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Search results 1 to 100 out of 259 for Ids

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Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
3423 | IDS
Type: gene
Organism: human
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Gene
541272 | IDS
Type: gene
Organism: cattle
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Gene
422392 | IDS
Type: gene
Organism: chicken
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Gene
559959 | ids
Type: gene
Organism: zebrafish
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Gene
700892 | IDS
Type: gene
Organism: macaque, rhesus
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Gene
100135738 | ids
Type: gene
Organism: frog, western clawed
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Gene
363513 | Ids
Type: gene
Organism: rat
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Gene
492194 | IDS
Type: gene
Organism: dog, domestic
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Gene
465896 | IDS
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:96417 | Ids
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR035874 | IDS
Type: Family
Description: Iduronate 2-sulfatase is a sulfatase enzyme that catalyze the hydrolysis of sulfate ester bonds from a wide variety of substrates, including steroids, carbohydrates and proteins. Iduronate 2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate [, , ]. Mutations in the iduronate 2-sulfatase gene that result in enzymatic deficiency lead to the sex-linked mucopolysaccharidosis type II, also known as Hunter syndrome [].
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Gene
106050102 | LOC106050102
Type: gene
Organism: human
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Publication
19679226 | J:154335
First Author: Polito VA
Year: 2009
Journal: Am J Hum Genet
Title: IDS crossing of the blood-brain barrier corrects CNS defects in MPSII mice.
Volume: 85
Issue: 2
Pages: 296-301
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Protein
Q08890
Organism: Mus musculus/domesticus
Length: 552  
Fragment?: false
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Protein
Q684Q4
Organism: Mus musculus/domesticus
Length: 392  
Fragment?: true
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Protein
Q3V1R8
Organism: Mus musculus/domesticus
Length: 572  
Fragment?: true
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Publication
9734337 | -
First Author: Medeiros MG
Year: 1998
Journal: Comp Biochem Physiol B Biochem Mol Biol
Title: New pathway of heparan sulphate degradation. Iduronate sulphatase and N-sulphoglucosamine 6-sulphatase act on the polymer chain prior to depolymerisation by a N-sulpho-glucosaminidase and glycuronidases in the mollusc Tagelus gibbus.
Volume: 119
Issue: 3
Pages: 539-47
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Publication
1442257 | -
 
First Author: Freeman C
Year: 1992
Journal: Adv Exp Med Biol
Title: Lysosomal degradation of heparin and heparan sulphate.
Volume: 313
Pages: 121-34
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Publication
2222422 | -
First Author: Bielicki J
Year: 1990
Journal: Biochem J
Title: Human liver iduronate-2-sulphatase. Purification, characterization and catalytic properties.
Volume: 271
Issue: 1
Pages: 75-86
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Publication
1303211 | -
First Author: Bunge S
Year: 1992
Journal: Hum Mol Genet
Title: Mutation analysis of the iduronate-2-sulfatase gene in patients with mucopolysaccharidosis type II (Hunter syndrome).
Volume: 1
Issue: 5
Pages: 335-9
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Publication
12572850 | J:108761
First Author: Muenzer J
Year: 2002
Journal: Acta Paediatr Suppl
Title: Enzyme replacement therapy in mucopolysaccharidosis type II (Hunter syndrome): a preliminary report.
Volume: 91
Issue: 439
Pages: 98-9
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Publication
8325651 | J:12763
First Author: Daniele A
Year: 1993
Journal: Genomics
Title: Cloning and characterization of the cDNA for the murine iduronate sulfatase gene.
Volume: 16
Issue: 3
Pages: 755-7
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Publication
28334757 | J:242249
First Author: Costa R
Year: 2017
Journal: Hum Mol Genet
Title: Perturbations in cell signaling elicit early cardiac defects in mucopolysaccharidosis type II.
Volume: 26
Issue: 9
Pages: 1643-1655
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Publication
20652491 | J:294717
First Author: Jung SC
Year: 2010
Journal: Mol Cells
Title: Characterization of a novel mucopolysaccharidosis type II mouse model and recombinant AAV2/8 vector-mediated gene therapy.
