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Search results 1 to 100 out of 108 for Hook1

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0.027s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Mendoza-Lujambio I
Year: 2002
Journal: Hum Mol Genet
Title: The Hook1 gene is non-functional in the abnormal spermatozoon head shape (azh) mutant mouse.
Volume: 11
Issue: 14
Pages: 1647-58
Publication
First Author: Weimer JM
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Elevation of Hook1 in a disease model of Batten disease does not affect a novel interaction between Ankyrin G and Hook1.
Volume: 330
Issue: 4
Pages: 1176-81
Publication
First Author: Schwarz T
Year: 2017
Journal: Eur J Cell Biol
Title: Ccdc181 is a microtubule-binding protein that interacts with Hook1 in haploid male germ cells and localizes to the sperm tail and motile cilia.
Volume: 96
Issue: 3
Pages: 276-288
Publication
First Author: Zhou J
Year: 2009
Journal: Development
Title: RIM-BP3 is a manchette-associated protein essential for spermiogenesis.
Volume: 136
Issue: 3
Pages: 373-82
Publication
First Author: Xie JC
Year: 2018
Journal: Am J Transl Res
Title: Hypoxia increases amyloid-β level in exosomes by enhancing the interaction between CD147 and Hook1.
Volume: 10
Issue: 1
Pages: 150-163
Publication
First Author: Richardson SC
Year: 2004
Journal: Mol Biol Cell
Title: Mammalian late vacuole protein sorting orthologues participate in early endosomal fusion and interact with the cytoskeleton.
Volume: 15
Issue: 3
Pages: 1197-210
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Meistrich ML
Year: 1990
Journal: Am J Anat
Title: Abnormal manchette development in spermatids of azh/azh mutant mice.
Volume: 188
Issue: 1
Pages: 74-86
Publication
First Author: Meistrich ML
Year: 1994
Journal: Mol Reprod Dev
Title: Deficiency in fertilization by morphologically abnormal sperm produced by azh mutant mice.
Volume: 37
Issue: 1
Pages: 69-77
Publication
First Author: Russell LD
Year: 1991
Journal: Am J Anat
Title: Linkage of manchette microtubules to the nuclear envelope and observations of the role of the manchette in nuclear shaping during spermiogenesis in rodents.
Volume: 192
Issue: 2
Pages: 97-120
Publication
First Author: Akutsu H
Year: 2001
Journal: Biol Reprod
Title: Offspring from normal mouse oocytes injected with sperm heads from the azh/azh mouse display more severe sperm tail abnormalities than the original mutant.
Volume: 64
Issue: 1
Pages: 249-56
Publication
First Author: Mochida K
Year: 1999
Journal: Mol Reprod Dev
Title: Structural and biochemical features of fractionated spermatid manchettes and sperm axonemes of the azh/azh mutant mouse.
Volume: 52
Issue: 4
Pages: 434-44
Publication  
First Author: Hugenholtz AP
Year: 1984
Journal: Mouse News Lett
Title: Abnormal spermatazoon head shape
Volume: 71
Pages: 35
GXD Expression    
Probe: MGI:5637962
Assay Type: Northern blot
Annotation Date: 2015-06-01
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5637973
Age: postnatal day 45
Image: 2
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5637962
Assay Type: Northern blot
Annotation Date: 2015-06-01
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5637973
Age: postnatal day 45
Image: 2
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5637962
Assay Type: Northern blot
Annotation Date: 2015-06-01
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5637973
Age: postnatal day 45
Image: 2
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:5811404
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1640617
Pattern: Uniform
Stage: TS17
Assay Id: MGI:5823633
Age: embryonic day 10.5
Image: Hook1_a64_E10.5a_RF_JL
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5811404
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1640617
Pattern: Uniform
Stage: TS17
Assay Id: MGI:5823633
Age: embryonic day 10.5
Image: Hook1_a64_E10.5b_RF_JL
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:5811404
