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Search results 1 to 100 out of 279 for Huwe1

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: dog, domestic
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Zhao X
Year: 2008
Journal: Nat Cell Biol
Title: The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein.
Volume: 10
Issue: 6
Pages: 643-53
Publication
First Author: Fok KL
Year: 2017
Journal: Endocrinology
Title: Huwe1 Regulates the Establishment and Maintenance of Spermatogonia by Suppressing DNA Damage Response.
Volume: 158
Issue: 11
Pages: 4000-4016
Publication
First Author: Eisa AA
Year: 2020
Journal: iScience
Title: X-Linked Huwe1 Is Essential for Oocyte Maturation and Preimplantation Embryo Development.
Volume: 23
Issue: 9
Pages: 101523
Publication
First Author: Feng WW
Year: 2023
Journal: iScience
Title: Hepatic Huwe1 loss protects mice from non-alcoholic fatty liver disease through lipid metabolic rewiring.
Volume: 26
Issue: 12
Pages: 108405
Publication
First Author: Guo Y
Year: 2020
Journal: J Clin Invest
Title: HUWE1 mediates inflammasome activation and promotes host defense against bacterial infection.
Volume: 130
Issue: 12
Pages: 6301-6316
Publication
First Author: Bose R
Year: 2017
Journal: Sci Rep
Title: Ubiquitin Ligase Huwe1 Modulates Spermatogenesis by Regulating Spermatogonial Differentiation and Entry into Meiosis.
Volume: 7
Issue: 1
Pages: 17759
Publication
First Author: D'Arca D
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Huwe1 ubiquitin ligase is essential to synchronize neuronal and glial differentiation in the developing cerebellum.
Volume: 107
Issue: 13
Pages: 5875-80
Publication
First Author: Yang D
Year: 2017
Journal: Cancer Res
Title: Huwe1 Sustains Normal Ovarian Epithelial Cell Transformation and Tumor Growth through the Histone H1.3-H19 Cascade.
Volume: 77
Issue: 18
Pages: 4773-4784
Publication  
First Author: Spanjaard A
Year: 2022
Journal: Front Immunol
Title: Huwe1 supports B-cell development, B-cell-dependent immunity, somatic hypermutation and class switch recombination by regulating proliferation.
Volume: 13
Pages: 986863
Publication
First Author: King B
Year: 2016
Journal: Nat Immunol
Title: The ubiquitin ligase Huwe1 regulates the maintenance and lymphoid commitment of hematopoietic stem cells.
Volume: 17
Issue: 11
Pages: 1312-1321
Publication  
First Author: Chen LJ
Year: 2016
Journal: Sci Rep
Title: HUWE1 plays important role in mouse preimplantation embryo development and the dysregulation is associated with poor embryo development in humans.
Volume: 6
Pages: 37928
Publication
First Author: Zhao X
Year: 2009
Journal: Dev Cell
Title: The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain.
Volume: 17
Issue: 2
Pages: 210-21
Publication
First Author: Myant KB
Year: 2017
Journal: EMBO Mol Med
Title: HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation.
Volume: 9
Issue: 2
Pages: 181-197
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Publication
First Author: Yin L
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: E3 ligases Arf-bp1 and Pam mediate lithium-stimulated degradation of the circadian heme receptor Rev-erb alpha.
Volume: 107
Issue: 25
Pages: 11614-9
Publication
First Author: Wang L
Year: 2014
Journal: Diabetologia
Title: Dichotomous role of pancreatic HUWE1/MULE/ARF-BP1 in modulating beta cell apoptosis in mice under physiological and genotoxic conditions.
Volume: 57
Issue: 9
Pages: 1889-98
Publication
First Author: Urbán N
Year: 2016
Journal: Science
Title: Return to quiescence of mouse neural stem cells by degradation of a proactivation protein.
Volume: 353
Issue: 6296
Pages: 292-5
Publication
First Author: Delbridge ARD
Year: 2019
Journal: Cell Rep
Title: Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation and Female-Specific Neural Tube Defects.
Volume: 27
Issue: 2
Pages: 442-454.e5
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Zhang J
Year: 2011
Journal: Genes Dev
Title: Mule determines the apoptotic response to HDAC inhibitors by targeted ubiquitination and destruction of HDAC2.
