: Histone chaperone HIRA regulates neural progenitor cell proliferation and neurogenesis via β-catenin.
Volume: 216
Issue: 7
Pages: 1975-1992
Publication
First Author: Blake GET
Year: 2021
Journal: Nat Commun
Title: Defective folate metabolism causes germline epigenetic instability and distinguishes Hira as a phenotype inheritance biomarker.
Volume: 12
Issue: 1
Pages: 3714
Publication
First Author: Valenzuela N
Year: 2016
Journal: Dis Model Mech
Title: Cardiomyocyte-specific conditional knockout of the histone chaperone HIRA in mice results in hypertrophy, sarcolemmal damage and focal replacement fibrosis.
Volume: 9
Issue: 3
Pages: 335-45
Publication
First Author: Soni S
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Transcription factor EKLF (KLF1) recruitment of the histone chaperone HIRA is essential for β-globin gene expression.
Volume: 111
Issue: 37
Pages: 13337-42
Publication
First Author: Jeanne M
Year: 2021
Journal: Hum Genet
Title: Haploinsufficiency of the HIRA gene located in the 22q11 deletion syndrome region is associated with abnormal neurodevelopment and impaired dendritic outgrowth.
Volume: 140
Issue: 6
Pages: 885-896
Publication
First Author: Scamps C
Year: 1996
Journal: Biochim Biophys Acta
Title: The HIR protein family: isolation and characterization of a complete murine cDNA.
Volume: 1306
Issue: 1
Pages: 5-8
Publication
First Author: Roberts C
Year: 2002
Journal: Mol Cell Biol
Title: Targeted mutagenesis of the Hira gene results in gastrulation defects and patterning abnormalities of mesoendodermal derivatives prior to early embryonic lethality.
Volume: 22
Issue: 7
Pages: 2318-28
Publication
First Author: Wilming LG
Year: 1997
Journal: Hum Mol Genet
Title: The murine homologue of HIRA, a DiGeorge syndrome candidate gene, is expressed in embryonic structures affected in human CATCH22 patients.
Volume: 6
Issue: 2
Pages: 247-58
Publication
First Author: van der Heijden GW
Year: 2005
Journal: Mech Dev
Title: Asymmetry in histone H3 variants and lysine methylation between paternal and maternal chromatin of the early mouse zygote.
Volume: 122
Issue: 9
Pages: 1008-22
Publication
First Author: Halford S
Year: 1993
Journal: Hum Mol Genet
Title: Isolation of a putative transcriptional regulator from the region of 22q11 deleted in DiGeorge syndrome, Shprintzen syndrome and familial congenital heart disease.
Volume: 2
Issue: 12
Pages: 2099-107
Publication
First Author: Lorain S
Year: 2001
Journal: Biochim Biophys Acta
Title: Identification of human and mouse HIRA-interacting protein-5 (HIRIP5), two mammalian representatives in a family of phylogenetically conserved proteins with a role in the biogenesis of Fe/S proteins.
Volume: 1517
Issue: 3
Pages: 376-83
GO Term
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
UniProt Feature
Begin: 1
Description: Protein HIRA
Type: chain
End: 1015
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Lin CJ
Year: 2014
Journal: Dev Cell
Title: Hira-mediated H3.3 incorporation is required for DNA replication and ribosomal RNA transcription in the mouse zygote.
Volume: 30
Issue: 3
Pages: 268-79
Publication
First Author: Chen C
Year: 2020
Journal: Cell Rep
Title: HIRA, a DiGeorge Syndrome Candidate Gene, Confers Proper Chromatin Accessibility on HSCs and Supports All Stages of Hematopoiesis.
Volume: 30
Issue: 7
Pages: 2136-2149.e4
Protein Domain
Type: Conserved_site
Description: The HirA B (Histone regulatory homologue A binding) motif is the essential binding interface between and ASF1a, of approx. 40 residues. It forms an antiparallel β-hairpin that binds perpendicular to the strands of the β-sandwich of ASF1a N-terminal core domain, via β-sheet, salt bridge and van der Waals interactions []. The two histone chaperone proteins, HIRA and ASF1a, form a heterodimer with histones H3 and H4. HIRA is the human orthologue of Hir proteins known to silence histone gene expression and create transcriptionally silent heterochromatin in yeast, flies, plants and humans. The HIR complex is composed of HIR1, HIR2, HIR3 and HPC2, and interacts with ASF1. The HIR complex cooperates with ASF1 to promote replication-independent chromatin assembly. The HIR complex is also required for the periodic repression of three of the four histone gene loci during cell cycle as well as for autogenous regulation of the HTA1-HTB1 locus by H2A and H2B. DNA-binding by the HIR complex may repress transcription by inhibiting nucleosome remodeling by the SWI/SNF complex. The HIR complex may also be required for transcriptional silencing of centromeric, telomeric and mating-type loci in the absence of CAF-1.
Publication
First Author: Goldberg AD
Year: 2010
Journal: Cell
Title: Distinct factors control histone variant H3.3 localization at specific genomic regions.
