Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
sheep |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
horse |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
pig, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
wallaby, tammar |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
The insulin family of proteins groups together several evolutionarily related active peptides []: these include insulin [, ], relaxin [, ], insect prothoracicotropic hormone (bombyxin) [], insulin-like growth factors (IGF1 and IGF2) [, ], mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP) (gene INSL4), locust insulin-related peptide (LIRP), molluscan insulin-related peptides (MIP), and Caenorhabditis elegans insulin-like peptides. The 3D structures of a number of family members have been determined [, , ]. The fold comprises two polypeptide chains (A and B) linked by two disulphide bonds: all share a conserved arrangement of 4 cysteines in their A chain, the first of which is linked by a disulphide bond to the third, while the second and fourth are linked by interchain disulphide bonds to cysteines in the B chain. The IGFs, or somatomedins, play a key role in pre-adolescent mammalian growth. IGF2 appears to be induced by placental lactogen and is thought to play a role in foetal development []. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Davies K |
Year: |
2002 |
Journal: |
Development |
Title: |
Disruption of mesodermal enhancers for Igf2 in the minute mutant. |
Volume: |
129 |
Issue: |
7 |
Pages: |
1657-68 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1333147 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-04-06 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603915 |
Pattern: |
Not Specified |
Stage: |
TS15 |
Assay Id: |
MGI:1333503 |
Age: |
embryonic day 9.5 |
Image: |
Igf2 Control |
|
Specimen Label: |
Igf2 Control |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cattanach BM |
Year: |
2000 |
Journal: |
Hum Mol Genet |
Title: |
Two imprinted gene mutations: three phenotypes. |
Volume: |
9 |
Issue: |
15 |
Pages: |
2263-73 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442718 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271120 |
Pattern: |
Scattered |
Stage: |
TS20 |
Assay Id: |
MGI:4450870 |
Age: |
embryonic day 12.5 |
Image: |
Igf2 - E12.5 |
Note: |
There is strong, scattered staining in the postmitotic neurons in the cortical plate of the cerebral cortex. |
Specimen Label: |
Igf2 - E12.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442718 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271122 |
Pattern: |
Scattered |
Stage: |
TS22 |
Assay Id: |
MGI:4450870 |
Age: |
embryonic day 14.5 |
Image: |
Igf2 - E14.5 |
Note: |
There is strong, scattered staining in the postmitotic neurons in the cortical plate of the cerebral cortex. |
Specimen Label: |
Igf2 - E14.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442718 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271222 |
Pattern: |
Scattered |
Stage: |
TS22 |
Assay Id: |
MGI:4450870 |
Age: |
embryonic day 14.5 |
Image: |
Igf2 - E14.5 |
Note: |
There is strong, scattered staining in the postmitotic neurons in the intermediate zone of the cerebral cortex. |
Specimen Label: |
Igf2 - E14.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442718 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271224 |
Pattern: |
Scattered |
Stage: |
TS24 |
Assay Id: |
MGI:4450870 |
Age: |
embryonic day 16.5 |
Image: |
Igf2 - E16.5 |
Note: |
There is strong, scattered staining in the postmitotic neurons in the intermediate zone of the cerebral cortex. |
Specimen Label: |
Igf2 - E16.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442718 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754322 |
Pattern: |
Scattered |
Stage: |
TS22 |
Assay Id: |
MGI:4450870 |
Age: |
embryonic day 14.5 |
Image: |
Igf2 - E14.5 |
Note: |
