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Search results 1 to 89 out of 89 for Hmces

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Categories

Hits by Category

Hits by Strain

Type Details Score
Gene
56941 | HMCES
Type: gene
Organism: human
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Gene
394754 | hmces
Type: gene
Organism: frog, western clawed
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Gene
500251 | Hmces
Type: gene
Organism: rat
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Gene
484628 | HMCES
Type: gene
Organism: dog, domestic
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Gene
738273 | HMCES
Type: gene
Organism: chimpanzee
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Gene
530527 | HMCES
Type: gene
Organism: cattle
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Gene
416015 | HMCES
Type: gene
Organism: chicken
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Gene
560402 | hmces
Type: gene
Organism: zebrafish
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Gene
703524 | HMCES
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1914053 | Hmces
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
31806351 | J:285016
First Author: Shukla V
Year: 2020
Journal: Mol Cell
Title: HMCES Functions in the Alternative End-Joining Pathway of the DNA DSB Repair during Class Switch Recombination in B Cells.
Volume: 77
Issue: 2
Pages: 384-394.e4
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Publication
35450882 | J:343116
First Author: Wu L
Year: 2022
Journal: Genes Dev
Title: HMCES protects immunoglobulin genes specifically from deletions during somatic hypermutation.
Volume: 36
Issue: 7-8
Pages: 433-450
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Publication
35039639 | J:344038
First Author: Pan Y
Year: 2022
Journal: Leukemia
Title: HMCES safeguards genome integrity and long-term self-renewal of hematopoietic stem cells during stress responses.
Volume: 36
Issue: 4
Pages: 1123-1131
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Publication
29020633 | J:254234
First Author: Kweon SM
Year: 2017
Journal: Cell Rep
Title: Erasure of Tet-Oxidized 5-Methylcytosine by a SRAP Nuclease.
Volume: 21
Issue: 2
Pages: 482-494
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Protein
A0A0N4SWG0
Organism: Mus musculus/domesticus
Length: 76  
Fragment?: false
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Protein
Q8R1M0
Organism: Mus musculus/domesticus
Length: 353  
Fragment?: false
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Protein Coding Gene
MGP_CAROLIEiJ_G0028622 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0031003 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0030969 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0030900 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0030982 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0030728 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1914053 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0031439 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0030091 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0030666 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0030822 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0030775 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0030899 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0030808 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0031466 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0029806 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0030172 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0022360 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0029634 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:6154275
Assay Type: RT-PCR
Annotation Date: 2018-05-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:6154285
Age: embryonic day 9.5
Image: S2
Specimen Label: WT
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6154275
Assay Type: RT-PCR
Annotation Date: 2018-05-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:6154285
Age: embryonic day 9.5
Image: S2
Specimen Label: Srap1 KO
Detected: false
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6154275
Assay Type: RT-PCR
Annotation Date: 2018-05-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6154285
Age: postnatal week 12
Image: S2
Specimen Label: brain
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6154275
Assay Type: RT-PCR
Annotation Date: 2018-05-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:6154285
Age: postnatal week 12
Image: S2
Specimen Label: heart
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6154275
Assay Type: RT-PCR
Annotation Date: 2018-05-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:6154285
Age: postnatal week 12
Image: S2
Specimen Label: lung
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:6154275
Assay Type: RT-PCR
Annotation Date: 2018-05-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:6154285
Age: postnatal week 12
Image: S2
Specimen Label: thymus
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Probe: MGI:6154275
Assay Type: RT-PCR
Annotation Date: 2018-05-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:6154285
Age: postnatal week 12
Image: S2
Specimen Label: skin
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
   
Probe: MGI:6154275
Assay Type: RT-PCR
Annotation Date: 2018-05-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:6154285
Age: postnatal week 12
Image: S2
Specimen Label: kidney
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
   
Probe: MGI:6154275
Assay Type: RT-PCR
Annotation Date: 2018-05-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287428
Stage: TS28
Assay Id: MGI:6154285
Age: postnatal week 12
Image: S2
Specimen Label: intestine
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
   
Probe: MGI:6154275
Assay Type: RT-PCR
Annotation Date: 2018-05-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6154285
Age: postnatal week 12
Image: S2
Specimen Label: liver
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
   
Probe: MGI:6154275
Assay Type: RT-PCR
Annotation Date: 2018-05-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750328
Stage: TS28
Assay Id: MGI:6154285
Age: postnatal week 12
Image: S2
Specimen Label: pancreas
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
   
Probe: MGI:6154275
Assay Type: RT-PCR
Annotation Date: 2018-05-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1893928
Stage: TS28
Assay Id: MGI:6154285
Age: postnatal week 12
Image: S2
Specimen Label: colon
Detected: true
Specimen Num: 14
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GXD Expression
GXD Expression
   
