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Search results 1 to 100 out of 1515 for Hnf4a

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1.398s

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
3172 | HNF4A
Type: gene
Organism: human
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Gene
100492541 | hnf4a
Type: gene
Organism: frog, western clawed
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Gene
25735 | Hnf4a
Type: gene
Organism: rat
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Gene
458269 | HNF4A
Type: gene
Organism: chimpanzee
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Gene
485884 | HNF4A
Type: gene
Organism: dog, domestic
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Gene
509200 | HNF4A
Type: gene
Organism: cattle
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Gene
419198 | HNF4A
Type: gene
Organism: chicken
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Gene
322358 | hnf4a
Type: gene
Organism: zebrafish
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Gene
717972 | HNF4A
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR039067 | HNF4A
Type: Family
Description: HNF4A (also known as TCF14) is a member of the steroid-thyroid hormone receptor superfamily. HNF4A interacts with regulatory elements in promoters and enhancers of the genes involved in cholesterol fatty acid and glucose metabolism [, ]. It is an upstream regulator of HNF1A expression []. HNF4A regulates the expression of genes in the liver, pancreas, kidney, intestine, and other tissues. It is essential for development of the liver [, ]and regulates growth and function of islet beta-cells in the pancreas [, ]. Mutations in the HFN4A gene result in type 1 MODY (MODY1), a monogenic form of non-insulin-dependent type 2 diabetes [, ]. HNF4A is also involved in circadian rhythm maintenance in liver and colon cells as it transrepresses CLOCK:BMAL1 heterodimer activity [].
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Protein Coding Gene
MGI:109128 | Hnf4a
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
30530698 | J:283180
First Author: Qu M
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks.
Volume: 115
Issue: 52
Pages: E12305-E12312
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Gene
101927219 | HNF4A-AS1
Type: gene
Organism: human
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Publication
15761495 | J:97364
First Author: Gupta RK
Year: 2005
Journal: J Clin Invest
Title: The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion.
Volume: 115
Issue: 4
Pages: 1006-15
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Publication
8945471 | J:48113
First Author: Yamagata K
Year: 1996
Journal: Nature
Title: Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)
Volume: 384
Issue: 6608
Pages: 458-60
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Publication
11158324 | J:67396
First Author: Hayhurst GP
Year: 2001
Journal: Mol Cell Biol
Title: Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis.
Volume: 21
Issue: 4
Pages: 1393-403
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GXD Expression
GXD Expression
 
Probe: MGI:3055326
Assay Type: Immunohistochemistry
Annotation Date: 2021-03-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1885226
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6513189
Age: embryonic day 18.5
Image: S1E HNF4A Hnf4gKO
Specimen Label: S1E HNF4A Hnf4gKO
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
Probe: MGI:3055326
Assay Type: Immunohistochemistry
Annotation Date: 2021-03-30
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3283426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6513189
Age: embryonic day 18.5
Image: 2E HNF4A Cdx2KO
Note: Authors report reduced expression.
Specimen Label: 2E HNF4A Cdx2KO
Detected: true
Specimen Num: 16
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GXD Expression
GXD Expression
 
Probe: MGI:3055326
Assay Type: Immunohistochemistry
Annotation Date: 2021-03-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1885226
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6513189
Age: embryonic day 18.5
Image: S1E HNF4A WT
Specimen Label: S1E HNF4A WT
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:3055326
Assay Type: Immunohistochemistry
Annotation Date: 2021-03-30
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1885226
Stage: TS26
Assay Id: MGI:6513189
Age: embryonic day 18.5
Image: S1E HNF4A Hnf4agDKO
Specimen Label: S1E HNF4A Hnf4agDKO
Detected: false
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:3055326
Assay Type: Immunohistochemistry
Annotation Date: 2021-03-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3283426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6513189
Age: embryonic day 18.5
Image: 2E HNF4A WT
Specimen Label: 2E HNF4A WT
Detected: true
Specimen Num: 15
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GXD Expression
GXD Expression
   