There is strong, scattered staining in the ventricular zone of the dorsal thalamus and prethalamus. |
Specimen Label: |
Igf2 - E14.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442718 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754324 |
Pattern: |
Scattered |
Stage: |
TS24 |
Assay Id: |
MGI:4450870 |
Age: |
embryonic day 16.5 |
Image: |
Igf2 - E16.5 |
Note: |
There is strong, scattered staining in the ventricular zone of the dorsal thalamus and prethalamus. |
Specimen Label: |
Igf2 - E16.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442718 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1753720 |
Pattern: |
Scattered |
Stage: |
TS20 |
Assay Id: |
MGI:4450870 |
Age: |
embryonic day 12.5 |
Image: |
Igf2 - E12.5 |
Note: |
There is strong, scattered staining the mantle zone of the dorsal and ventral POAs, the PVH, VMH and ARH nuclei, the AVH and anterior and posterior IDs. |
Specimen Label: |
Igf2 - E12.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442718 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1753722 |
Pattern: |
Scattered |
Stage: |
TS22 |
Assay Id: |
MGI:4450870 |
Age: |
embryonic day 14.5 |
Image: |
Igf2 - E14.5 |
Note: |
There is strong, scattered staining in the mantle zone of the dorsal and ventral POAs, the PVH, VMH and ARH nuclei, the AVH and anterior and posterior IDs. |
Specimen Label: |
Igf2 - E14.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442718 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271822 |
Pattern: |
Scattered |
Stage: |
TS22 |
Assay Id: |
MGI:4450870 |
Age: |
embryonic day 14.5 |
Image: |
Igf2 - E14.5 |
Note: |
There is strong, scattered staining in the mantle zone of the premam, mam and supramam zones and the TT. |
Specimen Label: |
Igf2 - E14.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442718 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271824 |
Pattern: |
Scattered |
Stage: |
TS24 |
Assay Id: |
MGI:4450870 |
Age: |
embryonic day 16.5 |
Image: |
Igf2 - E16.5 |
Note: |
There is strong, scattered staining in the mantle zone of the premam, mam and supramam zones. |
Specimen Label: |
Igf2 - E16.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442718 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Very strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1690819 |
Pattern: |
Non-Uniform |
Stage: |
TS19 |
Assay Id: |
MGI:4450870 |
Age: |
embryonic day 11.5 |
Image: |
Igf2 - E11.5 |
Note: |
There is very strong staining in the VZ of the AVH & strong, scattered staining in the dorsal thalamus, the prethalamus, dorsal & ventral POAs, the PVH, VMH & ARH nuclei, the anterior & posterior IDs, the premam, mam & supramam zones & the TT. |
Specimen Label: |
Igf2 - E11.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442718 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Very strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1753920 |
Pattern: |
Non-Uniform |
Stage: |
TS20 |
Assay Id: |
MGI:4450870 |
Age: |
embryonic day 12.5 |
Image: |
Igf2 - E12.5 |
Note: |
There is very strong staining in the ventricular zone of the AVH and strong, scattered staining in the dorsal and ventral POAs, the PVH, VMH and ARH nuclei and anterior and posterior IDs. |
Specimen Label: |
Igf2 - E12.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442718 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Very strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1753924 |
Pattern: |
Non-Uniform |
Stage: |
TS24 |
Assay Id: |
MGI:4450870 |
Age: |
embryonic day 16.5 |
Image: |
Igf2 - E16.5 |
Note: |
There is very strong staining in the ventricular zone of the AVH and strong, scattered staining in the dorsal and ventral POAs, the PVH, SCH, DMH, VMH and ARH nuclei, the DAH and the PH. |
Specimen Label: |
Igf2 - E16.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442718 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1691119 |
Pattern: |
Scattered |
Stage: |
TS19 |
Assay Id: |
MGI:4450870 |
