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Search results 1 to 100 out of 113 for Hvcn1

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Hits by Pathway

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Hits by Category

Type Details Score
Gene
84329 | HVCN1
Type: gene
Organism: human
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Gene
304485 | Hvcn1
Type: gene
Organism: rat
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Gene
737161 | HVCN1
Type: gene
Organism: chimpanzee
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Gene
608547 | HVCN1
Type: gene
Organism: dog, domestic
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Gene
616570 | HVCN1
Type: gene
Organism: cattle
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Gene
416871 | HVCN1
Type: gene
Organism: chicken
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Gene
436618 | hvcn1
Type: gene
Organism: zebrafish
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Gene
709745 | HVCN1
Type: gene
Organism: macaque, rhesus
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Gene
496712 | hvcn1
Type: gene
Organism: frog, western clawed
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Protein Domain
IPR031846 | Hvcn1
Type: Family
Description: Voltage-gated hydrogen channel 1 (Hvcn1, also known as Hv1 or VSOP) mediates the voltage-dependent proton permeability of excitable membranes. It forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient []. It is required for high-level superoxide production by phagocytes []. It has also been shown to regulate human sperm motility through activating alkalization-activated calcium channels []. The structure of Hvcn1 has been solved [].
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Protein Coding Gene
MGI:1921346 | Hvcn1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
19285483 | J:148032
First Author: Okochi Y
Year: 2009
Journal: Biochem Biophys Res Commun
Title: Voltage-gated proton channel is expressed on phagosomes.
Volume: 382
Issue: 2
Pages: 274-9
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Publication
20139987 | J:158627
First Author: Capasso M
Year: 2010
Journal: Nat Immunol
Title: HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species.
Volume: 11
Issue: 3
Pages: 265-72
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Publication
25885273 | J:233483
First Author: Levine AP
Year: 2015
Journal: PLoS One
Title: Alkalinity of neutrophil phagocytic vacuoles is modulated by HVCN1 and has consequences for myeloperoxidase activity.
Volume: 10
Issue: 4
Pages: e0125906
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Publication
24584463 | -
First Author: Takeshita K
Year: 2014
Journal: Nat Struct Mol Biol
Title: X-ray crystal structure of voltage-gated proton channel.
Volume: 21
Issue: 4
Pages: 352-7
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Publication
22020278 | -
First Author: Musset B
Year: 2011
Journal: Nature
Title: Aspartate 112 is the selectivity filter of the human voltage-gated proton channel.
Volume: 480
Issue: 7376
Pages: 273-7
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Publication
20144758 | -
First Author: Lishko PV
Year: 2010
Journal: Cell
Title: Acid extrusion from human spermatozoa is mediated by flagellar voltage-gated proton channel.
Volume: 140
Issue: 3
Pages: 327-37
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Protein
D3Z019
Organism: Mus musculus/domesticus
Length: 168  
Fragment?: true
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Protein
Q3U2S8
Organism: Mus musculus/domesticus
Length: 269  
Fragment?: false
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Publication
23231444 | J:195096
First Author: Sasaki M
Year: 2013
Journal: Biochem J
Title: Autoimmune disorder phenotypes in Hvcn1-deficient mice.
Volume: 450
Issue: 2
Pages: 295-301
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Publication
28628214 | J:245117
First Author: Kawai T
Year: 2017
Journal: J Neurochem
Title: Unconventional role of voltage-gated proton channels (VSOP/Hv1) in regulation of microglial ROS production.
Volume: 142
Issue: 5
Pages: 686-699
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Publication
32303121 | J:298111
First Author: Okochi Y
Year: 2020
Journal: J Leukoc Biol
Title: Hv1/VSOP regulates neutrophil directional migration and ERK activity by tuning ROS production.
Volume: 107
Issue: 5
Pages: 819-831
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Publication
24415791 | J:345000
First Author: El Chemaly A
Year: 2014
Journal: J Leukoc Biol
Title: Hv1 proton channels differentially regulate the pH of neutrophil and macrophage phagosomes by sustaining the production of phagosomal ROS that inhibit the delivery of vacuolar ATPases.
Volume: 95
Issue: 5
Pages: 827-839
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Publication
25990245 | J:242742
First Author: Okochi Y
Year: 2016
Journal: J Leukoc Biol
Title: The voltage-gated proton channel Hv1/VSOP inhibits neutrophil granule release.
Volume: 99
Issue: 1
Pages: 7-19
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Publication
35472029 | J:326448
 
