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Search results 1 to 100 out of 633 for Icos

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Categories

Hits by Pathway

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Hits by Strain

Type Details Score
Gene
29851 | ICOS
Type: gene
Organism: human
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Gene
100493997 | icos
Type: gene
Organism: frog, western clawed
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Gene
403456 | ICOS
Type: gene
Organism: dog, domestic
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Gene
747295 | ICOS
Type: gene
Organism: chimpanzee
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Gene
64545 | Icos
Type: gene
Organism: rat
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Gene
507026 | ICOS
Type: gene
Organism: cattle
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Gene
424105 | ICOS
Type: gene
Organism: chicken
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Gene
705788 | ICOS
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1858745 | Icos
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR039943 | ICOS
Type: Family
Description: ICOS is an inducible T-cell co-stimulator with homology to CD28 []. CD28 and ICOS function similarly during expansion, survival and differentiation of T cells. They are necessary for proper IgG responses. However, CD28 induces IL-2 production, while ICOS is more potent in the induction of IL-10 production [].
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Publication
11343123 | J:66702
First Author: Tafuri A
Year: 2001
Journal: Nature
Title: ICOS is essential for effective T-helper-cell responses.
Volume: 409
Issue: 6816
Pages: 105-9
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Gene
102723996 | LOC102723996
Type: gene
Organism: human
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Publication
10657606 | J:60318
First Author: Ling V
Year: 2000
Journal: J Immunol
Title: Cutting edge: identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor.
Volume: 164
Issue: 4
Pages: 1653-7
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Publication
18178815 | J:130966
First Author: Burmeister Y
Year: 2008
Journal: J Immunol
Title: ICOS controls the pool size of effector-memory and regulatory T cells.
Volume: 180
Issue: 2
Pages: 774-82
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Publication
21925472 | J:177367
First Author: Maeda S
Year: 2011
Journal: Am J Pathol
Title: Inducible costimulator (ICOS) and ICOS ligand signaling has pivotal roles in skin wound healing via cytokine production.
Volume: 179
Issue: 5
Pages: 2360-9
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Publication
11343122 | J:87124
First Author: McAdam AJ
Year: 2001
Journal: Nature
Title: ICOS is critical for CD40-mediated antibody class switching.
Volume: 409
Issue: 6816
Pages: 102-5
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Publication
28002569 | J:254593
First Author: Kunishige T
Year: 2016
Journal: Invest Ophthalmol Vis Sci
Title: Protective Role of ICOS and ICOS Ligand in Corneal Transplantation and in Maintenance of Immune Privilege.
Volume: 57
Issue: 15
Pages: 6815-6823
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Publication
34932944 | J:321767
First Author: Peng C
Year: 2022
Journal: Immunity
Title: Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8+ tissue-resident memory T cells.
Volume: 55
Issue: 1
Pages: 98-114.e5
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Publication
21364749 | J:171076
First Author: Moore TV
Year: 2011
Journal: PLoS One
Title: Protective effector memory CD4 T cells depend on ICOS for survival.
Volume: 6
Issue: 2
Pages: e16529
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Publication
18390703 | J:134245
First Author: Watanabe M
Year: 2008
Journal: J Immunol
Title: Down-regulation of ICOS ligand by interaction with ICOS functions as a regulatory mechanism for immune responses.
Volume: 180
Issue: 8
Pages: 5222-34
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Publication
26249010 | J:233095
First Author: Paclik D
Year: 2015
Journal: Eur J Immunol
Title: ICOS regulates the pool of group 2 innate lymphoid cells under homeostatic and inflammatory conditions in mice.
Volume: 45
Issue: 10
Pages: 2766-72
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Publication
21636296 | J:174012
First Author: Choi YS
Year: 2011
Journal: Immunity
Title: ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6.
Volume: 34
Issue: 6
Pages: 932-46
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Publication
10760791 | J:61649
First Author: Mages HW
Year: 2000
Journal: Eur J Immunol
Title: Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS ligand.