Age: |
embryonic day 11.5 |
Image: |
Igf2 - E11.5 |
Note: |
There is strong, scattered staining in the postmitotic neurons in the intermediate zone and cortical plate of the cerebral cortex and in the mantle zone of the ganglionic eminences. |
Specimen Label: |
Igf2 - E11.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442718 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754720 |
Pattern: |
Scattered |
Stage: |
TS20 |
Assay Id: |
MGI:4450870 |
Age: |
embryonic day 12.5 |
Image: |
Igf2 - E12.5 |
Note: |
There is strong, scattered staining in the ventricular zone of the cerebral cortex. |
Specimen Label: |
Igf2 - E12.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442718 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754722 |
Pattern: |
Scattered |
Stage: |
TS22 |
Assay Id: |
MGI:4450870 |
Age: |
embryonic day 14.5 |
Image: |
Igf2 - E14.5 |
Note: |
There is strong, scattered staining in the ventricular zone of the cerebral cortex. |
Specimen Label: |
Igf2 - E14.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442718 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271022 |
Pattern: |
Scattered |
Stage: |
TS22 |
Assay Id: |
MGI:4450870 |
Age: |
embryonic day 14.5 |
Image: |
Igf2 - E14.5 |
Note: |
There is strong, scattered staining in the ventricular zone of the premam, mam and supramam zones and the TT. |
Specimen Label: |
Igf2 - E14.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442718 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271024 |
Pattern: |
Scattered |
Stage: |
TS24 |
Assay Id: |
MGI:4450870 |
Age: |
embryonic day 16.5 |
Image: |
Igf2 - E16.5 |
Note: |
There is strong, scattered staining in the ventricular zone of the premam, mam and supramam zones. |
Specimen Label: |
Igf2 - E16.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442718 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3266520 |
Pattern: |
Scattered |
Stage: |
TS20 |
Assay Id: |
MGI:4450870 |
Age: |
embryonic day 12.5 |
Image: |
Igf2 - E12.5 |
Note: |
There is strong, scattered staining in the ventricular and mantle zones of the ganglionic eminences. |
Specimen Label: |
Igf2 - E12.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442718 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3266522 |
Pattern: |
Scattered |
Stage: |
TS22 |
Assay Id: |
MGI:4450870 |
Age: |
embryonic day 14.5 |
Image: |
Igf2 - E14.5 |
Note: |
There is strong, scattered staining in the ventricular and mantle zones of the ganglionic eminences. |
Specimen Label: |
Igf2 - E14.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442718 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754122 |
Pattern: |
Scattered |
Stage: |
TS22 |
Assay Id: |
MGI:4450870 |
Age: |
embryonic day 14.5 |
Image: |
Igf2 - E14.5 |
Note: |
There is strong, scattered staining in the mantle zone of the dorsal thalamus and prethalamus. |
Specimen Label: |
Igf2 - E14.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442718 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754124 |
Pattern: |
Scattered |
Stage: |
TS24 |
Assay Id: |
MGI:4450870 |
Age: |
embryonic day 16.5 |
Image: |
Igf2 - E16.5 |
Note: |
There is strong, scattered staining in the mantle zone of the dorsal thalamus and prethalamus. |
Specimen Label: |
Igf2 - E16.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3724421 |
Assay Type: |
RNA in situ |
Annotation Date: |
2009-01-15 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:2622022 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:3826225 |
Age: |
embryonic day 14.5 |
Image: |
Additional file 4 Igf2 |
|
Specimen Label: |
Additional file 4 Igf2 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442718 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271124 |
Pattern: |
Scattered |
Stage: |
TS24 |
Assay Id: |
MGI:4450870 |
Age: |
embryonic day 16.5 |
Image: |
Igf2 - E16.5 |
Note: |
There is strong, scattered staining in the postmitotic neurons in the cortical plate of the cerebral cortex. |
