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Search results 1 to 100 out of 518 for Icos

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Domain
Type: Family
Description: ICOS is an inducible T-cell co-stimulator with homology to CD28 []. CD28 and ICOS function similarly during expansion, survival and differentiation of T cells. They are necessary for proper IgG responses. However, CD28 induces IL-2 production, while ICOS is more potent in the induction of IL-10 production [].
Publication
First Author: Tafuri A
Year: 2001
Journal: Nature
Title: ICOS is essential for effective T-helper-cell responses.
Volume: 409
Issue: 6816
Pages: 105-9
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Ling V
Year: 2000
Journal: J Immunol
Title: Cutting edge: identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor.
Volume: 164
Issue: 4
Pages: 1653-7
Publication
First Author: Burmeister Y
Year: 2008
Journal: J Immunol
Title: ICOS controls the pool size of effector-memory and regulatory T cells.
Volume: 180
Issue: 2
Pages: 774-82
Publication
First Author: Maeda S
Year: 2011
Journal: Am J Pathol
Title: Inducible costimulator (ICOS) and ICOS ligand signaling has pivotal roles in skin wound healing via cytokine production.
Volume: 179
Issue: 5
Pages: 2360-9
Publication
First Author: McAdam AJ
Year: 2001
Journal: Nature
Title: ICOS is critical for CD40-mediated antibody class switching.
Volume: 409
Issue: 6816
Pages: 102-5
Publication
First Author: Kunishige T
Year: 2016
Journal: Invest Ophthalmol Vis Sci
Title: Protective Role of ICOS and ICOS Ligand in Corneal Transplantation and in Maintenance of Immune Privilege.
Volume: 57
Issue: 15
Pages: 6815-6823
Publication
First Author: Moore TV
Year: 2011
Journal: PLoS One
Title: Protective effector memory CD4 T cells depend on ICOS for survival.
Volume: 6
Issue: 2
Pages: e16529
Publication
First Author: Watanabe M
Year: 2008
Journal: J Immunol
Title: Down-regulation of ICOS ligand by interaction with ICOS functions as a regulatory mechanism for immune responses.
Volume: 180
Issue: 8
Pages: 5222-34
Publication
First Author: Paclik D
Year: 2015
Journal: Eur J Immunol
Title: ICOS regulates the pool of group 2 innate lymphoid cells under homeostatic and inflammatory conditions in mice.
Volume: 45
Issue: 10
Pages: 2766-72
Publication
First Author: Choi YS
Year: 2011
Journal: Immunity
Title: ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6.
Volume: 34
Issue: 6
Pages: 932-46
Publication
First Author: Mages HW
Year: 2000
Journal: Eur J Immunol
Title: Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS ligand.
Volume: 30
Issue: 4
Pages: 1040-7
Publication
First Author: Kaneda H
Year: 2005
Journal: Biochem Biophys Res Commun
Title: ICOS costimulates invariant NKT cell activation.
Volume: 327
Issue: 1
Pages: 201-7
Publication
First Author: van Berkel ME
Year: 2006
Journal: Immunol Lett
Title: CD28 and ICOS: similar or separate costimulators of T cells?
Volume: 105
Issue: 2
Pages: 115-22
Publication
First Author: Gajewska BU
Year: 2005
Journal: J Immunol
Title: B7RP-1 is not required for the generation of Th2 responses in a model of allergic airway inflammation but is essential for the induction of inhalation tolerance.
Volume: 174
Issue: 5
Pages: 3000-5
Publication
First Author: Akiba H
Year: 2005
Journal: J Immunol
Title: The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo.
Volume: 175
Issue: 4
Pages: 2340-8
Publication
First Author: Dong C
Year: 2001
Journal: Nature
Title: ICOS co-stimulatory receptor is essential for T-cell activation and function.
Volume: 409
Issue: 6816
Pages: 97-101
Publication
First Author: Lu H
Year: 2009
Journal: J Leukoc Biol
Title: Suppression of T cell costimulator ICOS by Delta9-tetrahydrocannabinol.
Volume: 85
Issue: 2
Pages: 322-9
Publication
First Author: Panneton V
Year: 2018
Journal: J Immunol
Title: ICOS Signaling Controls Induction and Maintenance of Collagen-Induced Arthritis.
