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Search results 1 to 100 out of 130 for Hsd17b3

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0.038s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Domain
Type: Family
Description: Testosterone 17-beta-dehydrogenase 3 (HSD17B3) is involved in the pathway testosterone biosynthesis. It catalyses the conversion of the androstenedione to testosterone, which is responsible for the normal fetal development of male genitalia. It is predominantly expressed in the testes and utilizes NADPH as a cofactor. Mutations in the HSD17B3 gene cause 17beta-hydroxysteroid dehydrogenase type 3 (17beta-HSD3) deficiency cause 46, XY Disorders of Sex Development (46, XY DSD) [].
Gene
Type: gene
Organism: human
Publication
First Author: Sipilä P
Year: 2020
Journal: FASEB J
Title: The lack of HSD17B3 in male mice results in disturbed Leydig cell maturation and endocrine imbalance akin to humans with HSD17B3 deficiency.
Volume: 34
Issue: 5
Pages: 6111-6128
Publication
First Author: Engeli RT
Year: 2016
Journal: J Steroid Biochem Mol Biol
Title: Biochemical analyses and molecular modeling explain the functional loss of 17β-hydroxysteroid dehydrogenase 3 mutant G133R in three Tunisian patients with 46, XY Disorders of Sex Development.
Volume: 155
Issue: Pt A
Pages: 147-54
Protein
Organism: Mus musculus/domesticus
Length: 123  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 193  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 305  
Fragment?: false
Publication
First Author: Rebourcet D
Year: 2020
Journal: FASEB J
Title: Ablation of the canonical testosterone production pathway via knockout of the steroidogenic enzyme HSD17B3, reveals a novel mechanism of testicular testosterone production.
Volume: 34
Issue: 8
Pages: 10373-10386
Publication
First Author: Howerton CL
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Targeted placental deletion of OGT recapitulates the prenatal stress phenotype including hypothalamic mitochondrial dysfunction.
Volume: 111
Issue: 26
Pages: 9639-44
Publication
First Author: Bergeron F
Year: 2019
Journal: Andrology
Title: Phosphorylation of GATA4 serine 105 but not serine 261 is required for testosterone production in the male mouse.
Volume: 7
Issue: 3
Pages: 357-372
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression      
Probe: MGI:3029491
Assay Type: RT-PCR
Annotation Date: 2004-03-10
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3029844
Age: postnatal day 30
Specimen Label: Type 3
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3029491
Assay Type: RT-PCR
Annotation Date: 2004-03-10
Strength: Present
Sex: Male
Emaps: EMAPS:1797223
Stage: TS23
Assay Id: MGI:3029847
Age: embryonic day 15.5
Specimen Label: fetal 15.5
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3029491
Assay Type: RT-PCR
Annotation Date: 2004-03-10
Strength: Present
Sex: Male
Emaps: EMAPS:1797225
Stage: TS25
Assay Id: MGI:3029847
Age: embryonic day 17.0
Specimen Label: fetal 17.0
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3029491
Assay Type: RT-PCR
Annotation Date: 2004-03-10
Strength: Present
Sex: Male
Emaps: EMAPS:1797227
Stage: TS27
Assay Id: MGI:3029847
Age: postnatal day 1
Specimen Label: postnatal 1
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3029491
Assay Type: RT-PCR
Annotation Date: 2004-03-10
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3029847
Age: postnatal day 5
Specimen Label: postnatal day 5
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3029491
Assay Type: RT-PCR
Annotation Date: 2004-03-10
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3029847
Age: postnatal day 10
Specimen Label: postnatal day 10
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3029491
Assay Type: RT-PCR
Annotation Date: 2004-03-10
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3029847
Age: postnatal day 20
Specimen Label: postnatal day 20
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3029491
Assay Type: RT-PCR
Annotation Date: 2004-03-10
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3029847
Age: postnatal day 25
