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Search results 1 to 100 out of 106 for Hrc

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
3270 | HRC
Type: gene
Organism: human
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Gene
key_38140 | HRC
Type: gene
Organism: rabbit, European
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Gene
292905 | Hrc
Type: gene
Organism: rat
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Gene
484386 | HRC
Type: gene
Organism: dog, domestic
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Gene
456413 | HRC
Type: gene
Organism: chimpanzee
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Gene
617610 | HRC
Type: gene
Organism: cattle
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Gene
718647 | HRC
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:96226 | Hrc
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR015666 | HRC
Type: Family
Description: The histidine-rich calcium-binding protein of sarcoplasmic reticulum (HRC) may play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle []. This protein is very acidic (31% of Asp and Glu) and rich in histidine (13%). The sequenceof HRC contains 10 tandem repeats of a 26 to 29 amino acid residues domain. This domain starts with an invariant hexapeptide (HRHRGH), followed by a stretch of acidic residues. The end of the domain consists of an almost invariant nonapeptide (STESDRHQA). The highly acidic central cores of each repeat are likely to constitute the calcium-binding sites of HRC.
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Protein
B9EIW1
Organism: Mus musculus/domesticus
Length: 723  
Fragment?: false
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Publication
15082771 | J:152216
First Author: Anderson JP
Year: 2004
Journal: Mol Cell Biol
Title: HRC is a direct transcriptional target of MEF2 during cardiac, skeletal, and arterial smooth muscle development in vivo.
Volume: 24
Issue: 9
Pages: 3757-68
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Publication
26410369 | J:258492
First Author: Liu B
Year: 2015
Journal: Cardiovasc Res
Title: Ablation of HRC alleviates cardiac arrhythmia and improves abnormal Ca handling in CASQ2 knockout mice prone to CPVT.
Volume: 108
Issue: 2
Pages: 299-311
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Publication
8288260 | J:15617
First Author: Brown SD
Year: 1993
Journal: Genomics
Title: Mapping the Hrc gene to proximal mouse chromosome 7: delineation of a conserved linkage group with human 19q.
Volume: 18
Issue: 2
Pages: 459-61
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Protein
Q9QZV4
Organism: Mus musculus/domesticus
Length: 726  
Fragment?: false
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Protein
Q9WVE4
Organism: Mus musculus/domesticus
Length: 738  
Fragment?: false
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Protein
G5E8J6
Organism: Mus musculus/domesticus
Length: 738  
Fragment?: false
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Protein
A0A1B0GQY1
Organism: Mus musculus/domesticus
Length: 78  
Fragment?: false
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Publication
2808365 | -
First Author: Hofmann SL
Year: 1989
Journal: J Biol Chem
Title: Molecular cloning of a histidine-rich Ca2+-binding protein of sarcoplasmic reticulum that contains highly conserved repeated elements.
Volume: 264
Issue: 30
Pages: 18083-90
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Publication
28859293 | J:243733
First Author: Tzimas C
Year: 2017
Journal: Cardiovasc Res
Title: Impaired calcium homeostasis is associated with sudden cardiac death and arrhythmias in a genetic equivalent mouse model of the human HRC-Ser96Ala variant.
Volume: 113
Issue: 11
Pages: 1403-1417
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Publication
15777620 | J:97586
First Author: Hong S
Year: 2005
Journal: Biochim Biophys Acta
Title: Complementary DNA cloning, genomic characterization and expression analysis of a mammalian gene encoding histidine-rich calcium binding protein.
Volume: 1727
Issue: 3
Pages: 188-96
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Publication
10462052 | J:56892
First Author: Ridgeway AG
Year: 1999
Journal: FEBS Lett
Title: Cloning, tissue distribution, subcellular localization and overexpression of murine histidine-rich Ca2+ binding protein.
Volume: 456
Issue: 3
Pages: 399-402
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Publication
17030629 | J:117648
First Author: Jaehnig EJ
Year: 2006
Journal: Mol Cell Biol
Title: Increased susceptibility to isoproterenol-induced cardiac hypertrophy and impaired weight gain in mice lacking the histidine-rich calcium-binding protein.
Volume: 26
Issue: 24
Pages: 9315-26
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Publication
2037293 | J:11193
First Author: Hofmann SL
Year: 1991
Journal: Genomics
Title: cDNA and genomic cloning of HRC, a human sarcoplasmic reticulum protein, and localization of the gene to human chromosome 19 and mouse chromosome 7.
Volume: 9
Issue: 4
Pages: 656-69
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Publication
23553082 | J:275091
First Author: Park CS
Year: 2013
Journal: Basic Res Cardiol
Title: Targeted ablation of the histidine-rich Ca(2+)-binding protein (HRC) gene is associated with abnormal SR Ca(2+)-cycling and severe pathology under pressure-overload stress.
Volume: 108
Issue: 3
Pages: 344
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Publication
16600288 | J:108863
First Author: Gregory KN
Year: 2006
Journal: J Mol Cell Cardiol
Title: Histidine-rich Ca binding protein: a regulator of sarcoplasmic reticulum calcium sequestration and cardiac function.
Volume: 40
Issue: 5
Pages: 653-65
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Publication
17526652 | J:126060
First Author: Arvanitis DA
Year: 2007
Journal: Am J Physiol Heart Circ Physiol
Title: Histidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPase.
Volume: 293
Issue: 3
Pages: H1581-9
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Protein Coding Gene
MGP_CAROLIEiJ_G0029711 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0032214 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0032193 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0032129 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0032205 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0031921 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_96226 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0032697 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0031249 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0031885 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0032043 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0031994 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0032121 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0032031 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0032713 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0030972 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0031366 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0012936 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0030809 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
       
