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Search results 1 to 46 out of 46 for Ick

0.021s

Type

Details

Score

Gene

421896 | ICK

Type:	gene
Organism:	chicken

•

Protein

D3YZV1

Organism:	Mus musculus/domesticus
Length:	28
Fragment?:	true

•

Protein

Q3UZZ3

Organism:	Mus musculus/domesticus
Length:	539
Fragment?:	false

•

Protein

Q9D7Q7

Organism:	Mus musculus/domesticus
Length:	100
Fragment?:	false

•

Protein

Q3V314

Organism:	Mus musculus/domesticus
Length:	416
Fragment?:	true

•

Protein

Q3U4K6

Organism:	Mus musculus/domesticus
Length:	629
Fragment?:	false

•

Publication

24797473 | J:211665

First Author:	Chaya T
Year:	2014
Journal:	EMBO J
Title:	ICK is essential for cell type-specific ciliogenesis and the regulation of ciliary transport.
Volume:	33
Issue:	11
Pages:	1227-42

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Protein

Q9JKV2

Organism:	Mus musculus/domesticus
Length:	629
Fragment?:	false

•

Protein

Q69ZV0

Organism:	Mus musculus/domesticus
Length:	503
Fragment?:	true

•

Ontology Term

- | Knottin

•

UniProt Feature

Begin:	1
Description:	Serine/threonine-protein kinase ICK
Type:	chain
End:	629

•

Publication

25243405 | J:233668

First Author:	Broekhuis JR
Year:	2014
Journal:	PLoS One
Title:	Regulation of cilium length and intraflagellar transport by the RCK-kinases ICK and MOK in renal epithelial cells.
Volume:	9
Issue:	9
Pages:	e108470

•

Publication

27069622 | J:258310

First Author:	Oud MM
Year:	2016
Journal:	Cilia
Title:	A novel ICK mutation causes ciliary disruption and lethal endocrine-cerebro-osteodysplasia syndrome.
Volume:	5

Pages:	8

•

Publication

24853502 | J:211652

First Author:	Moon H
Year:	2014
Journal:	Proc Natl Acad Sci U S A
Title:	Intestinal cell kinase, a protein associated with endocrine-cerebro-osteodysplasia syndrome, is a key regulator of cilia length and Hedgehog signaling.
Volume:	111
Issue:	23
Pages:	8541-6

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Publication

29539279 | J:309178

First Author:	Bailey JN
Year:	2018
Journal:	N Engl J Med
Title:	Variant Intestinal-Cell Kinase in Juvenile Myoclonic Epilepsy.
Volume:	378
Issue:	11
Pages:	1018-1028

•

Publication

28115485 | J:239604

First Author:	Okamoto S
Year:	2017
Journal:	J Neurosci
Title:	Ick Ciliary Kinase Is Essential for Planar Cell Polarity Formation in Inner Ear Hair Cells and Hearing Function.
Volume:	37
Issue:	8
Pages:	2073-2085

•

Publication

10699974 | J:60781

First Author:	Togawa K
Year:	2000
Journal:	J Cell Physiol
Title:	Intestinal cell kinase (ICK) localizes to the crypt region and requires a dual phosphorylation site found in map kinases.
Volume:	183
Issue:	1
Pages:	129-39

•

Publication

15988018 | -

First Author:	Fu Z
Year:	2005
Journal:	Mol Cell Biol
Title:	Activation of a nuclear Cdc2-related kinase within a mitogen-activated protein kinase-like TDY motif by autophosphorylation and cyclin-dependent protein kinase-activating kinase.
Volume:	25
Issue:	14
Pages:	6047-64

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DO Term

DOID:0111325 | juvenile myoclonic epilepsy 10

•

Publication

33406803 | -

First Author:	Korolkova Y
Year:	2021
Journal:	Toxins (Basel)
Title:	New Insectotoxin from Tibellus Oblongus Spider Venom Presents Novel Adaptation of ICK Fold.
Volume:	13
Issue:	1

•

Gene

22858 | CILK1

Type:	gene
Organism:	human

•

Protein Coding Gene

MGI:1934157 | Cilk1

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Publication

15066414 | -

First Author:	Liang S
Year:	2004
Journal:	Toxicon
Title:	An overview of peptide toxins from the venom of the Chinese bird spider Selenocosmia huwena Wang [=Ornithoctonus huwena (Wang)].
Volume:	43
Issue:	5
Pages:	575-85

•

Protein Domain

IPR012625 | Toxin_20

Type:	Family
Description:	This entry consists of the huwentoxin-II (HWTX-II) family of toxins secreted by spiders. These toxins are found in venom that secreted from the bird spider Selenocosmia huwena Wang. The HWTX-II adopts a novel scaffold different from the ICK motif that is found in other huwentoxins. HWTX-II consists of 37 amino acids residues including six cysteines involved in three disulphide bridges [].