Volume: 200
Issue: 9
Pages: 3067-3076
Publication
First Author: Prevot N
Year: 2010
Journal: Eur J Immunol
Title: Abrogation of ICOS/ICOS ligand costimulation in NOD mice results in autoimmune deviation toward the neuromuscular system.
Volume: 40
Issue: 8
Pages: 2267-76
Publication
First Author: Bertram EM
Year: 2002
Journal: Eur J Immunol
Title: Role of ICOS versus CD28 in antiviral immunity.
Volume: 32
Issue: 12
Pages: 3376-85
Publication
First Author: van Berkel ME
Year: 2005
Journal: J Immunol
Title: ICOS contributes to T cell expansion in CTLA-4 deficient mice.
Volume: 175
Issue: 1
Pages: 182-8
Publication
First Author: Hawiger D
Year: 2008
Journal: J Immunol
Title: ICOS mediates the development of insulin-dependent diabetes mellitus in nonobese diabetic mice.
Volume: 180
Issue: 5
Pages: 3140-7
Publication
First Author: Lischke T
Year: 2012
Journal: J Immunol
Title: Comprehensive analysis of CD4+ T cells in the decision between tolerance and immunity in vivo reveals a pivotal role for ICOS.
Volume: 189
Issue: 1
Pages: 234-44
Publication
First Author: Nurieva RI
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: B7h is required for T cell activation, differentiation, and effector function.
Volume: 100
Issue: 24
Pages: 14163-8
Publication
First Author: Montes-Casado M
Year: 2019
Journal: PLoS One
Title: ICOS deficiency hampers the homeostasis, development and function of NK cells.
Volume: 14
Issue: 7
Pages: e0219449
Publication
First Author: Stone EL
Year: 2015
Journal: Immunity
Title: ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation.
Volume: 42
Issue: 2
Pages: 239-251
Publication
First Author: Kadkhoda K
Year: 2011
Journal: Int Immunol
Title: ICOS ligand expression is essential for allergic airway hyperresponsiveness.
Volume: 23
Issue: 4
Pages: 239-49
Publication
First Author: Bossaller L
Year: 2006
Journal: J Immunol
Title: ICOS deficiency is associated with a severe reduction of CXCR5+CD4 germinal center Th cells.
Volume: 177
Issue: 7
Pages: 4927-32
Publication
First Author: Humphreys IR
Year: 2006
Journal: Eur J Immunol
Title: A critical role for ICOS co-stimulation in immune containment of pulmonary influenza virus infection.
Volume: 36
Issue: 11
Pages: 2928-38
Publication
First Author: Schaefer JS
Year: 2010
Journal: J Leukoc Biol
Title: ICOS promotes IL-17 synthesis in colonic intraepithelial lymphocytes in IL-10-/- mice.
Volume: 87
Issue: 2
Pages: 301-8
Publication
First Author: Busse M
Year: 2012
Journal: J Immunol
Title: ICOS mediates the generation and function of CD4+CD25+Foxp3+ regulatory T cells conveying respiratory tolerance.
Volume: 189
Issue: 4
Pages: 1975-82
Publication
First Author: O'Brien CA
Year: 2020
Journal: PLoS One
Title: ICOS-deficient and ICOS YF mutant mice fail to control Toxoplasma gondii infection of the brain.
Volume: 15
Issue: 1
Pages: e0228251
Publication
First Author: Miyamoto K
Year: 2005
Journal: J Immunol
Title: The ICOS molecule plays a crucial role in the development of mucosal tolerance.
Volume: 175
Issue: 11
Pages: 7341-7
Publication
First Author: Redpath SA
Year: 2013
Journal: Eur J Immunol
Title: ICOS controls Foxp3(+) regulatory T-cell expansion, maintenance and IL-10 production during helminth infection.
Volume: 43
Issue: 3
Pages: 705-15
Publication
First Author: Rehage N
Year: 2018
Journal: Nat Commun
Title: Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA.
Volume: 9
Issue: 1
Pages: 299
Publication
First Author: Landuyt AE
Year: 2019
Journal: J Immunol
Title: Cutting Edge: ICOS-Deficient Regulatory T Cells Display Normal Induction of Il10 but Readily Downregulate Expression of Foxp3.
Volume: 202
Issue: 4
Pages: 1039-1044
Publication
First Author: Shilling RA
Year: 2009
Journal: Cell Immunol
Title: CD28 and ICOS play complementary non-overlapping roles in the development of Th2 immunity in vivo.