Volume: 30
Issue: 1
Pages: 13-8
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Publication
22704483 | J:188058
First Author: Higuchi T
Year: 2012
Journal: Mol Genet Metab
Title: Enzyme replacement therapy (ERT) procedure for mucopolysaccharidosis type II (MPS II) by intraventricular administration (IVA) in murine MPS II.
Volume: 107
Issue: 1-2
Pages: 122-8
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Publication
22847837 | J:294523
First Author: Hong SH
Year: 2012
Journal: Am J Med Genet A
Title: Auditory characteristics and therapeutic effects of enzyme replacement in mouse model of the mucopolysaccharidosis (MPS) II.
Volume: 158A
Issue: 9
Pages: 2131-8
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Publication
16505002 | J:108242
First Author: Cardone M
Year: 2006
Journal: Hum Mol Genet
Title: Correction of Hunter syndrome in the MPSII mouse model by AAV2/8-mediated gene delivery.
Volume: 15
Issue: 7
Pages: 1225-36
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Publication
20876612 | J:166549
First Author: Polito VA
Year: 2010
Journal: Hum Mol Genet
Title: Correction of CNS defects in the MPSII mouse model via systemic enzyme replacement therapy.
Volume: 19
Issue: 24
Pages: 4871-85
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Publication
29648648 | J:265087
First Author: Bellesso S
Year: 2018
Journal: Hum Mol Genet
Title: FGF signaling deregulation is associated with early developmental skeletal defects in animal models for mucopolysaccharidosis type II (MPSII).
Volume: 27
Issue: 13
Pages: 2262-2275
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Publication
15149955 | J:279930
First Author: Coronado-Pons I
Year: 2004
Journal: Am J Physiol Endocrinol Metab
Title: Identification of iduronate-2-sulfatase in mouse pancreatic islets.
Volume: 287
Issue: 5
Pages: E983-90
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Publication
28207863 | J:248521
First Author: Gleitz HF
Year: 2017
Journal: PLoS One
Title: Identification of age-dependent motor and neuropsychological behavioural abnormalities in a mouse model of Mucopolysaccharidosis Type II.
Volume: 12
Issue: 2
Pages: e0172435
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Publication
37188686 | J:343337
First Author: Mashima R
Year: 2023
Journal: Sci Rep
Title: A novel mucopolysaccharidosis type II mouse model with an iduronate-2-sulfatase-P88L mutation.
Volume: 13
Issue: 1
Pages: 7865
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Publication
35226042 | J:342207
 
First Author: Arguello A
Year: 2022
Journal: J Exp Med
Title: Molecular architecture determines brain delivery of a transferrin receptor-targeted lysosomal enzyme.
Volume: 219
Issue: 3
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Publication
8678976 | J:34207
First Author: de Gouyon B
Year: 1996
Journal: Mamm Genome
Title: Comparative mapping on the mouse X chromosome defines a myotubular myopathy equivalent region.
Volume: 7
Issue: 8
Pages: 575-9
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Publication
35816218 | J:342208
First Author: Maccari F
Year: 2022
Journal: J Mol Med (Berl)
Title: Glycosaminoglycan signatures in body fluids of mucopolysaccharidosis type II mouse model under long-term enzyme replacement therapy.
Volume: 100
Issue: 8
Pages: 1169-1179
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Publication
29606503 | J:326306
First Author: Sonoda H
Year: 2018
Journal: Mol Ther
Title: A Blood-Brain-Barrier-Penetrating Anti-human Transferrin Receptor Antibody Fusion Protein for Neuronopathic Mucopolysaccharidosis II.
Volume: 26
Issue: 5
Pages: 1366-1374
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Publication
23568409 | J:292616
First Author: Sorrentino NC
Year: 2013
Journal: EMBO Mol Med
Title: A highly secreted sulphamidase engineered to cross the blood-brain barrier corrects brain lesions of mice with mucopolysaccharidoses type IIIA.
