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Search results 1 to 100 out of 1345 for Hnf4a

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Type Details Score
Gene
3172 | HNF4A
Type: gene
Organism: human
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Gene
485884 | HNF4A
Type: gene
Organism: dog, domestic
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Gene
509200 | HNF4A
Type: gene
Organism: cattle
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Gene
419198 | HNF4A
Type: gene
Organism: chicken
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Gene
322358 | hnf4a
Type: gene
Organism: zebrafish
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Gene
717972 | HNF4A
Type: gene
Organism: macaque, rhesus
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Gene
100492541 | hnf4a
Type: gene
Organism: frog, western clawed
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Gene
25735 | Hnf4a
Type: gene
Organism: rat
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Gene
458269 | HNF4A
Type: gene
Organism: chimpanzee
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Protein Domain
IPR039067 | HNF4A
Type: Family
Description: HNF4A (also known as TCF14) is a member of the steroid-thyroid hormone receptor superfamily. HNF4A interacts with regulatory elements in promoters and enhancers of the genes involved in cholesterol fatty acid and glucose metabolism [, ]. It is an upstream regulator of HNF1A expression []. HNF4A regulates the expression of genes in the liver, pancreas, kidney, intestine, and other tissues. It is essential for development of the liver [, ]and regulates growth and function of islet beta-cells in the pancreas [, ]. Mutations in the HFN4A gene result in type 1 MODY (MODY1), a monogenic form of non-insulin-dependent type 2 diabetes [, ]. HNF4A is also involved in circadian rhythm maintenance in liver and colon cells as it transrepresses CLOCK:BMAL1 heterodimer activity [].
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Protein Coding Gene
MGI:109128 | Hnf4a
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
30530698 | J:283180
First Author: Qu M
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks.
Volume: 115
Issue: 52
Pages: E12305-E12312
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Gene
101927219 | HNF4A-AS1
Type: gene
Organism: human
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Publication
15761495 | J:97364
First Author: Gupta RK
Year: 2005
Journal: J Clin Invest
Title: The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion.
Volume: 115
Issue: 4
Pages: 1006-15
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Publication
8945471 | J:48113
First Author: Yamagata K
Year: 1996
Journal: Nature
Title: Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)
Volume: 384
Issue: 6608
Pages: 458-60
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Publication
11158324 | J:67396
First Author: Hayhurst GP
Year: 2001
Journal: Mol Cell Biol
Title: Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis.
Volume: 21
Issue: 4
Pages: 1393-403
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GXD Expression
GXD Expression
 
Probe: MGI:3055326
Assay Type: Immunohistochemistry
Annotation Date: 2021-03-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3283426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6513189
Age: embryonic day 18.5
Image: 2E HNF4A WT
Specimen Label: 2E HNF4A WT
Detected: true
Specimen Num: 15
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GXD Expression
GXD Expression
Probe: MGI:3055326
Assay Type: Immunohistochemistry
Annotation Date: 2021-03-30
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3283426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6513189
Age: embryonic day 18.5
Image: 2E HNF4A Cdx2KO
Note: Authors report reduced expression.
Specimen Label: 2E HNF4A Cdx2KO
Detected: true
Specimen Num: 16
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GXD Expression
GXD Expression
   
Probe: MGI:3055326
Assay Type: Immunohistochemistry
Annotation Date: 2021-03-30
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1885226
Stage: TS26
Assay Id: MGI:6513189
Age: embryonic day 18.5
Image: S1E HNF4A Hnf4aKO
Specimen Label: S1E HNF4A Hnf4aKO
Detected: false
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:3055326
Assay Type: Immunohistochemistry
Annotation Date: 2021-03-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1885226
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6513189
Age: embryonic day 18.5
Image: S1E HNF4A WT
Specimen Label: S1E HNF4A WT
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:3055326
Assay Type: Immunohistochemistry
Annotation Date: 2021-03-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1885226
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6513189
Age: embryonic day 18.5
Image: S1E HNF4A Hnf4gKO
Specimen Label: S1E HNF4A Hnf4gKO
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:3055326
Assay Type: Immunohistochemistry
Annotation Date: 2021-03-30
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1885226
Stage: TS26
Assay Id: MGI:6513189
Age: embryonic day 18.5
Image: S1E HNF4A Hnf4agDKO
Specimen Label: S1E HNF4A Hnf4agDKO
Detected: false
Specimen Num: 8
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GXD Expression
GXD Expression
     