Volume: 259
Issue: 2
Pages: 177-84
Publication
First Author: Wong SC
Year: 2009
Journal: Cell Immunol
Title: Functional hierarchy and relative contribution of the CD28/B7 and ICOS/B7-H2 costimulatory pathways to T cell-mediated delayed-type hypersensitivity.
Volume: 256
Issue: 1-2
Pages: 64-71
Publication
First Author: Clay BS
Year: 2009
Journal: PLoS One
Title: Inducible costimulator expression regulates the magnitude of Th2-mediated airway inflammation by regulating the number of Th2 cells.
Volume: 4
Issue: 11
Pages: e7525
Publication
First Author: Tesciuba AG
Year: 2008
Journal: J Immunol
Title: ICOS costimulation expands Th2 immunity by augmenting migration of lymphocytes to draining lymph nodes.
Volume: 181
Issue: 2
Pages: 1019-24
Publication
First Author: Wong KA
Year: 2019
Journal: J Immunol
Title: T Cell-Intrinsic IL-6R Signaling Is Required for Optimal ICOS Expression and Viral Control during Chronic Infection.
Volume: 203
Issue: 6
Pages: 1509-1520
Publication
First Author: Yu XZ
Year: 2006
Journal: J Immunol
Title: Opposing effects of ICOS on graft-versus-host disease mediated by CD4 and CD8 T cells.
Volume: 176
Issue: 12
Pages: 7394-401
Publication
First Author: Moguche AO
Year: 2015
Journal: J Exp Med
Title: ICOS and Bcl6-dependent pathways maintain a CD4 T cell population with memory-like properties during tuberculosis.
Volume: 212
Issue: 5
Pages: 715-28
Publication
First Author: O'Brien CA
Year: 2019
Journal: J Immunol
Title: IL-10 and ICOS Differentially Regulate T Cell Responses in the Brain during Chronic Toxoplasma gondii Infection.
Volume: 202
Issue: 6
Pages: 1755-1766
Publication
First Author: Mahajan S
Year: 2007
Journal: Eur J Immunol
Title: The role of ICOS in the development of CD4 T cell help and the reactivation of memory T cells.
Volume: 37
Issue: 7
Pages: 1796-808
Publication
First Author: Wikenheiser DJ
Year: 2016
Journal: J Immunol
Title: The Costimulatory Molecule ICOS Regulates Host Th1 and Follicular Th Cell Differentiation in Response to Plasmodium chabaudi chabaudi AS Infection.
Volume: 196
Issue: 2
Pages: 778-91
Publication
First Author: Marriott CL
Year: 2015
Journal: Eur J Immunol
Title: ICOS is required for the generation of both central and effector CD4(+) memory T-cell populations following acute bacterial infection.
Volume: 45
Issue: 6
Pages: 1706-15
Publication
First Author: Vogel KU
Year: 2013
Journal: Immunity
Title: Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation.
Volume: 38
Issue: 4
Pages: 655-68
Publication
First Author: Watanabe M
Year: 2012
Journal: Eur J Immunol
Title: AP-1 is involved in ICOS gene expression downstream of TCR/CD28 and cytokine receptor signaling.
Volume: 42
Issue: 7
Pages: 1850-62
Protein
Organism: Mus musculus
Length: 200  
Fragment?: false
Protein
Organism: Mus musculus
Length: 223  
Fragment?: false
Protein
Organism: Mus musculus
Length: 200  
Fragment?: false
Protein
Organism: Mus musculus
Length: 200  
Fragment?: false
Protein
Organism: Mus musculus
Length: 200  
Fragment?: false
Protein
Organism: Mus musculus
Length: 223  
Fragment?: false
Protein
Organism: Mus musculus
Length: 200  
Fragment?: false
Publication
First Author: Akbari O
Year: 2008
Journal: J Immunol
Title: ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survival.
Volume: 180
Issue: 8
Pages: 5448-56
Publication
First Author: Odegard JM
Year: 2009
Journal: J Immunol
Title: ICOS controls effector function but not trafficking receptor expression of kidney-infiltrating effector T cells in murine lupus.
Volume: 182
Issue: 7
Pages: 4076-84
Publication
First Author: Vidric M
Year: 2005
Journal: J Immunol
Title: Cooperation between 4-1BB and ICOS in the immune response to influenza virus revealed by studies of CD28/ICOS-deficient mice.
