Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
guinea pig |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhao YX |
Year: |
2019 |
Journal: |
Am J Physiol Endocrinol Metab |
Title: |
Stimulation of histamine H4 receptor participates in cold-induced browning of subcutaneous white adipose tissue. |
Volume: |
317 |
Issue: |
6 |
Pages: |
E1158-E1171 |
|
•
•
•
•
•
|
Publication |
First Author: |
del Rio R |
Year: |
2012 |
Journal: |
J Immunol |
Title: |
Histamine H4 receptor optimizes T regulatory cell frequency and facilitates anti-inflammatory responses within the central nervous system. |
Volume: |
188 |
Issue: |
2 |
Pages: |
541-7 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu C |
Year: |
2001 |
Journal: |
J Pharmacol Exp Ther |
Title: |
Comparison of human, mouse, rat, and guinea pig histamine H4 receptors reveals substantial pharmacological species variation. |
Volume: |
299 |
Issue: |
1 |
Pages: |
121-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hartwig C |
Year: |
2015 |
Journal: |
Eur J Immunol |
Title: |
The histamine H4 -receptor (H4 R) regulates eosinophilic inflammation in ovalbumin-induced experimental allergic asthma in mice. |
Volume: |
45 |
Issue: |
4 |
Pages: |
1129-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Glatzer F |
Year: |
2013 |
Journal: |
J Allergy Clin Immunol |
Title: |
Histamine induces proliferation in keratinocytes from patients with atopic dermatitis through the histamine 4 receptor. |
Volume: |
132 |
Issue: |
6 |
Pages: |
1358-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Verta R |
Year: |
2021 |
Journal: |
Biomolecules |
Title: |
The Interplay between Histamine H4 Receptor and the Kidney Function: The Lesson from H4 Receptor Knockout Mice. |
Volume: |
11 |
Issue: |
10 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Schirmer B |
Year: |
2020 |
Journal: |
Cancers (Basel) |
Title: |
Genetic Deficiency of the Histamine H(4)-Receptor Reduces Experimental Colorectal Carcinogenesis in Mice. |
Volume: |
12 |
Issue: |
4 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Sanna MD |
Year: |
2018 |
Journal: |
Neuropharmacology |
Title: |
Activation of ERK/CREB pathway in noradrenergic neurons contributes to hypernociceptive phenotype in H4 receptor knockout mice after nerve injury. |
Volume: |
128 |
|
Pages: |
340-350 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wunschel EJ |
Year: |
2017 |
Journal: |
Front Pharmacol |
Title: |
Lack of Histamine H(4)-Receptor Expression Aggravates TNBS-Induced Acute Colitis Symptoms in Mice. |
Volume: |
8 |
|
Pages: |
642 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nicoud MB |
Year: |
2020 |
Journal: |
Br J Cancer |
Title: |
Study of the antitumour effects and the modulation of immune response by histamine in breast cancer. |
Volume: |
122 |
Issue: |
3 |
Pages: |
348-360 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schirmer B |
Year: |
2015 |
Journal: |
Biochem Pharmacol |
Title: |
Proinflammatory role of the histamine H4 receptor in dextrane sodium sulfate-induced acute colitis. |
Volume: |
98 |
Issue: |
1 |
Pages: |
102-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nent E |
Year: |
2013 |
Journal: |
Int Immunol |
Title: |
Histamine 4 receptor plays an important role in auto-antibody-induced arthritis. |
Volume: |
25 |
Issue: |
7 |
Pages: |
437-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Morgan RK |
Year: |
2007 |
Journal: |
J Immunol |
Title: |
Histamine 4 receptor activation induces recruitment of FoxP3+ T cells and inhibits allergic asthma in a murine model. |
Volume: |
178 |
Issue: |
12 |
Pages: |
8081-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schirmer B |
Year: |
2018 |
Journal: |
Front Immunol |
Title: |
In vivo Evidence for Partial Activation of Eosinophils via the Histamine H4-Receptor: Adoptive Transfer Experiments Using Eosinophils From H4R-/- and H4R+/+ Mice. |
Volume: |
9 |
|
Pages: |
2119 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hofstra CL |
Year: |
2003 |
Journal: |
J Pharmacol Exp Ther |
Title: |
Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cells. |
Volume: |
305 |
Issue: |
3 |
Pages: |
1212-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Leite-de-Moraes MC |
Year: |
2009 |
Journal: |
J Immunol |
Title: |
Cutting edge: histamine receptor H4 activation positively regulates in vivo IL-4 and IFN-gamma production by invariant NKT cells. |
Volume: |
182 |
Issue: |
3 |
Pages: |
1233-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Desai P |
Year: |
2011 |
Journal: |
Eur J Immunol |
Title: |
Histamine Hâ‚„ receptor activation enhances LPS-induced IL-6 production in mast cells via ERK and PI3K activation. |
Volume: |
41 |
Issue: |
6 |
Pages: |
1764-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rossbach K |
Year: |
2011 |
Journal: |
Neuroscience |
Title: |
Histamine H1, H3 and H4 receptors are involved in pruritus. |
Volume: |
190 |
|
Pages: |
89-102 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dunford PJ |
Year: |
2006 |
Journal: |
J Immunol |
Title: |
The histamine H4 receptor mediates allergic airway inflammation by regulating the activation of CD4+ T cells. |
Volume: |
176 |
Issue: |
11 |
Pages: |
7062-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dunford PJ |
Year: |
2007 |
Journal: |
J Allergy Clin Immunol |
Title: |
Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus. |
Volume: |
119 |
Issue: |
1 |
Pages: |
176-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wechsler JB |
Year: |
2018 |
Journal: |
Mucosal Immunol |
Title: |
Histamine drives severity of innate inflammation via histamine 4 receptor in murine experimental colitis. |
Volume: |
11 |
Issue: |
3 |
Pages: |
861-870 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakazawa S |
Year: |
2014 |
Journal: |
Eur J Immunol |
Title: |
Histamine synthesis is required for granule maturation in murine mast cells. |
Volume: |
44 |
Issue: |
1 |
Pages: |
204-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Saligrama N |
Year: |
2013 |
Journal: |
J Immunol |
Title: |
Systemic lack of canonical histamine receptor signaling results in increased resistance to autoimmune encephalomyelitis. |
Volume: |
191 |
Issue: |
2 |
Pages: |
614-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Saligrama N |
Year: |
2012 |
Journal: |
Eur J Immunol |
Title: |
Combinatorial roles for histamine H1-H2 and H3-H4 receptors in autoimmune inflammatory disease of the central nervous system. |
Volume: |
42 |
Issue: |
6 |
Pages: |
1536-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shiraishi Y |
Year: |
2013 |
Journal: |
J Immunol |
Title: |
Sequential engagement of FcεRI on Mast Cells and Basophil Histamine H(4) Receptor and FcεRI in Allergic Rhinitis. |
Volume: |
190 |
Issue: |
2 |
Pages: |
539-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Erdogmus S |
Year: |
2019 |
Journal: |
Nat Commun |
Title: |
Helix 8 is the essential structural motif of mechanosensitive GPCRs. |
Volume: |
10 |
Issue: |
1 |
Pages: |
5784 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
International Knockout Mouse Consortium |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of modified allele data from IKMC and creation of new knockout alleles |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
International Mouse Strain Resource |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Helmholtz Zentrum Muenchen GmbH |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
Year: |
2001 |
|
Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
262
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Allele |
Name: |
neuropeptide Y receptor Y2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
|
•
•
•
•
•
|