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640619
Pattern: Uniform
Stage: TS19
Assay Id: MGI:5823633
Age: embryonic day 11.5
Image: Hook1_a64_E11.5a_RF_JL
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:5811404
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640619
Pattern: Uniform
Stage: TS19
Assay Id: MGI:5823633
Age: embryonic day 11.5
Image: Hook1_a64_E11.5b_RF_JL
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:5811404
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1603917
Pattern: Widespread
Stage: TS17
Assay Id: MGI:5823633
Age: embryonic day 10.5
Image: Hook1_a64_E10.5a_JL
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:5811404
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1603917
Pattern: Widespread
Stage: TS17
Assay Id: MGI:5823633
Age: embryonic day 10.5
Image: Hook1_a64_E10.5b_JL
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:5811404
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Pattern: Widespread
Stage: TS19
Assay Id: MGI:5823633
Age: embryonic day 11.5
Image: Hook1_a64_E11.5a_JL
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:5811404
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Pattern: Widespread
Stage: TS19
Assay Id: MGI:5823633
Age: embryonic day 11.5
Image: Hook1_a64_E11.5b_JL
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:6378745
Assay Type: Immunohistochemistry
Annotation Date: 2019-12-03
Strength: Present
Sex: Male
Emaps: EMAPS:3148628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6378821
Age: postnatal adult
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:6378745
Assay Type: Immunohistochemistry
Annotation Date: 2019-12-03
Strength: Present
Sex: Male
Emaps: EMAPS:3148628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6378821
Age: postnatal adult
Note: Homozygous mutant testis expressed equivalent cytoplasmic protein in spermatids.
Detected: true
Specimen Num: 2
Publication
First Author: Schumacher JM
Year: 1998
Journal: Biol Reprod
Title: Spermatid perinuclear ribonucleic acid-binding protein binds microtubules in vitro and associates with abnormal manchettes in vivo in mice.
Volume: 59
Issue: 1
Pages: 69-76
Publication
First Author: Moreno RD
Year: 2006
Journal: Dev Biol
Title: Assembly of spermatid acrosome depends on microtubule organization during mammalian spermiogenesis.
Volume: 293
Issue: 1
Pages: 218-27
Publication
First Author: Meistrich ML
Year: 1992
Journal: J Hered
Title: Mapping of the azh locus to mouse chromosome 4.
Volume: 83
Issue: 1
Pages: 56-61
Publication  
First Author: Meistrich ML
Year: 1990
Journal: Mouse Genome
Title: Mapping of azh
Volume: 86
Pages: 258
Publication  
First Author: Snider PL
Year: 2019
Journal: J Cardiovasc Dev Dis
Title: Analysis of Uncharacterized mKiaa1211 Expression during Mouse Development and Cardiovascular Morphogenesis.
Volume: 6
Issue: 2
Publication
First Author: Nayernia K
Year: 2003
Journal: J Biol Chem
Title: Inactivation of a testis-specific Lis1 transcript in mice prevents spermatid differentiation and causes male infertility.
Volume: 278
Issue: 48
Pages: 48377-85
Publication
First Author: Appler JM
Year: 2013
Journal: J Neurosci
Title: Gata3 is a critical regulator of cochlear wiring.
Volume: 33
Issue: 8
Pages: 3679-91
Publication      
First Author: Toronto Centre for Phenogenomics
Year: 2013
Journal: MGI Direct Data Submission
Title: Strains and alleles submitted by Toronto Centre for Phenogenomics (NorCOMM2, funded by Genome Canada and Ontario Genomics Institute OGI-051).
Publication
First Author: Lewandowski JP
Year: 2015
Journal: Dev Biol
Title: Spatiotemporal regulation of GLI target genes in the mammalian limb bud.
Volume: 406
Issue: 1
Pages: 92-103
Publication      
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Interaction Experiment
Description: Elevation of Hook1 in a disease model of Batten disease does not affect a novel interaction between Ankyrin G and Hook1.