Volume: 5
Issue: 5
Pages: 675-90
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Publication
30064964 | J:326250
First Author: Tanaka N
Year: 2018
Journal: Mol Genet Metab
Title: Evaluation of cerebrospinal fluid heparan sulfate as a biomarker of neuropathology in a murine model of mucopolysaccharidosis type II using high-sensitivity LC/MS/MS.
Volume: 125
Issue: 1-2
Pages: 53-58
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Protein Coding Gene
MGP_CAROLIEiJ_G0033125 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0035776 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0035759 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0035680 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0035746 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0035449 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_96417 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0036276 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0034741 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0035424 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0035577 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0035528 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0035665 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0035563 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0036297 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0034441 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0034883 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0031667 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0034279 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
17876721 | J:259752
First Author: Garcia AR
Year: 2007
Journal: J Inherit Metab Dis
Title: The characterization of a murine model of mucopolysaccharidosis II (Hunter syndrome).
Volume: 30
Issue: 6
Pages: 924-34
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Publication
22279584 | J:342192
First Author: Calias P
Year: 2012
Journal: PLoS One
Title: CNS penetration of intrathecal-lumbar idursulfase in the monkey, dog and mouse: implications for neurological outcomes of lysosomal storage disorder.
Volume: 7
Issue: 1
Pages: e30341
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Publication
8352760 | J:14030
First Author: Daniele A
Year: 1993
Journal: Biochem Biophys Res Commun
Title: The mouse iduronate sulfatase gene: identification of a novel transcript.
Volume: 194
Issue: 3
Pages: 1030-7
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GXD Expression
GXD Expression
 
Probe: MGI:1053798
Assay Type: RNA in situ
Annotation Date: 2010-07-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754920
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:4462273
Age: embryonic day 12.5
Image: 1M
Specimen Label: 1M
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:1053798
Assay Type: RNA in situ
Annotation Date: 2010-07-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754922
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4462273
Age: embryonic day 14.5
Image: 1N
Specimen Label: 1N
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:1053798
Assay Type: RNA in situ
Annotation Date: 2010-07-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754922
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4462273
Age: embryonic day 14.5
Image: 3D
Specimen Label: 3D
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:1053798
Assay Type: RNA in situ
Annotation Date: 2010-07-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1859024
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:4462273
Age: embryonic day 16.5
Image: 4J
Note: Expression was detected in the inner neuroblastic layer.
Specimen Label: 4J
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:1053798
Assay Type: RNA in situ
Annotation Date: 2010-07-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754420
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:4462273
Age: embryonic day 12.5
Image: 1M
Specimen Label: 1M
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:1053798
Assay Type: RNA in situ
Annotation Date: 2010-07-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4462273
Age: embryonic day 14.5
Image: 1N
Specimen Label: 1N
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:1053798
Assay Type: RNA in situ
Annotation Date: 2010-07-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4462273
Age: embryonic day 14.5
Image: 3D
Specimen Label: 3D
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:1053798
Assay Type: RNA in situ
Annotation Date: 2010-07-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666820
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:4462273
Age: embryonic day 12.5
Image: 1M
Specimen Label: 1M
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:1053798
Assay Type: RNA in situ
Annotation Date: 2010-07-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666822
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4462273
Age: embryonic day 14.5
Image: 1N
Specimen Label: 1N
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:1053798
Assay Type: RNA in situ
Annotation Date: 2010-07-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666822
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4462273
Age: embryonic day 14.5
Image: 3G
Specimen Label: 3G
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:1053798
Assay Type: RNA in situ
Annotation Date: 2010-07-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1646920
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:4462273
Age: embryonic day 12.5
Image: 1M
Specimen Label: 1M
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:1053798
Assay Type: RNA in situ
Annotation Date: 2010-07-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1646917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4462273
Age: embryonic day 10.5
Specimen Label: not shown
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:1053798
Assay Type: RNA in situ
Annotation Date: 2010-07-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1679722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4462273
Age: embryonic day 14.5
Image: 3D
Specimen Label: 3D
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:1053798
Assay Type: RNA in situ
Annotation Date: 2010-07-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754020
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:4462273
Age: embryonic day 12.5
Image: 1M
Specimen Label: 1M
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:1053798
Assay Type: RNA in situ
Annotation Date: 2010-07-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754022
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4462273
Age: embryonic day 14.5
Image: 1N
Specimen Label: 1N
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:1053798
Assay Type: RNA in situ
Annotation Date: 2010-07-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754022
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4462273
Age: embryonic day 14.5
Image: 3D
Specimen Label: 3D
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:1053798
Assay Type: RNA in situ
Annotation Date: 2010-07-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757720
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:4462273
Age: embryonic day 12.5
Image: 1M
Specimen Label: 1M
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:1053798
Assay Type: RNA in situ
Annotation Date: 2010-07-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4462273
Age: embryonic day 14.5
Image: 1N
Specimen Label: 1N
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:1053798
Assay Type: RNA in situ
Annotation Date: 2010-07-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757722
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:4462273
Age: embryonic day 14.5
Image: 3G
Note: Expression was detected in the ventral horn.
Specimen Label: 3G
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:1053798
Assay Type: RNA in situ
Annotation Date: 2010-07-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1717122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:4462273
Age: embryonic day 14.5
Image: 4D
Note: Expression was detected in the inner neuroblastic layer.
Specimen Label: 4D
Detected: true
Specimen Num: 5
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Publication
1937018 | J:11526
First Author: Habara-Ohkubo A
Year: 1991
Journal: Gene
Title: Cloning and expression of a cDNA encoding mouse indoleamine 2,3-dioxygenase.
Volume: 105
Issue: 2
Pages: 221-7
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Publication
34681597 | J:342201
 
First Author: Giugliani R
Year: 2021
Journal: Int J Mol Sci
Title: Enzyme Replacement Therapy with Pabinafusp Alfa for Neuronopathic Mucopolysaccharidosis II: An Integrated Analysis of Preclinical and Clinical Data.
Volume: 22
Issue: 20
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Publication
27228099 | J:252451
First Author: Salvalaio M
Year: 2016
Journal: PLoS One
Title: Targeted Polymeric Nanoparticles for Brain Delivery of High Molecular Weight Molecules in Lysosomal Storage Disorders.
Volume: 11
Issue: 5
Pages: e0156452
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Publication
27590924 | J:238333
First Author: Yokoi T
Year: 2016
Journal: Mol Genet Metab
Title: Non-myeloablative preconditioning with ACK2 (anti-c-kit antibody) is efficient in bone marrow transplantation for murine models of mucopolysaccharidosis type II.
Volume: 119
Issue: 3
Pages: 232-238
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Publication
22096577 | J:180969
First Author: Ohmi K
Year: 2011
Journal: PLoS One
Title: Defects in the medial entorhinal cortex and dentate gyrus in the mouse model of Sanfilippo syndrome type B.
Volume: 6
Issue: 11
Pages: e27461
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Publication
20643830 | J:163462
First Author: Buono M
Year: 2010
Journal: J Exp Med
Title: Sulfatase modifying factor 1-mediated fibroblast growth factor signaling primes hematopoietic multilineage development.
Volume: 207
Issue: 8
Pages: 1647-60
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Publication
8439729 | J:4132
First Author: Angel TA
Year: 1993
Journal: Mamm Genome
Title: Genetic mapping of the X-linked dominant mutations striated (Str) and bare patches (Bpa) to a 600-kb region of the mouse X chromosome: implications for mapping human disorders in Xq28.
Volume: 4
Issue: 3
Pages: 171-6
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Publication
15962010 | J:99578
First Author: Zito E
Year: 2005
Journal: EMBO Rep
Title: Sulphatase activities are regulated by the interaction of sulphatase-modifying factor 1 with SUMF2.
Volume: 6
Issue: 7
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