Volume: 175
Issue: 11
Pages: 7288-96
Publication
First Author: Pedros C
Year: 2016
Journal: Nat Immunol
Title: A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1.
Volume: 17
Issue: 7
Pages: 825-33
Publication
First Author: Leavenworth JW
Year: 2015
Journal: Nat Immunol
Title: A p85α-osteopontin axis couples the receptor ICOS to sustained Bcl-6 expression by follicular helper and regulatory T cells.
Volume: 16
Issue: 1
Pages: 96-106
Publication
First Author: Nie X
Year: 2012
Journal: Clin Immunol
Title: Lipopolysaccharide mediated mast cells induce IL-10 producing regulatory T cells through the ICOSL/ICOS axis.
Volume: 142
Issue: 3
Pages: 269-79
Publication
First Author: Kadkhoda K
Year: 2010
Journal: J Immunol
Title: Th1 cytokine responses fail to effectively control Chlamydia lung infection in ICOS ligand knockout mice.
Volume: 184
Issue: 7
Pages: 3780-8
Publication
First Author: Moore TV
Year: 2011
Journal: Am J Respir Cell Mol Biol
Title: Inducible costimulator controls migration of T cells to the lungs via down-regulation of CCR7 and CD62L.
Volume: 45
Issue: 4
Pages: 843-50
Publication
First Author: Chen Y
Year: 2012
Journal: J Immunol
Title: Murine regulatory T cells contain hyperproliferative and death-prone subsets with differential ICOS expression.
Volume: 188
Issue: 4
Pages: 1698-707
Publication
First Author: Ling V
Year: 2001
Journal: Genomics
Title: Assembly and annotation of human chromosome 2q33 sequence containing the CD28, CTLA4, and ICOS gene cluster: analysis by computational, comparative, and microarray approaches.
Volume: 78
Issue: 3
Pages: 155-68
Publication
First Author: Bauquet AT
Year: 2009
Journal: Nat Immunol
Title: The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells.
Volume: 10
Issue: 2
Pages: 167-75
Publication
First Author: Pot C
Year: 2009
Journal: J Immunol
Title: Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells.
Volume: 183
Issue: 2
Pages: 797-801
Publication
First Author: Linterman MA
Year: 2009
Journal: Immunity
Title: Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS.
Volume: 30
Issue: 2
Pages: 228-41
Publication
First Author: Shi J
Year: 2018
Journal: Immunity
Title: PD-1 Controls Follicular T Helper Cell Positioning and Function.
Volume: 49
Issue: 2
Pages: 264-274.e4
Publication
First Author: Nurieva R
Year: 2006
Journal: EMBO J
Title: T-cell tolerance or function is determined by combinatorial costimulatory signals.
Volume: 25
Issue: 11
Pages: 2623-33
Publication
First Author: Ou X
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Deficiency in TNFRSF13B (TACI) expands T-follicular helper and germinal center B cells via increased ICOS-ligand expression but impairs plasma cell survival.
Volume: 109
Issue: 38
Pages: 15401-6
Publication
First Author: Usui Y
Year: 2006
Journal: Eur J Immunol
Title: The role of the ICOS/B7RP-1 T cell costimulatory pathway in murine experimental autoimmune uveoretinitis.
Volume: 36
Issue: 11
Pages: 3071-81
Publication
First Author: Shi LZ
Year: 2019
Journal: Cancer Immunol Res
Title: Blockade of CTLA-4 and PD-1 Enhances Adoptive T-cell Therapy Efficacy in an ICOS-Mediated Manner.
Volume: 7
Issue: 11
Pages: 1803-1812
Publication  
First Author: Briet C
Year: 2017
Journal: Front Immunol
Title: The Spontaneous Autoimmune Neuromyopathy in ICOSL-/- NOD Mice Is CD4+ T-Cell and Interferon-γ Dependent.
Volume: 8
Pages: 287
Publication
First Author: Ling V
Year: 2001
Journal: J Immunol
Title: Differential expression of inducible costimulator-ligand splice variants: lymphoid regulation of mouse GL50-B and human GL50 molecules.
Volume: 166
Issue: 12
Pages: 7300-8
Publication
First Author: Sperling AI
Year: 2001
Journal: Nat Immunol
Title: ICOS costimulation: It's not just for TH2 cells anymore.
Volume: 2
Issue: 7
Pages: 573-4
Publication
First Author: Iiyama R
Year: 2003
Journal: Immunol Lett
Title: The role of inducible co-stimulator (ICOS)/B7-related protein-1 (B7RP-1) interaction in the functional development of Peyer's patches.
Volume: 88
Issue: 1
Pages: 63-70
Publication
First Author: Ozkaynak E
Year: 2001
Journal: Nat Immunol
Title: Importance of ICOS-B7RP-1 costimulation in acute and chronic allograft rejection.
Volume: 2
Issue: 7
Pages: 591-6
Publication
First Author: Chung Y
Year: 2008
Journal: J Immunol
Title: A critical role of costimulation during intrathymic development of invariant NK T cells.
Volume: 180
Issue: 4
Pages: 2276-83
Publication
First Author: Pepper M
Year: 2011
Journal: Immunity
Title: Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells.
Volume: 35
Issue: 4
Pages: 583-95
Publication
First Author: Weinstein JS
Year: 2014
Journal: J Immunol
Title: B cells in T follicular helper cell development and function: separable roles in delivery of ICOS ligand and antigen.
Volume: 192
Issue: 7
Pages: 3166-79
Publication
First Author: Maazi H
Year: 2015
Journal: Immunity
Title: ICOS:ICOS-ligand interaction is required for type 2 innate lymphoid cell function, homeostasis, and induction of airway hyperreactivity.
Volume: 42
Issue: 3
Pages: 538-51
UniProt Feature
Begin: 47
Description: ICOS ligand
Type: chain
End: 322
Publication
First Author: Greenwald RJ
Year: 2002
Journal: J Immunol
Title: Cutting edge: inducible costimulator protein regulates both Th1 and Th2 responses to cutaneous leishmaniasis.
Volume: 168
Issue: 3
Pages: 991-5
Publication
First Author: Tada Y
Year: 2006
Journal: Clin Immunol
Title: Role of inducible costimulator in the development of lupus in MRL/lpr mice.
Volume: 120
Issue: 2
Pages: 179-88
Publication
First Author: Dong C
Year: 2001
Journal: J Immunol
Title: Cutting edge: critical role of inducible costimulator in germinal center reactions.
Volume: 166
Issue: 6
Pages: 3659-62
Publication
First Author: Stolberg VR
Year: 2005
Journal: Cell Immunol
Title: Analysis of inducible costimulatory molecule participation during the induction and elicitation of granulomatous responses to mycobacterial and schistosomal antigens.
Volume: 237
Issue: 1
Pages: 45-54
Publication
First Author: Dong C
Year: 2003
Journal: J Autoimmun
Title: Regulation of immune and autoimmune responses by ICOS.
Volume: 21
Issue: 3
Pages: 255-60
Publication
First Author: Kornete M
Year: 2012
Journal: J Immunol
Title: ICOS-dependent homeostasis and function of Foxp3+ regulatory T cells in islets of nonobese diabetic mice.
Volume: 188
Issue: 3
Pages: 1064-74
Publication
First Author: Gigoux M
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase.
Volume: 106
Issue: 48
Pages: 20371-6
Publication
First Author: Li J
Year: 2013
Journal: J Immunol
Title: Phosphatidylinositol 3-kinase-independent signaling pathways contribute to ICOS-mediated T cell costimulation in acute graft-versus-host disease in mice.
Volume: 191
Issue: 1
Pages: 200-7
Publication
First Author: Watanabe M
Year: 2005
Journal: J Immunol
Title: ICOS-mediated costimulation on Th2 differentiation is achieved by the enhancement of IL-4 receptor-mediated signaling.
Volume: 174
Issue: 4
Pages: 1989-96
Publication
First Author: Chen H
Year: 2014
Journal: Cancer Immunol Res
Title: CD4 T cells require ICOS-mediated PI3K signaling to increase T-Bet expression in the setting of anti-CTLA-4 therapy.
Volume: 2
Issue: 2
Pages: 167-76
Publication
First Author: Vidric M
Year: 2006
Journal: Infect Immun
Title: Role for inducible costimulator in control of Salmonella enterica serovar Typhimurium infection in mice.
Volume: 74
Issue: 2
Pages: 1050-61