Protein
Organism: Mus musculus
Length: 233  
Fragment?: true
Protein
Organism: Mus musculus
Length: 366  
Fragment?: true
Protein Domain
Type: Domain
Description: The Hook family consists of several proteins from different eukaryotic organisms, first identified in Drosophila melanogaster in which play a role in endocytic cargo sorting []. In Drosophila and fungi there is a single Hook gene, whereas mammals have three Hook genes, Hook1, Hook2 and Hook3. Endogenous Hook3 binds to Golgi membranes while both Hook1 and Hook2 are localised to discrete but unidentified cellular structures [, ]. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubule structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head []. They are a widely expressed class of dynein-associated cargo adaptor proteins which include different domains. The N-terminal part of these proteins is sufficient to form a stable complex with dynein-dynactin and includes the most conserved region within the first 160 amino acids, termed the Hook domain. This domain is followed by three coiled-coil domains, important for dimerization and activation of dynein-dynactin complex motility, and then a C-terminal domain that binds a variety of proteins specific for each Hook isoform, involved in binding to specific organelles (organelle-binding domains). All mammalian Hook isoforms form a complex with Fused Toes and the Fused Toes- and Hook-interacting protein; fungal homologues of these proteins are important for dynein-mediated early endosome transport by linking Hook to the cargo [].This entry represents the central coiled-coiled region and the divergent C-terminal domain from Hook proteins.
Publication
First Author: Walenta JH
Year: 2001
Journal: J Cell Biol
Title: The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins.
Volume: 152
Issue: 5
Pages: 923-34
Publication
First Author: Schroeder CM
Year: 2016
Journal: J Cell Biol
Title: Assembly and activation of dynein-dynactin by the cargo adaptor protein Hook3.
Volume: 214
Issue: 3
Pages: 309-18
Publication
First Author: Narayanan R
Year: 2000
Journal: J Neurobiol
Title: Drosophila endosomal proteins hook and deep orange regulate synapse size but not synaptic vesicle recycling.
Volume: 45
Issue: 2
Pages: 105-19
Publication
First Author: Marivin A
Year: 2019
Journal: J Cell Biol
Title: GPCR-independent activation of G proteins promotes apical cell constriction in vivo.
Volume: 218
Issue: 5
Pages: 1743-1763
Publication
First Author: Nechipurenko IV
Year: 2016
Journal: Dev Cell
Title: A Conserved Role for Girdin in Basal Body Positioning and Ciliogenesis.
Volume: 38
Issue: 5
Pages: 493-506
Protein Domain
Type: Domain
Description: This entry includes residues in the first 160 amino acids at the N-terminal of Hook, which is the most conserved region and necessary for dynein-dynactin interaction. It interacts with dynein light intermediate chain 1 (LIC1) []. This domain is also found in protein Daple []and Girdin []which are G-protein modulators involved in ciliogenesis and cilium morphology, integrity of the actin cytoskeleton, formation of actin stress fibres and lamellipodia and membrane sorting in the early endosome.The Hook family consists of several proteins from different eukaryotic organisms, first identified in Drosophila melanogaster in which play a role in endocytic cargo sorting []. In Drosophila and fungi there is a single Hook gene, whereas mammals have three Hook genes, Hook1, Hook2 and Hook3. Endogenous Hook3 binds to Golgi membranes while both Hook1 and Hook2 are localised to discrete but unidentified cellular structures [, ]. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubule structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head []. They are a widely expressedclass of dynein-associated cargo adaptor proteins which include different domains. The N-terminal part of these proteins is sufficient to form a stable complex with dynein-dynactin and includes the most conserved region within the first 160 amino acids, termed the Hook domain. This domain is followed by three coiled-coil domains, important for dimerization and activation of dynein-dynactin complex motility, and then a C-terminal domain that binds a variety of proteins specific for each Hook isoform, involved in binding to specific organelles (organelle-binding domains). All mammalian Hook isoforms form a complex with Fused Toes and the Fused Toes- and Hook-interacting protein; fungal homologues of these proteins are important for dynein-mediated early endosome transport by linking Hook to the cargo [].
Protein
Organism: Mus musculus
Length: 716  
Fragment?: false
Protein
Organism: Mus musculus
Length: 728  
Fragment?: false
Protein
Organism: Mus musculus
Length: 718  
Fragment?: false
Protein
Organism: Mus musculus
Length: 720  
Fragment?: false
Protein
Organism: Mus musculus
Length: 715  
Fragment?: false
Protein
Organism: Mus musculus
Length: 692  
Fragment?: false
Protein
Organism: Mus musculus
Length: 692  
Fragment?: false
Protein
Organism: Mus musculus
Length: 611  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1481  
Fragment?: false