First Author: Coe D
Year: 2022
Journal: JCI Insight
Title: Loss of voltage-gated hydrogen channel 1 expression reveals heterogeneous metabolic adaptation to intracellular acidification by T cells.
Volume: 7
Issue: 10
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Publication
33040408 | J:316349
First Author: Kawai T
Year: 2020
Journal: FASEB J
Title: Regulation of hepatic oxidative stress by voltage-gated proton channels (Hv1/VSOP) in Kupffer cells and its potential relationship with glucose metabolism.
Volume: 34
Issue: 12
Pages: 15805-15821
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Publication
33127821 | J:300727
First Author: Montes-Cobos E
Year: 2020
Journal: J Immunol
Title: Voltage-Gated Proton Channel Hv1 Controls TLR9 Activation in Plasmacytoid Dendritic Cells.
Volume: 205
Issue: 11
Pages: 3001-3010
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Protein Coding Gene
MGP_CAROLIEiJ_G0027699 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0030044 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0030009 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0029945 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0030020 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0029737 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1921346 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0030473 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0029146 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0029707 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0029857 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0029813 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0029946 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0029844 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0030514 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0028860 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0029221 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0024279 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0028697 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
16556803 | J:108335
First Author: Sasaki M
Year: 2006
Journal: Science
Title: A voltage sensor-domain protein is a voltage-gated proton channel.
Volume: 312
Issue: 5773
Pages: 589-92
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Publication
19805063 | J:153699
First Author: Morgan D
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Voltage-gated proton channels maintain pH in human neutrophils during phagocytosis.
Volume: 106
Issue: 42
Pages: 18022-7
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Publication
22569364 | J:345041
 
First Author: Fujiwara Y
Year: 2012
Journal: Nat Commun
Title: The cytoplasmic coiled-coil mediates cooperative gating temperature sensitivity in the voltage-gated H(+) channel Hv1.
Volume: 3
Pages: 816
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Publication
23165764 | J:206054
First Author: Fujiwara Y
Year: 2013
Journal: J Physiol
Title: Gating of the designed trimeric/tetrameric voltage-gated H+ channel.
Volume: 591
Issue: 3
Pages: 627-40
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Publication
31949049 | J:286544
First Author: Pang H
Year: 2020
Journal: J Biol Chem
Title: Loss of the voltage-gated proton channel Hv1 decreases insulin secretion and leads to hyperglycemia and glucose intolerance in mice.
Volume: 295
Issue: 11
Pages: 3601-3613
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Publication
19372380 | J:148273
First Author: Ramsey IS
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst.
Volume: 106
Issue: 18
Pages: 7642-7
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Publication
37395288 | J:339454
First Author: Li Y
Year: 2023
Journal: Glia
Title: Knockout of microglial Hv1 proton channel reduces neurotoxic A1 astrocytes and neuronal damage via the ROS/STAT3 pathway after spinal cord injury.
Volume: 71
Issue: 10
Pages: 2418-2436
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Publication
27470181 | J:235941
First Author: Tian DS
Year: 2016
Journal: J Neurochem
Title: Deficiency in the voltage-gated proton channel Hv1 increases M2 polarization of microglia and attenuates brain damage from photothrombotic ischemic stroke.
Volume: 139
Issue: 1
Pages: 96-105
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Publication
20026664 | J:156823
First Author: El Chemaly A
Year: 2010
Journal: J Exp Med
Title: VSOP/Hv1 proton channels sustain calcium entry, neutrophil migration, and superoxide production by limiting cell depolarization and acidification.
Volume: 207
Issue: 1
Pages: 129-39
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Publication
34547291 | J:312778
First Author: Pang H
Year: 2021
Journal: J Biol Chem
Title: Mice lacking the proton channel Hv1 exhibit sex-specific differences in glucose homeostasis.
Volume: 297
Issue: 4
Pages: 101212
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Publication
33866247 | J:311080
 
First Author: Du H
Year: 2021
Journal: Int Immunopharmacol
Title: Deficiency of voltage-gated proton channel Hv1 aggravates ovalbumin-induced allergic lung asthma in mice.
Volume: 96
Pages: 107640
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Publication
36660473 | J:332665
First Author: Zhao R
Year: 2023
Journal: iScience
Title: Protection from acute lung injury by a peptide designed to inhibit the voltage-gated proton channel.
Volume: 26
Issue: 1
Pages: 105901
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Publication
32049639 | J:301158
 