Probe: MGI:6154275
Assay Type: RT-PCR
Annotation Date: 2018-05-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3511228
Stage: TS28
Assay Id: MGI:6154285
Age: postnatal week 12
Image: S2
Specimen Label: adipose
Detected: true
Specimen Num: 15
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GXD Expression
GXD Expression
   
Probe: MGI:6154275
Assay Type: RT-PCR
Annotation Date: 2018-05-03
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:6154285
Age: postnatal week 12
Image: S2
Specimen Label: testes
Detected: true
Specimen Num: 16
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GXD Expression
GXD Expression
   
Probe: MGI:6154275
Assay Type: RT-PCR
Annotation Date: 2018-05-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:6154285
Age: postnatal week 12
Image: S2
Specimen Label: spleen
Detected: true
Specimen Num: 17
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Publication
- | J:104881
     
First Author: The RIKEN BioResource Center
Year: 2006
Journal: Unpublished
Title: Information obtained from The RIKEN BioResource Center
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
Begin: 2
Description: Abasic site processing protein HMCES
Type: chain
End: 353
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Publication
30554877 | -
First Author: Mohni KN
Year: 2019
Journal: Cell
Title: HMCES Maintains Genome Integrity by Shielding Abasic Sites in Single-Strand DNA.
Volume: 176
Issue: 1-2
Pages: 144-153.e13
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Publication
23434322 | -
First Author: Spruijt CG
Year: 2013
Journal: Cell
Title: Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives.
Volume: 152
Issue: 5
Pages: 1146-59
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Publication
23945014 | -
 
First Author: Aravind L
Year: 2013
Journal: Biol Direct
Title: Novel autoproteolytic and DNA-damage sensing components in the bacterial SOS response and oxidized methylcytosine-induced eukaryotic DNA demethylation systems.
Volume: 8
Pages: 20
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Publication
31235915 | -
First Author: Thompson PS
Year: 2019
Journal: Nat Struct Mol Biol
Title: Protection of abasic sites during DNA replication by a stable thiazolidine protein-DNA cross-link.
Volume: 26
Issue: 7
Pages: 613-618
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Protein Domain
IPR036590 | SRAP-like
Type: Homologous_superfamily
Description: This entry represents the SOS response associated peptidase (SRAP) superfamily.The SRAP (SOS-response associated peptidase) family is characterised by the SRAP domain with a novel thiol autopeptidase activity, whose active site in human HMCES is comprised of the catalytic triad residues C2, E127, and H210 []. SRAP proteins are evolutionarily conserved in all domains of life. For instance, human HMCES and E. coli YedK are similar in both sequence and structure []. HMCES was originally identified as a possible reader of 5hmC in embryonic stem cell extracts using a double-stranded DNA molecule containing 5hmC as bait []. The bacterial members have operonic associations with the SOS DNA damage response, mutagenic translesion DNA polymerases, non-homologous DNA-ending-joining networks that employ Ku and an ATP-dependent ligase, and other repair systems []. Abasic (AP) sites are one of the most common DNA lesions that block replicative polymerases. SRAP proteins shield the AP site from endonucleases and error-prone polymerases []. Both HMCES and YedK have been found to preferentially bind ssDNA and efficiently form DNA-protein crosslinks (DPCs) to AP sites in ssDNA. They crosslink to AP sites via a stable thiazolidine DNA-protein linkage formed with the N-erminal cysteine and the aldehyde form of the AP deoxyribose []. In B Cells, HMCES has also been shown to mediate microhomology-mediated alternative-end-joining through its SRAP domain [].
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Protein Domain
IPR003738 | SRAP
Type: Family
Description: The SRAP (SOS-response associated peptidase) family is characterised by the SRAP domain with a novel thiol autopeptidase activity, whose active site in human HMCES is comprised of the catalytic triad residues C2, E127, and H210 []. SRAP proteins are evolutionarily conserved in all domains of life. For instance, human HMCES and E. coli YedK are similar in both sequence and structure []. HMCES was originally identified as a possible reader of 5hmC in embryonic stem cell extracts using a double-stranded DNA molecule containing 5hmC as bait []. The bacterial members have operonic associations with the SOS DNA damage response, mutagenic translesion DNA polymerases, non-homologous DNA-ending-joining networks that employ Ku and an ATP-dependent ligase, and other repair systems []. Abasic (AP) sites are one of the most common DNA lesions that block replicative polymerases. SRAP proteins shield the AP site from endonucleases and error-prone polymerases []. Both HMCES and YedK have been found to preferentially bind ssDNA and efficiently form DNA-protein crosslinks (DPCs) to AP sites in ssDNA. They crosslink to AP sites via a stable thiazolidine DNA-protein linkage formed with the N-erminal cysteine and the aldehyde form of the AP deoxyribose []. In B Cells, HMCES has also been shown to mediate microhomology-mediated alternative-end-joining through its SRAP domain [].
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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Cambridge CB2 3EH, United Kingdom