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Search results 1 to 100 out of 3351 for Hprt

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Hits by Pathway

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Type Details Score
Gene
key_18914 | HPRT
Type: gene
Organism: sheep
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Gene
key_19499 | HPRT
Type: gene
Organism: pig, domestic
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Gene
key_19970 | HPRT
Type: gene
Organism: lemur, mouse
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Gene
key_20597 | HPRT
Type: gene
Organism: cat, domestic
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Strain
MGI:2160805 | Hprt
Attribute String: mutant stock
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Publication
- | J:13718
 
First Author: Day C
Year: 1977
Journal: Mouse News Lett
Title: HPRT mobility alteration, Hma.
Volume: 57
Pages: 10
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Heritable Phenotypic Marker
MGI:96111 | Hma
Type: heritable_phenotypic_marker
Organism: mouse, laboratory
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Publication
540025 | J:6291
First Author: Nesbitt MN
Year: 1979
Journal: Biochem Genet
Title: Isoenzyme pattern of HPRT in murine erythrocytes: control by an autosomal locus.
Volume: 17
Issue: 9-10
Pages: 957-64
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Publication
10331952 | J:48897
First Author: Ben-Zur T
Year: 1999
Journal: Genomics
Title: Mapping homologs of Drosophila odd Oz (odz): Doc4/Odz4 to mouse chromosome 7, Odz1 to mouse chromosome 11; and ODZ3 to human chromosome Xq25.
Volume: 58
Issue: 1
Pages: 102-3
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Allele
Hma<+> | MGI:2431029
   
Name: HPRT mobility alteration; wild type
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Publication
- | J:15486
   
