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Search results 1 to 100 out of 324 for Ier3

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
8870 | IER3
Type: gene
Organism: human
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Gene
100497513 | ier3
Type: gene
Organism: frog, western clawed
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Gene
294235 | Ier3
Type: gene
Organism: rat
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Gene
481708 | IER3
Type: gene
Organism: dog, domestic
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Gene
462547 | IER3
Type: gene
Organism: chimpanzee
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Gene
505455 | IER3
Type: gene
Organism: cattle
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Gene
100857932 | IER3
Type: gene
Organism: chicken
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Gene
701939 | IER3
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:104814 | Ier3
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
105379695 | IER3-AS1
Type: gene
Organism: human
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Publication
25250570 | J:217621
First Author: Garcia MN
Year: 2014
Journal: J Clin Invest
Title: IER3 supports KRASG12D-dependent pancreatic cancer development by sustaining ERK1/2 phosphorylation.
Volume: 124
Issue: 11
Pages: 4709-22
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Publication
19773435 | J:153609
First Author: Steensma DP
Year: 2009
Journal: Cancer Res
Title: Rearrangements and amplification of IER3 (IEX-1) represent a novel and recurrent molecular abnormality in myelodysplastic syndromes.
Volume: 69
Issue: 19
Pages: 7518-23
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Publication
28353642 | J:302906
 
First Author: Zhou Q
Year: 2017
Journal: Int J Mol Sci
Title: Dysregulated IER3 Expression is Associated with Enhanced Apoptosis in Titin-Based Dilated Cardiomyopathy.
Volume: 18
Issue: 4
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Publication
12510147 | J:81101
First Author: Wu MX
Year: 2003
Journal: Apoptosis
Title: Roles of the stress-induced gene IEX-1 in regulation of cell death and oncogenesis.
Volume: 8
Issue: 1
Pages: 11-8
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Publication
24311782 | J:258419
First Author: Stachel I
Year: 2014
Journal: J Biol Chem
Title: Modulation of nuclear factor E2-related factor-2 (Nrf2) activation by the stress response gene immediate early response-3 (IER3) in colonic epithelial cells: a novel mechanism of cellular adaption to inflammatory stress.
Volume: 289
Issue: 4
Pages: 1917-29
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Protein Coding Gene
MGP_CAROLIEiJ_G0021532 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0023652 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0023607 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0023577 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0023612 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0023378 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_104814 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0024054 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0022869 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0023356 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0023480 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0023451 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0023560 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0023472 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0024097 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0022620 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0022935 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0020526 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0022439 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
8437864 | J:3978
First Author: Charles CH
Year: 1993
Journal: Oncogene
Title: Genomic structure, cDNA sequence, and expression of gly96, a growth factor-inducible immediate-early gene encoding a short-lived glycosylated protein.
Volume: 8
Issue: 3
Pages: 797-801
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Publication
16166241 | J:131099
First Author: Sommer SL
Year: 2006
Journal: J Appl Physiol (1985)
Title: Elevated blood pressure and cardiac hypertrophy after ablation of the gly96/IEX-1 gene.
Volume: 100
Issue: 2
Pages: 707-16
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Publication
25036043 | J:219025
First Author: Brahmbhatt A
Year: 2014
Journal: PLoS One
Title: The role of Iex-1 in the pathogenesis of venous neointimal hyperplasia associated with hemodialysis arteriovenous fistula.
Volume: 9
Issue: 7
Pages: e102542
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Publication
19714745 | J:258796
First Author: Sina C
Year: 2010
Journal: Inflamm Bowel Dis
Title: Ablation of gly96/immediate early gene-X1 (gly96/iex-1) aggravates DSS-induced colitis in mice: role for gly96/iex-1 in the regulation of NF-kappaB.
Volume: 16
Issue: 2
Pages: 320-331
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Publication
19923449 | J:157504
First Author: Akilov OE
Year: 2009
Journal: J Immunol
Title: Enhanced susceptibility to Leishmania infection in resistant mice in the absence of immediate early response gene X-1.
Volume: 183
Issue: 12
Pages: 7994-8003
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Publication
24849666 | J:281413
First Author: Zhang Q
Year: 2014
Journal: J Cereb Blood Flow Metab
Title: Low-level laser therapy effectively prevents secondary brain injury induced by immediate early responsive gene X-1 deficiency.
Volume: 34
Issue: 8
Pages: 1391-401
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Publication
20713914 | J:195182
First Author: Shahid M
Year: 2010
Journal: Hypertension
Title: Impaired 3',5'-cyclic adenosine monophosphate-mediated signaling in immediate early responsive gene X-1-deficient vascular smooth muscle cells.
Volume: 56
Issue: 4
Pages: 705-12
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Publication
27063893 | J:301947
 