Probe: MGI:5634742
Assay Type: RT-PCR
Annotation Date: 2015-05-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160399
Stage: TS09
Assay Id: MGI:5634749
Age: embryonic day 6.5
Specimen Label: Hnf4a
Detected: true
Specimen Num: 1
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Publication
21852396 | -
First Author: DeLaForest A
Year: 2011
Journal: Development
Title: HNF4A is essential for specification of hepatic progenitors from human pluripotent stem cells.
Volume: 138
Issue: 19
Pages: 4143-53
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Publication
35443180 | J:325085
First Author: Hunter AL
Year: 2022
Journal: Cell Rep
Title: HNF4A modulates glucocorticoid action in the liver.
Volume: 39
Issue: 3
Pages: 110697
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Publication
16800817 | -
First Author: Adamson AW
Year: 2006
Journal: Biochem J
Title: Hepatocyte nuclear factor-4alpha contributes to carbohydrate-induced transcriptional activation of hepatic fatty acid synthase.
Volume: 399
Issue: 2
Pages: 285-95
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Publication
11679424 | J:107187
First Author: Shih DQ
Year: 2001
Journal: Diabetes
Title: Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism.
Volume: 50
Issue: 11
Pages: 2472-80
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Publication
16917892 | -
First Author: Ellard S
Year: 2006
Journal: Hum Mutat
Title: Mutations in the genes encoding the transcription factors hepatocyte nuclear factor 1 alpha (HNF1A) and 4 alpha (HNF4A) in maturity-onset diabetes of the young.
Volume: 27
Issue: 9
Pages: 854-69
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Publication
11463573 | -
First Author: Ryffel GU
Year: 2001
Journal: J Mol Endocrinol
Title: Mutations in the human genes encoding the transcription factors of the hepatocyte nuclear factor (HNF)1 and HNF4 families: functional and pathological consequences.
Volume: 27
Issue: 1
Pages: 11-29
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Publication
17923767 | -
 
First Author: Maestro MA
Year: 2007
Journal: Endocr Dev
Title: Distinct roles of HNF1beta, HNF1alpha, and HNF4alpha in regulating pancreas development, beta-cell function and growth.
Volume: 12
Pages: 33-45
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Publication
30046000 | J:266356
 
First Author: Marable SS
Year: 2018
Journal: JCI Insight
Title: Hnf4a deletion in the mouse kidney phenocopies Fanconi renotubular syndrome.
Volume: 3
Issue: 14
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Publication
25263553 | J:323555
First Author: Alder O
Year: 2014
Journal: Cell Rep
Title: Hippo signaling influences HNF4A and FOXA2 enhancer switching during hepatocyte differentiation.
Volume: 9
Issue: 1
Pages: 261-271
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Publication
38297077 | J:345656
First Author: Thakur A
Year: 2024
Journal: Commun Biol
Title: HNF4A guides the MLL4 complex to establish and maintain H3K4me1 at gene regulatory elements.
Volume: 7
Issue: 1
Pages: 144
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Publication
35792863 | J:332531
 
First Author: Lei X
Year: 2022
Journal: J Exp Med
Title: Epithelial HNF4A shapes the intraepithelial lymphocyte compartment via direct regulation of immune signaling molecules.
Volume: 219
Issue: 8
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Protein
P49698
Organism: Mus musculus/domesticus
Length: 474  
Fragment?: false
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Protein
B9VVT6
Organism: Mus musculus/domesticus
Length: 413  
Fragment?: true
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Protein
B9VVT5
Organism: Mus musculus/domesticus
Length: 403  
Fragment?: true
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Protein
Z4YKX0
Organism: Mus musculus/domesticus
Length: 465  
Fragment?: false
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Protein
A2A5I6
Organism: Mus musculus/domesticus
Length: 191  
Fragment?: true
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Publication
34732735 | J:315703
First Author: Qu M
Year: 2021
Journal: Nat Commun
Title: HNF4A defines tissue-specific circadian rhythms by beaconing BMAL1::CLOCK chromatin binding and shaping the rhythmic chromatin landscape.
Volume: 12
Issue: 1
Pages: 6350
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Publication
27233607 | J:236044
First Author: Yahoo N
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Forced expression of Hnf4a induces hepatic gene activation through directed differentiation.
Volume: 476
Issue: 4
Pages: 313-318
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Protein
B9VVT7
Organism: Mus musculus/domesticus
Length: 353  
Fragment?: false
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Protein
A2ICG8
Organism: Mus musculus/domesticus
Length: 350  
Fragment?: true
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Publication
17407387 | J:134163
First Author: Pearson ER
Year: 2007
Journal: PLoS Med
Title: Macrosomia and hyperinsulinaemic hypoglycaemia in patients with heterozygous mutations in the HNF4A gene.
Volume: 4
Issue: 4
Pages: e118
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Publication
25209997 | J:228779
 