First Author: Melton DW
Year: 1987
Title: HPRT gene organization and expression
Volume: 4
Pages: 34-76
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Publication
- | J:3478
First Author: Moore TF
Year: 1992
Journal: Mouse Genome
Title: Failure to detect age-related reactivation at the Hprt locus
Volume: 90
Issue: 4
Pages: 687-89
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Publication
3029599 | J:15485
First Author: Kuehn MR
Year: 1987
Journal: Nature
Title: A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice.
Volume: 326
Issue: 6110
Pages: 295-8
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Allele
Cyp1a2<tm1Dwn> | MGI:2182351
Name: cytochrome P450, family 1, subfamily a, polypeptide 2; targeted mutation 1, Daniel W Nebert
Allele Type: Targeted
Attribute String: Null/knockout
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Publication
18932256 | J:148743
First Author: Kim TM
Year: 2008
Journal: Genesis
Title: High-throughput knock-in coupling gene targeting with the HPRT minigene and Cre-mediated recombination.
Volume: 46
Issue: 12
Pages: 732-7
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Publication
31574190 | J:294102
First Author: Vogel M
Year: 2019
Journal: Stem Cells
Title: HPRT and Purine Salvaging Are Critical for Hematopoietic Stem Cell Function.
Volume: 37
Issue: 12
Pages: 1606-1614
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Publication
2912572 | J:161048
First Author: Thompson S
Year: 1989
Journal: Cell
Title: Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells.
Volume: 56
Issue: 2
Pages: 313-21
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Publication
9661901 | J:48442
First Author: Bol SA
Year: 1998
Journal: Cancer Res
Title: Elevated frequencies of benzo(a)pyrene-induced Hprt mutations in internal tissue of XPA-deficient mice.
Volume: 58
Issue: 13
Pages: 2850-6
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Publication
8218641 | J:14843
First Author: Shannon M
Year: 1993
Journal: Biol Reprod
Title: Expression of the Hprt gene during spermatogenesis: implications for sex-chromosome inactivation.
Volume: 49
Issue: 4
Pages: 770-8
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Publication
10198428 | J:54484
First Author: Fukagawa T
Year: 1999
Journal: Nucleic Acids Res
Title: The chicken HPRT gene: a counter selectable marker for the DT40 cell line.
Volume: 27
Issue: 9
Pages: 1966-9
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Publication
11015585 | J:62746
First Author: Guillot PV
Year: 2000
Journal: Physiol Genomics
Title: Targeting of human eNOS promoter to the Hprt locus of mice leads to tissue-restricted transgene expression.
Volume: 2
Issue: 2
Pages: 77-83
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Publication
2899912 | J:9273
First Author: Isamat M
Year: 1988
Journal: Somat Cell Mol Genet
Title: Characterization, evolutionary relationships, and chromosome location of processed mouse HPRT pseudogene.
Volume: 14
Issue: 4
Pages: 359-69
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Publication
15177560 | J:90703
First Author: Heaney JD
Year: 2004
Journal: Genomics
Title: Tissue-specific expression of a BAC transgene targeted to the Hprt locus in mouse embryonic stem cells.
Volume: 83
Issue: 6
Pages: 1072-82
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Publication
- | J:38009
First Author: McGregor DB
Year: 1996
Journal: Toxicol In Vitro
Title: Mutagenic responses of L5178Y mouse cells at the tk and hprt loci.
Volume: 10
Issue: 5
Pages: 643-647
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Protein
P00493
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: false
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Strain
MGI:5498343 | C57BL/6N-Hprt1<tm1(CMV-cre)Wtsi>/WtsiOulu
Attribute String: coisogenic, mutant strain, targeted mutation
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Publication
7641713 | J:29303
First Author: Skopek TR
Year: 1995
Journal: Environ Mol Mutagen
Title: Relative sensitivity of the endogenous hprt gene and lacI transgene in ENU-treated Big Blue B6C3F1 mice.
Volume: 26
Issue: 1
Pages: 9-15
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Publication
11015584 | J:62744
First Author: Evans V
Year: 2000
Journal: Physiol Genomics
Title: Targeting the Hprt locus in mice reveals differential regulation of Tie2 gene expression in the endothelium.
Volume: 2
Issue: 2
Pages: 67-75
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Publication
3186749 | J:161049
First Author: Doetschman T
Year: 1988
Journal: Proc Natl Acad Sci U S A
Title: Targeted mutation of the Hprt gene in mouse embryonic stem cells.
Volume: 85
Issue: 22
Pages: 8583-7
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Publication
19141541 | J:157969
First Author: Palais G
Year: 2009
Journal: Physiol Genomics
Title: Targeted transgenesis at the HPRT locus: an efficient strategy to achieve tightly controlled in vivo conditional expression with the tet system.
Volume: 37
Issue: 2
Pages: 140-6
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Publication
3022138 | J:20089
First Author: Lock LF
Year: 1986
Journal: Mol Cell Biol
Title: Methylation of the mouse hprt gene differs on the active and inactive X chromosomes.
Volume: 6
Issue: 3
Pages: 914-24
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Publication
8176360 | J:17691
First Author: Pravtcheva DD
Year: 1994
Journal: J Exp Zool
Title: Mosaic expression of an Hprt transgene integrated in a region of Y heterochromatin.
Volume: 268
Issue: 6
Pages: 452-68
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Publication
1440055 | J:161072
First Author: Selfridge J
Year: 1992
Journal: Somat Cell Mol Genet
Title: Gene targeting using a mouse HPRT minigene/HPRT-deficient embryonic stem cell system: inactivation of the mouse ERCC-1 gene.
Volume: 18
Issue: 4
Pages: 325-36
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Publication
3683574 | J:161050
First Author: Doetschman T
Year: 1987
Journal: Nature
Title: Targetted correction of a mutant HPRT gene in mouse embryonic stem cells.
Volume: 330
Issue: 6148
Pages: 576-8
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Publication
9205113 | J:41459
First Author: Tsuda H
Year: 1997
Journal: Genomics
Title: Inactivation of the mouse HPRT locus by a 203-bp retroposon insertion and a 55-kb gene-targeted deletion: establishment of new HPRT-deficient mouse embryonic stem cell lines.
Volume: 42
Issue: 3
Pages: 413-21
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Publication
8672124 | J:34477
First Author: Masson W
Year: 1996
Journal: Mamm Genome
Title: The use of compound heterozygotes and Hprt selection to analyze X-linked mottled alleles associated with prenatal lethality.
Volume: 7
Issue: 7
Pages: 486-9
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Publication
2551779 | J:26039
First Author: Palella TD
Year: 1989
Journal: Gene