Probe: MGI:3758277
Assay Type: RT-PCR
Annotation Date: 2007-10-15
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3758283
Age: postnatal adult
Specimen Label: B
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3758277
Assay Type: RT-PCR
Annotation Date: 2007-10-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3758283
Age: postnatal adult
Specimen Label: H
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
       
Probe: MGI:3758277
Assay Type: RT-PCR
Annotation Date: 2007-10-15
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3758283
Age: postnatal adult
Specimen Label: K
Specimen Num: 3
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GXD Expression
GXD Expression
       
Probe: MGI:3758277
Assay Type: RT-PCR
Annotation Date: 2007-10-15
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3758283
Age: postnatal adult
Specimen Label: Li
Specimen Num: 4
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GXD Expression
GXD Expression
       
Probe: MGI:3758277
Assay Type: RT-PCR
Annotation Date: 2007-10-15
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3758283
Age: postnatal adult
Specimen Label: Lu
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:3758277
Assay Type: RT-PCR
Annotation Date: 2007-10-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:3758283
Age: postnatal adult
Specimen Label: Sk
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
       
Probe: MGI:3758277
Assay Type: RT-PCR
Annotation Date: 2007-10-15
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3758283
Age: postnatal adult
Specimen Label: Sp
Specimen Num: 7
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GXD Expression
GXD Expression
       
Probe: MGI:3758277
Assay Type: RT-PCR
Annotation Date: 2007-10-15
Strength: Not Specified
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3758283
Age: postnatal adult
Specimen Label: T
Specimen Num: 8
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GXD Expression
GXD Expression
     
Probe: MGI:3758277
Assay Type: RT-PCR
Annotation Date: 2007-10-15
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:3758284
Age: embryonic day 7.5
Specimen Label: 7.5
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3758277
Assay Type: RT-PCR
Annotation Date: 2007-10-15
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:3758284
Age: embryonic day 8.5
Specimen Label: 8.5
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:3758277
Assay Type: RT-PCR
Annotation Date: 2007-10-15
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:3758284
Age: embryonic day 10.5
Specimen Label: 10.5
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:3758277
Assay Type: RT-PCR
Annotation Date: 2007-10-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:3758284
Age: embryonic day 12.5
Specimen Label: 12.5
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:3758277
Assay Type: RT-PCR
Annotation Date: 2007-10-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:3758284
Age: embryonic day 14.5
Specimen Label: 14.5
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:3758277
Assay Type: RT-PCR
Annotation Date: 2007-10-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603924
Stage: TS24
Assay Id: MGI:3758284
Age: embryonic day 16.5
Specimen Label: 16.5
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:3758277
Assay Type: RT-PCR
Annotation Date: 2007-10-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603926
Stage: TS26
Assay Id: MGI:3758284
Age: embryonic day 18.5
Specimen Label: 18.5
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:3758277
Assay Type: RT-PCR
Annotation Date: 2007-10-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610527
Stage: TS27
Assay Id: MGI:3758285
Age: postnatal day 1
Specimen Label: 1
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3758277
Assay Type: RT-PCR
Annotation Date: 2007-10-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3758285
Age: postnatal day 5
Specimen Label: 5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:3758277
Assay Type: RT-PCR
Annotation Date: 2007-10-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3758285
Age: postnatal day 20
Specimen Label: 20
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:3758277
Assay Type: RT-PCR
Annotation Date: 2007-10-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3758285
Age: postnatal day 40
Specimen Label: 40
Detected: true
Specimen Num: 4
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Publication
8643601 | J:33253
First Author: Ivandic BT
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: A locus on chromosome 7 determines myocardial cell necrosis and calcification (dystrophic cardiac calcinosis) in mice.
Volume: 93
Issue: 11
Pages: 5483-8
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Publication
9878516 | J:51569
First Author: van den Broek FA
Year: 1998
Journal: Biochem Biophys Res Commun
Title: Genetic analysis of dystrophic cardiac calcification in DBA/2 mice.
Volume: 253
Issue: 2
Pages: 204-8
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Publication
12115029 | J:76777
First Author: Colinayo VV
Year: 2002
Journal: Mamm Genome
Title: Genetic characterization of the Dyscalc locus.
Volume: 13
Issue: 6
Pages: 283-8
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Publication
11526197 | J:72021
First Author: Ivandic BT
Year: 2001
Journal: Physiol Genomics
Title: New Dyscalc loci for myocardial cell necrosis and calcification (dystrophic cardiac calcinosis) in mice.
Volume: 6
Issue: 3
Pages: 137-44
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Publication
8812484 | J:34617
First Author: Stubbs L
Year: 1996
Journal: Genomics
Title: Detailed comparative map of human chromosome 19q and related regions of the mouse genome.
Volume: 35
Issue: 3
Pages: 499-508
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Author
Raatgeep HRC
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Publication
24805197 | J:219041
 