Volume: 30
Issue: 4
Pages: 1040-7
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Publication
15629449 | J:95353
First Author: Kaneda H
Year: 2005
Journal: Biochem Biophys Res Commun
Title: ICOS costimulates invariant NKT cell activation.
Volume: 327
Issue: 1
Pages: 201-7
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Protein
Q9WVS0
Organism: Mus musculus/domesticus
Length: 200  
Fragment?: false
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Publication
16580736 | -
First Author: van Berkel ME
Year: 2006
Journal: Immunol Lett
Title: CD28 and ICOS: similar or separate costimulators of T cells?
Volume: 105
Issue: 2
Pages: 115-22
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Publication
30523347 | J:322112
First Author: Wan Z
Year: 2020
Journal: Cell Mol Immunol
Title: Transmembrane domain-mediated Lck association underlies bystander and costimulatory ICOS signaling.
Volume: 17
Issue: 2
Pages: 143-152
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Publication
16081804 | J:107507
First Author: Akiba H
Year: 2005
Journal: J Immunol
Title: The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo.
Volume: 175
Issue: 4
Pages: 2340-8
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Publication
15728513 | J:97721
First Author: Gajewska BU
Year: 2005
Journal: J Immunol
Title: B7RP-1 is not required for the generation of Th2 responses in a model of allergic airway inflammation but is essential for the induction of inhalation tolerance.
Volume: 174
Issue: 5
Pages: 3000-5
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Publication
11343121 | J:87123
First Author: Dong C
Year: 2001
Journal: Nature
Title: ICOS co-stimulatory receptor is essential for T-cell activation and function.
Volume: 409
Issue: 6816
Pages: 97-101
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Publication
18988696 | J:145192
First Author: Lu H
Year: 2009
Journal: J Leukoc Biol
Title: Suppression of T cell costimulator ICOS by Delta9-tetrahydrocannabinol.
Volume: 85
Issue: 2
Pages: 322-9
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Publication
29581356 | J:261486
First Author: Panneton V
Year: 2018
Journal: J Immunol
Title: ICOS Signaling Controls Induction and Maintenance of Collagen-Induced Arthritis.
Volume: 200
Issue: 9
Pages: 3067-3076
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Publication
35806368 | J:337610
 
First Author: Stoppa I
Year: 2022
Journal: Int J Mol Sci
Title: ICOSL Stimulation by ICOS-Fc Accelerates Cutaneous Wound Healing In Vivo.
Volume: 23
Issue: 13
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Publication
20544729 | J:165756
First Author: Prevot N
Year: 2010
Journal: Eur J Immunol
Title: Abrogation of ICOS/ICOS ligand costimulation in NOD mice results in autoimmune deviation toward the neuromuscular system.
Volume: 40
Issue: 8
Pages: 2267-76
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Publication
34925367 | J:337622
 
First Author: Ramavath NN
Year: 2021
Journal: Front Immunol
Title: Inducible T-Cell Costimulator Mediates Lymphocyte/Macrophage Interactions During Liver Repair.
Volume: 12
Pages: 786680
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Publication
12432568 | J:80851
First Author: Bertram EM
Year: 2002
Journal: Eur J Immunol
Title: Role of ICOS versus CD28 in antiviral immunity.
Volume: 32
Issue: 12
Pages: 3376-85
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Publication
15972646 | J:100564
First Author: van Berkel ME
Year: 2005
Journal: J Immunol
Title: ICOS contributes to T cell expansion in CTLA-4 deficient mice.
Volume: 175
Issue: 1
Pages: 182-8
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Publication
18292537 | J:131529
First Author: Hawiger D
Year: 2008
Journal: J Immunol
Title: ICOS mediates the development of insulin-dependent diabetes mellitus in nonobese diabetic mice.
Volume: 180
Issue: 5
Pages: 3140-7
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Publication
27296665 | J:329789
First Author: Mittereder N
Year: 2016
Journal: J Immunol
Title: Loss of Immune Tolerance Is Controlled by ICOS in Sle1 Mice.