Probe: MGI:3055326
Assay Type: Immunohistochemistry
Annotation Date: 2021-03-30
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1885226
Stage: TS26
Assay Id: MGI:6513189
Age: embryonic day 18.5
Image: S1E HNF4A Hnf4aKO
Specimen Label: S1E HNF4A Hnf4aKO
Detected: false
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:5634742
Assay Type: RT-PCR
Annotation Date: 2015-05-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160399
Stage: TS09
Assay Id: MGI:5634749
Age: embryonic day 6.5
Specimen Label: Hnf4a
Detected: true
Specimen Num: 1
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Publication
21852396 | -
First Author: DeLaForest A
Year: 2011
Journal: Development
Title: HNF4A is essential for specification of hepatic progenitors from human pluripotent stem cells.
Volume: 138
Issue: 19
Pages: 4143-53
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Publication
35443180 | J:325085
First Author: Hunter AL
Year: 2022
Journal: Cell Rep
Title: HNF4A modulates glucocorticoid action in the liver.
Volume: 39
Issue: 3
Pages: 110697
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Publication
16800817 | -
First Author: Adamson AW
Year: 2006
Journal: Biochem J
Title: Hepatocyte nuclear factor-4alpha contributes to carbohydrate-induced transcriptional activation of hepatic fatty acid synthase.
Volume: 399
Issue: 2
Pages: 285-95
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Publication
11679424 | J:107187
First Author: Shih DQ
Year: 2001
Journal: Diabetes
Title: Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism.
Volume: 50
Issue: 11
Pages: 2472-80
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Publication
16917892 | -
First Author: Ellard S
Year: 2006
Journal: Hum Mutat
Title: Mutations in the genes encoding the transcription factors hepatocyte nuclear factor 1 alpha (HNF1A) and 4 alpha (HNF4A) in maturity-onset diabetes of the young.
Volume: 27
Issue: 9
Pages: 854-69
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Publication
11463573 | -
First Author: Ryffel GU
Year: 2001
Journal: J Mol Endocrinol
Title: Mutations in the human genes encoding the transcription factors of the hepatocyte nuclear factor (HNF)1 and HNF4 families: functional and pathological consequences.
Volume: 27
Issue: 1
Pages: 11-29
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Publication
17923767 | -
 
First Author: Maestro MA
Year: 2007
Journal: Endocr Dev
Title: Distinct roles of HNF1beta, HNF1alpha, and HNF4alpha in regulating pancreas development, beta-cell function and growth.
Volume: 12
Pages: 33-45
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Publication
30046000 | J:266356
 
First Author: Marable SS
Year: 2018
Journal: JCI Insight
Title: Hnf4a deletion in the mouse kidney phenocopies Fanconi renotubular syndrome.
Volume: 3
Issue: 14
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Publication
25263553 | J:323555
First Author: Alder O
Year: 2014
Journal: Cell Rep
Title: Hippo signaling influences HNF4A and FOXA2 enhancer switching during hepatocyte differentiation.
Volume: 9
Issue: 1
Pages: 261-271
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Protein
P49698
Organism: Mus musculus/domesticus
Length: 474  
Fragment?: false
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Protein
B9VVT6
Organism: Mus musculus/domesticus
Length: 413  
Fragment?: true
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Protein
B9VVT5
Organism: Mus musculus/domesticus
Length: 403  
Fragment?: true
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Protein
Z4YKX0
Organism: Mus musculus/domesticus
Length: 465  
Fragment?: false
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Protein
A2A5I6
Organism: Mus musculus/domesticus
Length: 191  
Fragment?: true
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Protein
B9VVT7
Organism: Mus musculus/domesticus
Length: 353  
Fragment?: false
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Protein
A2ICG8
Organism: Mus musculus/domesticus
Length: 350  
Fragment?: true
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Publication
38297077 | J:345656
First Author: Thakur A
Year: 2024
Journal: Commun Biol
Title: HNF4A guides the MLL4 complex to establish and maintain H3K4me1 at gene regulatory elements.
Volume: 7
Issue: 1
Pages: 144
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Publication
35792863 | J:332531
 
First Author: Lei X
Year: 2022
Journal: J Exp Med
Title: Epithelial HNF4A shapes the intraepithelial lymphocyte compartment via direct regulation of immune signaling molecules.
Volume: 219
Issue: 8
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Publication
34732735 | J:315703
First Author: Qu M
Year: 2021
Journal: Nat Commun
Title: HNF4A defines tissue-specific circadian rhythms by beaconing BMAL1::CLOCK chromatin binding and shaping the rhythmic chromatin landscape.
Volume: 12
Issue: 1
Pages: 6350
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Publication
27233607 | J:236044
First Author: Yahoo N
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Forced expression of Hnf4a induces hepatic gene activation through directed differentiation.
Volume: 476
Issue: 4
Pages: 313-318
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Publication
17407387 | J:134163
First Author: Pearson ER
Year: 2007
Journal: PLoS Med
Title: Macrosomia and hyperinsulinaemic hypoglycaemia in patients with heterozygous mutations in the HNF4A gene.
Volume: 4
Issue: 4
Pages: e118
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Publication
25209997 | J:228779
 