Specimen Label: |
Igf2 - E16.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442718 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271220 |
Pattern: |
Scattered |
Stage: |
TS20 |
Assay Id: |
MGI:4450870 |
Age: |
embryonic day 12.5 |
Image: |
Igf2 - E12.5 |
Note: |
There is strong, scattered staining in the postmitotic neurons in the intermediate zone of the cerebral cortex. |
Specimen Label: |
Igf2 - E12.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442718 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754320 |
Pattern: |
Scattered |
Stage: |
TS20 |
Assay Id: |
MGI:4450870 |
Age: |
embryonic day 12.5 |
Image: |
Igf2 - E12.5 |
Note: |
There is strong, scattered staining in the ventricular zone of the dorsal thalamus and prethalamus. |
Specimen Label: |
Igf2 - E12.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442718 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1753724 |
Pattern: |
Scattered |
Stage: |
TS24 |
Assay Id: |
MGI:4450870 |
Age: |
embryonic day 16.5 |
Image: |
Igf2 - E16.5 |
Note: |
There is strong, scattered staining in the mantle zone of the dorsal and ventral POAs, the PVH, SCH, DMH, VMH and ARH nuclei, the AVH, the DAH and the PH. |
Specimen Label: |
Igf2 - E16.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442718 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1691319 |
Pattern: |
Scattered |
Stage: |
TS19 |
Assay Id: |
MGI:4450870 |
Age: |
embryonic day 11.5 |
Image: |
Igf2 - E11.5 |
Note: |
There is strong, scattered staining in the ventricular zone of the cerebral cortex and the ganglionic eminences. |
Specimen Label: |
Igf2 - E11.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442718 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271820 |
Pattern: |
Scattered |
Stage: |
TS20 |
Assay Id: |
MGI:4450870 |
Age: |
embryonic day 12.5 |
Image: |
Igf2 - E12.5 |
Note: |
There is strong, scattered staining in the mantle zone of the premam, mam and supramam zones and the TT. |
Specimen Label: |
Igf2 - E12.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442718 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Very strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1753922 |
Pattern: |
Non-Uniform |
Stage: |
TS22 |
Assay Id: |
MGI:4450870 |
Age: |
embryonic day 14.5 |
Image: |
Igf2 - E14.5 |
Note: |
There is very strong staining in the ventricular zone of the AVH and strong, scattered staining in the dorsal and ventral POAs, the PVH, VMH and ARH nuclei and anterior and posterior IDs. |
Specimen Label: |
Igf2 - E14.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442718 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754724 |
Pattern: |
Scattered |
Stage: |
TS24 |
Assay Id: |
MGI:4450870 |
Age: |
embryonic day 16.5 |
Image: |
Igf2 - E16.5 |
Note: |
There is strong, scattered staining in the ventricular zone of the cerebral cortex. |
Specimen Label: |
Igf2 - E16.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442718 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271020 |
Pattern: |
Scattered |
Stage: |
TS20 |
Assay Id: |
MGI:4450870 |
Age: |
embryonic day 12.5 |
Image: |
Igf2 - E12.5 |
Note: |
There is strong, scattered staining in the ventricular zone of the premam, mam and supramam zones and the TT. |
Specimen Label: |
Igf2 - E12.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442718 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3266524 |
Pattern: |
Scattered |
Stage: |
TS24 |
Assay Id: |
MGI:4450870 |
Age: |
embryonic day 16.5 |
Image: |
Igf2 - E16.5 |
Note: |
There is strong, scattered staining in the ventricular and mantle zones of the ganglionic eminences. |
Specimen Label: |
Igf2 - E16.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442718 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1690619 |
Pattern: |
Scattered |
Stage: |
TS19 |
Assay Id: |
MGI:4450870 |
Age: |
embryonic day 11.5 |