Specimen Label: postnatal day 25
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3029491
Assay Type: RT-PCR
Annotation Date: 2004-03-10
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3029847
Age: postnatal day 30
Specimen Label: postnatal day 30
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:3029491
Assay Type: RT-PCR
Annotation Date: 2004-03-10
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3029847
Age: postnatal day 90
Specimen Label: postnatal day 90
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:6161680
Assay Type: Northern blot
Annotation Date: 2018-06-22
Strength: Absent
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:6162031
Age: postnatal adult
Specimen Label: Ovary
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:6161680
Assay Type: Northern blot
Annotation Date: 2018-06-22
Strength: Absent
Sex: Female
Emaps: EMAPS:2991528
Stage: TS28
Assay Id: MGI:6162031
Age: postnatal adult
Specimen Label: Uterus
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:6161680
Assay Type: Northern blot
Annotation Date: 2018-06-22
Strength: Absent
Sex: Female
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6162031
Age: postnatal adult
Specimen Label: Brain
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:6161680
Assay Type: Northern blot
Annotation Date: 2018-06-22
Strength: Absent
Sex: Female
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:6162031
Age: postnatal adult
Specimen Label: Placenta
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:6161680
Assay Type: Northern blot
Annotation Date: 2018-06-22
Strength: Absent
Sex: Female
Emaps: EMAPS:1775928
Stage: TS28
Assay Id: MGI:6162031
Age: postnatal adult
Specimen Label: Mammary glands
Detected: false
Specimen Num: 5
GXD Expression      
Probe: MGI:6161680
Assay Type: Northern blot
Annotation Date: 2018-06-22
Strength: Absent
Sex: Female
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:6162031
Age: postnatal adult
Specimen Label: Spleen
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:6161680
Assay Type: Northern blot
Annotation Date: 2018-06-22
Strength: Absent
Sex: Female
Emaps: EMAPS:1842628
Stage: TS28
Assay Id: MGI:6162031
Age: postnatal adult
Specimen Label: Adrenals
Detected: false
Specimen Num: 7
GXD Expression      
Probe: MGI:6161680
Assay Type: Northern blot
Annotation Date: 2018-06-22
Strength: Absent
Sex: Female
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:6162031
Age: postnatal adult
Specimen Label: Heart
Detected: false
Specimen Num: 8
GXD Expression      
Probe: MGI:6161680
Assay Type: Northern blot
Annotation Date: 2018-06-22
Strength: Absent
Sex: Female
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:6162031
Age: postnatal adult
Specimen Label: Kidney
Detected: false
Specimen Num: 9
GXD Expression      
Probe: MGI:6161680
Assay Type: Northern blot
Annotation Date: 2018-06-22
Strength: Absent
Sex: Female
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6162031
Age: postnatal adult
Specimen Label: Liver
Detected: false
Specimen Num: 10
GXD Expression      
Probe: MGI:6161680
Assay Type: Northern blot
Annotation Date: 2018-06-22
Strength: Absent
Sex: Male
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6162042
Age: postnatal adult
Specimen Label: Liver
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:6161680
Assay Type: Northern blot
Annotation Date: 2018-06-22
Strength: Absent
Sex: Male
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:6162042
Age: postnatal adult
Specimen Label: Kidney
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:6161680
Assay Type: Northern blot
Annotation Date: 2018-06-22
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6162042
Age: postnatal adult
Specimen Label: Brain
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:6161680
Assay Type: Northern blot
Annotation Date: 2018-06-22
Strength: Absent
Sex: Male
Emaps: EMAPS:1842628
Stage: TS28
Assay Id: MGI:6162042
Age: postnatal adult
Specimen Label: Adrenals
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:6161680
Assay Type: Northern blot
Annotation Date: 2018-06-22
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:6162042