First Author: Shahid M
Year: 2016
Journal: Sci Rep
Title: IEX-1 deficiency induces browning of white adipose tissue and resists diet-induced obesity.
Volume: 6
Pages: 24135
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Publication
22798682 | J:189744
First Author: Zhi L
Year: 2012
Journal: J Immunol
Title: Enhanced Th17 differentiation and aggravated arthritis in IEX-1-deficient mice by mitochondrial reactive oxygen species-mediated signaling.
Volume: 189
Issue: 4
Pages: 1639-47
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Publication
30050123 | J:270026
First Author: Zhang Q
Year: 2019
Journal: Leukemia
Title: Uncoupling of CD71 shedding with mitochondrial clearance in reticulocytes in a subset of myelodysplastic syndromes.
Volume: 33
Issue: 1
Pages: 217-229
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Publication
11753682 | J:132165
First Author: Schilling D
Year: 2001
Journal: Oncogene
Title: IEX-1, an immediate early gene, increases the rate of apoptosis in keratinocytes.
Volume: 20
Issue: 55
Pages: 7992-7
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Publication
11782530 | J:73983
First Author: Zhang Y
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice.
Volume: 99
Issue: 2
Pages: 878-83
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Publication
14534530 | J:86066
First Author: Zhang Y
Year: 2003
Journal: Oncogene
Title: Development of T-cell lymphomas in Emu-IEX-1 mice.
Volume: 22
Issue: 44
Pages: 6845-51
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GXD Expression
GXD Expression
     
Probe: MGI:3654913
Assay Type: RT-PCR
Annotation Date: 2006-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185813
Stage: TS13
Assay Id: MGI:3654933
Age: embryonic day 8.5
Specimen Label: None
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:6192464
Assay Type: RT-PCR
Annotation Date: 2018-08-01
Strength: Present
Sex: Female
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:6192476
Age: postnatal adult
Specimen Label: placenta normoxia
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:6192464
Assay Type: RT-PCR
Annotation Date: 2018-08-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:6192476
Age: embryonic day 20.0
Specimen Label: brain normoxia
Detected: true
Specimen Num: 3
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Publication
19096392 | J:158073
First Author: Shen L
Year: 2009
Journal: Cell Death Differ
Title: IEX-1 targets mitochondrial F1Fo-ATPase inhibitor for degradation.
Volume: 16
Issue: 4
Pages: 603-12
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Publication
20467439 | J:186356
First Author: Pawlikowska P
Year: 2010
Journal: Cell Death Differ
Title: ATM-dependent expression of IEX-1 controls nuclear accumulation of Mcl-1 and the DNA damage response.
Volume: 17
Issue: 11
Pages: 1739-50
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Publication
22550081 | J:194587
First Author: Ustyugova IV
Year: 2012
Journal: Mol Cancer Res
Title: IEX-1 deficiency protects against colonic cancer.
Volume: 10
Issue: 6
Pages: 760-7
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Publication
24184684 | J:207699
First Author: de Laval B
Year: 2014
Journal: Blood
Title: Thrombopoietin promotes NHEJ DNA repair in hematopoietic stem cells through specific activation of Erk and NF-κB pathways and their target, IEX-1.
Volume: 123
Issue: 4
Pages: 509-19
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Publication
20926767 | J:166934
First Author: Trollmann R
Year: 2010
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Late-gestational systemic hypoxia leads to a similar early gene response in mouse placenta and developing brain.
Volume: 299
Issue: 6
Pages: R1489-99
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Publication
11004510 | J:66308
First Author: Takahashi Y
Year: 2000
Journal: Biochim Biophys Acta
Title: Identification of cAMP analogue inducible genes in RAW264 macrophages.
Volume: 1492
Issue: 2-3
Pages: 385-94
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Publication
38388531 | J:345604
First Author: Werren EA
Year: 2024
Journal: Nat Commun
Title: TREX tetramer disruption alters RNA processing necessary for corticogenesis in THOC6 Intellectual Disability Syndrome.
Volume: 15
Issue: 1
Pages: 1640
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Publication
15799026 | J:100371
First Author: Okada A
Year: 2005
Journal: Birth Defects Res A Clin Mol Teratol
Title: Identification of early-responsive genes correlated to valproic acid-induced neural tube defects in mice.
Volume: 73
Issue: 4
Pages: 229-38
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Publication
23565059 | J:197686
First Author: Shang Y
Year: 2013
Journal: PLoS Biol
Title: Transcriptional corepressors HIPK1 and HIPK2 control angiogenesis via TGF-β-TAK1-dependent mechanism.
Volume: 11
Issue: 4
Pages: e1001527
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Publication
38014633 | J:343799
 