Volume: 197
Issue: 2
Pages: 491-503
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Publication
22661090 | J:188938
First Author: Lischke T
Year: 2012
Journal: J Immunol
Title: Comprehensive analysis of CD4+ T cells in the decision between tolerance and immunity in vivo reveals a pivotal role for ICOS.
Volume: 189
Issue: 1
Pages: 234-44
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Publication
14615582 | J:86697
First Author: Nurieva RI
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: B7h is required for T cell activation, differentiation, and effector function.
Volume: 100
Issue: 24
Pages: 14163-8
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Publication
31283790 | J:277248
First Author: Montes-Casado M
Year: 2019
Journal: PLoS One
Title: ICOS deficiency hampers the homeostasis, development and function of NK cells.
Volume: 14
Issue: 7
Pages: e0219449
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Publication
25692700 | J:259421
First Author: Stone EL
Year: 2015
Journal: Immunity
Title: ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation.
Volume: 42
Issue: 2
Pages: 239-251
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Publication
16982935 | J:139302
First Author: Bossaller L
Year: 2006
Journal: J Immunol
Title: ICOS deficiency is associated with a severe reduction of CXCR5+CD4 germinal center Th cells.
Volume: 177
Issue: 7
Pages: 4927-32
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Publication
17039567 | J:116989
First Author: Humphreys IR
Year: 2006
Journal: Eur J Immunol
Title: A critical role for ICOS co-stimulation in immune containment of pulmonary influenza virus infection.
Volume: 36
Issue: 11
Pages: 2928-38
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Publication
21402623 | J:172077
First Author: Kadkhoda K
Year: 2011
Journal: Int Immunol
Title: ICOS ligand expression is essential for allergic airway hyperresponsiveness.
Volume: 23
Issue: 4
Pages: 239-49
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Publication
19889730 | J:157120
First Author: Schaefer JS
Year: 2010
Journal: J Leukoc Biol
Title: ICOS promotes IL-17 synthesis in colonic intraepithelial lymphocytes in IL-10-/- mice.
Volume: 87
Issue: 2
Pages: 301-8
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Publication
22815292 | J:189731
First Author: Busse M
Year: 2012
Journal: J Immunol
Title: ICOS mediates the generation and function of CD4+CD25+Foxp3+ regulatory T cells conveying respiratory tolerance.
Volume: 189
Issue: 4
Pages: 1975-82
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Publication
23319295 | J:193831
First Author: Redpath SA
Year: 2013
Journal: Eur J Immunol
Title: ICOS controls Foxp3(+) regulatory T-cell expansion, maintenance and IL-10 production during helminth infection.
Volume: 43
Issue: 3
Pages: 705-15
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Publication
29676593 | J:319299
First Author: Van DV
Year: 2018
Journal: Am J Respir Cell Mol Biol
Title: ICOS Costimulation Differentially Affects T Cells in Secondary Lymphoid Organs and Inflamed Tissues.
Volume: 59
Issue: 4
Pages: 437-447
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Publication
31978191 | J:284045
First Author: O'Brien CA
Year: 2020
Journal: PLoS One
Title: ICOS-deficient and ICOS YF mutant mice fail to control Toxoplasma gondii infection of the brain.
Volume: 15
Issue: 1
Pages: e0228251
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Publication
16301640 | J:122137
First Author: Miyamoto K
Year: 2005
Journal: J Immunol
Title: The ICOS molecule plays a crucial role in the development of mucosal tolerance.
Volume: 175
Issue: 11
Pages: 7341-7
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Publication
29352114 | J:258592
First Author: Rehage N
Year: 2018
Journal: Nat Commun
Title: Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA.
Volume: 9
Issue: 1
Pages: 299
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Publication
27235509 | J:321320
First Author: Buus TB
Year: 2016
Journal: Oncotarget
Title: Development of interleukin-17-producing Vγ2+ γδ T cells is reduced by ICOS signaling in the thymus.