First Author: Alpern D
Year: 2014
Journal: Elife
Title: TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation.
Volume: 3
Pages: e03613
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Publication
25488664 | J:273287
First Author: San Roman AK
Year: 2015
Journal: J Biol Chem
Title: Transcription factors GATA4 and HNF4A control distinct aspects of intestinal homeostasis in conjunction with transcription factor CDX2.
Volume: 290
Issue: 3
Pages: 1850-60
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Publication
37526424 | J:341340
First Author: Kelly C
Year: 2023
Journal: mBio
Title: Spontaneous episodic inflammation in the intestines of mice lacking HNF4A is driven by microbiota and associated with early life microbiota alterations.
Volume: 14
Issue: 4
Pages: e0150423
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GXD Expression
GXD Expression
     
Probe: MGI:6174942
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6190528
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Hnf4a
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:6174942
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6190528
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Hnf4a
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6174942
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:6190528
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Hnf4a
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:6174942
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:6190528
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Hnf4a
Detected: false
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:6174942
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190528
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Hnf4a
Detected: false
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:6174942
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190528
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Hnf4a
Detected: false
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:6174942
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190528
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Hnf4a
Detected: false
Specimen Num: 7
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GXD Expression
GXD Expression
Probe: MGI:5448181
Assay Type: Immunohistochemistry
Annotation Date: 2013-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:5448231
Age: embryonic day 15.5
Image: 5G/I
Note: Expression in some Neurog3-expressing endocrine cell precursors. Authors report that the frequency of Hnf4a and Neurog3 co-expressing cells decreased as development proceeded.
Specimen Label: 5G/I
Detected: true
Specimen Num: 9
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Publication
31108460 | J:286009
 
First Author: Zhang X
Year: 2019
Journal: Redox Biol
Title: Ferroptosis is governed by differential regulation of transcription in liver cancer.
Volume: 24
Pages: 101211
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Publication
37079387 | J:336552
 
First Author: Martinez-Calle M
Year: 2023
Journal: J Clin Invest
Title: Transcription factor HNF4α2 promotes osteogenesis and prevents bone abnormalities in mice with renal osteodystrophy.
Volume: 133
Issue: 11
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Publication
22589549 | J:188369
First Author: Sato Y
Year: 2012
Journal: J Biol Chem
Title: Anks4b, a novel target of HNF4α protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells.
Volume: 287
Issue: 27
Pages: 23236-45
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Publication
30988513 | J:282638
First Author: Chen L
Year: 2019
Journal: Nat Genet
Title: A reinforcing HNF4-SMAD4 feed-forward module stabilizes enterocyte identity.
Volume: 51
Issue: 5
Pages: 777-785
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Publication
24980432 | J:224356
First Author: Chahar S
Year: 2014
Journal: Mol Cell Biol
Title: Chromatin profiling reveals regulatory network shifts and a protective role for hepatocyte nuclear factor 4α during colitis.
Volume: 34
Issue: 17
Pages: 3291-304
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Publication
38111711 | J:343623
 
First Author: Deans JR
Year: 2023
Journal: Front Endocrinol (Lausanne)
Title: HNF4α isoforms regulate the circadian balance between carbohydrate and lipid metabolism in the liver.
Volume: 14
Pages: 1266527
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Publication
30862908 | J:275866
First Author: Girard R
Year: 2019
Journal: Sci Rep
Title: HNF4α is a novel regulator of intestinal glucose-dependent insulinotropic polypeptide.
Volume: 9
Issue: 1
Pages: 4200
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Publication
23129810 | J:192828
First Author: Verzi MP
Year: 2013
Journal: Mol Cell Biol
Title: Intestinal master transcription factor CDX2 controls chromatin access for partner transcription factor binding.
Volume: 33
Issue: 2
Pages: 281-92
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Publication
22241473 | J:182767
First Author: Bonzo JA
Year: 2012
Journal: J Biol Chem
Title: Suppression of hepatocyte proliferation by hepatocyte nuclear factor 4α in adult mice.
Volume: 287
Issue: 10
Pages: 7345-56
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Publication
32622843 | J:298133
 
First Author: Thymiakou E
Year: 2020
Journal: Metabolism
Title: Defects in High Density Lipoprotein metabolism and hepatic steatosis in mice with liver-specific ablation of Hepatocyte Nuclear Factor 4A.
Volume: 110
Pages: 154307
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Publication
28838957 | J:247907
First Author: Yao J
Year: 2017
Journal: J Cell Biol
Title: Vascular endothelium plays a key role in directing pulmonary epithelial cell differentiation.
Volume: 216
Issue: 10
Pages: 3369-3385
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Publication
21062980 | J:166855
First Author: Darsigny M
Year: 2010
Journal: Cancer Res
Title: Hepatocyte nuclear factor-4alpha promotes gut neoplasia in mice and protects against the production of reactive oxygen species.
Volume: 70
Issue: 22
Pages: 9423-33
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Publication
36796223 | J:334455
 
