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Search results 1 to 100 out of 121 for Hook1

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
51361 | HOOK1
Type: gene
Organism: human
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Gene
100125063 | hook1
Type: gene
Organism: frog, western clawed
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Gene
313370 | Hook1
Type: gene
Organism: rat
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Gene
479553 | HOOK1
Type: gene
Organism: dog, domestic
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Gene
456895 | HOOK1
Type: gene
Organism: chimpanzee
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Gene
785042 | HOOK1
Type: gene
Organism: cattle
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Gene
424675 | HOOK1
Type: gene
Organism: chicken
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Gene
570393 | hook1
Type: gene
Organism: zebrafish
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Gene
693504 | HOOK1
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1925213 | Hook1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
12075009 | J:77010
First Author: Mendoza-Lujambio I
Year: 2002
Journal: Hum Mol Genet
Title: The Hook1 gene is non-functional in the abnormal spermatozoon head shape (azh) mutant mouse.
Volume: 11
Issue: 14
Pages: 1647-58
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Publication
15823567 | J:97449
First Author: Weimer JM
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Elevation of Hook1 in a disease model of Batten disease does not affect a novel interaction between Ankyrin G and Hook1.
Volume: 330
Issue: 4
Pages: 1176-81
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Publication
28283191 | J:241007
First Author: Schwarz T
Year: 2017
Journal: Eur J Cell Biol
Title: Ccdc181 is a microtubule-binding protein that interacts with Hook1 in haploid male germ cells and localizes to the sperm tail and motile cilia.
Volume: 96
Issue: 3
Pages: 276-288
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Publication
19091768 | J:144218
First Author: Zhou J
Year: 2009
Journal: Development
Title: RIM-BP3 is a manchette-associated protein essential for spermiogenesis.
Volume: 136
Issue: 3
Pages: 373-82
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Publication
29423001 | J:277903
First Author: Xie JC
Year: 2018
Journal: Am J Transl Res
Title: Hypoxia increases amyloid-β level in exosomes by enhancing the interaction between CD147 and Hook1.
Volume: 10
Issue: 1
Pages: 150-163
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Publication
14668490 | J:90042
First Author: Richardson SC
Year: 2004
Journal: Mol Biol Cell
Title: Mammalian late vacuole protein sorting orthologues participate in early endosomal fusion and interact with the cytoskeleton.
Volume: 15
Issue: 3
Pages: 1197-210
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Protein Coding Gene
MGP_CAROLIEiJ_G0026172 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0028458 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0028421 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0028368 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0028439 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0028152 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1925213 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0028878 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0027592 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0028121 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0028271 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0028238 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0028371 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0028266 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0028916 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0027317 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0027670 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0028509 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0027138 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
2346121 | J:19242
First Author: Meistrich ML
Year: 1990
Journal: Am J Anat
Title: Abnormal manchette development in spermatids of azh/azh mutant mice.
Volume: 188
Issue: 1
Pages: 74-86
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Publication
1759685 | J:19269
First Author: Russell LD
Year: 1991
Journal: Am J Anat
Title: Linkage of manchette microtubules to the nuclear envelope and observations of the role of the manchette in nuclear shaping during spermiogenesis in rodents.
Volume: 192
Issue: 2
Pages: 97-120
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Publication
- | J:13990
 
First Author: Hugenholtz AP
Year: 1984
Journal: Mouse News Lett
Title: Abnormal spermatazoon head shape
Volume: 71
Pages: 35
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Publication
11133681 | J:68453
First Author: Akutsu H
Year: 2001
Journal: Biol Reprod
Title: Offspring from normal mouse oocytes injected with sperm heads from the azh/azh mouse display more severe sperm tail abnormalities than the original mutant.
Volume: 64
Issue: 1
Pages: 249-56
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Publication
10092124 | J:53384
First Author: Mochida K
Year: 1999
Journal: Mol Reprod Dev
Title: Structural and biochemical features of fractionated spermatid manchettes and sperm axonemes of the azh/azh mutant mouse.
Volume: 52
Issue: 4
Pages: 434-44
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Publication
8129933 | J:16158
First Author: Meistrich ML
Year: 1994
Journal: Mol Reprod Dev
Title: Deficiency in fertilization by morphologically abnormal sperm produced by azh mutant mice.
Volume: 37
Issue: 1
Pages: 69-77
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GXD Expression
GXD Expression
   