Volume: 25
Issue: 24
Pages: 2610-8
GXD Expression  
Probe: MGI:6259638
Assay Type: RNA in situ
Annotation Date: 2018-12-10
Strength: Present
Sex: Male
Emaps: EMAPS:1605911
Pattern: Not Specified
Stage: TS11
Assay Id: MGI:6259648
Age: embryonic day 7.5
Note: Expression from the active X was detected.
Specimen Label: Table S1
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:6259638
Assay Type: RNA in situ
Annotation Date: 2018-12-10
Strength: Present
Sex: Male
Emaps: EMAPS:1605810
Pattern: Regionally restricted
Stage: TS10
Assay Id: MGI:6259648
Age: embryonic day 7.0
Note: Expression from the active X was detected.
Specimen Label: Table S1
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:6259638
Assay Type: RNA in situ
Annotation Date: 2018-12-10
Strength: Present
Sex: Male
Emaps: EMAPS:1605811
Pattern: Not Specified
Stage: TS11
Assay Id: MGI:6259648
Age: embryonic day 7.5
Note: Expression from the active X was detected.
Specimen Label: Table S1
Detected: true
Specimen Num: 6
GXD Expression
Probe: MGI:6259638
Assay Type: RNA in situ
Annotation Date: 2018-12-10
Strength: Present
Sex: Female
Emaps: EMAPS:1605810
Pattern: Not Specified
Stage: TS10
Assay Id: MGI:6259648
Age: embryonic day 7.0
Image: 1E,F
Note: Monoallelic expression was detected on the active X.
Specimen Label: 1E,F
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4425113
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Pattern: Ubiquitous
Stage: TS23
Assay Id: MGI:4825488
Age: embryonic day 14.5
Image: euxassay_012743_15
Specimen Label: euxassay_012743_15
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:6259638
Assay Type: RNA in situ
Annotation Date: 2018-12-10
Strength: Present
Sex: Female
Emaps: EMAPS:1603910
Pattern: Not Specified
Stage: TS10
Assay Id: MGI:6259648
Age: embryonic day 7.0
Note: Expression was detected from the active X in the majority of cells in all lineages at this stage.
Specimen Label: not shown
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:6259638
Assay Type: RNA in situ
Annotation Date: 2018-12-10
Strength: Present
Sex: Male
Emaps: EMAPS:1603910
Pattern: Regionally restricted
Stage: TS10
Assay Id: MGI:6259648
Age: embryonic day 7.0
Note: Expression from the active X was detected.
Specimen Label: Table S1
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:6259638
Assay Type: RNA in situ
Annotation Date: 2018-12-10
Strength: Present
Sex: Male
Emaps: EMAPS:1603911
Pattern: Not Specified
Stage: TS11
Assay Id: MGI:6259648
Age: embryonic day 7.5
Note: Expression from the active X was detected.
Specimen Label: Table S1
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:7343876
Assay Type: Immunohistochemistry
Annotation Date: 2022-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:7343906
Age: embryonic day 13.5
Image: 2G
Specimen Label: 2G
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:6259638
Assay Type: RNA in situ
Annotation Date: 2018-12-10
Strength: Present
Sex: Female
Emaps: EMAPS:1604210
Pattern: Not Specified
Stage: TS10
Assay Id: MGI:6259648
Age: embryonic day 7.0
Note: Expression was detected from the active X in the majority of cells in all lineages at this stage.
Specimen Label: not shown
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:6259638
Assay Type: RNA in situ
Annotation Date: 2018-12-10
Strength: Present
Sex: Male
Emaps: EMAPS:1604210
Pattern: Not Specified
Stage: TS10
Assay Id: MGI:6259648
Age: embryonic day 7.0
Note: Expression from the active X was detected in the ectoplacental cone and chorion.
Specimen Label: Table S1
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:6259638
Assay Type: RNA in situ
Annotation Date: 2018-12-10
Strength: Present
Sex: Female
Emaps: EMAPS:3187710
Pattern: Not Specified
Stage: TS10
Assay Id: MGI:6259648
Age: embryonic day 7.0
Note: Over 30% of trophoblast giant cells showed some degree of biallelic expression at this stage.
Specimen Label: Table 1
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:6259638
Assay Type: RNA in situ
Annotation Date: 2018-12-10
Strength: Present
Sex: Female
Emaps: EMAPS:3187712
Pattern: Not Specified
Stage: TS12
Assay Id: MGI:6259648
Age: embryonic day 8.0
Image: 2B
Note: Monoallelic expression was detected.
Specimen Label: 2B
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:6259638
Assay Type: RNA in situ
Annotation Date: 2018-12-10
Strength: Present
Sex: Male
Emaps: EMAPS:3187710
Pattern: Regionally restricted
Stage: TS10
Assay Id: MGI:6259648
Age: embryonic day 7.0
Note: Expression from the active X was detected.
Specimen Label: Table S1
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:6259638
Assay Type: RNA in situ
Annotation Date: 2018-12-10
Strength: Present
Sex: Male
Emaps: EMAPS:3187711
Pattern: Not Specified
Stage: TS11
Assay Id: MGI:6259648
Age: embryonic day 7.5
Note: Expression from the active X was detected.
Specimen Label: Table S1
Detected: true
Specimen Num: 6
GXD Expression
Probe: MGI:6259638
Assay Type: RNA in situ
Annotation Date: 2018-12-10
Strength: Present
Sex: Female
Emaps: EMAPS:3187710
Pattern: Not Specified
Stage: TS10
Assay Id: MGI:6259648
Age: embryonic day 7.0
Image: 1E,F
Note: Biallelic expression was detected on both the inactive and active X.
Specimen Label: 1E,F
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:6259638
Assay Type: RNA in situ
Annotation Date: 2018-12-10
Strength: Present
Sex: Male
Emaps: EMAPS:1611211
Pattern: Not Specified
Stage: TS11
Assay Id: MGI:6259648
Age: embryonic day 7.5
Note: Expression from the active X was detected.
Specimen Label: Table S1
Detected: true
Specimen Num: 6
GXD Expression
Probe: MGI:7343876
Assay Type: Immunohistochemistry
Annotation Date: 2022-10-06
Strength: Present
Sex: Male
Emaps: EMAPS:3292728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7343906
Age: postnatal month 1
Image: 3Ai
Note: Expressed in nucleus and cytoplasm in some of the beta-cells.
Specimen Label: 3Ai
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7343876
Assay Type: Immunohistochemistry
Annotation Date: 2022-10-06
Strength: Absent
Sex: Male
Emaps: EMAPS:3292728
Stage: TS28
Assay Id: MGI:7343906
Age: postnatal month 1
Image: 3Aiv
Specimen Label: 3Aiv
Detected: false
Specimen Num: 3
GXD Expression
Probe: MGI:7343876
Assay Type: Immunohistochemistry
Annotation Date: 2022-10-06
Strength: Present
Sex: Male
Emaps: EMAPS:3292728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7343906
Age: postnatal month 1
Image: 3Aiv
Note: Similar as in the control.
Specimen Label: 3Aiv
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:7343876
Assay Type: Immunohistochemistry
Annotation Date: 2022-10-06
Strength: Present
Sex: Male
Emaps: EMAPS:3292728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7343906
Age: postnatal month 1
Image: 3Ai
Specimen Label: 3Ai
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:7343876
Assay Type: Immunohistochemistry
Annotation Date: 2022-10-06
Strength: Present
Sex: Male
Emaps: EMAPS:3565128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7343906
Age: postnatal month 1
Image: 3Ai
Specimen Label: 3Ai
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:7343876
Assay Type: Immunohistochemistry
Annotation Date: 2022-10-06
Strength: Present
Sex: Male
Emaps: EMAPS:3565128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7343906
Age: postnatal month 1
Image: 3Aiv
Note: Similar as in the control.
Specimen Label: 3Aiv
Detected: true
Specimen Num: 3
Publication    
First Author: Seki N
Year: 1999
Journal: GenBank Submission
Title: Mus musculus mRNA for KIAA312p, partial cds
Pages: AB025966
Publication
First Author: Markkanen E
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Regulation of oxidative DNA damage repair by DNA polymerase λ and MutYH by cross-talk of phosphorylation and ubiquitination.