Title: Expression of human HPRT mRNA in brains of mice infected with a recombinant herpes simplex virus-1 vector.
Volume: 80
Issue: 1
Pages: 137-44
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Publication
1518807 | J:845
First Author: Skopek TR
Year: 1992
Journal: Proc Natl Acad Sci U S A
Title: Mutational spectrum at the Hprt locus in splenic T cells of B6C3F1 mice exposed to N-ethyl-N-nitrosourea.
Volume: 89
Issue: 17
Pages: 7866-70
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Publication
12893685 | J:127987
First Author: Minami T
Year: 2003
Journal: Arterioscler Thromb Vasc Biol
Title: Ets motifs are necessary for endothelial cell-specific expression of a 723-bp Tie-2 promoter/enhancer in Hprt targeted transgenic mice.
Volume: 23
Issue: 11
Pages: 2041-7
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Publication
34799437 | J:341282
First Author: Hosoya T
Year: 2022
Journal: J Am Soc Nephrol
Title: Xanthine Oxidoreductase Inhibitors Suppress the Onset of Exercise-Induced AKI in High HPRT Activity Urat1-Uox Double Knockout Mice.
Volume: 33
Issue: 2
Pages: 326-341
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Publication
23804752 | J:202270
First Author: Guibinga GH
Year: 2013
Journal: Hum Mol Genet
Title: Deficiency of the purine metabolic gene HPRT dysregulates microRNA-17 family cluster and guanine-based cellular functions: a role for EPAC in Lesch-Nyhan syndrome.
Volume: 22
Issue: 22
Pages: 4502-15
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Publication
12840110 | J:133813
First Author: Dobrovolsky VN
Year: 2003
Journal: Mutagenesis
Title: Pms2 deficiency results in increased mutation in the Hprt gene but not the Tk gene of Tk(+/-) transgenic mice.
Volume: 18
Issue: 4
Pages: 365-70
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Publication
7686258 | J:12924
First Author: Walker VE
Year: 1993
Journal: Mutat Res
Title: A mouse model for the study of in vivo mutational spectra: sequence specificity of ethylene oxide at the hprt locus.
Volume: 288
Issue: 1
Pages: 151-62
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Publication
10625648 | J:81515
First Author: Cvetkovic B
Year: 2000
Journal: J Biol Chem
Title: Appropriate tissue- and cell-specific expression of a single copy human angiotensinogen transgene specifically targeted upstream of the HPRT locus by homologous recombination.
Volume: 275
Issue: 2
Pages: 1073-8
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Publication
10213084 | J:53707
First Author: Sturm K
Year: 1999
Journal: Int J Dev Biol
Title: Pgk1 and Hprt gene activity in the peri-implantation mouse embryo is influenced by the parental origin of the X-chromosome.
Volume: 43
Issue: 1
Pages: 69-73
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Publication
2349238 | J:161047
First Author: Reid LH
Year: 1990
Journal: Proc Natl Acad Sci U S A
Title: Regulatory elements in the introns of the human HPRT gene are necessary for its expression in embryonic stem cells.
Volume: 87
Issue: 11
Pages: 4299-303
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Publication
10407678 | J:58063
First Author: Vivian JL
Year: 1999
Journal: Biotechniques
Title: Temporal, spatial and tissue-specific expression of a myogenin-lacZ transgene targeted to the Hprt locus in mice.
Volume: 27
Issue: 1
Pages: 154-62
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Publication
1487143 | J:3647
First Author: Magin TM
Year: 1992
Journal: Gene
Title: A position- and orientation-dependent element in the first intron is required for expression of the mouse hprt gene in embryonic stem cells.
Volume: 122
Issue: 2
Pages: 289-96
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Publication
9530621 | J:46661
First Author: Kushi A
Year: 1998
Journal: Mamm Genome
Title: Generation of mutant mice with large chromosomal deletion by use of irradiated ES cells--analysis of large deletion around hprt locus of ES cell.
Volume: 9
Issue: 4
Pages: 269-73
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Publication
3471389 | J:8663
First Author: Lyon MF
Year: 1987
Journal: Cytogenet Cell Genet
Title: Localization of the Hprt locus by in situ hybridization and distribution of loci on the mouse X-chromosome.
Volume: 44
Issue: 2-3
Pages: 163-6
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Publication
7738405 | J:26591
First Author: Klarmann B
Year: 1995
Journal: Int J Radiat Biol
Title: Mutant frequency at the H-2K class 1 and HPRT genes in T lymphocytes from the X-ray-exposed mouse.
Volume: 67
Issue: 4
Pages: 421-30
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Publication
10462721 | J:58048
First Author: Dobrovolsky VN
Year: 1999
Journal: Environ Mol Mutagen
Title: Molecular analysis of in vivo mutations induced by N-ethyl-N-nitrosourea in the autosomal Tk and the X-linked Hprt genes of mouse lymphocytes.
Volume: 34
Issue: 1
Pages: 30-8
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Publication
26295470 | J:260022
First Author: Noda A
Year: 2015
Journal: PLoS One
Title: Creation of Mice Bearing a Partial Duplication of HPRT Gene Marked with a GFP Gene and Detection of Revertant Cells In Situ as GFP-Positive Somatic Cells.
Volume: 10
Issue: 8
Pages: e0136041
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Publication
14517346 | J:85673
First Author: Diaz M
Year: 2003
Journal: Mol Cancer Res
Title: Decreased frequency and highly aberrant spectrum of ultraviolet-induced mutations in the hprt gene of mouse fibroblasts expressing antisense RNA to DNA polymerase zeta.
Volume: 1
Issue: 11
Pages: 836-47
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Publication
7959788 | J:19410
First Author: George AM
Year: 1994
Journal: Genomics
Title: Analysis of Mnk, the murine homologue of the locus for Menkes disease, in normal and mottled (Mo) mice.
Volume: 22
Issue: 1
Pages: 27-35
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Publication
12885172 | J:159603
First Author: McEwan C
Year: 2003
Journal: Transgenic Res
Title: A simple genotyping assay for the Hprt null allele in mice produced from the HM-1 and E14TG2a mouse embryonic stem cell lines.
Volume: 12
Issue: 4
Pages: 519-20
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Publication
291939 | J:6224
First Author: Francke U
Year: 1979
Journal: Proc Natl Acad Sci U S A
Title: Assignment of the gene for cytoplasmic superoxide dismutase (Sod-1) to a region of chromosome 16 and of Hprt to a region of the X chromosome in the mouse.
Volume: 76
Issue: 10
Pages: 5230-3
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Allele
Hbb<tm1.1(HBG1,HBB*)Ryan> | MGI:3843171
Name: hemoglobin beta chain complex; targeted mutation 1.1, Thomas M Ryan
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence, Null/knockout
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Protein Coding Gene
MGI:96217 | Hprt1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
- | J:12713
 