First Author: Katano W
Year: 2023
Journal: Development
Title: Sall1 and Sall4 cooperatively interact with Myocd and SRF to promote cardiomyocyte proliferation by regulating CDK and cyclin genes.
Volume: 150
Issue: 24
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Publication
36843585 | J:333829
 
First Author: Lopez-Tello J
Year: 2023
Journal: Front Endocrinol (Lausanne)
Title: Characterization of placental endocrine function and fetal brain development in a mouse model of small for gestational age.
Volume: 14
Pages: 1116770
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Publication
11044609 | J:65651
First Author: Neidhardt L
Year: 2000
Journal: Mech Dev
Title: Large-scale screen for genes controlling mammalian embryogenesis, using high-throughput gene expression analysis in mouse embryos.
Volume: 98
Issue: 1-2
Pages: 77-94
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:101977
     
First Author: The Jackson Laboratory
Year: 2005
Journal: Unpublished
Title: Information obtained from The Jackson Laboratory, Bar Harbor, ME
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Publication
- | J:157064
     
First Author: University of California, Davis
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the University of California, Davis
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Ier3<em1Smoc> | MGI:7290316
Name: immediate early response 3; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6428885 | C57BL/6JSmoc-Ier3<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Pathway
R-MMU-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
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Protein
P46694
Organism: Mus musculus/domesticus
Length: 160  
Fragment?: false
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Publication
9703517 | -
First Author: Wu MX
Year: 1998
Journal: Science
Title: IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival.
Volume: 281
Issue: 5379
Pages: 998-1001
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Publication
16456541 | -
First Author: Letourneux C
Year: 2006
Journal: EMBO J
Title: B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK.
Volume: 25
Issue: 4
Pages: 727-38
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Publication
12356731 | -
First Author: Garcia J
Year: 2002
Journal: EMBO J
Title: IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation.
Volume: 21
Issue: 19
Pages: 5151-63
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Protein Domain
IPR024829 | IEX-1
Type: Family
Description: Radiation-inducible immediate-early gene IEX-1 is a protein that in humans is encoded by the IER3 gene. The protein is involved in cell proliferation and survival, including the protection of cells from TNF-induced apoptosis []. It is rapidly induced by growth factors, viral infections or chemical carcinogens [].IEX-1 has a dual role in extracellular signal-regulated kinase (ERK) signalling. Upon phosphorylation by ERK, IEX-1 acquires the ability to inhibit cell death induced by various stimuli. In turn, by binding to active ERK, IEX-1 potentiates ERK activation in response to various growth factors [, ].
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Protein Coding Gene
MGI:98427 | Il1rl1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1858745 | Icos
Type: protein_coding_gene
Organism: mouse, laboratory
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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Cambridge CB2 3EH, United Kingdom