First Author: Alpern D
Year: 2014
Journal: Elife
Title: TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation.
Volume: 3
Pages: e03613
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Publication
25488664 | J:273287
First Author: San Roman AK
Year: 2015
Journal: J Biol Chem
Title: Transcription factors GATA4 and HNF4A control distinct aspects of intestinal homeostasis in conjunction with transcription factor CDX2.
Volume: 290
Issue: 3
Pages: 1850-60
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Publication
37526424 | J:341340
First Author: Kelly C
Year: 2023
Journal: mBio
Title: Spontaneous episodic inflammation in the intestines of mice lacking HNF4A is driven by microbiota and associated with early life microbiota alterations.
Volume: 14
Issue: 4
Pages: e0150423
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GXD Expression
GXD Expression
     
Probe: MGI:6174942
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:6190528
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Hnf4a
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:6174942
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190528
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Hnf4a
Detected: false
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:6174942
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6190528
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Hnf4a
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:6174942
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6190528
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Hnf4a
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6174942
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:6190528
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Hnf4a
Detected: false
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:6174942
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190528
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Hnf4a
Detected: false
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:6174942
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190528
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Hnf4a
Detected: false
Specimen Num: 7
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GXD Expression
GXD Expression
Probe: MGI:5448181
Assay Type: Immunohistochemistry
Annotation Date: 2013-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:5448231
Age: embryonic day 15.5
Image: 5G/I
Note: Expression in some Neurog3-expressing endocrine cell precursors. Authors report that the frequency of Hnf4a and Neurog3 co-expressing cells decreased as development proceeded.
Specimen Label: 5G/I
Detected: true
Specimen Num: 9
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Publication
31108460 | J:286009
 
First Author: Zhang X
Year: 2019
Journal: Redox Biol
Title: Ferroptosis is governed by differential regulation of transcription in liver cancer.
Volume: 24
Pages: 101211
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Publication
37079387 | J:336552
 
First Author: Martinez-Calle M
Year: 2023
Journal: J Clin Invest
Title: Transcription factor HNF4α2 promotes osteogenesis and prevents bone abnormalities in mice with renal osteodystrophy.
Volume: 133
Issue: 11
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Publication
22589549 | J:188369
First Author: Sato Y
Year: 2012
Journal: J Biol Chem
Title: Anks4b, a novel target of HNF4α protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells.
Volume: 287
Issue: 27
Pages: 23236-45
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Publication
30988513 | J:282638
First Author: Chen L
Year: 2019
Journal: Nat Genet
Title: A reinforcing HNF4-SMAD4 feed-forward module stabilizes enterocyte identity.
Volume: 51
Issue: 5
Pages: 777-785
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Publication
24980432 | J:224356
First Author: Chahar S
Year: 2014
Journal: Mol Cell Biol
Title: Chromatin profiling reveals regulatory network shifts and a protective role for hepatocyte nuclear factor 4α during colitis.
Volume: 34
Issue: 17
Pages: 3291-304
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Publication
38111711 | J:343623
 
First Author: Deans JR
Year: 2023
Journal: Front Endocrinol (Lausanne)
Title: HNF4α isoforms regulate the circadian balance between carbohydrate and lipid metabolism in the liver.
Volume: 14
Pages: 1266527
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Publication
23129810 | J:192828
First Author: Verzi MP
Year: 2013
Journal: Mol Cell Biol
Title: Intestinal master transcription factor CDX2 controls chromatin access for partner transcription factor binding.
Volume: 33
Issue: 2
Pages: 281-92
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Publication
30862908 | J:275866
First Author: Girard R
Year: 2019
Journal: Sci Rep
Title: HNF4α is a novel regulator of intestinal glucose-dependent insulinotropic polypeptide.
Volume: 9
Issue: 1
Pages: 4200
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Publication
34973414 | J:319851
First Author: Thymiakou E
Year: 2022
Journal: Biochim Biophys Acta Mol Cell Biol Lipids
Title: Intestine-specific ablation of the Hepatocyte Nuclear Factor 4a (Hnf4a) gene in mice has minimal impact on serum lipids and ileum gene expression profile due to upregulation of its paralog Hnf4g.
Volume: 1867
Issue: 3
Pages: 159108
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Publication
32622843 | J:298133
 
First Author: Thymiakou E
Year: 2020
Journal: Metabolism
Title: Defects in High Density Lipoprotein metabolism and hepatic steatosis in mice with liver-specific ablation of Hepatocyte Nuclear Factor 4A.
Volume: 110
Pages: 154307
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Publication
28838957 | J:247907
First Author: Yao J
Year: 2017
Journal: J Cell Biol
Title: Vascular endothelium plays a key role in directing pulmonary epithelial cell differentiation.
Volume: 216
Issue: 10
Pages: 3369-3385
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Publication
21062980 | J:166855
First Author: Darsigny M
Year: 2010
Journal: Cancer Res
Title: Hepatocyte nuclear factor-4alpha promotes gut neoplasia in mice and protects against the production of reactive oxygen species.
Volume: 70
Issue: 22
Pages: 9423-33
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Publication
36796223 | J:334455
 
First Author: Kim D
Year: 2023
Journal: Biochem Biophys Res Commun
Title: Keratin 79 is a PPARA target that is highly expressed by liver damage.
Volume: 650
Pages: 132-136
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Publication
22241473 | J:182767
First Author: Bonzo JA
Year: 2012
Journal: J Biol Chem
Title: Suppression of hepatocyte proliferation by hepatocyte nuclear factor 4α in adult mice.
Volume: 287
Issue: 10
Pages: 7345-56
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Publication
24427299 | J:212199
First Author: Zhang Q
Year: 2014
Journal: PLoS One
Title: Alterations of epigenetic signatures in hepatocyte nuclear factor 4α deficient mouse liver determined by improved ChIP-qPCR and (h)MeDIP-qPCR assays.
Volume: 9
Issue: 1
Pages: e84925
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Publication
30721564 | J:294462
First Author: Sartor C
Year: 2019
Journal: Liver Int
Title: The concomitant loss of APC and HNF4α in adult hepatocytes does not contribute to hepatocarcinogenesis driven by β-catenin activation.
Volume: 39
Issue: 4
Pages: 727-739
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Publication
27752141 | J:253755
 
First Author: Burdin DV
Year: 2016
Journal: Sci Rep
Title: Diabetes-linked transcription factor HNF4α regulates metabolism of endogenous methylarginines and β-aminoisobutyric acid by controlling expression of alanine-glyoxylate aminotransferase 2.
Volume: 6
Pages: 35503
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Publication
27820600 | J:238554
First Author: Kaminski MM
Year: 2016
Journal: Nat Cell Biol
Title: Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors.
Volume: 18
Issue: 12
Pages: 1269-1280
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Publication
20551221 | J:163339
First Author: Hoffman BG
Year: 2010
Journal: Genome Res
Title: Locus co-occupancy, nucleosome positioning, and H3K4me1 regulate the functionality of FOXA2-, HNF4A-, and PDX1-bound loci in islets and liver.
Volume: 20
Issue: 8
Pages: 1037-51
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Publication
21186337 | J:173588
First Author: Kanazawa T
Year: 2011
Journal: J Vet Med Sci
Title: Hepatocyte nuclear factor 4 alpha is associated with mesenchymal-epithelial transition in developing kidneys of C57BL/6 mice.
Volume: 73
Issue: 5
Pages: 601-7
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Publication
30773487 | J:278017
First Author: Han X
Year: 2019
Journal: Stem Cell Reports
Title: Lineage Tracing Reveals the Bipotency of SOX9+ Hepatocytes during Liver Regeneration.
Volume: 12
Issue: 3
Pages: 624-638
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Publication
31345929 | J:284137
 
First Author: Chen L
Year: 2019
Journal: Development
Title: HNF4 factors control chromatin accessibility and are redundantly required for maturation of the fetal intestine.
Volume: 146
Issue: 19
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Publication
16618389 | J:124920
First Author: Garrison WD
Year: 2006
Journal: Gastroenterology
Title: Hepatocyte nuclear factor 4alpha is essential for embryonic development of the mouse colon.
Volume: 130
Issue: 4
Pages: 1207-20
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Protein Coding Gene
MGP_CAROLIEiJ_G0024618 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0026825 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0026791 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0026762 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0026800 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0026542 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_109128 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0027248 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0026003 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0026519 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0026657 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0026623 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0026760 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0026645 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0027304 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0025737 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0026073 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0026062 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0025540 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
7999795 | J:22110
First Author: Hata S
Year: 1995
Journal: Biochim Biophys Acta
Title: Identification of two splice isoforms of mRNA for mouse hepatocyte nuclear factor 4 (HNF-4).
Volume: 1260
Issue: 1
Pages: 55-61
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Publication
9421506 | J:45483
First Author: Nakhei H
Year: 1998
Journal: Nucleic Acids Res
Title: An alternative splice variant of the tissue specific transcription factor HNF4alpha predominates in undifferentiated murine cell types.
Volume: 26
Issue: 2
Pages: 497-504
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Publication
14666509 | J:87353
First Author: Sugimoto M
Year: 2003
Journal: Genesis
Title: Tetraploid embryos rescue the early defects of tw5/tw5 mouse embryos.
Volume: 37
Issue: 4
Pages: 162-71
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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