Volume: 109
Issue: 2
Pages: 437-42
Publication
First Author: Okazaki N
Year: 2002
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 9
Issue: 5
Pages: 179-88
Publication  
First Author: Hao Z
Year: 2017
Journal: Nat Commun
Title: K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression.
Volume: 8
Pages: 14003
Publication
First Author: Dominguez-Brauer C
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: E3 ubiquitin ligase Mule targets β-catenin under conditions of hyperactive Wnt signaling.
Volume: 114
Issue: 7
Pages: E1148-E1157
Publication
First Author: Bain CC
Year: 2017
Journal: Nat Commun
Title: TGFβR signalling controls CD103+CD11b+ dendritic cell development in the intestine.
Volume: 8
Issue: 1
Pages: 620
Publication
First Author: Harris L
Year: 2021
Journal: Cell Stem Cell
Title: Coordinated changes in cellular behavior ensure the lifelong maintenance of the hippocampal stem cell population.
Volume: 28
Issue: 5
Pages: 863-876.e6
Publication
First Author: Zhang X
Year: 2011
Journal: EMBO J
Title: USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1.
Volume: 30
Issue: 11
Pages: 2177-89
Publication
First Author: Hao Z
Year: 2012
Journal: J Exp Med
Title: The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis.
Volume: 209
Issue: 1
Pages: 173-86
Publication
First Author: Qi CF
Year: 2013
Journal: Leuk Res
Title: Homeostatic defects in B cells deficient in the E3 ubiquitin ligase ARF-BP1 are restored by enhanced expression of MYC.
Volume: 37
Issue: 12
Pages: 1680-9
Publication
First Author: Yang Y
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: E3 ubiquitin ligase Mule ubiquitinates Miz1 and is required for TNFalpha-induced JNK activation.
Volume: 107
Issue: 30
Pages: 13444-9
Publication
First Author: Dominguez-Brauer C
Year: 2016
Journal: Cell Stem Cell
Title: Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation.
Volume: 19
Issue: 2
Pages: 205-216
Publication
First Author: Tsuchiya KD
Year: 2000
Journal: Mamm Genome
Title: Chromosomal domains and escape from X inactivation: comparative X inactivation analysis in mouse and human.
Volume: 11
Issue: 10
Pages: 849-54
Publication
First Author: Plafker SM
Year: 2002
Journal: Mol Cell Biol
Title: Ribosomal protein L12 uses a distinct nuclear import pathway mediated by importin 11.
Volume: 22
Issue: 4
Pages: 1266-75
Publication  
First Author: Dadson K
Year: 2017
Journal: Sci Rep
Title: The E3 ligase Mule protects the heart against oxidative stress and mitochondrial dysfunction through Myc-dependent inactivation of Pgc-1α and Pink1.
Volume: 7
Pages: 41490
Publication
First Author: Kon N
Year: 2012
Journal: J Biol Chem
Title: Inactivation of arf-bp1 induces p53 activation and diabetic phenotypes in mice.
Volume: 287
Issue: 7
Pages: 5102-11
Publication
First Author: Corbel C
Year: 2013
Journal: Development
Title: Unusual chromatin status and organization of the inactive X chromosome in murine trophoblast giant cells.
Volume: 140
Issue: 4
Pages: 861-72
Publication
First Author: Masui O
Year: 2023
Journal: Nat Cell Biol
Title: Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages.
Volume: 25
Issue: 1
Pages: 134-144
Publication
First Author: Inoue S
Year: 2013
Journal: Genes Dev
Title: Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15.
Volume: 27
Issue: 10
Pages: 1101-14
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication
First Author: Gehman LT
Year: 2012
Journal: Genes Dev
Title: The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function.
Volume: 26
Issue: 5
Pages: 445-60
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication
First Author: Cox BJ
Year: 2010
Journal: Genome Res
Title: Phenotypic annotation of the mouse X chromosome.
Volume: 20
Issue: 8
Pages: 1154-64
Publication      
First Author: Cox BJ
Year: 2010
Journal: MGI Direct Data Submission
Title: Phenotypic annotation of the mouse X chromosome
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity