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Search results 1 to 100 out of 865 for Htt

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0.053s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Danio rerio
Gene
Type: gene
Organism: Drosophila melanogaster
Gene
Type: gene
Organism: Rattus norvegicus
Strain
Attribute String: strain family
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Sathasivam K
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease.
Volume: 110
Issue: 6
Pages: 2366-70
Publication
First Author: Biagioli M
Year: 2015
Journal: Hum Mol Genet
Title: Htt CAG repeat expansion confers pleiotropic gains of mutant huntingtin function in chromatin regulation.
Volume: 24
Issue: 9
Pages: 2442-57
Publication
First Author: Huang K
Year: 2011
Journal: Hum Mol Genet
Title: Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14.
Volume: 20
Issue: 17
Pages: 3356-65
Publication
First Author: Carty N
Year: 2015
Journal: PLoS One
Title: Characterization of HTT inclusion size, location, and timing in the zQ175 mouse model of Huntington's disease: an in vivo high-content imaging study.
Volume: 10
Issue: 4
Pages: e0123527
Publication
First Author: Pham HTT
Year: 2018
Journal: J Clin Invest
Title: STAT5BN642H is a driver mutation for T cell neoplasia.
Volume: 128
Issue: 1
Pages: 387-401
Publication  
First Author: Southwell AL
Year: 2018
Journal: Sci Transl Med
Title: Huntingtin suppression restores cognitive function in a mouse model of Huntington's disease.
Volume: 10
Issue: 461
Publication
First Author: Southwell AL
Year: 2013
Journal: Hum Mol Genet
Title: A fully humanized transgenic mouse model of Huntington disease.
Volume: 22
Issue: 1
Pages: 18-34
Publication
First Author: Huang B
Year: 2015
Journal: Neuron
Title: Mutant huntingtin downregulates myelin regulatory factor-mediated myelin gene expression and affects mature oligodendrocytes.
Volume: 85
Issue: 6
Pages: 1212-26
Publication
First Author: Kolodziejczyk K
Year: 2014
Journal: PLoS One
Title: Striatal synaptic dysfunction and hippocampal plasticity deficits in the Hu97/18 mouse model of Huntington disease.
Volume: 9
Issue: 4
Pages: e94562
Publication  
First Author: Silva FR
Year: 2017
Journal: Neurobiol Aging
Title: N-type Ca2+ channels are affected by full-length mutant huntingtin expression in a mouse model of Huntington's disease.
Volume: 55
Pages: 1-10
Publication  
First Author: Van Raamsdonk JM
Year: 2006
Journal: BMC Neurosci
Title: Wild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington disease.
Volume: 7
Pages: 80
Publication
First Author: Hodgson JG
Year: 1999
Journal: Neuron
Title: A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.
Volume: 23
Issue: 1
Pages: 181-92
Publication  
First Author: Soylu-Kucharz R
Year: 2016
Journal: Sci Rep
Title: Metabolic and behavioral effects of mutant huntingtin deletion in Sim1 neurons in the BACHD mouse model of Huntington's disease.
Volume: 6
Pages: 28322
Publication  
First Author: Oakeshott S
Year: 2012
Journal: PLoS Curr
Title: A mixed fixed ratio/progressive ratio procedure reveals an apathy phenotype in the BAC HD and the z_Q175 KI mouse models of Huntington's disease.
Volume: 4
Pages: e4f972cffe82c0
Publication
First Author: Wood TE
Year: 2019
Journal: Hum Mol Genet
Title: Mutant huntingtin reduction in astrocytes slows disease progression in the BACHD conditional Huntington's disease mouse model.
Volume: 28
Issue: 3
Pages: 487-500
Publication
First Author: Hyrskyluoto A
Year: 2014
Journal: Hum Mol Genet
Title: Ubiquitin-specific protease-14 reduces cellular aggregates and protects against mutant huntingtin-induced cell degeneration: involvement of the proteasome and ER stress-activated kinase IRE1α.
Volume: 23
Issue: 22
Pages: 5928-39
Publication
First Author: Chandra A
Year: 2016
Journal: Hum Mol Genet
Title: Enhanced mitochondrial biogenesis ameliorates disease phenotype in a full-length mouse model of Huntington's disease.
Volume: 25
Issue: 11
Pages: 2269-2282
Publication
First Author: Petkau TL
Year: 2019
Journal: Hum Mol Genet
Title: Mutant huntingtin expression in microglia is neither required nor sufficient to cause the Huntington's disease-like phenotype in BACHD mice.
Volume: 28
Issue: 10
Pages: 1661-1670
Publication
First Author: Gu X
Year: 2009
Journal: Neuron
Title: Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice.
Volume: 64
Issue: 6
Pages: 828-40
Publication
First Author: Lundh SH
Year: 2012
Journal: PLoS One
Title: Expression of mutant huntingtin in leptin receptor-expressing neurons does not control the metabolic and psychiatric phenotype of the BACHD mouse.
Volume: 7
Issue: 12
Pages: e51168
Publication
First Author: Reindl W
Year: 2019
Journal: PLoS One
Title: Meso scale discovery-based assays for the detection of aggregated huntingtin.
Volume: 14
Issue: 3
Pages: e0213521
Publication
First Author: Leavitt BR
Year: 2001
Journal: Am J Hum Genet
Title: Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo.
Volume: 68
Issue: 2
Pages: 313-24
Publication
First Author: Gu X
Year: 2015
Journal: Neuron
Title: N17 Modifies mutant Huntingtin nuclear pathogenesis and severity of disease in HD BAC transgenic mice.
Volume: 85
Issue: 4
Pages: 726-41
Author
Author
Author
Publication
First Author: Neto JL
Year: 2017
Journal: Genetics
Title: Genetic Contributors to Intergenerational CAG Repeat Instability in Huntington's Disease Knock-In Mice.
Volume: 205
Issue: 2
Pages: 503-516
Publication
First Author: Baldo B
Year: 2013
Journal: PLoS One
Title: Maintenance of basal levels of autophagy in Huntington's disease mouse models displaying metabolic dysfunction.
Volume: 8
Issue: 12
Pages: e83050
Publication
First Author: Menalled L
Year: 2009
Journal: Neurobiol Dis
Title: Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models.
Volume: 35
Issue: 3
Pages: 319-36
Publication
First Author: Molero AE
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Selective expression of mutant huntingtin during development recapitulates characteristic features of Huntington's disease.
Volume: 113
Issue: 20
Pages: 5736-41
Publication
First Author: Francelle L
Year: 2015
Journal: Neurobiol Aging
Title: Striatal long noncoding RNA Abhd11os is neuroprotective against an N-terminal fragment of mutant huntingtin in vivo.
Volume: 36
Issue: 3
Pages: 1601.e7-16
Publication    
First Author: Atherton JF
Year: 2016
Journal: Elife
Title: Early dysfunction and progressive degeneration of the subthalamic nucleus in mouse models of Huntington's disease.
Volume: 5
Publication
First Author: Zhao X
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington's disease.
Volume: 113
Issue: 38
Pages: E5655-64
Publication
First Author: Näf D
Year: 2001
Journal: Hum Mol Genet
Title: Mouse models for the Wolf-Hirschhorn deletion syndrome.
Volume: 10
Issue: 2
Pages: 91-8
Publication
First Author: Menalled LB
Year: 2003
Journal: J Comp Neurol
Title: Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats.
Volume: 465
Issue: 1
Pages: 11-26
Publication
First Author: Cheng C
Year: 2018
Journal: Hum Mol Genet
Title: The long non-coding RNA NEAT1 is elevated in polyglutamine repeat expansion diseases and protects from disease gene-dependent toxicities.
Volume: 27
Issue: 24
Pages: 4303-4314
Publication
First Author: Estrada-Sánchez AM
Year: 2015
Journal: J Neurosci
Title: Cortical efferents lacking mutant huntingtin improve striatal neuronal activity and behavior in a conditional mouse model of Huntington's disease.
Volume: 35
Issue: 10
Pages: 4440-51
Publication
First Author: Francelle L
Year: 2015
Journal: Hum Mol Genet
Title: Loss of the thyroid hormone-binding protein Crym renders striatal neurons more vulnerable to mutant huntingtin in Huntington's disease.
Volume: 24
Issue: 6
Pages: 1563-73
Publication
First Author: Savas JN
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Huntington's disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies.
Volume: 105
Issue: 31
Pages: 10820-5
Publication
First Author: Slow EJ
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions.
Volume: 102
Issue: 32
Pages: 11402-7
Publication
First Author: Benn CL
Year: 2008
Journal: J Neurosci
Title: Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner.
Volume: 28
Issue: 42
Pages: 10720-33
Publication
First Author: Benn CL
Year: 2005
Journal: Hum Mol Genet
Title: Contribution of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington's disease.
Volume: 14
Issue: 20
Pages: 3065-78
Publication
First Author: Jeong H
Year: 2009
Journal: Cell
Title: Acetylation targets mutant huntingtin to autophagosomes for degradation.
Volume: 137
Issue: 1
Pages: 60-72
Publication
First Author: Ismailoglu I
Year: 2014
Journal: Dev Biol
Title: Huntingtin protein is essential for mitochondrial metabolism, bioenergetics and structure in murine embryonic stem cells.
Volume: 391
Issue: 2
Pages: 230-40
Publication  
First Author: Arteaga-Bracho EE
Year: 2016
Journal: Neurobiol Dis
Title: Postnatal and adult consequences of loss of huntingtin during development: Implications for Huntington's disease.
Volume: 96
Pages: 144-155
Publication
First Author: Graham RK
Year: 2006
Journal: Cell
Title: Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.
Volume: 125
Issue: 6
Pages: 1179-91
Publication
First Author: Weydt P
Year: 2006
Journal: Cell Metab
Title: Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration.
Volume: 4
Issue: 5
Pages: 349-62
Publication
First Author: Marcora E
Year: 2010
Journal: Hum Mol Genet
Title: The Huntington's disease mutation impairs Huntingtin's role in the transport of NF-κB from the synapse to the nucleus.
Volume: 19
Issue: 22
Pages: 4373-84
Publication
First Author: Morfini GA
Year: 2009
Journal: Nat Neurosci
Title: Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin.
Volume: 12
Issue: 7
Pages: 864-71
Publication
First Author: Yu D
Year: 2012
Journal: Cell
Title: Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression.
Volume: 150
Issue: 5
Pages: 895-908
Publication
First Author: Yang S
Year: 2017
Journal: J Clin Invest
Title: CRISPR/Cas9-mediated gene editing ameliorates neurotoxicity in mouse model of Huntington's disease.
Volume: 127
Issue: 7
Pages: 2719-2724
Publication
First Author: Grima JC
Year: 2017
Journal: Neuron
Title: Mutant Huntingtin Disrupts the Nuclear Pore Complex.
Volume: 94
Issue: 1
Pages: 93-107.e6
Publication
First Author: Trushina E
Year: 2004
Journal: Mol Cell Biol
Title: Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro.
Volume: 24
Issue: 18
Pages: 8195-209
Publication  
First Author: Ma B
Year: 2011
Journal: Sci Rep
Title: Huntingtin mediates dendritic transport of β-actin mRNA in rat neurons.
Volume: 1
Pages: 140
Publication
First Author: Bertaux F
Year: 1998
Journal: FEBS Lett
Title: HAP1-huntingtin interactions do not contribute to the molecular pathology in Huntington's disease transgenic mice.
Volume: 426
Issue: 2
Pages: 229-32
Publication
First Author: Schimenti JC
Year: 2000
Journal: Genome Res
Title: Interdigitated deletion complexes on mouse chromosome 5 induced by irradiation of embryonic stem cells.
Volume: 10
Issue: 7
Pages: 1043-50
Publication
First Author: Kudo T
Year: 2011
Journal: Exp Neurol
Title: Dysfunctions in circadian behavior and physiology in mouse models of Huntington's disease.
Volume: 228
Issue: 1
Pages: 80-90
Publication  
First Author: Oakeshott S
Year: 2011
Journal: PLoS Curr
Title: HD mouse models reveal clear deficits in learning to perform a simple instrumental response.