First Author: Pang H
Year: 2020
Journal: BMJ Open Diabetes Res Care
Title: Loss of voltage-gated proton channel Hv1 leads to diet-induced obesity in mice.
Volume: 8
Issue: 1
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Publication
33158440 | J:313493
First Author: Chen M
Year: 2020
Journal: J Neuroinflammation
Title: Deficiency of microglial Hv1 channel is associated with activation of autophagic pathway and ROS production in LPC-induced demyelination mouse model.
Volume: 17
Issue: 1
Pages: 333
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Publication
29550486 | J:271658
First Author: Wang X
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Deficiency of voltage-gated proton channel Hv1 attenuates streptozotocin-induced β-cell damage.
Volume: 498
Issue: 4
Pages: 975-980
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Publication
31769505 | J:287879
First Author: Yu Y
Year: 2020
Journal: J Neurochem
Title: Microglial Hv1 proton channels promote white matter injuries after chronic hypoperfusion in mice.
Volume: 152
Issue: 3
Pages: 350-367
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Publication
28676401 | J:271486
First Author: Yu Y
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Hv1 proton channel facilitates production of ROS and pro-inflammatory cytokines in microglia and enhances oligodendrocyte progenitor cells damage from oxygen-glucose deprivation in vitro.
Volume: 498
Issue: 1
Pages: 1-8
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Publication
33404063 | J:332697
First Author: Kawai T
Year: 2021
Journal: J Neurochem
Title: Heterogeneity of microglial proton channel in different brain regions and its relationship with aging.
Volume: 157
Issue: 3
Pages: 624-641
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Publication
28961043 | J:279635
First Author: Kawai T
Year: 2018
Journal: Channels (Austin)
Title: Mechanistic insight into the suppression of microglial ROS production by voltage-gated proton channels (VSOP/Hv1).
Volume: 12
Issue: 1
Pages: 1-8
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Publication
18583477 | J:248283
First Author: Koch HP
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Multimeric nature of voltage-gated proton channels.
Volume: 105
Issue: 26
Pages: 9111-6
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Publication
17948262 | J:126332
First Author: Suenaga T
Year: 2007
Journal: Eur J Immunol
Title: Cloning of B cell-specific membrane tetraspanning molecule BTS possessing B cell proliferation-inhibitory function.
Volume: 37
Issue: 11
Pages: 3197-207
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Publication
24140009 | J:210046
First Author: Kurokawa T
Year: 2014
Journal: Biochim Biophys Acta
Title: Mapping of sites facing aqueous environment of voltage-gated proton channel at resting state: a study with PEGylation protection.
Volume: 1838
Issue: 1 Pt B
Pages: 382-7
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Publication
22487729 | J:344997
First Author: Song JH
Year: 2012
Journal: Neurosci Lett
Title: Dextromethorphan inhibition of voltage-gated proton currents in BV2 microglial cells.
Volume: 516
Issue: 1
Pages: 94-8
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GXD Expression
GXD Expression
   
Probe: MGI:4461903
Assay Type: RNA in situ
Annotation Date: 2010-07-27
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1616415
Stage: TS15
Assay Id: MGI:4462046
Age: embryonic day 9.5
Image: S3A antisense
Specimen Label: S3A antisense
Detected: false
Specimen Num: 1
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Publication
26173779 | J:226078
First Author: Liu J
Year: 2015
Journal: J Neurochem
Title: Microglial Hv1 proton channel promotes cuprizone-induced demyelination through oxidative damage.
Volume: 135
Issue: 2
Pages: 347-56
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Publication
30967259 | J:290755
First Author: Wang X
Year: 2019
Journal: Biochem Biophys Res Commun
Title: Hv1-deficiency protects β cells from glucotoxicity through regulation of NOX4 level.
Volume: 513
Issue: 2
Pages: 434-438
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Publication
22157818 | J:181760
First Author: Rybicka JM
Year: 2012
Journal: EMBO J
Title: Phagosomal proteolysis in dendritic cells is modulated by NADPH oxidase in a pH-independent manner.
Volume: 31
Issue: 4
Pages: 932-44
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Publication
22388960 | J:191259
First Author: Wu LJ
Year: 2012
Journal: Nat Neurosci
Title: The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke.
Volume: 15
Issue: 4
Pages: 565-73
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Publication
33081841 | J:344757
First Author: Murugan M
Year: 2020
Journal: Mol Brain
Title: The voltage-gated proton channel Hv1 contributes to neuronal injury and motor deficits in a mouse model of spinal cord injury.
Volume: 13
Issue: 1
Pages: 143
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Publication
33336163 | J:305294
First Author: Er-Lukowiak M
Year: 2020
Journal: iScience
Title: A P2rx7 Passenger Mutation Affects the Vitality and Function of T cells in Congenic Mice.
Volume: 23
Issue: 12
Pages: 101870
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Publication
16357211 | J:103820
First Author: Reiter JF
Year: 2006
Journal: Genes Dev
Title: Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition.
Volume: 20
Issue: 1
Pages: 22-7
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:155856
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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