•

Publication

18606178 | -

First Author:	Villegas E
Year:	2008
Journal:	Toxicon
Title:	Biochemical characterization of cysteine-rich peptides from Oxyopes sp. venom that block calcium ion channels.
Volume:	52
Issue:	2
Pages:	228-36

•

Publication

27997708 | -

First Author:	Nadezhdin KD
Year:	2017
Journal:	Protein Sci
Title:	Modular toxin from the lynx spider Oxyopes takobius: Structure of spiderine domains in solution and membrane-mimicking environment.
Volume:	26
Issue:	3
Pages:	611-616

•

Publication

24462682 | -

First Author:	Sachkova MY
Year:	2014
Journal:	FEBS Lett
Title:	Genes and evolution of two-domain toxins from lynx spider venom.
Volume:	588
Issue:	5
Pages:	740-5

•

Publication

24118933 | -

First Author:	Vassilevski AA
Year:	2013
Journal:	FEBS J
Title:	Spider toxins comprising disulfide-rich and linear amphipathic domains: a new class of molecules identified in the lynx spider Oxyopes takobius.
Volume:	280
Issue:	23
Pages:	6247-61

•

Protein Domain

IPR044061 | OXYTX_ICK

Type:

Domain

Description:

Spiders are widely acknowledged to produce potent and selective toxins. In addition to the conventional neurotoxins and cytotoxins, venom of lynx spiders (genus Oxyopes) was found to contain two-domain modular toxins named spiderines: OspTx1a, 1b, 2a and 2b [, , ]. Spiderines consist of two distinct modules separated by a short linker. The N-terminal part (~40 residues) contains no cysteine residues, is highly cationic, forms amphipathic alpha- helical structures in a membrane-mimicking environment, and shows potent cytolytic effects on cells of various origins. The short linker resembles closely the processing quadruplet motif (PQM), which is known to indicate the processing cleavage site in precursors of spider toxins and separate the prosequence from the mature chain. The C-terminal part (~60 residues) is a disulfide rich domain reticulated by five S-S bridges that is homologous to one-domain oxytoxins (OxyTx1 and OxyTx2) from Oxypes species. Oxytoxins are disulphide-rich polypeptides that contain five disulfide bridges and block L-, N- and P/Q-type voltage-sensitive calcium ion channels (VSCCs) []. The core of the oxytoxin-like domain is the inhibitor cystine knot (ICK) or knottin motif. The domain is stabilised by five disulfides and 13 hydrogen bonds. Two antiparallel β-strands form a short β-sheet, and there are two β-turns in the N-terminal part of of the domain. C1-C5, C2-C6, and C4-C9 disulfides contribute to the ICK motif, whereas C7-C8 stabilises the extended loop of the β-hairpin and C3-C10 staples the lengthy C-terminal of the domain to its core [].This entry represents the oxytoxin-type ICK domain.

•

Publication

27466187 | J:238577

First Author:	Paige Taylor S
Year:	2016
Journal:	Hum Mol Genet
Title:	An inactivating mutation in intestinal cell kinase, ICK, impairs hedgehog signalling and causes short rib-polydactyly syndrome.
Volume:	25
Issue:	18
Pages:	3998-4011

•

Publication

30782830 | J:274025

First Author:	Kunova Bosakova M
Year:	2019
Journal:	Proc Natl Acad Sci U S A
Title:	Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase.