Volume: 140
Issue: 5
Pages: 678-91
Publication
First Author: Sarai N
Year: 2013
Journal: EMBO J
Title: WHSC1 links transcription elongation to HIRA-mediated histone H3.3 deposition.
Volume: 32
Issue: 17
Pages: 2392-406
Publication
First Author: Yang JH
Year: 2011
Journal: Biochem Biophys Res Commun
Title: Histone chaperones cooperate to mediate Mef2-targeted transcriptional regulation during skeletal myogenesis.
Volume: 407
Issue: 3
Pages: 541-7
Publication
First Author: Song TY
Year: 2012
Journal: Biochem Biophys Res Commun
Title: The role of histone chaperones in osteoblastic differentiation of C2C12 myoblasts.
Volume: 423
Issue: 4
Pages: 726-32
Publication
First Author: Devaraju P
Year: 2017
Journal: Mol Psychiatry
Title: Haploinsufficiency of the 22q11.2 microdeletion gene Mrpl40 disrupts short-term synaptic plasticity and working memory through dysregulation of mitochondrial calcium.
Volume: 22
Issue: 9
Pages: 1313-1326
Publication
First Author: Stark KL
Year: 2008
Journal: Nat Genet
Title: Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model.
Volume: 40
Issue: 6
Pages: 751-60
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Mattei MG
Year: 1994
Journal: Genomics
Title: Mapping of the Tuple1 gene to mouse chromosome 16A-B1.
Volume: 23
Issue: 3
Pages: 717-8
GXD Expression      
Probe: MGI:2678802
Assay Type: Northern blot
Annotation Date: 2003-11-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2576528
Stage: TS28
Assay Id: MGI:2678803
Age: postnatal
Specimen Label: Not shown
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689517
Stage: TS17
Assay Id: MGI:3028147
Age: embryonic day 10.5
Image: 1
Specimen Label: fnm/fb
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1611717
Stage: TS17
Assay Id: MGI:3028147
Age: embryonic day 10.5
Image: 1
Specimen Label: ba
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610417
Stage: TS17
Assay Id: MGI:3028147
Age: embryonic day 10.5
Image: 1
Specimen Label: aah
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640617
Stage: TS17
Assay Id: MGI:3028147
Age: embryonic day 10.5
Image: 1
Specimen Label: flb
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603916
Stage: TS16
Assay Id: MGI:3028186
Age: embryonic day 10.0
Image: 2
Specimen Label: E10 Whole
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:3028186
Age: embryonic day 14.0
Image: 2
Specimen Label: E14 Whole
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689420
Stage: TS20
Assay Id: MGI:3028186
Age: embryonic day 12.0
Image: 2
Specimen Label: E12 Brain
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689422
Stage: TS22
Assay Id: MGI:3028186
Age: embryonic day 14.0
Image: 2
Specimen Label: E14 Brain
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:3028186
Age: embryonic day 18.0
Image: 2
Specimen Label: E18 Brain
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:3028186
Age: postnatal day 0
Image: 2
Specimen Label: P0 Brain
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3028186
Age: postnatal day 7
Image: 2
Specimen Label: P7 Brain
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3028186
Age: postnatal day 25
Image: 2
Specimen Label: P25 Brain
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3028186
Age: postnatal adult
Image: 2
Specimen Label: Adult Brain
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280928
Stage: TS28
Assay Id: MGI:3028223
Age: postnatal adult
Image: 3
Specimen Label: Olf Bulb
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689528
Stage: TS28
Assay Id: MGI:3028223
Age: postnatal adult
Image: 3
Specimen Label: Amygdala
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267328
Stage: TS28
Assay Id: MGI:3028223
Age: postnatal adult
Image: 3
Specimen Label: Bas Ganglia
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284528
Stage: TS28
Assay Id: MGI:3028223
Age: postnatal adult
Image: 3
Specimen Label: Hippoc
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:3028223
Age: postnatal adult
Image: 3
Specimen Label: Cortex
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754028
Stage: TS28
Assay Id: MGI:3028223
Age: postnatal adult
Image: 3
Specimen Label: Thalamus
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697428
Stage: TS28
Assay Id: MGI:3028223
Age: postnatal adult
Image: 3
Specimen Label: Mesen
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:3028223
Age: postnatal adult
Image: 3
Specimen Label: Cerebel
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Stage: TS28
Assay Id: MGI:3028223
Age: postnatal adult
Image: 3
Specimen Label: Brainstem
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Stage: TS28
Assay Id: MGI:3028223
Age: postnatal adult
Image: 3
Specimen Label: Sp Cord
Detected: true
Specimen Num: 10
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3028274
Age: postnatal adult
Image: 3
Specimen Label: Brain
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3028274
Age: postnatal adult
Image: 3
Specimen Label: Heart
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3028274
Age: postnatal adult
Image: 3
Specimen Label: Lung
Detected: true
Specimen Num: 3