Volume: 3
Pages: RRN1282
Publication
First Author: Cowan CM
Year: 2008
Journal: J Neurosci
Title: Polyglutamine-modulated striatal calpain activity in YAC transgenic huntington disease mouse model: impact on NMDA receptor function and toxicity.
Volume: 28
Issue: 48
Pages: 12725-35
Publication  
First Author: Pan Y
Year: 2016
Journal: Sci Rep
Title: Inhibition of DNA Methyltransferases Blocks Mutant Huntingtin-Induced Neurotoxicity.
Volume: 6
Pages: 31022
Publication
First Author: Milnerwood AJ
Year: 2007
Journal: J Physiol
Title: Corticostriatal synaptic function in mouse models of Huntington's disease: early effects of huntingtin repeat length and protein load.
Volume: 585
Issue: Pt 3
Pages: 817-31
Publication    
First Author: Yao Y
Year: 2015
Journal: Elife
Title: A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity.
Volume: 4
Publication  
First Author: Gomez-Pastor R
Year: 2017
Journal: Nat Commun
Title: Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington's disease.
Volume: 8
Pages: 14405
Publication
First Author: El-Daher MT
Year: 2015
Journal: EMBO J
Title: Huntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation.
Volume: 34
Issue: 17
Pages: 2255-71
Publication
First Author: Barnat M
Year: 2017
Journal: Neuron
Title: Huntingtin-Mediated Multipolar-Bipolar Transition of Newborn Cortical Neurons Is Critical for Their Postnatal Neuronal Morphology.
Volume: 93
Issue: 1
Pages: 99-114
Publication
First Author: Kim YJ
Year: 2006
Journal: Neurobiol Dis
Title: Lysosomal proteases are involved in generation of N-terminal huntingtin fragments.
Volume: 22
Issue: 2
Pages: 346-56
Publication  
First Author: Zeng L
Year: 2015
Journal: Neurobiol Dis
Title: Differential recruitment of UBQLN2 to nuclear inclusions in the polyglutamine diseases HD and SCA3.
Volume: 82
Pages: 281-288
Publication
First Author: Bhat KP
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Differential ubiquitination and degradation of huntingtin fragments modulated by ubiquitin-protein ligase E3A.
Volume: 111
Issue: 15
Pages: 5706-11
Publication
First Author: Luo S
Year: 2008
Journal: Hum Mol Genet
Title: p21-activated kinase 1 promotes soluble mutant huntingtin self-interaction and enhances toxicity.
Volume: 17
Issue: 6
Pages: 895-905
Publication
First Author: Dietrich P
Year: 2017
Journal: PLoS Genet
Title: Elimination of huntingtin in the adult mouse leads to progressive behavioral deficits, bilateral thalamic calcification, and altered brain iron homeostasis.
Volume: 13
Issue: 7
Pages: e1006846
Publication
First Author: Rozas JL
Year: 2011
Journal: J Neurosci
Title: Increased neurotransmitter release at the neuromuscular junction in a mouse model of polyglutamine disease.
Volume: 31
Issue: 3
Pages: 1106-13
Publication  
First Author: Moily NS
Year: 2017
Journal: Mol Cell Neurosci
Title: Transcriptional profiles for distinct aggregation states of mutant Huntingtin exon 1 protein unmask new Huntington's disease pathways.
Volume: 83
Pages: 103-112
Publication
First Author: Schilling G
Year: 2004
Journal: Hum Mol Genet
Title: Nuclear-targeting of mutant huntingtin fragments produces Huntington's disease-like phenotypes in transgenic mice.
Volume: 13
Issue: 15
Pages: 1599-610
Publication
First Author: Van Raamsdonk JM
Year: 2006
Journal: Hum Mol Genet
Title: Body weight is modulated by levels of full-length huntingtin.
Volume: 15
Issue: 9
Pages: 1513-23
Publication
First Author: Wang CE
Year: 2008
Journal: Hum Mol Genet
Title: Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease.
Volume: 17
Issue: 17
Pages: 2738-51
Publication
First Author: Yan J
Year: 2016
Journal: J Cell Sci
Title: Germline deletion of huntingtin causes male infertility and arrested spermiogenesis in mice.
Volume: 129
Issue: 3
Pages: 492-501
Publication
First Author: Southwell AL
Year: 2016
Journal: Hum Mol Genet
Title: An enhanced Q175 knock-in mouse model of Huntington disease with higher mutant huntingtin levels and accelerated disease phenotypes.
Volume: 25
Issue: 17
Pages: 3654-3675
Publication
First Author: Lo Sardo V
Year: 2012
Journal: Nat Neurosci
Title: An evolutionary recent neuroepithelial cell adhesion function of huntingtin implicates ADAM10-Ncadherin.
Volume: 15
Issue: 5
Pages: 713-21
Publication
First Author: Ament SA
Year: 2017
Journal: Hum Mol Genet
Title: High resolution time-course mapping of early transcriptomic, molecular and cellular phenotypes in Huntington's disease CAG knock-in mice across multiple genetic backgrounds.
Volume: 26
Issue: 5
Pages: 913-922
Publication
First Author: Vázquez-Manrique RP
Year: 2016
Journal: Hum Mol Genet
Title: AMPK activation protects from neuronal dysfunction and vulnerability across nematode, cellular and mouse models of Huntington's disease.
Volume: 25
Issue: 6
Pages: 1043-58
Publication
First Author: Hölter SM
Year: 2013
Journal: PLoS One
Title: A broad phenotypic screen identifies novel phenotypes driven by a single mutant allele in Huntington's disease CAG knock-in mice.
Volume: 8
Issue: 11
Pages: e80923
Publication
First Author: Yin X
Year: 2016
Journal: Hum Mol Genet
Title: Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington's disease.
Volume: 25
Issue: 9
Pages: 1739-53
Publication
First Author: Suelves N
Year: 2017
Journal: Sci Rep
Title: A selective inhibitor of histone deacetylase 3 prevents cognitive deficits and suppresses striatal CAG repeat expansions in Huntington's disease mice.
Volume: 7
Issue: 1
Pages: 6082
Publication
First Author: Ramos EM
Year: 2015
Journal: Mamm Genome
Title: Chromosome substitution strain assessment of a Huntington's disease modifier locus.
Volume: 26
Issue: 3-4
Pages: 119-30
Publication
First Author: Van Raamsdonk JM
Year: 2005
Journal: Hum Mol Genet
Title: Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington disease.
Volume: 14
Issue: 10
Pages: 1379-92
Publication
First Author: Pla P
Year: 2013
Journal: PLoS One
Title: Huntingtin acts non cell-autonomously on hippocampal neurogenesis and controls anxiety-related behaviors in adult mouse.
Volume: 8
Issue: 9
Pages: e73902
Publication
First Author: Heng MY
Year: 2010
Journal: Hum Mol Genet
Title: Early autophagic response in a novel knock-in model of Huntington disease.
Volume: 19
Issue: 19
Pages: 3702-20
Publication
First Author: Jansen AH
Year: 2017
Journal: Glia
Title: Frequency of nuclear mutant huntingtin inclusion formation in neurons and glia is cell-type-specific.
Volume: 65
Issue: 1
Pages: 50-61
Publication
First Author: Orr AL
Year: 2008
Journal: J Neurosci
Title: N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking.
Volume: 28
Issue: 11
Pages: 2783-92
Publication
First Author: Li X
Year: 2010
Journal: Hum Mol Genet
Title: Inhibiting the ubiquitin-proteasome system leads to preferential accumulation of toxic N-terminal mutant huntingtin fragments.
Volume: 19
Issue: 12
Pages: 2445-55
Publication
First Author: Sun X
Year: 2014
Journal: Hum Mol Genet
Title: Phosphorodiamidate morpholino oligomers suppress mutant huntingtin expression and attenuate neurotoxicity.
Volume: 23
Issue: 23
Pages: 6302-17
Publication
First Author: Hsiao HY
Year: 2013
Journal: Hum Mol Genet
Title: A critical role of astrocyte-mediated nuclear factor-κB-dependent inflammation in Huntington's disease.
Volume: 22
Issue: 9
Pages: 1826-42
Publication
First Author: Sathasivam K
Year: 2010
Journal: Hum Mol Genet
Title: Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of Huntington's disease.
Volume: 19
Issue: 1
Pages: 65-78