Image: |
Igf2 - E11.5 |
Note: |
There is strong, scattered staining in the mantle zone of the dorsal thalamus, prethalamus, dorsal and ventral POAs, the PVH, VMH and ARH nuclei, the AVH, the anterior and posterior IDs, the premam, mam and supramam zones and the TT. |
Specimen Label: |
Igf2 - E11.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442718 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754120 |
Pattern: |
Scattered |
Stage: |
TS20 |
Assay Id: |
MGI:4450870 |
Age: |
embryonic day 12.5 |
Image: |
Igf2 - E12.5 |
Note: |
There is strong, scattered staining in the mantle zone of the dorsal thalamus and prethalamus. |
Specimen Label: |
Igf2 - E12.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Peters J |
Year: |
2004 |
Journal: |
Brief Funct Genomic Proteomic |
Title: |
Identification and characterisation of imprinted genes in the mouse. |
Volume: |
2 |
Issue: |
4 |
Pages: |
320-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Eden S |
Year: |
2001 |
Journal: |
EMBO J |
Title: |
An upstream repressor element plays a role in Igf2 imprinting. |
Volume: |
20 |
Issue: |
13 |
Pages: |
3518-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dull TJ |
Year: |
1984 |
Journal: |
Nature |
Title: |
Insulin-like growth factor II precursor gene organization in relation to insulin gene family. |
Volume: |
310 |
Issue: |
5980 |
Pages: |
777-81 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
103
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Leighton PA |
Year: |
1995 |
Journal: |
Genes Dev |
Title: |
An enhancer deletion affects both H19 and Igf2 expression. |
Volume: |
9 |
Issue: |
17 |
Pages: |
2079-89 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
180
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Blundell TL |
Year: |
1980 |
Journal: |
Nature |
Title: |
Hormone families: pancreatic hormones and homologous growth factors. |
Volume: |
287 |
Issue: |
5785 |
Pages: |
781-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bell GI |
Year: |
1979 |
Journal: |
Nature |
Title: |
Nucleotide sequence of a cDNA clone encoding human preproinsulin. |
Volume: |
282 |
Issue: |
5738 |
Pages: |
525-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bell GI |
Year: |
1980 |
Journal: |
Nature |
Title: |
Sequence of the human insulin gene. |
Volume: |
284 |
Issue: |
5751 |
Pages: |
26-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cooke RM |
Year: |
1991 |
Journal: |
Biochemistry |
Title: |
Solution structure of human insulin-like growth factor 1: a nuclear magnetic resonance and restrained molecular dynamics study. |
Volume: |
30 |
Issue: |
22 |
Pages: |
5484-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brange J |
Year: |
1997 |
Journal: |
Proteins |
Title: |
A model of insulin fibrils derived from the x-ray crystal structure of a monomeric insulin (despentapeptide insulin). |
Volume: |
27 |
Issue: |
4 |
Pages: |
507-16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Garibay-Tupas JL |
Year: |
1999 |
Journal: |
J Mol Endocrinol |
Title: |
Analysis of the 5'-upstream regions of the human relaxin H1 and H2 genes and their chromosomal localization on chromosome 9p24.1 by radiation hybrid and breakpoint mapping. |
Volume: |
23 |
Issue: |
3 |
Pages: |
355-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gunnersen JM |
Year: |
1996 |
Journal: |
Mol Cell Endocrinol |
Title: |
Expression of human relaxin genes: characterization of a novel alternatively-spliced human relaxin mRNA species. |
Volume: |
118 |
Issue: |
1-2 |
Pages: |
85-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kondo H |
Year: |
1996 |
Journal: |
J Mol Biol |
Title: |
Multiple gene copies for bombyxin, an insulin-related peptide of the silkmoth Bombyx mori: structural signs for gene rearrangement and duplication responsible for generation of multiple molecular forms of bombyxin. |
Volume: |
259 |
Issue: |
5 |
Pages: |