Volume: 7
Issue: 15
Pages: 19341-54
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Publication
19646680 | J:152804
First Author: Shilling RA
Year: 2009
Journal: Cell Immunol
Title: CD28 and ICOS play complementary non-overlapping roles in the development of Th2 immunity in vivo.
Volume: 259
Issue: 2
Pages: 177-84
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Protein
Q3V3X2
Organism: Mus musculus/domesticus
Length: 200  
Fragment?: false
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Protein
Q5SUZ7
Organism: Mus musculus/domesticus
Length: 200  
Fragment?: false
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Protein
A2A6A6
Organism: Mus musculus/domesticus
Length: 223  
Fragment?: false
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Protein
Q5SUZ8
Organism: Mus musculus/domesticus
Length: 223  
Fragment?: false
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Protein
D0E8G6
Organism: Mus musculus/domesticus
Length: 200  
Fragment?: false
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Protein
A2A6A7
Organism: Mus musculus/domesticus
Length: 200  
Fragment?: false
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Publication
33881452 | J:321725
 
First Author: Mittelsteadt KL
Year: 2021
Journal: J Exp Med
Title: ICOS signaling limits regulatory T cell accumulation and function in visceral adipose tissue.
Volume: 218
Issue: 6
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Publication
19249753 | J:148551
First Author: Wong SC
Year: 2009
Journal: Cell Immunol
Title: Functional hierarchy and relative contribution of the CD28/B7 and ICOS/B7-H2 costimulatory pathways to T cell-mediated delayed-type hypersensitivity.
Volume: 256
Issue: 1-2
Pages: 64-71
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Publication
25918344 | J:222784
First Author: Moguche AO
Year: 2015
Journal: J Exp Med
Title: ICOS and Bcl6-dependent pathways maintain a CD4 T cell population with memory-like properties during tuberculosis.
Volume: 212
Issue: 5
Pages: 715-28
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Publication
30718297 | J:273123
First Author: O'Brien CA
Year: 2019
Journal: J Immunol
Title: IL-10 and ICOS Differentially Regulate T Cell Responses in the Brain during Chronic Toxoplasma gondii Infection.
Volume: 202
Issue: 6
Pages: 1755-1766
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Publication
31413107 | J:279280
First Author: Wong KA
Year: 2019
Journal: J Immunol
Title: T Cell-Intrinsic IL-6R Signaling Is Required for Optimal ICOS Expression and Viral Control during Chronic Infection.
Volume: 203
Issue: 6
Pages: 1509-1520
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Publication
16751384 | J:132339
First Author: Yu XZ
Year: 2006
Journal: J Immunol
Title: Opposing effects of ICOS on graft-versus-host disease mediated by CD4 and CD8 T cells.
Volume: 176
Issue: 12
Pages: 7394-401
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Publication
19888475 | J:155428
First Author: Clay BS
Year: 2009
Journal: PLoS One
Title: Inducible costimulator expression regulates the magnitude of Th2-mediated airway inflammation by regulating the number of Th2 cells.
Volume: 4
Issue: 11
Pages: e7525
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Publication
17549732 | J:123477
First Author: Mahajan S
Year: 2007
Journal: Eur J Immunol
Title: The role of ICOS in the development of CD4 T cell help and the reactivation of memory T cells.
Volume: 37
Issue: 7
Pages: 1796-808
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Publication
26667167 | J:251019
First Author: Wikenheiser DJ
Year: 2016
Journal: J Immunol
Title: The Costimulatory Molecule ICOS Regulates Host Th1 and Follicular Th Cell Differentiation in Response to Plasmodium chabaudi chabaudi AS Infection.
Volume: 196
Issue: 2
Pages: 778-91
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Publication
25754933 | J:229713
First Author: Marriott CL
Year: 2015
Journal: Eur J Immunol
Title: ICOS is required for the generation of both central and effector CD4(+) memory T-cell populations following acute bacterial infection.