First Author: Zhang JZ
Year: 2014
Journal: J Mol Cell Cardiol
Title: The arrhythmogenic human HRC point mutation S96A leads to spontaneous Ca(2+) release due to an impaired ability to buffer store Ca(2+).
Volume: 74
Pages: 22-31
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Allele
Tg(Tcra,Tcrb)HRCAll | MGI:3773741
Name: transgene insertion HRC, James P Allison
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Transgene
MGI:3773750 | Tg(Tcra,Tcrb)HRCAll
Type: transgene
Organism: mouse, laboratory
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Publication
30542112 | J:295149
First Author: Costes LMM
Year: 2019
Journal: Mucosal Immunol
Title: IL-10 signaling prevents gluten-dependent intraepithelial CD4+ cytotoxic T lymphocyte infiltration and epithelial damage in the small intestine.
Volume: 12
Issue: 2
Pages: 479-490
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Allele
Hrc<tm1.1Desa> | MGI:5911421
Name: histidine rich calcium binding protein; targeted mutation 1.1, Despina Sanoudou
Allele Type: Targeted
Attribute String: Humanized sequence
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Protein Domain
IPR019552 | Hist_rich_Ca-bd
Type: Repeat
Description: This entry represents a histidine-rich calcium-binding repeat which appears in proteins called histidine-rich-calcium binding proteins (HRC). HRC is a high capacity, low affinity Ca2+-binding protein, residing in the lumen of the sarcoplasmic reticulum. HRC binds directly to triadin. This binding interaction occurs between the histidine-rich region of HRC and multiple clusters of charged amino acids, named KEKE motifs, in the lumenal domain of triadin. This repeat is found in the acidic region of the protein, which can be long and variable. There is also a cysteine-rich region further towards the C terminus []. HRC may regulate sarcoplasmic reticular calcium transport, play a critical role in maintaining calcium homeostasis, and function in the heart. HRC is a candidate regulator of sarcoplasmic reticular calcium uptake.
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Genotype
Genotype
Symbol: Hrc/Hrc
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Publication
9721291 | -
First Author: Deng WL
Year: 1998
Journal: J Bacteriol
Title: Characterization of the hrpC and hrpRS operons of Pseudomonas syringae pathovars syringae, tomato, and glycinea and analysis of the ability of hrpF, hrpG, hrcC, hrpT, and hrpV mutants to elicit the hypersensitive response and disease in plants.
Volume: 180
Issue: 17
Pages: 4523-31
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Protein Domain
IPR009371 | T3SS_HrpF
Type: Family
Description: The species Pseudomonas syringae encompasses plant pathogens with differing host specificities and corresponding pathovar designations. P. syringae requires the Hrp (type III protein secretion) system, encoded by a 25-kb cluster of hrp and hrc genes, in order to elicit the hypersensitive response (HR) in nonhosts or to be pathogenic in hosts. The exact function of HrpF is unknown but the protein is needed for pathogenicity [].
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Publication
15863505 | J:100846
First Author: Maruyama M
Year: 2005
Journal: J Biol Chem
Title: Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells.
Volume: 280
Issue: 26
Pages: 24371-9
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