926-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sato A |
Year: |
1992 |
Journal: |
J Biochem |
Title: |
1H-NMR assignment and secondary structure of human insulin-like growth factor-I (IGF-I) in solution. |
Volume: |
111 |
Issue: |
4 |
Pages: |
529-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liao J |
Year: |
2021 |
Journal: |
Cell Rep |
Title: |
Prenatal correction of IGF2 to rescue the growth phenotypes in mouse models of Beckwith-Wiedemann and Silver-Russell syndromes. |
Volume: |
34 |
Issue: |
6 |
Pages: |
108729 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sakatani T |
Year: |
2005 |
Journal: |
Science |
Title: |
Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice. |
Volume: |
307 |
Issue: |
5717 |
Pages: |
1976-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ekström TJ |
Year: |
1994 |
Journal: |
Horm Res |
Title: |
Parental imprinting and the IGF2 gene. |
Volume: |
42 |
Issue: |
4-5 |
Pages: |
176-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakao K |
Year: |
2009 |
Journal: |
Biochem Biophys Res Commun |
Title: |
IGF2 modulates the microenvironment for osteoclastogenesis. |
Volume: |
378 |
Issue: |
3 |
Pages: |
462-6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2177638 |
Assay Type: |
Northern blot |
Annotation Date: |
2002-04-12 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1755028 |
|
Stage: |
TS28 |
Assay Id: |
MGI:2177649 |
Age: |
postnatal adult |
Image: |
4 |
|
Specimen Label: |
Igf2 2 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2177638 |
Assay Type: |
Northern blot |
Annotation Date: |
2002-04-12 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603923 |
|
Stage: |
TS23 |
Assay Id: |
MGI:2177649 |
Age: |
embryonic day 15.5 |
Image: |
4 |
|
Specimen Label: |
Igf2 1 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hammerle CM |
Year: |
2020 |
Journal: |
PLoS Genet |
Title: |
Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and function. |
Volume: |
16 |
Issue: |
10 |
Pages: |
e1009069 |
|
•
•
•
•
•
|
Publication |
First Author: |
Park KS |
Year: |
2017 |
Journal: |
Nucleic Acids Res |
Title: |
Loss of imprinting mutations define both distinct and overlapping roles for misexpression of IGF2 and of H19 lncRNA. |
Volume: |
45 |
Issue: |
22 |
Pages: |
12766-12779 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Heritable Phenotypic Marker |
Type: |
heritable_phenotypic_marker |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Weber M |
Year: |
2003 |
Journal: |
Mol Cell Biol |
Title: |
Genomic imprinting controls matrix attachment regions in the Igf2 gene. |
Volume: |
23 |
Issue: |
24 |
Pages: |
8953-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Duart-Garcia C |
Year: |
2014 |
Journal: |
Int J Genomics |
Title: |
Functional expression study of igf2 antisense transcript in mouse. |
Volume: |
2014 |
|
Pages: |
390296 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sun FL |
Year: |
1997 |
Journal: |
Nature |
Title: |
Transactivation of Igf2 in a mouse model of Beckwith-Wiedemann syndrome. |
Volume: |
389 |
Issue: |
6653 |
Pages: |
809-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Killian JK |
Year: |
2001 |
Journal: |
J Exp Zool |
Title: |
Monotreme IGF2 expression and ancestral origin of genomic imprinting. |
Volume: |
291 |
Issue: |
2 |
Pages: |
205-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Alzhanov D |
Year: |
2016 |
Journal: |
Physiol Genomics |
Title: |
Characterizing a distal muscle enhancer in the mouse Igf2 locus. |
Volume: |
48 |
Issue: |
2 |
Pages: |
167-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Haley VL |
Year: |
2012 |
Journal: |
EMBO Mol Med |
Title: |
Igf2 pathway dependency of the Trp53 developmental and tumour phenotypes. |
Volume: |
4 |
Issue: |
8 |
Pages: |
705-18 |
|
•
•
•
•
•
|
Publication |
First Author: |
Modi H |
Year: |
2015 |
Journal: |
Diabetes |
Title: |
Autocrine Action of IGF2 Regulates Adult β-Cell Mass and Function. |