First Author: Kim D
Year: 2023
Journal: Biochem Biophys Res Commun
Title: Keratin 79 is a PPARA target that is highly expressed by liver damage.
Volume: 650
Pages: 132-136
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Publication
30721564 | J:294462
First Author: Sartor C
Year: 2019
Journal: Liver Int
Title: The concomitant loss of APC and HNF4α in adult hepatocytes does not contribute to hepatocarcinogenesis driven by β-catenin activation.
Volume: 39
Issue: 4
Pages: 727-739
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Publication
27752141 | J:253755
 
First Author: Burdin DV
Year: 2016
Journal: Sci Rep
Title: Diabetes-linked transcription factor HNF4α regulates metabolism of endogenous methylarginines and β-aminoisobutyric acid by controlling expression of alanine-glyoxylate aminotransferase 2.
Volume: 6
Pages: 35503
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Publication
24427299 | J:212199
First Author: Zhang Q
Year: 2014
Journal: PLoS One
Title: Alterations of epigenetic signatures in hepatocyte nuclear factor 4α deficient mouse liver determined by improved ChIP-qPCR and (h)MeDIP-qPCR assays.
Volume: 9
Issue: 1
Pages: e84925
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Publication
27820600 | J:238554
First Author: Kaminski MM
Year: 2016
Journal: Nat Cell Biol
Title: Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors.
Volume: 18
Issue: 12
Pages: 1269-1280
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Publication
20551221 | J:163339
First Author: Hoffman BG
Year: 2010
Journal: Genome Res
Title: Locus co-occupancy, nucleosome positioning, and H3K4me1 regulate the functionality of FOXA2-, HNF4A-, and PDX1-bound loci in islets and liver.
Volume: 20
Issue: 8
Pages: 1037-51
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Publication
21186337 | J:173588
First Author: Kanazawa T
Year: 2011
Journal: J Vet Med Sci
Title: Hepatocyte nuclear factor 4 alpha is associated with mesenchymal-epithelial transition in developing kidneys of C57BL/6 mice.
Volume: 73
Issue: 5
Pages: 601-7
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Publication
30773487 | J:278017
First Author: Han X
Year: 2019
Journal: Stem Cell Reports
Title: Lineage Tracing Reveals the Bipotency of SOX9+ Hepatocytes during Liver Regeneration.
Volume: 12
Issue: 3
Pages: 624-638
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Publication
31345929 | J:284137
 
First Author: Chen L
Year: 2019
Journal: Development
Title: HNF4 factors control chromatin accessibility and are redundantly required for maturation of the fetal intestine.
Volume: 146
Issue: 19
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Publication
16618389 | J:124920
First Author: Garrison WD
Year: 2006
Journal: Gastroenterology
Title: Hepatocyte nuclear factor 4alpha is essential for embryonic development of the mouse colon.
Volume: 130
Issue: 4
Pages: 1207-20
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Protein Coding Gene
MGP_CAROLIEiJ_G0024618 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0026825 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0026791 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0026762 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0026800 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0026542 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_109128 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0027248 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0026003 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0026519 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0026657 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0026623 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0026760 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0026645 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0027304 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0025737 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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•
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Protein Coding Gene
MGP_WSBEiJ_G0026073 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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•
•
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Protein Coding Gene
MGP_PahariEiJ_G0026062 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0025540 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
7999795 | J:22110
First Author: Hata S
Year: 1995
Journal: Biochim Biophys Acta
Title: Identification of two splice isoforms of mRNA for mouse hepatocyte nuclear factor 4 (HNF-4).
Volume: 1260
Issue: 1
Pages: 55-61
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Publication
9421506 | J:45483
First Author: Nakhei H
Year: 1998
Journal: Nucleic Acids Res
Title: An alternative splice variant of the tissue specific transcription factor HNF4alpha predominates in undifferentiated murine cell types.
Volume: 26
Issue: 2
Pages: 497-504
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Publication
28882825 | J:273449
First Author: Muthusamy S
Year: 2018
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Hepatocyte nuclear factor 4α regulates the expression of intestinal epithelial Na+/H+ exchanger isoform 3.
Volume: 314
Issue: 1
Pages: G14-G21
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Publication
35968955 | J:328266
First Author: Foley SE
Year: 2022
Journal: mBio
Title: Microbial Metabolites Orchestrate a Distinct Multi-Tiered Regulatory Network in the Intestinal Epithelium That Directs P-Glycoprotein Expression.
Volume: 13
Issue: 4
Pages: e0199322
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