Volume: 45
Issue: 6
Pages: 1706-15
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Publication
25646266 | J:326351
First Author: Weber JP
Year: 2015
Journal: J Exp Med
Title: ICOS maintains the T follicular helper cell phenotype by down-regulating Krüppel-like factor 2.
Volume: 212
Issue: 2
Pages: 217-33
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Publication
18606653 | J:137473
First Author: Tesciuba AG
Year: 2008
Journal: J Immunol
Title: ICOS costimulation expands Th2 immunity by augmenting migration of lymphocytes to draining lymph nodes.
Volume: 181
Issue: 2
Pages: 1019-24
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Publication
23583643 | J:196136
First Author: Vogel KU
Year: 2013
Journal: Immunity
Title: Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation.
Volume: 38
Issue: 4
Pages: 655-68
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Publication
22585681 | J:187767
First Author: Watanabe M
Year: 2012
Journal: Eur J Immunol
Title: AP-1 is involved in ICOS gene expression downstream of TCR/CD28 and cytokine receptor signaling.
Volume: 42
Issue: 7
Pages: 1850-62
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Publication
36119089 | J:336977
 
First Author: Alves GF
Year: 2022
Journal: Front Immunol
Title: ICOS-Fc as innovative immunomodulatory approach to counteract inflammation and organ injury in sepsis.
Volume: 13
Pages: 992614
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Publication
16301634 | J:122143
First Author: Vidric M
Year: 2005
Journal: J Immunol
Title: Cooperation between 4-1BB and ICOS in the immune response to influenza virus revealed by studies of CD28/ICOS-deficient mice.
Volume: 175
Issue: 11
Pages: 7288-96
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Publication
18390727 | J:134254
First Author: Akbari O
Year: 2008
Journal: J Immunol
Title: ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survival.
Volume: 180
Issue: 8
Pages: 5448-56
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Publication
27135603 | J:257322
First Author: Pedros C
Year: 2016
Journal: Nat Immunol
Title: A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1.
Volume: 17
Issue: 7
Pages: 825-33
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Publication
19299705 | J:147130
First Author: Odegard JM
Year: 2009
Journal: J Immunol
Title: ICOS controls effector function but not trafficking receptor expression of kidney-infiltrating effector T cells in murine lupus.
Volume: 182
Issue: 7
Pages: 4076-84
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Publication
25436971 | J:222609
First Author: Leavenworth JW
Year: 2015
Journal: Nat Immunol
Title: A p85α-osteopontin axis couples the receptor ICOS to sustained Bcl-6 expression by follicular helper and regulatory T cells.
Volume: 16
Issue: 1
Pages: 96-106
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Publication
22154192 | J:181372
First Author: Nie X
Year: 2012
Journal: Clin Immunol
Title: Lipopolysaccharide mediated mast cells induce IL-10 producing regulatory T cells through the ICOSL/ICOS axis.
Volume: 142
Issue: 3
Pages: 269-79
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Publication
21421907 | J:190213
First Author: Moore TV
Year: 2011
Journal: Am J Respir Cell Mol Biol
Title: Inducible costimulator controls migration of T cells to the lungs via down-regulation of CCR7 and CD62L.
Volume: 45
Issue: 4
Pages: 843-50
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Publication
20190137 | J:160088
First Author: Kadkhoda K
Year: 2010
Journal: J Immunol
Title: Th1 cytokine responses fail to effectively control Chlamydia lung infection in ICOS ligand knockout mice.
Volume: 184
Issue: 7
Pages: 3780-8
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Publication
22231701 | J:181206
First Author: Chen Y
Year: 2012
Journal: J Immunol
Title: Murine regulatory T cells contain hyperproliferative and death-prone subsets with differential ICOS expression.
Volume: 188
Issue: 4
Pages: 1698-707
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Publication
11735222 | J:73271
First Author: Ling V
Year: 2001
Journal: Genomics
Title: Assembly and annotation of human chromosome 2q33 sequence containing the CD28, CTLA4, and ICOS gene cluster: analysis by computational, comparative, and microarray approaches.