Volume: |
64 |
Issue: |
12 |
Pages: |
4148-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Q |
Year: |
2023 |
Journal: |
Front Endocrinol (Lausanne) |
Title: |
Overexpression of IGF2 affects mouse weight and glycolipid metabolism and IGF2 is positively related to macrosomia. |
Volume: |
14 |
|
Pages: |
1030453 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1267017 |
Assay Type: |
RT-PCR |
Annotation Date: |
2015-10-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603916 |
|
Stage: |
TS16 |
Assay Id: |
MGI:5691926 |
Age: |
embryonic day 10.0 |
Image: |
8 |
|
Specimen Label: |
Igf2 N + |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Harper J |
Year: |
2006 |
Journal: |
Cancer Res |
Title: |
Soluble IGF2 receptor rescues Apc(Min/+) intestinal adenoma progression induced by Igf2 loss of imprinting. |
Volume: |
66 |
Issue: |
4 |
Pages: |
1940-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jones BK |
Year: |
2001 |
Journal: |
Hum Mol Genet |
Title: |
Deletion of a nuclease-sensitive region between the Igf2 and H19 genes leads to Igf2 misregulation and increased adiposity. |
Volume: |
10 |
Issue: |
8 |
Pages: |
807-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Murrell A |
Year: |
2001 |
Journal: |
EMBO Rep |
Title: |
An intragenic methylated region in the imprinted Igf2 gene augments transcription. |
Volume: |
2 |
Issue: |
12 |
Pages: |
1101-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sferruzzi-Perri AN |
Year: |
2011 |
Journal: |
Endocrinology |
Title: |
Placental-specific Igf2 deficiency alters developmental adaptations to undernutrition in mice. |
Volume: |
152 |
Issue: |
8 |
Pages: |
3202-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pant V |
Year: |
2004 |
Journal: |
Mol Cell Biol |
Title: |
Mutation of a single CTCF target site within the H19 imprinting control region leads to loss of Igf2 imprinting and complex patterns of de novo methylation upon maternal inheritance. |
Volume: |
24 |
Issue: |
8 |
Pages: |
3497-504 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dikkes P |
Year: |
2007 |
Journal: |
Brain Res |
Title: |
IGF2 knockout mice are resistant to kainic acid-induced seizures and neurodegeneration. |
Volume: |
1175 |
|
Pages: |
85-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fertan E |
Year: |
2023 |
Journal: |
Sci Rep |
Title: |
Noncanonical regulation of imprinted gene Igf2 by amyloid-beta 1-42 in Alzheimer's disease. |
Volume: |
13 |
Issue: |
1 |
Pages: |
2043 |
|
•
•
•
•
•
|
Publication |
First Author: |
Webber AL |
Year: |
1998 |
Journal: |
Nature |
Title: |
Location of enhancers is essential for the imprinting of H19 and Igf2 genes. |
Volume: |
391 |
Issue: |
6668 |
Pages: |
711-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pandey K |
Year: |
2023 |
Journal: |
Neuron |
Title: |
Neuronal activity drives IGF2 expression from pericytes to form long-term memory. |
Volume: |
111 |
Issue: |
23 |
Pages: |
3819-3836.e8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jones BK |
Year: |
1998 |
Journal: |
Genes Dev |
Title: |
Igf2 imprinting does not require its own DNA methylation or H19 RNA. |
Volume: |
12 |
Issue: |
14 |
Pages: |
2200-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schmidt JV |
Year: |
1999 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Enhancer competition between H19 and Igf2 does not mediate their imprinting. |
Volume: |
96 |
Issue: |
17 |
Pages: |
9733-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Feil R |
Year: |
1994 |
Journal: |
Development |
Title: |
Developmental control of allelic methylation in the imprinted mouse Igf2 and H19 genes. |
Volume: |
120 |
Issue: |
10 |
Pages: |
2933-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sandovici I |
Year: |
2021 |
Journal: |
Sci Rep |
Title: |
Autocrine IGF2 programmes β-cell plasticity under conditions of increased metabolic demand. |
Volume: |
11 |
Issue: |
1 |
Pages: |
7717 |
|
•
•
•
•
•
|