First Author: Law ML
Year: 1984
Journal: Cytogenet Cell Genet
Title: Genes coding for ouabain resistance (OUBR) and HPRT are syntenic in the mouse genome. (Abstracts of meeting presentations: Human gene mapping 7, Los Angeles Conference (1983) Seventh International Workshop on Human Gene Mapping)
Volume: 37 (1-4)
Pages: 518 (Abstr.) (399-616)
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Publication
19098001 | J:147906
First Author: Huo Y
Year: 2009
Journal: J Biol Chem
Title: Humanized Mouse Model of Cooley's Anemia.
Volume: 284
Issue: 8
Pages: 4889-96
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Genotype
Genotype
Symbol: Hbb/Hbb<+>
Background: involves: C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hbb/Hbb
Background: involves: C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:0112127 | HRPT-related hyperuricemia
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Publication
10074097 | -
First Author: Sauer J
Year: 1999
Journal: J Bacteriol
Title: Expression of the Methanobacterium thermoautotrophicum hpt gene, encoding hypoxanthine (Guanine) phosphoribosyltransferase, in Escherichia coli.
Volume: 181
Issue: 6
Pages: 1958-62
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Protein Domain
IPR026597 | HGPRTase-like
Type: Family
Description: This entryconsists of the hypoxanthine/guanine phosphoribosyltransferase (HPRT) and HPRT-like proteins. HPRT catalyses a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis []. HPRT-like proteins may catalyse a purine salvage reaction, the substrate is unknown.
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Publication
7685652 | J:23850
First Author: Ratcliff R
Year: 1993
Journal: Nat Genet
Title: Production of a severe cystic fibrosis mutation in mice by gene targeting.
Volume: 4
Issue: 1
Pages: 35-41
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Allele
Hprt1<tm1(tetO-lacZ)Frje> | MGI:4437604
Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Frederic Jaisser
Allele Type: Targeted
Attribute String: Inducible, Null/knockout, Reporter
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Allele
Hprt1<tm2(tetO-lacZ,-NR3C1)Frje> | MGI:4437607
Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 2, Frederic Jaisser
Allele Type: Targeted
Attribute String: Humanized sequence, Inducible, Inserted expressed sequence, Reporter
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Allele
Inhba<tm1Zuk> | MGI:1861957
Name: inhibin beta-A; targeted mutation 1, Martin M Matzuk
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Rhbdf1/Hba<tm1.1(RHBDF1/HBA)Ajhs> | MGI:5309139
 
Name: rhomboid 5 homolog 1; targeted mutation 1.1, Andrew JH Smith
Allele Type: Targeted
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Allele
Rhbdf1/Hba<tm1.1(RHBDF1/HBA)Ajhs> | MGI:5306771
 
Name: hemoglobin alpha chain complex; targeted mutation 1.1, Andrew JH Smith
Allele Type: Targeted
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GO Term
GO:0004422 | hypoxanthine phosphoribosyltransferase activity
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Allele
Pms1<tm1Lisk> | MGI:1857948
Name: PMS1 homolog 1, mismatch repair system component; targeted mutation 1, Michael Liskay
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Krt18<tm1Tmm> | MGI:2178045
Name: keratin 18; targeted mutation 1, Thomas M Magin
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Fst<tm1Zuk> | MGI:1857467
Name: follistatin; targeted mutation 1, Martin M Matzuk
Allele Type: Targeted
Attribute String: Null/knockout
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Strain
MGI:3759058 | 129S/SvEv-Inhba<tm1Zuk>
Attribute String: mutant strain, targeted mutation
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Strain
MGI:2164341 | B6;129S7-Inhba<tm1Zuk>/J
Attribute String: targeted mutation, mutant stock
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Strain
MGI:5655456 | either: (129S/SvEv-Inhba<tm1Zuk>) or (involves: 129S7/SvEvBrd * C57BL/6)
Attribute String: Not specified
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Strain
MGI:5320289 | B6.129S7-Inhba<tm1Zuk>
Attribute String: congenic, mutant strain, targeted mutation
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Publication
17592132 | J:122819
First Author: Tomaszewski J
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Essential roles of inhibin beta A in mouse epididymal coiling.
Volume: 104
Issue: 27
Pages: 11322-7
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Publication
9707328 | J:48941
First Author: Moore CS
Year: 1998
Journal: Dev Dyn
Title: Expression and function of activin beta A during mouse cardiac cushion tissue formation.
Volume: 212
Issue: 4
Pages: 548-62
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Publication
10662502 | J:124431
First Author: Davis AA
Year: 2000
Journal: Mol Cell Neurosci
Title: Activin A promotes progenitor differentiation into photoreceptors in rodent retina.
Volume: 15
Issue: 1
Pages: 11-21
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Allele
Rhbdf1/Hba<tm2.1Ajhs> | MGI:5309144
 
Name: rhomboid 5 homolog 1; targeted mutation 2.1, Andrew JH Smith
Allele Type: Targeted
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Allele
Htt<tm3Detl> | MGI:3043022
Name: huntingtin; targeted mutation 3, Peter J Detloff
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Rhbdf1/Hba<tm2.1Ajhs> | MGI:5309142
 
Name: hemoglobin alpha chain complex; targeted mutation 2.1, Andrew JH Smith
Allele Type: Targeted
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Allele
Cftr<tm1Cam> | MGI:1857544
Name: cystic fibrosis transmembrane conductance regulator; targeted mutation 1, University of Cambridge
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Lrrc17<tm1Nik> | MGI:4460700
 
Name: leucine rich repeat containing 17; targeted mutation 1, Nigel Killeen
Allele Type: Targeted
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Genotype
Genotype
Symbol: Inhba/Inhba
Background: either: (129S/SvEv-Inhba) or (involves: 129S7/SvEvBrd * C57BL/6)
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Inhba/Inhba
Background: involves: 129S7/SvEvBrd
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rhbdf1/Hba/Rhbdf1/Hba
Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rhbdf1/Hba/Rhbdf1/Hba
Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Inhba/Inhba<+>
Background: B6.129S7-Inhba
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Inhba/Inhba
Background: involves: 129S7/SvEvBrd * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Publication
8289781 | J:16483
First Author: Stacey A
Year: 1994
Journal: Mol Cell Biol
Title: Use of double-replacement gene targeting to replace the murine alpha-lactalbumin gene with its human counterpart in embryonic stem cells and mice.
Volume: 14
Issue: 2
Pages: 1009-16
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MP Term
MP:0012208 | abnormal hypoxanthine-guanine phosphoribosyltransferase level
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MP Term
MP:0012210 | increased hypoxanthine-guanine phosphoribosyltransferase level
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Publication
8485579 | J:4123
First Author: Wu CL
Year: 1993
Journal: Nat Genet
Title: Production of a model for Lesch-Nyhan syndrome in hypoxanthine phosphoribosyltransferase-deficient mice.
Volume: 3
Issue: 3
Pages: 235-40
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Publication
19912847 | J:2058
First Author: Jinnah HA
Year: 1992
Journal: Mol Cell Neurosci
Title: Localization of hypoxanthine-guanine phosphoribosyltransferase mRNA in the mouse brain by in situ hybridization.
Volume: 3
Issue: 1
Pages: 64-78
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Publication
21769670 | J:178814
First Author: Pickell L
Year: 2011
Journal: Mamm Genome
Title: Targeted insertion of two Mthfr promoters in mice reveals temporal- and tissue-specific regulation.
Volume: 22
Issue: 11-12
Pages: 635-47
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