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Search results 1 to 100 out of 869 for Hmgb1

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: cat, domestic
Gene
Type: gene
Organism: hamster, Chinese
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Family
Description: This entry represents HMGB1 (also known as HMG-1). It has been implicated as an important mediator of many chronic inflammatory diseases, including asthma [, ]. During infection or injury, activated immune cells and damaged cells release HMGB1 into the extracellular space, where HMGB1 functions as a proinflammatory mediator []. Intracellular HMGB1 also has a role during inflammation. Cytosolic HMGB1 regulates apoptosis by protecting the autophagy proteins beclin 1 and ATG5 from calpain-mediated cleavage during inflammation, therefore controlling the switch between the proautophagic and proapoptotic function []. Nuclear HMGB1 is engaged in many DNA activity-associated events.The high mobility group (HMG) proteins are the most abundant and ubiquitous nonhistone chromosomal proteins. They bind to DNA and to nucleosomes and are involved in the regulation of DNA-dependent processes such as transcription, replication, recombination, and DNA repair. They can be grouped into three families: HMGB (HMG 1/2), HMGN (HMG 14/17) and HMGA (HMG I/Y). The characteristic domains are: AT-hook for the HMGA family, the HMG Box for the HMGB family, and the nucleosome-binding domain (NBD) for the members of the HMGN family [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Zhu X
Year: 2015
Journal: J Clin Invest
Title: Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation.
Volume: 125
Issue: 3
Pages: 1098-110
GXD Expression
Probe: MGI:3826511
Assay Type: RNA in situ
Annotation Date: 2009-01-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Pattern: Widespread
Stage: TS22
Assay Id: MGI:3826662
Age: embryonic day 14.5
Image: 2 Hmgb1
Note: There was broad staining throughout the embryo.
Specimen Label: 2 Hmgb1
Detected: true
Specimen Num: 1
Publication
First Author: Andersson U
Year: 2002
Journal: J Leukoc Biol
Title: HMGB1 as a DNA-binding cytokine.
Volume: 72
Issue: 6
Pages: 1084-91
Publication
First Author: Lu B
Year: 2013
Journal: Protein Cell
Title: Regulation of HMGB1 release by inflammasomes.
Volume: 4
Issue: 3
Pages: 163-7
Publication
First Author: Liang Y
Year: 2015
Journal: Mol Cell Biochem
Title: HMGB1 binding to receptor for advanced glycation end products enhances inflammatory responses of human bronchial epithelial cells by activating p38 MAPK and ERK1/2.
Volume: 405
Issue: 1-2
Pages: 63-71
Protein
Organism: Mus musculus/domesticus
Length: 55  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 215  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 215  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 215  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 215  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 215  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 215  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 211  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 208  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 215  
Fragment?: false
Publication
First Author: González-Romero R
Year: 2015
Journal: Mol Biol Evol
Title: Evolution of high mobility group nucleosome-binding proteins and its implications for vertebrate chromatin specialization.
Volume: 32
Issue: 1
Pages: 121-31
Publication
First Author: Tang D
Year: 2010
Journal: J Cell Biol
Title: Endogenous HMGB1 regulates autophagy.
Volume: 190
Issue: 5
Pages: 881-92
GXD Expression
Probe: MGI:4839153
Assay Type: Immunohistochemistry
Annotation Date: 2010-11-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757727
Pattern: Single cells
Stage: TS27
Assay Id: MGI:4839209
Age: postnatal day 0
Image: 2A - Hmgb1
Note: Expression is present in oligodendrocytes and oligoendrocyte progenitors.
Specimen Label: 2A - Hmgb1
Detected: true
Specimen Num: 10
Publication
First Author: Banerjee S
Year: 2011
Journal: J Immunol
Title: Intracellular HMGB1 negatively regulates efferocytosis.
Volume: 187
Issue: 9
Pages: 4686-94
Publication  
First Author: Yang H
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: HMGB1 released from nociceptors mediates inflammation.
Volume: 118
Issue: 33
Publication
First Author: Wu H
Year: 2010
Journal: J Am Soc Nephrol
Title: HMGB1 contributes to kidney ischemia reperfusion injury.
Volume: 21
Issue: 11
Pages: 1878-90
Publication
First Author: Volchuk A
Year: 2020
Journal: Nat Commun
Title: Indirect regulation of HMGB1 release by gasdermin D.
Volume: 11
Issue: 1
Pages: 4561
Publication
First Author: Rovere-Querini P
Year: 2004
Journal: EMBO Rep
Title: HMGB1 is an endogenous immune adjuvant released by necrotic cells.