Volume: 78
Issue: 3
Pages: 155-68
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Publication
19098919 | J:144526
First Author: Bauquet AT
Year: 2009
Journal: Nat Immunol
Title: The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells.
Volume: 10
Issue: 2
Pages: 167-75
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Publication
19570826 | J:151633
First Author: Pot C
Year: 2009
Journal: J Immunol
Title: Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells.
Volume: 183
Issue: 2
Pages: 797-801
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Publication
19217324 | J:146622
First Author: Linterman MA
Year: 2009
Journal: Immunity
Title: Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS.
Volume: 30
Issue: 2
Pages: 228-41
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Publication
30076099 | J:299413
First Author: Shi J
Year: 2018
Journal: Immunity
Title: PD-1 Controls Follicular T Helper Cell Positioning and Function.
Volume: 49
Issue: 2
Pages: 264-274.e4
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Publication
30642977 | J:272885
First Author: Landuyt AE
Year: 2019
Journal: J Immunol
Title: Cutting Edge: ICOS-Deficient Regulatory T Cells Display Normal Induction of Il10 but Readily Downregulate Expression of Foxp3.
Volume: 202
Issue: 4
Pages: 1039-1044
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Publication
17039566 | J:116990
First Author: Usui Y
Year: 2006
Journal: Eur J Immunol
Title: The role of the ICOS/B7RP-1 T cell costimulatory pathway in murine experimental autoimmune uveoretinitis.
Volume: 36
Issue: 11
Pages: 3071-81
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Publication
16724117 | J:109521
First Author: Nurieva R
Year: 2006
Journal: EMBO J
Title: T-cell tolerance or function is determined by combinatorial costimulatory signals.
Volume: 25
Issue: 11
Pages: 2623-33
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Publication
22949644 | J:190155
First Author: Ou X
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Deficiency in TNFRSF13B (TACI) expands T-follicular helper and germinal center B cells via increased ICOS-ligand expression but impairs plasma cell survival.
Volume: 109
Issue: 38
Pages: 15401-6
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Publication
11390480 | J:69871
First Author: Ling V
Year: 2001
Journal: J Immunol
Title: Differential expression of inducible costimulator-ligand splice variants: lymphoid regulation of mouse GL50-B and human GL50 molecules.
Volume: 166
Issue: 12
Pages: 7300-8
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Publication
28424681 | J:244985
 
First Author: Briet C
Year: 2017
Journal: Front Immunol
Title: The Spontaneous Autoimmune Neuromyopathy in ICOSL-/- NOD Mice Is CD4+ T-Cell and Interferon-γ Dependent.
Volume: 8
Pages: 287
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Publication
31466995 | J:295221
First Author: Shi LZ
Year: 2019
Journal: Cancer Immunol Res
Title: Blockade of CTLA-4 and PD-1 Enhances Adoptive T-cell Therapy Efficacy in an ICOS-Mediated Manner.
Volume: 7
Issue: 11
Pages: 1803-1812
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Publication
11429535 | J:114030
First Author: Sperling AI
Year: 2001
Journal: Nat Immunol
Title: ICOS costimulation: It's not just for TH2 cells anymore.
Volume: 2
Issue: 7
Pages: 573-4
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Publication
12853164 | J:95728
First Author: Iiyama R
Year: 2003
Journal: Immunol Lett
Title: The role of inducible co-stimulator (ICOS)/B7-related protein-1 (B7RP-1) interaction in the functional development of Peyer's patches.
Volume: 88
Issue: 1
Pages: 63-70
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Publication
11429542 | J:133504
First Author: Ozkaynak E
Year: 2001
Journal: Nat Immunol
Title: Importance of ICOS-B7RP-1 costimulation in acute and chronic allograft rejection.
Volume: 2
Issue: 7
Pages: 591-6
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