•

Publication

28380258 | J:309653

First Author:	Tong Y
Year:	2017
Journal:	FEBS Lett
Title:	An essential role of intestinal cell kinase in lung development is linked to the perinatal lethality of human ECO syndrome.
Volume:	591
Issue:	9
Pages:	1247-1257

•

Publication

25014760 | -

First Author:	Bende NS
Year:	2014
Journal:	Nat Commun
Title:	A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a.
Volume:	5

Pages:	4350

•

Protein Domain

IPR035290 | Beta/Mu-DGTX-Dc1

Type:

Family

Description:

This family members are 56-59 residue mu-diguetoxin-1 and beta-diguetoxin-1 toxins, which have been isolated from the weaving spider, Diguetia canities. These toxins were isolated as a result of their potent insect paralytic activities, and designated beta-DGTX-Dc1a, mu-DGTX-Dc1b and mu-DGTX-Dc1c (formerly DTX9.2, DTX11 and DTX12) []. Diguetoxin-Dc1a (Dc1a) has been structurally characterised and shown to have disulfide bonds which form a classical inhibitor cysteine knot (ICK) motif in which the Cys13-Cys26 and Cys20-Cys40 disulfide bonds and the intervening sections of the polypeptide backbone form a 23-residue ring that is pierced by the Cys25-Cys54 disulfide bond. This ICK motif is commonly found in spider toxins, and this particular scaffold provides these peptides (so-called knottins) with an unusually high degree of chemical, thermal and biological stability. Dc1a contains an additional disulfide bond (Cys42-Cys52) that appears to serve as a molecular staple which limits the flexibility of a disordered serine-rich hairpin loop. The extended N terminus of Dc1a along with an unusually large loop between Cys26 and Cys40 enables the formation of an N-terminal three-stranded antiparallel β-sheet that is not found in any other knottin. The molecular surface of Dc1a contains a relatively uniform distribution of charged residues; moreover, there are no distinct clusters of hydrophobic residues that might mediate an interaction with lipid bilayers [].

•

Publication

29098359 | J:309376

First Author:	Ding M
Year:	2018
Journal:	Calcif Tissue Int
Title:	A Murine Model for Human ECO Syndrome Reveals a Critical Role of Intestinal Cell Kinase in Skeletal Development.
Volume:	102
Issue:	3
Pages:	348-357

•

Publication

25184386 | J:221534

First Author:	Bolick DT
Year:	2014
Journal:	PLoS One
Title:	Intestinal cell kinase is a novel participant in intestinal cell signaling responses to protein malnutrition.
Volume:	9
Issue:	9
Pages:	e106902

•

Publication

22741062 | -

First Author:	Windley MJ
Year:	2012
Journal:	Toxins (Basel)
Title:	Spider-venom peptides as bioinsecticides.
Volume:	4
Issue:	3
Pages:	191-227

•

Publication

12466851 | J:80000

First Author:	Okazaki Y
Year:	2002
Journal:	Nature
Title:	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume:	420
Issue:	6915
Pages:	563-73

•

Publication

11217851 | J:65060

First Author:	Kawai J
Year:	2001
Journal:	Nature
Title:	Functional annotation of a full-length mouse cDNA collection.
Volume:	409
Issue:	6821
Pages:	685-90

•

Publication

11042159 | J:68323

First Author:	Carninci P
Year:	2000
Journal:	Genome Res
Title:	Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Volume:	10
Issue:	10
Pages:	1617-30

•

Publication

10349636 | J:80645

First Author:	Carninci P
Year:	1999
Journal:	Methods Enzymol
Title:	High-efficiency full-length cDNA cloning.
Volume:	303

Pages:	19-44

•

Publication

11076861 | J:68324

First Author:	Shibata K
Year:	2000
Journal:	Genome Res
Title:	RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Volume:	10
Issue:	11
Pages:	1757-71

•

Publication

16141073 | -

First Author:	Katayama S
Year:	2005
Journal:	Science
Title:	Antisense transcription in the mammalian transcriptome.
Volume:	309
Issue:	5740
Pages:	1564-6

•

Publication

15489334 | -

First Author:	Gerhard DS
Year:	2004
Journal:	Genome Res
Title:	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume:	14
Issue:	10B
Pages:	2121-7

•

Publication

21183079 | J:292518

First Author:	Huttlin EL
Year:	2010
Journal:	Cell
Title:	A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume:	143
Issue:	7
Pages:	1174-89

•

Publication

19468303 | -

First Author:	Church DM
Year:	2009
Journal:	PLoS Biol
Title:	Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume:	7
Issue:	5
Pages:	e1000112

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