Volume: 5
Issue: 8
Pages: 825-30
Publication
First Author: Prasad R
Year: 2007
Journal: Mol Cell
Title: HMGB1 is a cofactor in mammalian base excision repair.
Volume: 27
Issue: 5
Pages: 829-41
Publication
First Author: Campana L
Year: 2014
Journal: J Immunol
Title: Leukocyte HMGB1 is required for vessel remodeling in regenerating muscles.
Volume: 192
Issue: 11
Pages: 5257-64
Publication
First Author: Miao J
Year: 2020
Journal: Exp Cell Res
Title: Nuclear HMGB1 promotes the phagocytic ability of macrophages.
Volume: 393
Issue: 1
Pages: 112037
Publication
First Author: Chen X
Year: 2018
Journal: Sci Rep
Title: Blockade of HMGB1 Attenuates Diabetic Nephropathy in Mice.
Volume: 8
Issue: 1
Pages: 8319
Publication
First Author: Vogel S
Year: 2015
Journal: J Clin Invest
Title: Platelet-derived HMGB1 is a critical mediator of thrombosis.
Volume: 125
Issue: 12
Pages: 4638-54
Publication
First Author: Su Z
Year: 2011
Journal: Eur J Immunol
Title: HMGB1 blockade attenuates experimental autoimmune myocarditis and suppresses Th17-cell expansion.
Volume: 41
Issue: 12
Pages: 3586-95
Publication
First Author: Ekanayaka SA
Year: 2016
Journal: Invest Ophthalmol Vis Sci
Title: Glycyrrhizin Reduces HMGB1 and Bacterial Load in Pseudomonas aeruginosa Keratitis.
Volume: 57
Issue: 13
Pages: 5799-5809
Publication
First Author: Singh B
Year: 2016
Journal: Eur J Immunol
Title: HMGB1 facilitates hypoxia-induced vWF upregulation through TLR2-MYD88-SP1 pathway.
Volume: 46
Issue: 10
Pages: 2388-2400
Publication
First Author: Mei L
Year: 2019
Journal: Sci Rep
Title: Paeonol attenuates inflammation by targeting HMGB1 through upregulating miR-339-5p.
Volume: 9
Issue: 1
Pages: 19370
Publication
First Author: Lamkanfi M
Year: 2010
Journal: J Immunol
Title: Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia.
Volume: 185
Issue: 7
Pages: 4385-92
Publication
First Author: Costello DA
Year: 2011
Journal: J Neurosci
Title: Interleukin-1alpha and HMGB1 mediate hippocampal dysfunction in SIGIRR-deficient mice.
Volume: 31
Issue: 10
Pages: 3871-9
Publication  
First Author: Tancharoen S
Year: 2016
Journal: Int J Mol Sci
Title: HMGB1 Promotes Intraoral Palatal Wound Healing through RAGE-Dependent Mechanisms.
Volume: 17
Issue: 11
Publication
First Author: Andersson A
Year: 2016
Journal: Nucleic Acids Res
Title: PKCα and HMGB1 antagonistically control hydrogen peroxide-induced poly-ADP-ribose formation.
Volume: 44
Issue: 16
Pages: 7630-45
Publication
First Author: Deng M
Year: 2018
Journal: Immunity
Title: The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis.
Volume: 49
Issue: 4
Pages: 740-753.e7
Publication  
First Author: Careccia G
Year: 2021
Journal: Sci Transl Med
Title: Rebalancing expression of HMGB1 redox isoforms to counteract muscular dystrophy.
Volume: 13
Issue: 596
Publication
First Author: Lu B
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation.
Volume: 111
Issue: 8
Pages: 3068-73
GXD Expression    
Probe: MGI:6174909
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6190519
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Hmgb1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6174909
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6190519
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Hmgb1
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6174909
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6190519
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Hmgb1
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6174909
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6190519
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Hmgb1
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6174909
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190519
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Hmgb1
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6174909
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190519
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Hmgb1
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6174909
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190519
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Hmgb1
Detected: true
Specimen Num: 7
Publication
First Author: Lu B
Year: 2012
Journal: Nature
Title: Novel role of PKR in inflammasome activation and HMGB1 release.
Volume: 488
Issue: 7413
Pages: 670-4
Publication
First Author: Hernandez C
Year: 2018
Journal: J Clin Invest
Title: HMGB1 links chronic liver injury to progenitor responses and hepatocarcinogenesis.
Volume: 128
Issue: 6
Pages: 2436-2451
Publication
First Author: Stark K
Year: 2016
Journal: Blood
Title: Disulfide HMGB1 derived from platelets coordinates venous thrombosis in mice.
Volume: 128
Issue: 20
Pages: 2435-2449
Publication
First Author: Khambu B
Year: 2018
Journal: J Clin Invest
Title: HMGB1 promotes ductular reaction and tumorigenesis in autophagy-deficient livers.
Volume: 128
Issue: 6
Pages: 2419-2435
Publication
First Author: Taniguchi N
Year: 2007
Journal: Mol Cell Biol
Title: Stage-specific secretion of HMGB1 in cartilage regulates endochondral ossification.
Volume: 27
Issue: 16
Pages: 5650-63
Publication
First Author: Bangert A
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Critical role of RAGE and HMGB1 in inflammatory heart disease.
Volume: 113
Issue: 2
Pages: E155-64
Publication
First Author: Zhang YG
Year: 2019
Journal: Autophagy
Title: Intestinal epithelial HMGB1 inhibits bacterial infection via STAT3 regulation of autophagy.
Volume: 15
Issue: 11
Pages: 1935-1953
Publication
First Author: Jiang W
Year: 2008
Journal: Mol Immunol
Title: The induction of HMGB1 release from RAW 264.7 cells by transfected DNA.
Volume: 45
Issue: 7
Pages: 2038-44
Publication
First Author: Giavara S
Year: 2005
Journal: Curr Biol
Title: Yeast Nhp6A/B and mammalian Hmgb1 facilitate the maintenance of genome stability.
Volume: 15
Issue: 1
Pages: 68-72
Publication
First Author: Kang R
Year: 2014
Journal: Gastroenterology
Title: Intracellular Hmgb1 inhibits inflammatory nucleosome release and limits acute pancreatitis in mice.
Volume: 146
Issue: 4
Pages: 1097-107
Publication
First Author: Ivanov S
Year: 2007
Journal: Blood
Title: A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA.
Volume: 110
Issue: 6
Pages: 1970-81
Publication
First Author: Boytard L
Year: 2020
Journal: Nat Commun
Title: Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages.
Volume: 11
Issue: 1
Pages: 4311
Publication
First Author: Venereau E
Year: 2012
Journal: J Exp Med
Title: Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release.
Volume: 209
Issue: 9
Pages: 1519-28
Publication
First Author: Tsung A
Year: 2005
Journal: J Exp Med
Title: The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion.
Volume: 201
Issue: 7
Pages: 1135-43
Publication
First Author: Enokido Y
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Age-dependent change of HMGB1 and DNA double-strand break accumulation in mouse brain.
Volume: 376
Issue: 1
Pages: 128-33
Publication
First Author: Youn JH
Year: 2006
Journal: J Immunol
Title: Nucleocytoplasmic shuttling of HMGB1 is regulated by phosphorylation that redirects it toward secretion.
Volume: 177
Issue: 11
Pages: 7889-97
Publication
First Author: Zhou H
Year: 2018
Journal: Blood Adv
Title: Platelet HMGB1 is required for efficient bacterial clearance in intra-abdominal bacterial sepsis in mice.
Volume: 2
Issue: 6
Pages: 638-648
Publication
First Author: Lee G
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Fully reduced HMGB1 accelerates the regeneration of multiple tissues by transitioning stem cells to GAlert.
Volume: 115
Issue: 19
Pages: E4463-E4472
Publication
First Author: Sitia G
Year: 2007
Journal: J Leukoc Biol
Title: Treatment with HMGB1 inhibitors diminishes CTL-induced liver disease in HBV transgenic mice.
Volume: 81
Issue: 1
Pages: 100-7
Publication
First Author: Rabadi MM
Year: 2012
Journal: Am J Physiol Renal Physiol
Title: Interaction between uric acid and HMGB1 translocation and release from endothelial cells.
Volume: 302
Issue: 6
Pages: F730-41
Publication
First Author: Chen C
Year: 2014
Journal: Stem Cells
Title: Effect of HMGB1 on the paracrine action of EPC promotes post-ischemic neovascularization in mice.
Volume: 32
Issue: 10
Pages: 2679-89
Publication
First Author: Wenzhao L
Year: 2019
Journal: Cell Cycle
Title: Dual regulatory roles of HMGB1 in inflammatory reaction of chondrocyte cells and mice.
Volume: 18
Issue: 18
Pages: 2268-2280
Publication
First Author: Ayoub M
Year: 2019
Journal: Sci Rep
Title: The immune mediated role of extracellular HMGB1 in a heterotopic model of bladder cancer radioresistance.
Volume: 9
Issue: 1
Pages: 6348
Publication  
First Author: Vidyanti AN
Year: 2020
Journal: Int J Mol Sci
Title: Role of HMGB1 in an Animal Model of Vascular Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion.
Volume: 21
Issue: 6
Publication  
First Author: Cao S
Year: 2018
Journal: Biomed Res Int
Title: Acetylation of HMGB1 by JNK1 Signaling Promotes LPS-Induced Peritoneal Mesothelial Cells Apoptosis.
Volume: 2018
Pages: 2649585
Publication
First Author: Zhao J
Year: 2020
Journal: Neurotherapeutics
Title: HMGB1 Is a Therapeutic Target and Biomarker in Diazepam-Refractory Status Epilepticus with Wide Time Window.
Volume: 17
Issue: 2
Pages: 710-721
Publication
First Author: Alves JN
Year: 2013
Journal: Arch Biochem Biophys
Title: Critical role for CCR2 and HMGB1 in induction of experimental endotoxic shock.
Volume: 537
Issue: 1
Pages: 72-81
Publication
First Author: Tohme S
Year: 2017
Journal: Hepatology
Title: Hypoxia mediates mitochondrial biogenesis in hepatocellular carcinoma to promote tumor growth through HMGB1 and TLR9 interaction.
Volume: 66
Issue: 1
Pages: 182-197
Publication
First Author: Ghaffari S
Year: 2021
Journal: Arterioscler Thromb Vasc Biol
Title: Endothelial HMGB1 Is a Critical Regulator of LDL Transcytosis via an SREBP2-SR-BI Axis.
Volume: 41
Issue: 1
Pages: 200-216
Publication  
First Author: Ferrara M
Year: 2020
Journal: Front Immunol
Title: Oxidation of HMGB1 Is a Dynamically Regulated Process in Physiological and Pathological Conditions.
Volume: 11
Pages: 1122
Publication
First Author: Kaya Z
Year: 2023
Journal: J Neuroinflammation
Title: Vesicular HMGB1 release from neurons stressed with spreading depolarization enables confined inflammatory signaling to astrocytes.
Volume: 20
Issue: 1
Pages: 295
Publication
First Author: Hoste E
Year: 2019
Journal: Cell Rep
Title: Epithelial HMGB1 Delays Skin Wound Healing and Drives Tumor Initiation by Priming Neutrophils for NET Formation.
Volume: 29
Issue: 9
Pages: 2689-2701.e4
Publication
First Author: Koutsodendris N
Year: 2023
Journal: Cell Rep
Title: APOE4-promoted gliosis and degeneration in tauopathy are ameliorated by pharmacological inhibition of HMGB1 release.
Volume: 42
Issue: 10
Pages: 113252
Publication
First Author: Davalos AR
Year: 2013
Journal: J Cell Biol
Title: p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes.
Volume: 201
Issue: 4
Pages: 613-29
Publication
First Author: Moreno JA
Year: 2013
Journal: Arterioscler Thromb Vasc Biol
Title: HMGB1 expression and secretion are increased via TWEAK-Fn14 interaction in atherosclerotic plaques and cultured monocytes.
Volume: 33
Issue: 3
Pages: 612-20
Publication
First Author: Xu J
Year: 2018
Journal: J Vasc Surg
Title: Chloroquine improves the response to ischemic muscle injury and increases HMGB1 after arterial ligation.
Volume: 67
Issue: 3
Pages: 910-921
Publication
First Author: Personnaz J
Year: 2022
Journal: Sci Adv
Title: Nuclear HMGB1 protects from nonalcoholic fatty liver disease through negative regulation of liver X receptor.
Volume: 8
Issue: 12
Pages: eabg9055
Publication
First Author: Yang R
Year: 2022
Journal: Cell Rep
Title: Posttranslational S-nitrosylation modification regulates HMGB1 secretion and promotes its proinflammatory and neurodegenerative effects.
Volume: 40
Issue: 11
Pages: 111330
Publication
First Author: Jiang Y
Year: 2020
Journal: Invest Ophthalmol Vis Sci
Title: Epac1 Requires AMPK Phosphorylation to Regulate HMGB1 in the Retinal Vasculature.
Volume: 61
Issue: 11
Pages: 33
Publication
First Author: Little AJ
Year: 2013
Journal: Nucleic Acids Res
Title: Cooperative recruitment of HMGB1 during V(D)J recombination through interactions with RAG1 and DNA.
Volume: 41
Issue: 5
Pages: 3289-301
Publication
First Author: Yanai H
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection.
Volume: 110
Issue: 51
Pages: 20699-704