Probe: MGI:5637962
Assay Type: Northern blot
Annotation Date: 2015-06-01
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5637973
Age: postnatal day 45
Image: 2
Specimen Label: +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5637962
Assay Type: Northern blot
Annotation Date: 2015-06-01
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5637973
Age: postnatal day 45
Image: 2
Specimen Label: +/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:5637962
Assay Type: Northern blot
Annotation Date: 2015-06-01
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5637973
Age: postnatal day 45
Image: 2
Specimen Label: -/-
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:5811404
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1640617
Pattern: Uniform
Stage: TS17
Assay Id: MGI:5823633
Age: embryonic day 10.5
Image: Hook1_a64_E10.5a_RF_JL
Specimen Label: Hook1_a64_E10.5a_RF_JL
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:5811404
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1640617
Pattern: Uniform
Stage: TS17
Assay Id: MGI:5823633
Age: embryonic day 10.5
Image: Hook1_a64_E10.5b_RF_JL
Specimen Label: Hook1_a64_E10.5b_RF_JL
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:5811404
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640619
Pattern: Uniform
Stage: TS19
Assay Id: MGI:5823633
Age: embryonic day 11.5
Image: Hook1_a64_E11.5a_RF_JL
Specimen Label: Hook1_a64_E11.5a_RF_JL
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:5811404
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640619
Pattern: Uniform
Stage: TS19
Assay Id: MGI:5823633
Age: embryonic day 11.5
Image: Hook1_a64_E11.5b_RF_JL
Specimen Label: Hook1_a64_E11.5b_RF_JL
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:5811404
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1603917
Pattern: Widespread
Stage: TS17
Assay Id: MGI:5823633
Age: embryonic day 10.5
Image: Hook1_a64_E10.5a_JL
Specimen Label: Hook1_a64_E10.5a_JL
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:5811404
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1603917
Pattern: Widespread
Stage: TS17
Assay Id: MGI:5823633
Age: embryonic day 10.5
Image: Hook1_a64_E10.5b_JL
Specimen Label: Hook1_a64_E10.5b_JL
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:5811404
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Pattern: Widespread
Stage: TS19
Assay Id: MGI:5823633
Age: embryonic day 11.5
Image: Hook1_a64_E11.5a_JL
Specimen Label: Hook1_a64_E11.5a_JL
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:5811404
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Pattern: Widespread
Stage: TS19
Assay Id: MGI:5823633
Age: embryonic day 11.5
Image: Hook1_a64_E11.5b_JL
Specimen Label: Hook1_a64_E11.5b_JL
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:6378745
Assay Type: Immunohistochemistry
Annotation Date: 2019-12-03
Strength: Present
Sex: Male
Emaps: EMAPS:3148628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6378821
Age: postnatal adult
Image: 5H
Specimen Label: 5H
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:6378745
Assay Type: Immunohistochemistry
Annotation Date: 2019-12-03
Strength: Present
Sex: Male
Emaps: EMAPS:3148628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6378821
Age: postnatal adult
Image: 5I
Note: Homozygous mutant testis expressed equivalent cytoplasmic protein in spermatids.
Specimen Label: 5I
Detected: true
Specimen Num: 2
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Publication
9674995 | J:89468
First Author: Schumacher JM
Year: 1998
Journal: Biol Reprod
Title: Spermatid perinuclear ribonucleic acid-binding protein binds microtubules in vitro and associates with abnormal manchettes in vivo in mice.
Volume: 59
Issue: 1
Pages: 69-76
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Publication
16540102 | J:108463
First Author: Moreno RD
Year: 2006
Journal: Dev Biol
Title: Assembly of spermatid acrosome depends on microtubule organization during mammalian spermiogenesis.
Volume: 293
Issue: 1
Pages: 218-27
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Publication
1552159 | J:3251
First Author: Meistrich ML
Year: 1992
Journal: J Hered
Title: Mapping of the azh locus to mouse chromosome 4.
Volume: 83
Issue: 1
Pages: 56-61
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Publication
- | J:14286
 
First Author: Meistrich ML
Year: 1990
Journal: Mouse Genome
Title: Mapping of azh
Volume: 86
Pages: 258
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Publication
31234534 | J:278327
 
First Author: Snider PL
Year: 2019
Journal: J Cardiovasc Dev Dis
Title: Analysis of Uncharacterized mKiaa1211 Expression during Mouse Development and Cardiovascular Morphogenesis.
Volume: 6
Issue: 2
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Publication
13129914 | J:86720
First Author: Nayernia K
Year: 2003
Journal: J Biol Chem
Title: Inactivation of a testis-specific Lis1 transcript in mice prevents spermatid differentiation and causes male infertility.
Volume: 278
Issue: 48
Pages: 48377-85
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Publication
23426694 | J:196086
First Author: Appler JM
Year: 2013
Journal: J Neurosci
Title: Gata3 is a critical regulator of cochlear wiring.
Volume: 33
Issue: 8
Pages: 3679-91
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Publication
- | J:200814
     
First Author: Toronto Centre for Phenogenomics
Year: 2013
Journal: MGI Direct Data Submission
Title: Strains and alleles submitted by Toronto Centre for Phenogenomics (NorCOMM2, funded by Genome Canada and Ontario Genomics Institute OGI-051).
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Publication
26238476 | J:226028
First Author: Lewandowski JP
Year: 2015
Journal: Dev Biol
Title: Spatiotemporal regulation of GLI target genes in the mammalian limb bud.
Volume: 406
Issue: 1
Pages: 92-103
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Publication
- | J:237616
     
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:80001
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Interaction Experiment
Weimer JM (2005)
Description: Elevation of Hook1 in a disease model of Batten disease does not affect a novel interaction between Ankyrin G and Hook1.
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Protein
F6W1A2
Organism: Mus musculus/domesticus
Length: 233  
Fragment?: true
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Protein
Q3UUZ6
Organism: Mus musculus/domesticus
Length: 366  
Fragment?: true
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Protein Domain
IPR008636 | Hook_C
Type: Domain
Description: The Hook family consists of several proteins from different eukaryotic organisms, first identified in Drosophila melanogaster in which play a role in endocytic cargo sorting []. In Drosophila and fungi there is a single Hook gene, whereas mammals have three Hook genes, Hook1, Hook2 and Hook3. Endogenous Hook3 binds to Golgi membranes while both Hook1 and Hook2 are localised to discrete but unidentified cellular structures [, ]. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubule structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head []. They are a widely expressed class of dynein-associated cargo adaptor proteins which include different domains. The N-terminal partof these proteins is sufficient to form a stable complex with dynein-dynactin and includes the most conserved region within the first 160 amino acids, termed the Hook domain. This domain is followed by three coiled-coil domains, important for dimerization and activation of dynein-dynactin complex motility, and then a C-terminal domain that binds a variety of proteins specific for each Hook isoform, involved in binding to specific organelles (organelle-binding domains). All mammalian Hook isoforms form a complex with Fused Toes and the Fused Toes- and Hook-interacting protein; fungal homologues of these proteins are important for dynein-mediated early endosome transport by linking Hook to the cargo [].This entry represents the central coiled-coiled region and the divergent C-terminal domain from Hook proteins.
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Publication
11238449 | -
First Author: Walenta JH
Year: 2001
Journal: J Cell Biol
Title: The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins.
Volume: 152
Issue: 5
Pages: 923-34
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Publication
27482052 | -
First Author: Schroeder CM
Year: 2016
Journal: J Cell Biol
Title: Assembly and activation of dynein-dynactin by the cargo adaptor protein Hook3.
Volume: 214
Issue: 3
Pages: 309-18
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Publication
11018772 | -
First Author: Narayanan R
Year: 2000
Journal: J Neurobiol
Title: Drosophila endosomal proteins hook and deep orange regulate synapse size but not synaptic vesicle recycling.
Volume: 45
Issue: 2
Pages: 105-19
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