Age: postnatal adult
Specimen Label: Testis
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:6161680
Assay Type: Northern blot
Annotation Date: 2018-06-22
Strength: Absent
Sex: Male
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:6162042
Age: postnatal adult
Specimen Label: Spleen
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:6161680
Assay Type: Northern blot
Annotation Date: 2018-06-22
Strength: Absent
Sex: Male
Emaps: EMAPS:1928728
Stage: TS28
Assay Id: MGI:6162042
Age: postnatal adult
Specimen Label: Prostate
Detected: false
Specimen Num: 7
GXD Expression      
Probe: MGI:6161680
Assay Type: Northern blot
Annotation Date: 2018-06-22
Strength: Absent
Sex: Male
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:6162042
Age: postnatal adult
Specimen Label: Heart
Detected: false
Specimen Num: 8
GXD Expression      
Probe: MGI:6161680
Assay Type: Northern blot
Annotation Date: 2018-06-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603910
Stage: TS10
Assay Id: MGI:6162106
Age: embryonic day 7.0
Specimen Label: 7
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:6161680
Assay Type: Northern blot
Annotation Date: 2018-06-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:6162106
Age: embryonic day 11.0
Specimen Label: 11
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:6161680
Assay Type: Northern blot
Annotation Date: 2018-06-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:6162106
Age: embryonic day 15.0
Specimen Label: 15
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:6161680
Assay Type: Northern blot
Annotation Date: 2018-06-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:6162106
Age: embryonic day 17.0
Specimen Label: 17
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:7486092
Assay Type: RT-PCR
Annotation Date: 2023-06-01
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:7486177
Age: postnatal week 4
Image: 3
Specimen Label: XX wt
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7486092
Assay Type: RT-PCR
Annotation Date: 2023-06-01
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:7486177
Age: postnatal week 4
Image: 3
Specimen Label: XY wt
Detected: true
Specimen Num: 2
Publication
First Author: Padua MB
Year: 2015
Journal: Endocrinology
Title: Combined loss of the GATA4 and GATA6 transcription factors in male mice disrupts testicular development and confers adrenal-like function in the testes.
Volume: 156
Issue: 5
Pages: 1873-86
Publication
First Author: Sha JA
Year: 1997
Journal: J Steroid Biochem Mol Biol
Title: Sequence of mouse 17beta-hydroxysteroid dehydrogenase type 3 cDNA and tissue distribution of the type 1 and type 3 isoform mRNAs.
Volume: 60
Issue: 1-2
Pages: 19-24
Publication
First Author: Sha J
Year: 1996
Journal: Biochem Biophys Res Commun
Title: Both reductive forms of 17 beta-hydroxysteroid dehydrogenase (types 1 and 3) are expressed during development in the mouse testis.
Volume: 222
Issue: 1
Pages: 90-4
Publication
First Author: Shima Y
Year: 2013
Journal: Mol Endocrinol
Title: Contribution of Leydig and Sertoli cells to testosterone production in mouse fetal testes.
Volume: 27
Issue: 1
Pages: 63-73
Publication
First Author: Baker PJ
Year: 1997
Journal: Mol Cell Endocrinol
Title: Localisation and regulation of 17beta-hydroxysteroid dehydrogenase type 3 mRNA during development in the mouse testis.
Volume: 133
Issue: 2
Pages: 127-33
Publication  
First Author: Mustonen MV
Year: 1997
Journal: Biochem J
Title: Cloning of mouse 17beta-hydroxysteroid dehydrogenase type 2, and analysing expression of the mRNAs for types 1, 2, 3, 4 and 5 in mouse embryos and adult tissues.
Volume: 325 ( Pt 1)
Pages: 199-205
Publication
First Author: Marshall KE
Year: 2002
Journal: Genome Biol
Title: In silico discovery of gene-coding variants in murine quantitative trait loci using strain-specific genome sequence databases.
Volume: 3
Issue: 12
Pages: RESEARCH0078
Publication
First Author: Umehara T
Year: 2016
Journal: Endocrinology
Title: Neuregulin 1 Regulates Proliferation of Leydig Cells to Support Spermatogenesis and Sexual Behavior in Adult Mice.
Volume: 157
Issue: 12
Pages: 4899-4913
Publication
First Author: Vainio S
Year: 1999
Journal: Nature
Title: Female development in mammals is regulated by Wnt-4 signalling.
Volume: 397
Issue: 6718
Pages: 405-9
Publication  
First Author: Whiley PAF
Year: 2023
Journal: Front Endocrinol (Lausanne)
Title: Testis exposure to unopposed/elevated activin A in utero affects somatic and germ cells and alters steroid levels mimicking phthalate exposure.
Volume: 14
Pages: 1234712
Publication
First Author: Blake GET
Year: 2021
Journal: Nat Commun
Title: Defective folate metabolism causes germline epigenetic instability and distinguishes Hira as a phenotype inheritance biomarker.
Volume: 12
Issue: 1
Pages: 3714
Publication
First Author: Kaftanovskaya EM
Year: 2015
Journal: FASEB J
Title: Genetic ablation of androgen receptor signaling in fetal Leydig cell lineage affects Leydig cell functions in adult testis.
Volume: 29
Issue: 6
Pages: 2327-37
Publication
First Author: Provost PR
Year: 2004
Journal: Am J Respir Crit Care Med
Title: A link between lung androgen metabolism and the emergence of mature epithelial type II cells.
Volume: 170
Issue: 3
Pages: 296-305
Publication  
First Author: Shima Y
Year: 2018
Journal: Development
Title: Fetal Leydig cells dedifferentiate and serve as adult Leydig stem cells.
Volume: 145
Issue: 23
Publication
First Author: Kumar DL
Year: 2018
Journal: Nat Commun
Title: A perivascular niche for multipotent progenitors in the fetal testis.
Volume: 9
Issue: 1
Pages: 4519
Publication
First Author: Miyado M
Year: 2012
Journal: Endocrinology
Title: Mamld1 deficiency significantly reduces mRNA expression levels of multiple genes expressed in mouse fetal Leydig cells but permits normal genital and reproductive development.
Volume: 153
Issue: 12
Pages: 6033-40
Publication
First Author: Chassot AA
Year: 2008
Journal: Hum Mol Genet
Title: Activation of beta-catenin signaling by Rspo1 controls differentiation of the mammalian ovary.
Volume: 17
Issue: 9
Pages: 1264-77
Publication
First Author: Zhang L
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Reprogramming of Sertoli cells to fetal-like Leydig cells by Wt1 ablation.
Volume: 112
Issue: 13
Pages: 4003-8
Publication
First Author: Rotgers E
Year: 2021
Journal: FASEB J
Title: Constitutive expression of Steroidogenic factor-1 (NR5A1) disrupts ovarian functions, fertility, and metabolic homeostasis in female mice.
Volume: 35
Issue: 8
Pages: e21770
Publication
First Author: Zhao L
Year: 2015
Journal: Development
Title: Female-to-male sex reversal in mice caused by transgenic overexpression of Dmrt1.
Volume: 142
Issue: 6
Pages: 1083-8
Publication  
First Author: Whiley PAF
Year: 2020
Journal: Endocrinology
Title: Activin A Determines Steroid Levels and Composition in the Fetal Testis.
Volume: 161
Issue: 7
Publication  
First Author: Souali-Crespo S
Year: 2023
Journal: Development
Title: Loss of NR5A1 in mouse Sertoli cells after sex determination changes cellular identity and induces cell death by anoikis.
Volume: 150
Issue: 24
Publication
First Author: Inoue M
Year: 2016
Journal: Endocrinology
Title: Isolation and Characterization of Fetal Leydig Progenitor Cells of Male Mice.
Volume: 157
Issue: 3
Pages: 1222-33
Publication
First Author: Prokopuk L
Year: 2022
Journal: Reproduction
Title: An essential role for Polycomb Repressive Complex 2 in the mouse ovary.
Volume: 163
Issue: 3
Pages: 167-182
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
Publication      
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute